Dihydrokainic acid (BioDeep_00000719685)

   


代谢物信息卡片


Dihydrokainic acid

化学式: C10H17NO4 (215.1157522)
中文名称: 二氢海藻酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1CNC(C1CC(=O)O)C(=O)O
InChI: InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

Dihydrokainic acid



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mikko Gynther, Aleksanteri Petsalo, Steen H Hansen, Lennart Bunch, Darryl S Pickering. Blood-brain barrier permeability and brain uptake mechanism of kainic acid and dihydrokainic acid. Neurochemical research. 2015 Mar; 40(3):542-9. doi: 10.1007/s11064-014-1499-4. [PMID: 25488153]
  • N Joe, V Scott, C H Brown. Glial regulation of extrasynaptic NMDA receptor-mediated excitation of supraoptic nucleus neurones during dehydration. Journal of neuroendocrinology. 2014 Jan; 26(1):35-42. doi: 10.1111/jne.12121. [PMID: 24267175]
  • Xianlin Sun, Jingquan Zhong, Deguo Wang, Jian Xu, Hao Su, Chunsheng An, Hongjun Zhu, Ji Yan. Increasing glutamate promotes ischemia-reperfusion-induced ventricular arrhythmias in rats in vivo. Pharmacology. 2014; 93(1-2):4-9. doi: 10.1159/000356311. [PMID: 24401762]
  • Sabry M Attia, Saleh A Bakheet. Effect of dihydrokainate on the capacity of repair of DNA damage and apoptosis induced by doxorubicin. Mutagenesis. 2013 May; 28(3):257-61. doi: 10.1093/mutage/ges079. [PMID: 23360835]
  • László Héja, Péter Barabás, Gabriella Nyitrai, Katalin A Kékesi, Bálint Lasztóczi, Orsolya Toke, Gábor Tárkányi, Karsten Madsen, Arne Schousboe, Arpád Dobolyi, Miklós Palkovits, Julianna Kardos. Glutamate uptake triggers transporter-mediated GABA release from astrocytes. PloS one. 2009 Sep; 4(9):e7153. doi: 10.1371/journal.pone.0007153. [PMID: 19777062]
  • Yuan Lin, Guilian Tian, Kenny Roman, Chalonda Handy, Joseph B Travers, Chien-Liang Glenn Lin, Robert L Stephens. Increased glial glutamate transporter EAAT2 expression reduces visceral nociceptive response in mice. American journal of physiology. Gastrointestinal and liver physiology. 2009 Jan; 296(1):G129-34. doi: 10.1152/ajpgi.90556.2008. [PMID: 19023027]
  • Emanuelle Sagot, Anders A Jensen, Darryl S Pickering, Xiaosui Pu, Michelle Umberti, Tine B Stensbøl, Birgitte Nielsen, Zeinab Assaf, Bétina Aboab, Jean Bolte, Thierry Gefflaut, Lennart Bunch. Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2. Journal of medicinal chemistry. 2008 Jul; 51(14):4085-92. doi: 10.1021/jm800091e. [PMID: 18578477]
  • Luca Raiteri, Simona Zappettini, Marco Milanese, Ernesto Fedele, Maurizio Raiteri, Giambattista Bonanno. Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations. Journal of neurochemistry. 2007 Nov; 103(3):952-61. doi: 10.1111/j.1471-4159.2007.04784.x. [PMID: 17662048]
  • Solveig Henjum, Bjørnar Hassel. High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study. Neurochemistry international. 2007 Apr; 50(5):696-702. doi: 10.1016/j.neuint.2007.01.002. [PMID: 17316904]
  • Barbara Begni, Lucio Tremolizzo, Cristina D'Orlando, Maria Serena Bono, Rosanna Garofolo, Marco Longoni, Carlo Ferrarese. Substrate-induced modulation of glutamate uptake in human platelets. British journal of pharmacology. 2005 Jul; 145(6):792-9. doi: 10.1038/sj.bjp.0706242. [PMID: 15880141]
  • Julie V Selkirk, Theodore H Stiefel, Ida M Stone, Greg S Naeve, Alan C Foster, David J Poulsen. Over-expression of the human EAAT2 glutamate transporter within neurons of mouse organotypic hippocampal slice cultures leads to increased vulnerability of CA1 pyramidal cells. The European journal of neuroscience. 2005 Apr; 21(8):2291-6. doi: 10.1111/j.1460-9568.2005.04059.x. [PMID: 15869527]
  • Nicolas Vanhoutte, Isabelle de Hemptinne, Céline Vermeiren, Jean-Marie Maloteaux, Emmanuel Hermans. In vitro differentiated neural stem cells express functional glial glutamate transporters. Neuroscience letters. 2004 Nov; 370(2-3):230-5. doi: 10.1016/j.neulet.2004.08.039. [PMID: 15488328]
  • Jia-hua Hu, Na Yang, Ying-hua Ma, Jie Jiang, Jin-fu Zhang, Jian Fei, Li-he Guo. Identification of glutamate transporters and receptors in mouse testis. Acta pharmacologica Sinica. 2004 Mar; 25(3):366-71. doi: NULL. [PMID: 15000892]
  • Yaxiong Yang, Gregory A Kinney, William J Spain, John C S Breitner, David G Cook. Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. Journal of neurochemistry. 2004 Mar; 88(6):1361-72. doi: 10.1046/j.1471-4159.2003.02279.x. [PMID: 15009636]
  • Chiara Zoia, Tiziana Cogliati, Elena Tagliabue, Guido Cavaletti, Gessica Sala, Gloria Galimberti, Ilaria Rivolta, Vincenzo Rossi, Lodovico Frattola, Carlo Ferrarese. Glutamate transporters in platelets: EAAT1 decrease in aging and in Alzheimer's disease. Neurobiology of aging. 2004 Feb; 25(2):149-57. doi: 10.1016/s0197-4580(03)00085-x. [PMID: 14749132]
  • Jia Hua Hu, Na Yang, Ying Hua Ma, Jie Jiang, Jin Fu Zhang, Jian Fei, Li He Guo. Identification of glutamate receptors and transporters in mouse and human sperm. Journal of andrology. 2004 Jan; 25(1):140-6. doi: 10.1002/j.1939-4640.2004.tb02769.x. [PMID: 14662797]
  • Yongmei Chen, Raymond A Swanson. The glutamate transporters EAAT2 and EAAT3 mediate cysteine uptake in cortical neuron cultures. Journal of neurochemistry. 2003 Mar; 84(6):1332-9. doi: 10.1046/j.1471-4159.2003.01630.x. [PMID: 12614333]
  • G Rebillard, J Ruel, R Nouvian, H Saleh, R Pujol, Y Dehnes, J Raymond, J L Puel, G Devau. Glutamate transporters in the guinea-pig cochlea: partial mRNA sequences, cellular expression and functional implications. The European journal of neuroscience. 2003 Jan; 17(1):83-92. doi: 10.1046/j.1460-9568.2003.02429.x. [PMID: 12534971]
  • Dwight E Bergles, Anastassios V Tzingounis, Craig E Jahr. Comparison of coupled and uncoupled currents during glutamate uptake by GLT-1 transporters. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002 Dec; 22(23):10153-62. doi: 10.1523/jneurosci.22-23-10153.2002. [PMID: 12451116]
  • Travis Denton, Todd Seib, Richard Bridges, Charles Thompson. Synthesis and preliminary evaluation of trans-3,4-conformationally-restricted glutamate and pyroglutamate analogues as novel EAAT2 inhibitors. Bioorganic & medicinal chemistry letters. 2002 Nov; 12(21):3209-13. doi: 10.1016/s0960-894x(02)00520-6. [PMID: 12372536]
  • S Gaillet, C Plachez, F Malaval, M F Bézine, M Récasens. Transient increase in the high affinity [3H]-L-glutamate uptake activity during in vitro development of hippocampal neurons in culture. Neurochemistry international. 2001 Apr; 38(4):293-301. doi: 10.1016/s0197-0186(00)00098-x. [PMID: 11137623]
  • D Trotti, M Aoki, P Pasinelli, U V Berger, N C Danbolt, R H Brown, M A Hediger. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. The Journal of biological chemistry. 2001 Jan; 276(1):576-82. doi: 10.1074/jbc.m003779200. [PMID: 11031254]
  • L M Levy, O Warr, D Attwell. Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 Dec; 18(23):9620-8. doi: 10.1523/jneurosci.18-23-09620.1998. [PMID: 9822723]
  • J Dunlop, H Beal McIlvain, Z Lou, R Franco. The pharmacological profile of L-glutamate transport in human NT2 neurones is consistent with excitatory amino acid transporter 2. European journal of pharmacology. 1998 Nov; 360(2-3):249-56. doi: 10.1016/s0014-2999(98)00675-x. [PMID: 9851592]
  • M A Moro, J C Leza, P Lorenzo, I Lizasoain. Peroxynitrite causes aspartate release from dissociated rat cerebellar granule neurones. Free radical research. 1998 Feb; 28(2):193-204. doi: 10.3109/10715769809065804. [PMID: 9645395]