L-745870 (BioDeep_00000719664)

   


代谢物信息卡片


3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine

化学式: C18H19ClN4 (326.1298164)
中文名称: 三氢氯酸L-745,870
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCN1CC2=CNC3=C2C=CC=N3)C4=CC=C(C=C4)Cl
InChI: InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
L-745870 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors[1][2][3].

同义名列表

2 个代谢物同义名

3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine; L-745870



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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文献列表

  • Ruchi Sharma, Aman George, Malika Nimmagadda, Davide Ortolan, Barbosa-Sabanero Karla, Zoya Qureshy, Devika Bose, Roba Dejene, Genqing Liang, Qin Wan, Justin Chang, Balendu Shekhar Jha, Omar Memon, Kiyoharu Joshua Miyagishima, Aaron Rising, Madhu Lal, Eric Hanson, Rebecca King, Mercedes Maria Campos, Marc Ferrer, Juan Amaral, David McGaughey, Kapil Bharti. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model. Nature communications. 2021 12; 12(1):7293. doi: 10.1038/s41467-021-27488-x. [PMID: 34911940]
  • Juan Gabriel Tejas-Juárez, Ana María Cruz-Martínez, Verónica Elsa López-Alonso, Brenda García-Iglesias, Juan Manuel Mancilla-Díaz, Benjamín Florán-Garduño, Rodrigo Erick Escartín-Pérez. Stimulation of dopamine D4 receptors in the paraventricular nucleus of the hypothalamus of male rats induces hyperphagia: involvement of glutamate. Physiology & behavior. 2014 Jun; 133(?):272-81. doi: 10.1016/j.physbeh.2014.04.040. [PMID: 24805978]
  • Philippe Huot, Tom H Johnston, James B Koprich, Ahmed Aman, Susan H Fox, Jonathan M Brotchie. L-745,870 reduces L-DOPA-induced dyskinesia in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. 2012 Aug; 342(2):576-85. doi: 10.1124/jpet.112.195693. [PMID: 22619253]
  • Cathérine Gebhard, Alexander Breitenstein, Alexander Akhmedov, Caroline E Gebhard, Giovanni G Camici, Thomas F Lüscher, Felix C Tanner. Amphetamines induce tissue factor and impair tissue factor pathway inhibitor: role of dopamine receptor type 4. European heart journal. 2010 Jul; 31(14):1780-91. doi: 10.1093/eurheartj/ehp598. [PMID: 20118172]
  • O Langer, C Halldin, Y Chou, J Sandell, C Swahn, K Någren, R Perrone, F Berardi, M Leopoldo, L Farde. Carbon-11 pb-12: an attempt to visualize the dopamine d(4) receptor in the primate brain with positron emission tomography. Nuclear medicine and biology. 2000 Nov; 27(8):707-14. doi: 10.1016/s0969-8051(00)00154-2. [PMID: 11150701]
  • K E Zhang, P H Kari, M R Davis, G Doss, T A Baillie, K P Vyas. Metabolism of A dopamine D(4)-selective antagonist in rat, monkey, and humans: formation of A novel mercapturic acid adduct. Drug metabolism and disposition: the biological fate of chemicals. 2000 Jun; 28(6):633-42. doi: NULL. [PMID: 10820134]
  • L Gazi, I Bobirnac, M Danzeisen, E Schüpbach, A T Bruinvels, S Geisse, B Sommer, D Hoyer, M Tricklebank, P Schoeffter. The agonist activities of the putative antipsychotic agents, L-745,870 and U-101958 in HEK293 cells expressing the human dopamine D4.4 receptor. British journal of pharmacology. 1998 Jul; 124(5):889-96. doi: 10.1038/sj.bjp.0701921. [PMID: 9692773]
  • S Patel, S Freedman, K L Chapman, F Emms, A E Fletcher, M Knowles, R Marwood, G Mcallister, J Myers, N Curtis, J J Kulagowski, P D Leeson, M Ridgill, M Graham, S Matheson, D Rathbone, A P Watt, L J Bristow, N M Rupniak, E Baskin, J J Lynch, C I Ragan. Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor. The Journal of pharmacology and experimental therapeutics. 1997 Nov; 283(2):636-47. doi: NULL. [PMID: 9353380]
  • C M Chavez-Eng, M L Constanzer, B K Matuszewski. Picogram determination of a novel dopamine D4 receptor antagonist in human plasma and urine by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 1997 Mar; 691(1):77-85. doi: 10.1016/s0378-4347(96)00395-7. [PMID: 9140760]