NU7441(KU-57788) (BioDeep_00000719808)
代谢物信息卡片
化学式: C25H19NO3S (413.1085584000001)
中文名称: KU-57788
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC5=C4SC6=CC=CC=C56
InChI: InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ashley N Chandra, Sayanthooran Saravanabavan, Gopala K Rangan. Role of DNA-Dependent Protein Kinase in Mediating Cyst Growth in Autosomal Dominant Polycystic Kidney Disease.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910512. [PMID: 34638853] - Noushin Miralaei, Ahmad Majd, Kamran Ghaedi, Maryam Peymani, Masoomeh Safaei. Integrated pan-cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance.
Cancer medicine.
2021 09; 10(18):6428-6441. doi:
10.1002/cam4.4161. [PMID: 34337875] - David K Harrison, Zachary J Waldrip, Lyle Burdine, Sara C Shalin, Marie Schluterman Burdine. DNA-PKcs Inhibition Extends Allogeneic Skin Graft Survival.
Transplantation.
2021 03; 105(3):540-549. doi:
10.1097/tp.0000000000003442. [PMID: 32890138] - Leticia Toledo-Sherman, Perla Breccia, Roger Cachope, Jennifer R Bate, Ivan Angulo-Herrera, Grant Wishart, Kim L Matthews, Sarah L Martin, Helen C Cox, George McAllister, Stephen D Penrose, Huw Vater, William Esmieu, Amanda Van de Poël, Rhea Van de Bospoort, Annelieke Strijbosch, Marieke Lamers, Philip Leonard, Rebecca E Jarvis, Wesley Blackaby, Karen Barnes, Maria Eznarriaga, Simon Dowler, Graham D Smith, David F Fischer, Ovadia Lazari, Dawn Yates, Mark Rose, Sung-Wook Jang, Ignacio Muñoz-Sanjuan, Celia Dominguez. Optimization of Potent and Selective Ataxia Telangiectasia-Mutated Inhibitors Suitable for a Proof-of-Concept Study in Huntington's Disease Models.
Journal of medicinal chemistry.
2019 03; 62(6):2988-3008. doi:
10.1021/acs.jmedchem.8b01819. [PMID: 30840447] - Bing Zheng, Jia-Hui Mao, Xiao-Qing Li, Lin Qian, Hua Zhu, Dong-Hua Gu, Xiao-Dong Pan. Over-expression of DNA-PKcs in renal cell carcinoma regulates mTORC2 activation, HIF-2α expression and cell proliferation.
Scientific reports.
2016 07; 6(?):29415. doi:
10.1038/srep29415. [PMID: 27412013] - R J Flassig, G Maubach, C Täger, K Sundmacher, M Naumann. Experimental design, validation and computational modeling uncover DNA damage sensing by DNA-PK and ATM.
Molecular bioSystems.
2014 Jul; 10(7):1978-86. doi:
10.1039/c4mb00093e. [PMID: 24833308] - Emily Mould, Philip Berry, David Jamieson, Christopher Hill, Celine Cano, Niu Tan, Sarah Elliott, Barbara Durkacz, David Newell, Elaine Willmore. Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity.
Biochemical pharmacology.
2014 Mar; 88(1):58-65. doi:
10.1016/j.bcp.2014.01.001. [PMID: 24418411]