Dihydrexidine (BioDeep_00000719674)
代谢物信息卡片
化学式: C17H17NO2 (267.1259)
中文名称: 二受体激动剂盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=CC(=C(C=C2C3C1NCC4=CC=CC=C34)O)O
InChI: InChI=1S/C17H17NO2/c19-15-7-10-5-6-14-17(13(10)8-16(15)20)12-4-2-1-3-11(12)9-18-14/h1-4,7-8,14,17-20H,5-6,9H2
描述信息
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:124993
- ChEBI: CHEBI:91996
- PubChem: 6603820
- PubChem: 60759
- PubChem: 5311070
- DrugBank: DB12890
- ChEMBL: CHEMBL25856
- ChEMBL: CHEMBL101446
- ChEMBL: CHEMBL4280145
- CAS: 174691-84-0
- CAS: 123039-93-0
- CAS: 757161-85-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Jennifer E Davoren, Deane Nason, Jotham Coe, Keith Dlugolenski, Christopher Helal, Anthony R Harris, Erik LaChapelle, Sidney Liang, Yue Liu, Rebecca O'Connor, Christine C Orozco, Brajesh K Rai, Michelle Salafia, Brian Samas, Wenjian Xu, Rouba Kozak, David Gray. Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.
Journal of medicinal chemistry.
2018 12; 61(24):11384-11397. doi:
10.1021/acs.jmedchem.8b01622. [PMID: 30431269] - Mark Slifstein, Raymond F Suckow, Jonathan A Javitch, Thomas Cooper, Jeffrey Lieberman, Anissa Abi-Dargham. Characterization of in vivo pharmacokinetic properties of the dopamine D1 receptor agonist DAR-0100A in nonhuman primates using PET with [11C] NNC112 and [11C] raclopride.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2011 Jan; 31(1):293-304. doi:
10.1038/jcbfm.2010.91. [PMID: 20571519] - Y Iris Chen, Ji-Kyung Choi, Haibo Xu, Jiaqian Ren, Susan L Andersen, Bruce G Jenkins. Pharmacologic neuroimaging of the ontogeny of dopamine receptor function.
Developmental neuroscience.
2010 Jul; 32(2):125-38. doi:
10.1159/000286215. [PMID: 20523024] - Mark S George, Christine E Molnar, Emily L Grenesko, Berry Anderson, Qiwen Mu, Kevin Johnson, Ziad Nahas, Michael Knable, Prabhavathi Fernandes, Jorge Juncos, Xuemei Huang, David E Nichols, Richard B Mailman. A single 20 mg dose of dihydrexidine (DAR-0100), a full dopamine D1 agonist, is safe and tolerated in patients with schizophrenia.
Schizophrenia research.
2007 Jul; 93(1-3):42-50. doi:
10.1016/j.schres.2007.03.011. [PMID: 17467956] - Jessica P Ryman-Rasmussen, David E Nichols, Richard B Mailman. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists.
Molecular pharmacology.
2005 Oct; 68(4):1039-48. doi:
10.1124/mol.105.012153. [PMID: 15985612] - P J Blanchet, J Fang, M Gillespie, L Sabounjian, K W Locke, R Gammans, M M Mouradian, T N Chase. Effects of the full dopamine D1 receptor agonist dihydrexidine in Parkinson's disease.
Clinical neuropharmacology.
1998 Nov; 21(6):339-43. doi:
NULL. [PMID: 9844789] - J D Kohli, P T Horn, D Glock, W K Brewster, D E Nichols. Dihydrexidine: a new potent peripheral dopamine D1 receptor agonist.
European journal of pharmacology.
1993 Apr; 235(1):31-5. doi:
10.1016/0014-2999(93)90816-z. [PMID: 8100195] - R M Kater, N Carulli, F L Iber. Differences in the rate of ethanol metabolism in recently drinking alcoholic and nondrinking subjects.
The American journal of clinical nutrition.
1969 Dec; 22(12):1608-17. doi:
10.1093/ajcn/22.12.1608. [PMID: 5362487]
