SB-222200 (BioDeep_00000719654)

   


代谢物信息卡片


3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide

化学式: C26H24N2O (380.18885339999997)
中文名称: 3-甲基-2-苯基-N-((1S)-1-苯基丙基)喹啉-4-甲酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C1=CC=CC=C1)NC(=O)C2=C(C(=NC3=CC=CC=C32)C4=CC=CC=C4)C
InChI: InChI=1S/C26H24N2O/c1-3-22(19-12-6-4-7-13-19)28-26(29)24-18(2)25(20-14-8-5-9-15-20)27-23-17-11-10-16-21(23)24/h4-17,22H,3H2,1-2H3,(H,28,29)/t22-/m0/s1

描述信息

SB-222200 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant NK-3 receptor antagonist. SB-222200 is developed for central nervous system (CNS) disorders[1].

同义名列表

2 个代谢物同义名

3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]quinoline-4-carboxamide; SB-222200



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代谢反应

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文献列表

  • Nicholas F Parchim, Wei Wang, Takayuki Iriyama, Olaide A Ashimi, Athar H Siddiqui, Sean Blackwell, Baha Sibai, Rodney E Kellems, Yang Xia. Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia. Hypertension (Dallas, Tex. : 1979). 2015 Feb; 65(2):430-9. doi: 10.1161/hypertensionaha.114.04439. [PMID: 25452470]
  • Suresh Ramaswamy, Stephanie B Seminara, Barkat Ali, Philippe Ciofi, Nisar A Amin, Tony M Plant. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus. Endocrinology. 2010 Sep; 151(9):4494-503. doi: 10.1210/en.2010-0223. [PMID: 20573725]
  • Gwendolen E Haley, Francis W Flynn. Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Oct; 295(4):R1158-67. doi: 10.1152/ajpregu.90402.2008. [PMID: 18650316]
  • Gwendolen E Haley, Francis W Flynn. Tachykinin NK3 receptor contribution to systemic release of vasopressin and oxytocin in response to osmotic and hypotensive challenge. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Aug; 293(2):R931-7. doi: 10.1152/ajpregu.00196.2007. [PMID: 17522129]
  • Gwendolen E Haley, Francis W Flynn. Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus. American journal of physiology. Regulatory, integrative and comparative physiology. 2006 May; 290(5):R1242-50. doi: 10.1152/ajpregu.00773.2005. [PMID: 16357093]
  • H M Sarau, J A Feild, R S Ames, J J Foley, P Nuthulaganti, D B Schmidt, P T Buckley, N A Elshourbagy, M E Brawner, M A Luttmann, G A Giardina, D W Hay. Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. European journal of pharmacology. 2001 Feb; 413(2-3):143-50. doi: 10.1016/s0014-2999(01)00732-4. [PMID: 11226387]
  • H M Sarau, D E Griswold, B Bush, W Potts, P Sandhu, D Lundberg, J J Foley, D B Schmidt, E F Webb, L D Martin, J J Legos, R G Whitmore, F C Barone, A D Medhurst, M A Luttmann, G A Giardina, D W Hay. Nonpeptide tachykinin receptor antagonists. II. Pharmacological and pharmacokinetic profile of SB-222200, a central nervous system penetrant, potent and selective NK-3 receptor antagonist. The Journal of pharmacology and experimental therapeutics. 2000 Oct; 295(1):373-81. doi: NULL. [PMID: 10992004]