sincalide (BioDeep_00000719705)
代谢物信息卡片
Cholecystokinin Octapeptide (sulfated) ammonium salt
化学式: C49H62N10O16S3 (1142.3507212000002)
中文名称: CCK八肽硫酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CSCCC(C(=O)NCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N)NC(=O)C(CC4=CC=C(C=C4)OS(=O)(=O)O)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C49H62N10O16S3/c1-76-18-16-34(55-47(69)37(58-44(66)32(50)23-41(61)62)21-28-12-14-30(15-13-28)75-78(72,73)74)45(67)53-26-40(60)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(70)56-35(17-19-77-2)46(68)59-39(24-42(63)64)49(71)57-36(43(51)65)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52H,16-24,26,50H2,1-2H3,(H2,51,65)(H,53,67)(H,54,60)(H,55,69)(H,56,70)(H,57,71)(H,58,66)(H,59,68)(H,61,62)(H,63,64)(H,72,73,74)/t32-,34-,35-,36-,37-,38-,39-/m0/s1
描述信息
V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CC - Tests for bile duct patency
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. CCK‐8 can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. CCK‐8 is a major bioactive segment of CCK that retains most of the biological activities of CCK[1][2][3].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135946
- KEGGdrug: D05845
- PubChem: 9833444
- DrugBank: DB09142
- ChEMBL: CHEMBL1121
- MeSH: Sincalide
- CAS: 25126-32-3
- medchemexpress: HY-P0093
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xinchen Tian, Fen Liu, Zijian Wang, Jiaqi Zhang, Qingbin Liu, Yiming Zhang, Dengtian Zhang, Chen Huang, Jing Zhao, Shulong Jiang. Modified Biejia Jianwan decoction restrains PD-L1-mediated immune evasion through the HIF-1α/STAT3/NF-κB signaling pathway.
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10.1016/j.jep.2023.117577. [PMID: 38104877] - Longfei Li, Qianqian Fan, Yixuan Zhao, Qian Zhang, Gaofeng Qin, Chen Li, Wei Li. Gentiopicroside ameliorates the lipopolysaccharide-induced inflammatory response and hypertrophy in chondrocytes.
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Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology.
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Journal of ethnopharmacology.
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Journal of ethnopharmacology.
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
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Applied biochemistry and biotechnology.
2023 May; ?(?):. doi:
10.1007/s12010-023-04520-y. [PMID: 37178251] - Chunli Hu, Xue Feng, Yanfen Ma, Dawei Wei, Lingkai Zhang, Shuzhe Wang, Yun Ma. CircADAMTS16 Inhibits Differentiation and Promotes Proliferation of Bovine Adipocytes by Targeting miR-10167-3p.
Cells.
2023 04; 12(8):. doi:
10.3390/cells12081175. [PMID: 37190084] - Alexander Tamalunas, Amin Wendt, Florian Springer, Victor Vigodski, Anna Ciotkowska, Beata Rutz, Ruixiao Wang, Ru Huang, Yuhan Liu, Heiko Schulz, Stephan Ledderose, Thomas Kolben, Giuseppe Magistro, Christian G Stief, Martin Hennenberg. Permixon®, hexane-extracted Serenoa repens, inhibits human prostate and bladder smooth muscle contraction and exerts growth-related functions in human prostate stromal cells.
Life sciences.
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Molecular metabolism.
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Journal of experimental & clinical cancer research : CR.
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Medicine.
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The Kaohsiung journal of medical sciences.
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Cellular & molecular biology letters.
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eLife.
2022 09; 11(?):. doi:
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Neoplasma.
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British journal of pharmacology.
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Scientific reports.
2022 06; 12(1):9215. doi:
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Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery.
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Anti-cancer agents in medicinal chemistry.
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Oxidative medicine and cellular longevity.
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10.1155/2022/6264474. [PMID: 36275890] - Lichuang Wu, Chenxian Su, Chuanhua Yang, Jinxing Liu, Yiheng Ye. TBX3 regulates the transcription of VEGFA to promote osteoblasts proliferation and microvascular regeneration.
PeerJ.
2022; 10(?):e13722. doi:
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Theranostics.
2022; 12(14):6291-6307. doi:
10.7150/thno.71456. [PMID: 36168624] - Feng Yu, Xian-Jun Pan, Jie Luo. Identification and Verification of Key Tumor Genes Associated with Diagnosis and Prognosis of Breast Cancer Based on Bioinformatics Analysis.
Disease markers.
2022; 2022(?):9041466. doi:
10.1155/2022/9041466. [PMID: 35686034] - Guangxian Mao, Zhimin Mu, Da Wu. Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer.
Human & experimental toxicology.
2021 Dec; 40(12_suppl):S318-S330. doi:
10.1177/09603271211041997. [PMID: 34477002] - Yu-Ye Xue, Yun-Yang Lu, Guang-Qiang Sun, Fei Fang, Yu-Qiang Ji, Hai-Feng Tang, Peng-Cheng Qiu, Guang Cheng. CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.
Die Pharmazie.
2021 05; 76(5):208-214. doi:
10.1691/ph.2021.1363. [PMID: 33964994] - Taleah Farasyn, Chao Xu, Wei Yue. Development of a Rat Sandwich-Cultured Hepatocytes Model Expressing Functional Human Organic Anion Transporting Polypeptide (OATP) 1B3: A Potential Screening Tool for Liver-Targeting Compounds.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2021; 24(?):475-483. doi:
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Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2020 Dec; 62(?):126626. doi:
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Esophagus : official journal of the Japan Esophageal Society.
2020 10; 17(4):456-467. doi:
10.1007/s10388-020-00735-8. [PMID: 32240421] - Tingying Jiao, Xinpeng Yao, Yingyuan Zhao, Yanying Zhou, Yue Gao, Shicheng Fan, Panpan Chen, Xuan Li, Yiming Jiang, Xiao Yang, Frank J Gonzalez, Min Huang, Huichang Bi. Dexamethasone-Induced Liver Enlargement Is Related to PXR/YAP Activation and Lipid Accumulation but Not Hepatocyte Proliferation.
Drug metabolism and disposition: the biological fate of chemicals.
2020 09; 48(9):830-839. doi:
10.1124/dmd.120.000061. [PMID: 32561593] - Yuchen Zhang, Melissa Ruggiero, Bruno Hagenbuch. OATP1B3 Expression and Function is Modulated by Coexpression with OCT1, OATP1B1, and NTCP.
Drug metabolism and disposition: the biological fate of chemicals.
2020 08; 48(8):622-630. doi:
10.1124/dmd.119.089847. [PMID: 32482756] - Can Wang, Cuili Zhang, Dongdong Wu, Lu Guo, Fali Zhao, Jinxin Lv, Lu Fu. Cholecystokinin octapeptide reduces myocardial fibrosis and improves cardiac remodeling in post myocardial infarction rats.
The international journal of biochemistry & cell biology.
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Cell research.
2020 03; 30(3):269-271. doi:
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European review for medical and pharmacological sciences.
2019 Sep; 23(18):7826-7834. doi:
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European review for medical and pharmacological sciences.
2019 May; 23(10):4066-4072. doi:
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Journal of medicinal chemistry.
2019 02; 62(3):1407-1419. doi:
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Mediators of inflammation.
2019; 2019(?):7241418. doi:
10.1155/2019/7241418. [PMID: 31915416] - H X Ren, Q C Tang, L Yan, H Xia, H S Luo. Evodiamine inhibits gastrointestinal motility via CCK and CCK1 receptor in water-avoidence stress rat model.
Life sciences.
2018 Sep; 209(?):210-216. doi:
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American journal of physiology. Endocrinology and metabolism.
2018 09; 315(3):E374-E385. doi:
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Life sciences.
2018 Jul; 204(?):71-77. doi:
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European review for medical and pharmacological sciences.
2018 06; 22(12):3635-3642. doi:
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The Journal of endocrinology.
2018 03; 236(3):137-150. doi:
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Diabetes, obesity & metabolism.
2018 02; 20(2):362-369. doi:
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Nutrition (Burbank, Los Angeles County, Calif.).
2017 Nov; 43-44(?):69-74. doi:
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Neuroreport.
2017 Jun; 28(9):533-539. doi:
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2017 May; 42(5):517-521. doi:
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Journal of ethnopharmacology.
2017 Apr; 202(?):28-37. doi:
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Molecules and cells.
2017 Feb; 40(2):109-116. doi:
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Immunopharmacology and immunotoxicology.
2017 Feb; 39(1):2-10. doi:
10.1080/08923973.2016.1255225. [PMID: 27875906] - Peng Li, Kun Ma, Hao-Yu Wu, Yan-Ping Wu, Bai-Xiang Li. Isoflavones Induce BEX2-Dependent Autophagy to Prevent ATR-Induced Neurotoxicity in SH-SY5Y Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 43(5):1866-1879. doi:
10.1159/000484075. [PMID: 29049987] - Shiqing Song, Faliang Lin, Pengyan Zhu, Changyan Wu, Shuling Zhao, Qiao Han, Xiaomei Li. Extract of Spatholobus suberctus Dunn ameliorates ischemia-induced injury by targeting miR-494.
PloS one.
2017; 12(9):e0184348. doi:
10.1371/journal.pone.0184348. [PMID: 28880896] - Aaron A May, Min Liu, Stephen C Woods, Denovan P Begg. CCK increases the transport of insulin into the brain.
Physiology & behavior.
2016 10; 165(?):392-7. doi:
10.1016/j.physbeh.2016.08.025. [PMID: 27570192] - Qing-Fang Meng, Zheng Zhang, Yan-Jun Wang, Wei Chen, Fei-Fei Li, Long-Tao Yue, Chang-Jun Zhang, Heng Li, Min Zhang, Cong-Cong Wang, Peng Zhang, Hui Chen, Rui-Sheng Duan, Shan-Mei Sun, Yan-Bin Li. Astilbin ameliorates experimental autoimmune myasthenia gravis by decreased Th17 cytokines and up-regulated T regulatory cells.
Journal of neuroimmunology.
2016 09; 298(?):138-45. doi:
10.1016/j.jneuroim.2016.07.016. [PMID: 27609287] - Hai-En Ning, Jiang-Hong Ling, Gang Linag, Zhi Zhang, Yu-Jiao Wang. [Effects of Chaihu Shugan Powder on the Cytoactivity of Rat Interstitial Cells of Cajal and Intracellu- lar Ca²+ Concentration].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2016 Sep; 36(9):1091-1096. doi:
NULL. [PMID: 30645849] - Zhong-Hou Rong, Hong-Yuan Chen, Xin-Xing Wang, Zhi-Yi Wang, Guo-Zhe Xian, Bang-Zhen Ma, Cheng-Kun Qin, Zhen-Hai Zhang. Effects of sphincter of Oddi motility on the formation of cholesterol gallstones.
World journal of gastroenterology.
2016 Jun; 22(24):5540-7. doi:
10.3748/wjg.v22.i24.5540. [PMID: 27350732] - ShreeRanga Nagaraj, Uma V Manjappara. Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters.
Biochimie.
2016 Jun; 125(?):126-30. doi:
10.1016/j.biochi.2016.03.009. [PMID: 27032885] - Bingwu Xie, Ranran Zhang, Huan Zhang, Anxiu Xu, Yi Deng, Yalin Lv, Feng Deng, Shicheng Wei. Decoration of heparin and bovine serum albumin on polysulfone membrane assisted via polydopamine strategy for hemodialysis.
Journal of biomaterials science. Polymer edition.
2016 06; 27(9):880-97. doi:
10.1080/09205063.2016.1169479. [PMID: 27018964] - JunYuan Zheng, JiangHong Wu, Jing Chen, Jie Liu, YingYing Lu, ChunLan Huang, GuoYong Hu, XingPeng Wang, Yue Zeng. Therapeutic effects of quercetin on early inflammation in hypertriglyceridemia-related acute pancreatitis and its mechanism.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2016 Mar; 16(2):200-10. doi:
10.1016/j.pan.2016.01.005. [PMID: 26873426] - Catherine Gibbons, Graham Finlayson, Phillipa Caudwell, Dominic-Luc Webb, Per M Hellström, Erik Näslund, John E Blundell. Postprandial profiles of CCK after high fat and high carbohydrate meals and the relationship to satiety in humans.
Peptides.
2016 Mar; 77(?):3-8. doi:
10.1016/j.peptides.2015.09.010. [PMID: 26429068] - Chengjin Zhao, Wenjuan Chen, Shirong Dai, Xiubing Zhang, Na Ban, Shaochen Fan, Zhen Bao, Jie Sun, Chaoyan Shen, Xiaojie Xia, Li Zhang, Jianbing Ren. Expression and clinical role of RBQ3 in gliomas.
Journal of the neurological sciences.
2015 Dec; 359(1-2):177-84. doi:
10.1016/j.jns.2015.10.058. [PMID: 26671109] - Nigel Irwin, Varun Pathak, Peter R Flatt. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice.
Diabetes.
2015 Aug; 64(8):2996-3009. doi:
10.2337/db15-0220. [PMID: 25883113] - Claire B de La Serre, Guillaume de Lartigue, Helen E Raybould. Chronic exposure to low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons.
Physiology & behavior.
2015 Feb; 139(?):188-94. doi:
10.1016/j.physbeh.2014.10.032. [PMID: 25446227] - Chun-feng Zhang, Kai Kang, Xin-miao Li, Bao-dong Xie. MicroRNA-136 Promotes Vascular Muscle Cell Proliferation Through the ERK1/2 Pathway by Targeting PPP2R2A in Atherosclerosis.
Current vascular pharmacology.
2015; 13(3):405-12. doi:
10.2174/1570161112666141118094612. [PMID: 25409743] - Ye Huang, Yuan Ma, Yujia Guo, Lang Zou, Hongwei Jin, Lijun Zhong, Yun Wu, Lihe Zhang, Zhenjun Yang. Exploring directional invasion of serum nuclease into siRNA duplexes by asymmetrical terminal modifications.
ChemMedChem.
2014 Sep; 9(9):2111-9. doi:
10.1002/cmdc.201402115. [PMID: 25044832] - Zhen-Hai Zhang, Cheng-Kun Qin, Shuo-Dong Wu, Jian Xu, Xian-Ping Cui, Zhi-Yi Wang, Guo-Zhe Xian. Roles of sphincter of Oddi motility and serum vasoactive intestinal peptide, gastrin and cholecystokinin octapeptide.
World journal of gastroenterology.
2014 Apr; 20(16):4730-6. doi:
10.3748/wjg.v20.i16.4730. [PMID: 24782626] - Zhen Li, Florence Shin Gee Cheung, Jian Zheng, Ting Chan, Ling Zhu, Fanfan Zhou. Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters.
Journal of biochemical and molecular toxicology.
2014 Feb; 28(2):91-7. doi:
10.1002/jbt.21540. [PMID: 24265111] - Rong-Ping Zhou, Gang Chen, Zhi-Li Shen, Li-Qun Pan. Cinobufacin suppresses cell proliferation via miR-494 in BGC- 823 gastric cancer cells.
Asian Pacific journal of cancer prevention : APJCP.
2014; 15(3):1241-5. doi:
10.7314/apjcp.2014.15.3.1241. [PMID: 24606447] - L M Nemtsov. [Blood serum cholecystokinin and clinical-functional variability of biliary pathology].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2014; ?(12):24-9. doi:
NULL. [PMID: 26058108] - Xiu-Li Zheng, Yu Yang, Bao-Jia Wang, Hong-Qu Tang, Xu-Rui Zheng, Jian-Hong Ye. [Changes of CCK-8, CGRP, SP, and VIP in the colon and the lung tissue of allergic asthma model rats: an experimental observation].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2013 Dec; 33(12):1668-71. doi:
". [PMID: 24517067] - Frank A Duca, Li Zhong, Mihai Covasa. Reduced CCK signaling in obese-prone rats fed a high fat diet.
Hormones and behavior.
2013 Nov; 64(5):812-7. doi:
10.1016/j.yhbeh.2013.09.004. [PMID: 24100196] - N Irwin, I A Montgomery, F P M O'Harte, P Frizelle, P R Flatt. Comparison of the independent and combined metabolic effects of subchronic modulation of CCK and GIP receptor action in obesity-related diabetes.
International journal of obesity (2005).
2013 Aug; 37(8):1058-63. doi:
10.1038/ijo.2012.179. [PMID: 23164696] - T F Degolier, D R Brown, G E Duke, M M Palmer, J R Swenson, R E Carraway. Neurotensin and cholecystokinin contract gallbladder circular muscle in chickens.
Poultry science.
2013 Aug; 92(8):2156-62. doi:
10.3382/ps.2013-03079. [PMID: 23873564] - Zong-Yang Li, Zhi Guo, Ya-Min Liu, Xin-Min Liu, Qi Chang, Yong-hong Liao, Rui-Le Pan. Neuroprotective effects of total saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells.
Journal of ethnopharmacology.
2013 Jul; 148(3):794-803. doi:
10.1016/j.jep.2013.04.057. [PMID: 23694845] - Chi-Chen Lu, Mei-Yi Lin, Syue-Yi Chen, Cheng-Huang Shen, Lih-Geeng Chen, Hsiao-Yen Hsieh, Michael W Y Chan, Cheng-Da Hsu. The investigation of a traditional Chinese medicine, Guizhi Fuling Wan (GFW) as an intravesical therapeutic agent for urothelial carcinoma of the bladder.
BMC complementary and alternative medicine.
2013 Feb; 13(?):44. doi:
10.1186/1472-6882-13-44. [PMID: 23433042] - Pingqian Zhao, Yuan Deng, Ping Gu, Yefei Wang, Huifang Zhou, Yamin Hu, Ping Chen, Xianqun Fan. Insulin-like growth factor 1 promotes the proliferation and adipogenesis of orbital adipose-derived stromal cells in thyroid-associated ophthalmopathy.
Experimental eye research.
2013 Feb; 107(?):65-73. doi:
10.1016/j.exer.2012.11.014. [PMID: 23219871] - Nigel Irwin, Pamela Frizelle, Finbarr P M O'Harte, Peter R Flatt. Metabolic effects of activation of CCK receptor signaling pathways by twice-daily administration of the enzyme-resistant CCK-8 analog, (pGlu-Gln)-CCK-8, in normal mice.
The Journal of endocrinology.
2013 Jan; 216(1):53-9. doi:
10.1530/joe-12-0353. [PMID: 23055535] - Subhankar Dolai, Tao Liang, Patrick P L Lam, Nestor A Fernandez, Subbulaksmi Chidambaram, Herbert Y Gaisano. Effects of ethanol metabolites on exocytosis of pancreatic acinar cells in rats.
Gastroenterology.
2012 Sep; 143(3):832-843.e7. doi:
10.1053/j.gastro.2012.06.011. [PMID: 22710192] - Bing Cao, Xu Zhang, Ni Yan, Shengliang Chen, Ying Li. Cholecystokinin enhances visceral pain-related affective memory via vagal afferent pathway in rats.
Molecular brain.
2012 Jun; 5(?):19. doi:
10.1186/1756-6606-5-19. [PMID: 22681758] - Ming-Ming Ma, Shi-Yang Li, Mi Wang, Yong-Yuan Guan. Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway.
Journal of cardiovascular pharmacology.
2012 Jun; 59(6):576-82. doi:
10.1097/fjc.0b013e318250ba2c. [PMID: 22392066] - Rui Yang, Jie Pu, Juan Guo, Feng Xu, Zheng Zhang, Youshan Zhao, Xi Zhang, Shucheng Gu, Chunkang Chang, Xiao Li. The biological behavior of SDF-1/CXCR4 in patients with myelodysplastic syndrome.
Medical oncology (Northwood, London, England).
2012 Jun; 29(2):1202-8. doi:
10.1007/s12032-011-9943-7. [PMID: 21556934] - Chiranjit Ghosh, Ha-Yull Chung, Rahul M Nandre, John Hwa Lee, Tae-Il Jeon, In-Sook Kim, Seung Hak Yang, Seong-Gu Hwang. An active extract of Ulmus pumila inhibits adipogenesis through regulation of cell cycle progression in 3T3-L1 cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Jun; 50(6):2009-15. doi:
10.1016/j.fct.2012.03.056. [PMID: 22445738] - Satoshi Miyamoto, Kenichi Shikata, Kyoko Miyasaka, Shinichi Okada, Motofumi Sasaki, Ryo Kodera, Daisho Hirota, Nobuo Kajitani, Tetsuharu Takatsuka, Hitomi Usui Kataoka, Shingo Nishishita, Chikage Sato, Akihiro Funakoshi, Hisakazu Nishimori, Haruhito Adam Uchida, Daisuke Ogawa, Hirofumi Makino. Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin.
Diabetes.
2012 Apr; 61(4):897-907. doi:
10.2337/db11-0402. [PMID: 22357963] - Tetsuya Tachibana, Kiyoko Matsuda, Motoko Kawamura, Hiroshi Ueda, Md Sakirul Islam Khan, Mark A Cline. Feeding-suppressive mechanism of sulfated cholecystokinin (26-33) in chicks.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2012 Apr; 161(4):372-8. doi:
10.1016/j.cbpa.2011.12.010. [PMID: 22227312] - Jingchuan Zhang, Robert C Ritter. Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms.
American journal of physiology. Regulatory, integrative and comparative physiology.
2012 Jan; 302(2):R264-73. doi:
10.1152/ajpregu.00114.2011. [PMID: 22031786] - Yoshihisa Shitara, Kumiko Takeuchi, Yoshiko Nagamatsu, Satomi Wada, Yuichi Sugiyama, Toshiharu Horie. Long-lasting inhibitory effects of cyclosporin A, but not tacrolimus, on OATP1B1- and OATP1B3-mediated uptake.
Drug metabolism and pharmacokinetics.
2012; 27(4):368-78. doi:
10.2133/dmpk.dmpk-11-rg-096. [PMID: 22240838] - Jin Chan, Tang Ying, Yang F Guang, Li X Lin, Tang Kai, Zhang Y Fang, Ye X Ting, Lin F Xing, Yang Y Ji. In vitro toxicity evaluation of 25-nm anatase TiO2 nanoparticles in immortalized keratinocyte cells.
Biological trace element research.
2011 Dec; 144(1-3):183-96. doi:
10.1007/s12011-011-9064-3. [PMID: 21552994] - Mei-Xian Xiang, Han-Wen Su, Jinyue Hu, Yun-Jun Yan. Stimulative effects of Polygonum amplexicaule var. sinense on osteoblastic MC3T3-E1 cells.
Pharmaceutical biology.
2011 Oct; 49(10):1091-6. doi:
10.3109/13880209.2011.568507. [PMID: 21595574] - Jia Guo, Hai-Yan Zhang, Tao Jin, Long Zhao, Li Wen, Lei Huang, Ping Xue, Zheng-Yu Cheng, Xiao-Nan Yang, Qing Xia. [Effect of chai qin cheng qi decoction on serum CCK-8 and calcium overload of pancreatic acinar in mice with acute pancreatitis].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2011 Sep; 42(5):704-6. doi:
NULL. [PMID: 22007503] - Ute I Schwarz, Henriette E Meyer zu Schwabedissen, Rommel G Tirona, Atsuko Suzuki, Brenda F Leake, Younes Mokrab, Kenji Mizuguchi, Richard H Ho, Richard B Kim. Identification of novel functional organic anion-transporting polypeptide 1B3 polymorphisms and assessment of substrate specificity.
Pharmacogenetics and genomics.
2011 Mar; 21(3):103-14. doi:
10.1097/fpc.0b013e328342f5b1. [PMID: 21278621] - Tomoyuki Iwata, Fumihiko Nozu, Michio Imawari. Ethanol impairs the assembly and disassembly of actin cytoskeleton and cell adhesion via the RhoA signaling pathway, catenin p120 and E-cadherin in CCK-stimulated pancreatic acini.
Biochemical and biophysical research communications.
2011 Feb; 405(4):558-63. doi:
10.1016/j.bbrc.2011.01.067. [PMID: 21262198] - Yuko Yamada, Kousaku Ohinata, Andrzej W Lipkowski, Masaaki Yoshikawa. Rapakinin, Arg-Ile-Tyr, derived from rapeseed napin, shows anti-opioid activity via the prostaglandin IP receptor followed by the cholecystokinin CCK(2) receptor in mice.
Peptides.
2011 Feb; 32(2):281-5. doi:
10.1016/j.peptides.2010.11.015. [PMID: 21129424]