Necrostatin-1 (BioDeep_00000719673)
代谢物信息卡片
5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidazolidinone
化学式: C13H13N3OS (259.0779288)
中文名称: Necrostatin-1
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
InChI: InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dan Sang, Xinyue Duan, Xiaoli Yu, Jiabin Zang, Lan Liu, Guifu Wu. PGAM5 regulates DRP1-mediated mitochondrial fission/mitophagy flux in lipid overload-induced renal tubular epithelial cell necroptosis.
Toxicology letters.
2023 Jan; 372(?):14-24. doi:
10.1016/j.toxlet.2022.10.003. [PMID: 36273635] - Rittibet Yapasert, Patompong Khaw-On, Ratana Banjerdpongchai. Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets.
Molecules (Basel, Switzerland).
2021 Dec; 26(24):. doi:
10.3390/molecules26247459. [PMID: 34946543] - Gang Xu, Ying Li, Shengyuan Zhang, Haoran Peng, Yunyun Wang, Dekang Li, Taijie Jin, Zhuohao He, Yilun Tong, Chunting Qi, Guowei Wu, Kangyun Dong, Jizhou Gou, Yang Liu, Tongyang Xiao, Jing Qu, Liang Li, Liang Liu, Ping Zhao, Zheng Zhang, Junying Yuan. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation.
Cell research.
2021 12; 31(12):1230-1243. doi:
10.1038/s41422-021-00578-7. [PMID: 34663909] - Dahae Lee, Noriko Yamabe, Heesu Lee, Hye Lim Lee, Dong-Wook Kim, Jae Wook Lee, Ki Sung Kang. Necrostatins regulate apoptosis, necroptosis, and inflammation in cisplatin-induced nephrotoxicity in LLC-PK1 cells.
Bioorganic & medicinal chemistry letters.
2021 09; 48(?):128256. doi:
10.1016/j.bmcl.2021.128256. [PMID: 34256117] - C Horvath, A Szobi, L Kindernay, T Ravingerova, A Adameova. Pleiotropic, non-cell death-associated effects of inhibitors of receptor-interacting protein kinase 1 in the heart.
Molecular and cellular biochemistry.
2021 Aug; 476(8):3079-3087. doi:
10.1007/s11010-021-04136-y. [PMID: 33811579] - Wulf Tonnus, Claudia Meyer, Christian Steinebach, Alexia Belavgeni, Anne von Mässenhausen, Nadia Zamora Gonzalez, Francesca Maremonti, Florian Gembardt, Nina Himmerkus, Markus Latk, Sophie Locke, Julian Marschner, Wenjun Li, Spencer Short, Sebastian Doll, Irina Ingold, Bettina Proneth, Christoph Daniel, Nazanin Kabgani, Rafael Kramann, Stephen Motika, Paul J Hergenrother, Stefan R Bornstein, Christian Hugo, Jan Ulrich Becker, Kerstin Amann, Hans-Joachim Anders, Daniel Kreisel, Derek Pratt, Michael Gütschow, Marcus Conrad, Andreas Linkermann. Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Nature communications.
2021 07; 12(1):4402. doi:
10.1038/s41467-021-24712-6. [PMID: 34285231] - Mohammad Javad Khodayar, Heibatullah Kalantari, Layasadat Khorsandi, Nematollah Ahangar, Azin Samimi, Hadis Alidadi. Taurine attenuates valproic acid-induced hepatotoxicity via modulation of RIPK1/RIPK3/MLKL-mediated necroptosis signaling in mice.
Molecular biology reports.
2021 May; 48(5):4153-4162. doi:
10.1007/s11033-021-06428-4. [PMID: 34032977] - Liyuan Cao, Wei Mu. Necrostatin-1 and necroptosis inhibition: Pathophysiology and therapeutic implications.
Pharmacological research.
2021 01; 163(?):105297. doi:
10.1016/j.phrs.2020.105297. [PMID: 33181319] - N E H Saleh, A H Saad, E A Elbassuoni, N F El-Tahawy, E A Abdel-Hakeem. Potential benefits of using hydrogen sulfide, vitamin E and necrostatin-1 to counteract acetaminophen‑induced hepatotoxicity in rats.
Bratislavske lekarske listy.
2021; 122(10):732-738. doi:
10.4149/bll_2021_117. [PMID: 34570575] - Yanping Wu, Haixia Chen, Nanxia Xuan, Lingren Zhou, Yinfang Wu, Chen Zhu, Miao Li, Qingyu Weng, Jiaxin Shen, Hao Zhang, Bin Zhang, Fen Lan, Lixia Xia, Xuefang Xiong, Zhouyang Li, Yun Zhao, Mindan Wu, Songmin Ying, Wen Li, Huahao Shen, Zhihua Chen. Induction of ferroptosis-like cell death of eosinophils exerts synergistic effects with glucocorticoids in allergic airway inflammation.
Thorax.
2020 11; 75(11):918-927. doi:
10.1136/thoraxjnl-2020-214764. [PMID: 32759385] - Huihui Huang, William W Jin, Ming Huang, Heyu Ji, Diane E Capen, Yin Xia, Junying Yuan, Teodor G Păunescu, Hua A Jenny Lu. Gentamicin-Induced Acute Kidney Injury in an Animal Model Involves Programmed Necrosis of the Collecting Duct.
Journal of the American Society of Nephrology : JASN.
2020 09; 31(9):2097-2115. doi:
10.1681/asn.2019020204. [PMID: 32641397] - G Warnes. Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes.
Apoptosis : an international journal on programmed cell death.
2020 08; 25(7-8):548-557. doi:
10.1007/s10495-020-01613-5. [PMID: 32495124] - Chun-Yu Liu, Min Wang, Hong-Min Yu, Fang-Xuan Han, Qiong-Shi Wu, Xing-Jun Cai, Hiroshi Kurihara, Yong-Xing Chen, Yi-Fang Li, Rong-Rong He. Ferroptosis is involved in alcohol-induced cell death in vivo and in vitro.
Bioscience, biotechnology, and biochemistry.
2020 Aug; 84(8):1621-1628. doi:
10.1080/09168451.2020.1763155. [PMID: 32419644] - Josef Stolberg-Stolberg, Meike Sambale, Uwe Hansen, Alexandra Schäfer Michael Raschke, Jessica Bertrand, Thomas Pap, Joanna Sherwood. Cartilage Trauma Induces Necroptotic Chondrocyte Death and Expulsion of Cellular Contents.
International journal of molecular sciences.
2020 Jun; 21(12):. doi:
10.3390/ijms21124204. [PMID: 32545631] - J Riegger, M Huber-Lang, R E Brenner. Crucial role of the terminal complement complex in chondrocyte death and hypertrophy after cartilage trauma.
Osteoarthritis and cartilage.
2020 05; 28(5):685-697. doi:
10.1016/j.joca.2020.01.004. [PMID: 31981738] - Zongliang Lu, Changpeng Wu, Mingxing Zhu, Wei Song, He Wang, Jiajia Wang, Jing Guo, Na Li, Jie Liu, Yanwu Li, Hongxia Xu. Ophiopogonin D' induces RIPK1‑dependent necroptosis in androgen‑dependent LNCaP prostate cancer cells.
International journal of oncology.
2020 Feb; 56(2):439-447. doi:
10.3892/ijo.2019.4945. [PMID: 31894265] - Qin Zhang, Siwei Wei, Jiayin Lu, Weijun Fu, Hui Chen, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng. Necrostatin-1 accelerates time to death in a rat model of cecal ligation and puncture and massively increases hepatocyte caspase-3 cleavage.
American journal of physiology. Gastrointestinal and liver physiology.
2019 04; 316(4):G551-G561. doi:
10.1152/ajpgi.00175.2018. [PMID: 30735454] - Ling Ling, Jingjing Wen, Liang Tao, Mengshu Zhao, Wenhao Ge, Lei Wang, Jianfa Zhang, Dan Weng. RIP1 and RIP3 contribute to Tributyltin-induced toxicity in vitro and in vivo.
Chemosphere.
2019 Mar; 218(?):589-598. doi:
10.1016/j.chemosphere.2018.11.140. [PMID: 30502697] - Ziqiao Yuan, Haoran Zhang, Muhammad Hasnat, Jiaxin Ding, Xi Chen, Peishi Liang, Lixin Sun, Luyong Zhang, Zhenzhou Jiang. A new perspective of triptolide-associated hepatotoxicity: Liver hypersensitivity upon LPS stimulation.
Toxicology.
2019 02; 414(?):45-56. doi:
10.1016/j.tox.2019.01.005. [PMID: 30633930] - Hao Liu, Mingzi Zhang, Xinhang Dong, Yifang Liu, Yan Hao, Youbin Wang. Necrostatin-1 protects against ischemia/reperfusion injury by inhibiting receptor-interacting protein 1 in a rat flap model.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS.
2019 Feb; 72(2):194-202. doi:
10.1016/j.bjps.2018.10.019. [PMID: 30509738] - Gyu-Tae Shin, Hwa Joung Lee, Ji Eun Park. Growth arrest and DNA damage 45γ is required for caspase-dependent renal tubular cell apoptosis.
PloS one.
2019; 14(2):e0212818. doi:
10.1371/journal.pone.0212818. [PMID: 30794682] - Takashi Kanou, Akihiro Ohsumi, Hyunhee Kim, Manyin Chen, Xiaohui Bai, Zehong Guan, David Hwang, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu. Inhibition of regulated necrosis attenuates receptor-interacting protein kinase 1-mediated ischemia-reperfusion injury after lung transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2018 10; 37(10):1261-1270. doi:
10.1016/j.healun.2018.04.005. [PMID: 29907500] - Adrián Szobi, Veronika Farkašová-Ledvényiová, Martin Lichý, Martina Muráriková, Slávka Čarnická, Tatiana Ravingerová, Adriana Adameová. Cardioprotection of ischaemic preconditioning is associated with inhibition of translocation of MLKL within the plasma membrane.
Journal of cellular and molecular medicine.
2018 09; 22(9):4183-4196. doi:
10.1111/jcmm.13697. [PMID: 29921042] - Peter Mikuš, Daniel Pecher, Drahomíra Rauová, Csaba Horváth, Adrián Szobi, Adriana Adameová. Determination of Novel Highly Effective Necrostatin Nec-1s in Rat Plasma by High Performance Liquid Chromatography Hyphenated with Quadrupole-Time-of-Flight Mass Spectrometry.
Molecules (Basel, Switzerland).
2018 Aug; 23(8):. doi:
10.3390/molecules23081946. [PMID: 30081531] - Yin-Zhuang Zhang, Lei Wang, Jie-Jie Zhang, Xiao-Ming Xiong, Di Zhang, Xuan-Meng Tang, Xiu-Ju Luo, Qi-Lin Ma, Jun Peng. Vascular peroxide 1 promotes ox-LDL-induced programmed necrosis in endothelial cells through a mechanism involving β-catenin signaling.
Atherosclerosis.
2018 07; 274(?):128-138. doi:
10.1016/j.atherosclerosis.2018.04.031. [PMID: 29772481] - Jun-Kai Yan, Wei-Hui Yan, Wei Cai. Fish oil-derived lipid emulsion induces RIP1-dependent and caspase 8-licensed necroptosis in IEC-6 cells through overproduction of reactive oxygen species.
Lipids in health and disease.
2018 Jun; 17(1):148. doi:
10.1186/s12944-018-0786-5. [PMID: 29935529] - Rachel P L van Swelm, Madelon Vos, Frank Verhoeven, Frank Thévenod, Dorine W Swinkels. Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis.
Cell death & disease.
2018 05; 9(5):550. doi:
10.1038/s41419-018-0568-z. [PMID: 29749404] - Diego Martin-Sanchez, Miguel Fontecha-Barriuso, Susana Carrasco, Maria Dolores Sanchez-Niño, Anne von Mässenhausen, Andreas Linkermann, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Jesus Egido, Alberto Ortiz, Ana Belen Sanz. TWEAK and RIPK1 mediate a second wave of cell death during AKI.
Proceedings of the National Academy of Sciences of the United States of America.
2018 04; 115(16):4182-4187. doi:
10.1073/pnas.1716578115. [PMID: 29588419] - Wei Dong, Zhilian Li, Yuanhan Chen, Li Zhang, Zhiming Ye, Huaban Liang, Ruizhao Li, Lixia Xu, Bin Zhang, Shuangxin Liu, Weidong Wang, Chunling Li, Wei Shi, Xinling Liang. Necrostatin-1 attenuates sepsis-associated acute kidney injury by promoting autophagosome elimination in renal tubular epithelial cells.
Molecular medicine reports.
2018 Feb; 17(2):3194-3199. doi:
10.3892/mmr.2017.8214. [PMID: 29257238] - Justin Steinman, Michael Epperly, Wen Hou, John Willis, Hong Wang, Renee Fisher, Bing Liu, Ivet Bahar, Travis McCaw, Valerian Kagan, Hulya Bayir, Jian Yu, Peter Wipf, Song Li, M Saiful Huq, Joel S Greenberger. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways.
Radiation research.
2018 01; 189(1):68-83. doi:
10.1667/rr14787.1. [PMID: 29140165] - Seok-Joo Kim, Sun-Mee Lee. Necrostatin-1 Protects Against D-Galactosamine and Lipopolysaccharide-Induced Hepatic Injury by Preventing TLR4 and RAGE Signaling.
Inflammation.
2017 Dec; 40(6):1912-1923. doi:
10.1007/s10753-017-0632-3. [PMID: 28752362] - Mohsen Honarpisheh, Orestes Foresto-Neto, Jyaysi Desai, Stefanie Steiger, Lidia Anguiano Gómez, Bastian Popper, Peter Boor, Hans-Joachim Anders, Shrikant R Mulay. Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape.
Scientific reports.
2017 Nov; 7(1):15523. doi:
10.1038/s41598-017-15804-9. [PMID: 29138474] - Anil Kumar Chauhan, Kyoung-Jin Min, Taeg Kyu Kwon. RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells.
Molecular and cellular biochemistry.
2017 Nov; 435(1-2):15-24. doi:
10.1007/s11010-017-3052-7. [PMID: 28466458] - Jean-Paul Decuypere, Laurens J Ceulemans, Tine Wylin, Wim Martinet, Diethard Monbaliu, Jacques Pirenne, Ina Jochmans. Plasmatic Villin 1 Is a Novel In Vivo Marker of Proximal Tubular Cell Injury During Renal Ischemia-Reperfusion.
Transplantation.
2017 11; 101(11):e330-e336. doi:
10.1097/tp.0000000000001876. [PMID: 28704336] - Fang Geng, Hang Yin, Zhe Li, Qin Li, Chaoran He, Zheng Wang, Junxian Yu. Quantitative analysis of necrostatin-1, a necroptosis inhibitor by LC-MS/MS and the study of its pharmacokinetics and bioavailability.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Nov; 95(?):1479-1485. doi:
10.1016/j.biopha.2017.09.063. [PMID: 28946210] - Jialun Luo, Yiming Tao, Xinling Liang, Yuanhan Chen, Li Zhang, Fen Jiang, Shuangxin Liu, Zhiming Ye, Zhilian Li, Wei Shi. Flow control effect of necrostatin-1 on cell death of the NRK-52E renal tubular epithelial cell line.
Molecular medicine reports.
2017 Jul; 16(1):57-62. doi:
10.3892/mmr.2017.6556. [PMID: 28487950] - Xia Xiao, Chunyang Du, Zhe Yan, Yonghong Shi, Huijun Duan, Yunzhuo Ren. Inhibition of Necroptosis Attenuates Kidney Inflammation and Interstitial Fibrosis Induced By Unilateral Ureteral Obstruction.
American journal of nephrology.
2017; 46(2):131-138. doi:
10.1159/000478746. [PMID: 28723681] - Xiaojing Li, Yingzi Ming, Ying Niu, Qianwen Liu, Qifa Ye. [Programmed necrosis: a new target for
ischemia reperfusion injury].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2016 Jul; 41(7):765-70. doi:
10.11817/j.issn.1672-7347.2016.07.017. [PMID: 27592584] - Wei Tian, Jieni Xiong, Saisa Zhu, Dong Xu, Hong Shen, Yongchuan Deng. mTOR signaling pathway is inhibited downstream of the cyclophilin D-mediated mitochondrial permeability transition in honokiol-triggered regulated necrosis.
Molecular medicine reports.
2016 Apr; 13(4):3227-35. doi:
10.3892/mmr.2016.4885. [PMID: 26936128] - Linghua Fan, Zhenwei Li, Zheng Fan, Yonqiang Wang. [The effect of necrostatin-1 on expression of liver monocyte chemotactic protein-1 in septic rats].
Zhonghua wei zhong bing ji jiu yi xue.
2016 Mar; 28(3):262-6. doi:
NULL. [PMID: 29917343] - Letizia Polito, Massimo Bortolotti, Manuela Pedrazzi, Daniele Mercatelli, Maria Giulia Battelli, Andrea Bolognesi. Apoptosis and necroptosis induced by stenodactylin in neuroblastoma cells can be completely prevented through caspase inhibition plus catalase or necrostatin-1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Jan; 23(1):32-41. doi:
10.1016/j.phymed.2015.11.006. [PMID: 26902405] - Vivian Regina Tristão, Edson A Pessoa, Renata Nakamichi, Luciana A Reis, Marcelo Costa Batista, Marcelino de Souza Durão Junior, Júlio Cesar Martins Monte. Synergistic effect of apoptosis and necroptosis inhibitors in cisplatin-induced nephrotoxicity.
Apoptosis : an international journal on programmed cell death.
2016 Jan; 21(1):51-9. doi:
10.1007/s10495-015-1190-5. [PMID: 26519037] - Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Li-Xiang Xue, Kun Xiong. Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation.
BMC neuroscience.
2015 Aug; 16(?):49. doi:
10.1186/s12868-015-0187-x. [PMID: 26238997] - Dirk Rosentreter, Dominik Funken, Jörg Reifart, Konstantin Mende, Markus Rentsch, Andrej Khandoga. RIP1-Dependent Programmed Necrosis is Negatively Regulated by Caspases During Hepatic Ischemia-Reperfusion.
Shock (Augusta, Ga.).
2015 Jul; 44(1):72-6. doi:
10.1097/shk.0000000000000371. [PMID: 26009812] - Yongjun Zhu, Hongwang Cui, Hua Gan, Yunfeng Xia, Lizhen Wang, Yuxuan Wang, Yue Sun. Necroptosis mediated by receptor interaction protein kinase 1 and 3 aggravates chronic kidney injury of subtotal nephrectomised rats.
Biochemical and biophysical research communications.
2015 Jun; 461(4):575-81. doi:
10.1016/j.bbrc.2015.03.164. [PMID: 25907058] - Hailin Zhao, Jiaolin Ning, Alexandre Lemaire, Foteini-Stefania Koumpa, James J Sun, Anthony Fung, Jianteng Gu, Bin Yi, Kaizhi Lu, Daqing Ma. Necroptosis and parthanatos are involved in remote lung injury after receiving ischemic renal allografts in rats.
Kidney international.
2015 Apr; 87(4):738-48. doi:
10.1038/ki.2014.388. [PMID: 25517913] - Jorge Soriano, Angeles Villanueva, Juan Carlos Stockert, Magdalena Cañete. Regulated necrosis in HeLa cells induced by ZnPc photodynamic treatment: a new nuclear morphology.
International journal of molecular sciences.
2014 Dec; 15(12):22772-85. doi:
10.3390/ijms151222772. [PMID: 25501332] - Qiu Chen, Xiaochun Xia, Shu Wu, Anqing Wu, Dandan Qi, Wei Liu, Fengmei Cui, Yang Jiao, Wei Zhu, Yongping Gu, Hongjian Gao, Xueguang Zhang, Jianping Cao. Apoptosis, necrosis, and autophagy in mouse intestinal damage after 15-Gy whole body irradiation.
Cell biochemistry and function.
2014 Dec; 32(8):647-56. doi:
10.1002/cbf.3068. [PMID: 25289565] - Jose Pedro Friedmann Angeli, Manuela Schneider, Bettina Proneth, Yulia Y Tyurina, Vladimir A Tyurin, Victoria J Hammond, Nadja Herbach, Michaela Aichler, Axel Walch, Elke Eggenhofer, Devaraj Basavarajappa, Olof Rådmark, Sho Kobayashi, Tobias Seibt, Heike Beck, Frauke Neff, Irene Esposito, Rüdiger Wanke, Heidi Förster, Olena Yefremova, Marc Heinrichmeyer, Georg W Bornkamm, Edward K Geissler, Stephen B Thomas, Brent R Stockwell, Valerie B O'Donnell, Valerian E Kagan, Joel A Schick, Marcus Conrad. Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.
Nature cell biology.
2014 Dec; 16(12):1180-91. doi:
10.1038/ncb3064. [PMID: 25402683] - Xinling Liang, Yuanhan Chen, Li Zhang, Fen Jiang, Wenjian Wang, Zhiming Ye, Shuangxin Liu, Chunping Yu, Wei Shi. Necroptosis, a novel form of caspase-independent cell death, contributes to renal epithelial cell damage in an ATP-depleted renal ischemia model.
Molecular medicine reports.
2014 Aug; 10(2):719-24. doi:
10.3892/mmr.2014.2234. [PMID: 24842629] - Guang Zhang, Chunping Jiang, Zhongxia Wang, Weibo Chen, Wen Gu, Yitao Ding. Dehydroabietic acid derivative QC2 induces oncosis in hepatocellular carcinoma cells.
BioMed research international.
2014; 2014(?):682197. doi:
10.1155/2014/682197. [PMID: 25110686] - Liya Zhang, Yaoli Cui, Bing Wang, Jinbao Yu, Yuliang Wang, Yongqiang Wang. [Protective effect of necrostatin-1 on the liver of rats with trauma induced hemorrhagic shock].
Zhonghua wei zhong bing ji jiu yi xue.
2014 Jan; 26(1):17-22. doi:
NULL. [PMID: 24649521] - Zhenyu Cai, Siriporn Jitkaew, Jie Zhao, Hsueh-Cheng Chiang, Swati Choksi, Jie Liu, Yvona Ward, Ling-Gang Wu, Zheng-Gang Liu. Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
Nature cell biology.
2014 Jan; 16(1):55-65. doi:
10.1038/ncb2883. [PMID: 24316671] - Andreas Linkermann, Jan-Ole Heller, Agnes Prókai, Joel M Weinberg, Federica De Zen, Nina Himmerkus, Attila J Szabó, Jan H Bräsen, Ulrich Kunzendorf, Stefan Krautwald. The RIP1-kinase inhibitor necrostatin-1 prevents osmotic nephrosis and contrast-induced AKI in mice.
Journal of the American Society of Nephrology : JASN.
2013 Oct; 24(10):1545-57. doi:
10.1681/asn.2012121169. [PMID: 23833261] - Grazyna Nowak, Sridharan Soundararajan, Ruben Mestril. Protein kinase C-α interaction with iHSP70 in mitochondria promotes recovery of mitochondrial function after injury in renal proximal tubular cells.
American journal of physiology. Renal physiology.
2013 Sep; 305(5):F764-76. doi:
10.1152/ajprenal.00061.2013. [PMID: 23804450] - C-Y Huang, W-T Kuo, Y-C Huang, T-C Lee, L C H Yu. Resistance to hypoxia-induced necroptosis is conferred by glycolytic pyruvate scavenging of mitochondrial superoxide in colorectal cancer cells.
Cell death & disease.
2013 May; 4(?):e622. doi:
10.1038/cddis.2013.149. [PMID: 23640464] - Kai Dong, Hong Zhu, Zhengyu Song, Yuanyuan Gong, Fenghua Wang, Wenqiu Wang, Zhi Zheng, Zhang Yu, Qing Gu, Xun Xu, Xiaodong Sun. Necrostatin-1 protects photoreceptors from cell death and improves functional outcome after experimental retinal detachment.
The American journal of pathology.
2012 Nov; 181(5):1634-41. doi:
10.1016/j.ajpath.2012.07.029. [PMID: 22940440] - Zizhang Ouyang, Shaohua Zhu, Jing Jin, Jia Li, Yuwen Qiu, Min Huang, Zhiying Huang. Necroptosis contributes to the cyclosporin A-induced cytotoxicity in NRK-52E cells.
Die Pharmazie.
2012 Aug; 67(8):725-32. doi:
. [PMID: 22957440] - Jindřiška Hammerová, Stjepan Uldrijan, Eva Táborská, Alena Hyršlová Vaculová, Iva Slaninová. Necroptosis modulated by autophagy is a predominant form of melanoma cell death induced by sanguilutine.
Biological chemistry.
2012 Jul; 393(7):647-58. doi:
10.1515/hsz-2011-0279. [PMID: 22944669] - Andreas Linkermann, Jan H Bräsen, Nina Himmerkus, Shuya Liu, Tobias B Huber, Ulrich Kunzendorf, Stefan Krautwald. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury.
Kidney international.
2012 Apr; 81(8):751-61. doi:
10.1038/ki.2011.450. [PMID: 22237751] - Guilherme B Fortes, Leticia S Alves, Rosane de Oliveira, Fabianno F Dutra, Danielle Rodrigues, Patricia L Fernandez, Thais Souto-Padron, María José De Rosa, Michelle Kelliher, Douglas Golenbock, Francis K M Chan, Marcelo T Bozza. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production.
Blood.
2012 Mar; 119(10):2368-75. doi:
10.1182/blood-2011-08-375303. [PMID: 22262768] - Vivian Regina Tristão, Paula Fernanda Gonçalves, Maria Aparecida Dalboni, Marcelo Costa Batista, Marcelino de Souza Durão, Júlio Cesar Martins Monte. Nec-1 protects against nonapoptotic cell death in cisplatin-induced kidney injury.
Renal failure.
2012; 34(3):373-7. doi:
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