JWH-133 (BioDeep_00000719651)
代谢物信息卡片
(6AR,10AR)-3-(1,1-Dimethylbutyl)-6A,7,10,10A-tetrahydro-6,6,9-trimethyl-6H-dibenzo[B,D]pyran
化学式: C22H32O (312.24530219999997)
中文名称: (6AR,10AR)-3-(1,1-二甲基丁基)-6A,7,10,10A-四氢-6,6,9-三甲基-6H-二苯并[B,D]吡喃
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC(C)(C)C1=CC2=C(C=C1)C3CC(=CCC3C(O2)(C)C)C
InChI: InChI=1S/C22H32O/c1-7-12-21(3,4)16-9-10-17-18-13-15(2)8-11-19(18)22(5,6)23-20(17)14-16/h8-10,14,18-19H,7,11-13H2,1-6H3/t18-,19+/m0/s1
数据库引用编号
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相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Claudia Llinas Del Torrent, Iu Raïch, Angel Gonzalez, Nil Casajuana-Martin, Jaume Lillo, Joan Biel Rebassa, Carlos Ferreiro-Vera, Verónica Sánchez de Medina, Rafael Franco, Gemma Navarro, Leonardo Pardo. The Leu/Val6.51 Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ9-Tetrahydrocannabinol.
Journal of chemical information and modeling.
2023 Aug; ?(?):. doi:
10.1021/acs.jcim.3c01054. [PMID: 37644761] - Nil Casajuana-Martin, Gemma Navarro, Angel Gonzalez, Claudia Llinas Del Torrent, Marc Gómez-Autet, Aleix Quintana García, Rafael Franco, Leonardo Pardo. A Single Point Mutation Blocks the Entrance of Ligands to the Cannabinoid CB2 Receptor via the Lipid Bilayer.
Journal of chemical information and modeling.
2022 11; 62(22):5771-5779. doi:
10.1021/acs.jcim.2c00865. [PMID: 36302505] - Ludovic Dumont, Aurélie Rives-Feraille, Marion Delessard, Justine Saulnier, Christine Rondanino, Nathalie Rives. Activation of the cannabinoid receptor type 2 by the agonist JWH133 promotes the first wave of in vitro spermatogenesis.
Andrology.
2021 03; 9(2):673-688. doi:
10.1111/andr.12928. [PMID: 33112479] - Murat Çakır, Suat Tekin, Aslı Okan, Pınar Çakan, Züleyha Doğanyiğit. The ameliorating effect of cannabinoid type 2 receptor activation on brain, lung, liver and heart damage in cecal ligation and puncture-induced sepsis model in rats.
International immunopharmacology.
2020 Jan; 78(?):105978. doi:
10.1016/j.intimp.2019.105978. [PMID: 31767546] - Qinggang Liu, Zonglong Wu, Yaxiao Liu, Lipeng Chen, Hongda Zhao, Hongda Guo, Kejia Zhu, Wenfu Wang, Shouzhen Chen, Nan Zhou, Yan Li, Benkang Shi. Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy.
Neurourology and urodynamics.
2020 01; 39(1):158-169. doi:
10.1002/nau.24205. [PMID: 31729056] - Murat Çakır, Suat Tekin, Züleyha Doğanyiğit, Pınar Çakan, Emin Kaymak. The protective effect of cannabinoid type 2 receptor activation on renal ischemia-reperfusion injury.
Molecular and cellular biochemistry.
2019 Dec; 462(1-2):123-132. doi:
10.1007/s11010-019-03616-6. [PMID: 31446615] - Berhanu Geresu, Ana Canseco-Alba, Branden Sanabria, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi, Ephrem Engidawork. Involvement of CB2 Receptors in the Neurobehavioral Effects of Catha Edulis (Vahl) Endl. (Khat) in Mice.
Molecules (Basel, Switzerland).
2019 Aug; 24(17):. doi:
10.3390/molecules24173164. [PMID: 31480324] - Ana Canseco-Alba, Norman Schanz, Branden Sanabria, Juan Zhao, Zhicheng Lin, Qing-Rong Liu, Emmanuel S Onaivi. Behavioral effects of psychostimulants in mutant mice with cell-type specific deletion of CB2 cannabinoid receptors in dopamine neurons.
Behavioural brain research.
2019 03; 360(?):286-297. doi:
10.1016/j.bbr.2018.11.043. [PMID: 30508607] - Marta Rodríguez-Arias, Francisco Navarrete, M Carmen Blanco-Gandia, M Carmen Arenas, María A Aguilar, Adrián Bartoll-Andrés, Olga Valverde, José Miñarro, Jorge Manzanares. Role of CB2 receptors in social and aggressive behavior in male mice.
Psychopharmacology.
2015 Aug; 232(16):3019-31. doi:
10.1007/s00213-015-3939-5. [PMID: 25921034] - Ying-Ying Yang, Shie-Liang Hsieh, Pei-Chang Lee, Yi-Chen Yeh, Kuei-Chuan Lee, Yun-Cheng Hsieh, Ying-Wen Wang, Tzung-Yan Lee, Yi-Hsiang Huang, Che-Chang Chan, Han-Chieh Lin. Long-term cannabinoid type 2 receptor agonist therapy decreases bacterial translocation in rats with cirrhosis and ascites.
Journal of hepatology.
2014 Nov; 61(5):1004-13. doi:
10.1016/j.jhep.2014.05.049. [PMID: 24953022] - Shin Fukuda, Hitoshi Kohsaka, Aiko Takayasu, Waka Yokoyama, Chie Miyabe, Yoshishige Miyabe, Masayoshi Harigai, Nobuyuki Miyasaka, Toshihiro Nanki. Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis.
BMC musculoskeletal disorders.
2014 Aug; 15(?):275. doi:
10.1186/1471-2474-15-275. [PMID: 25115332] - Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati, Jürg Gertsch. Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system.
ACS chemical biology.
2014 Jul; 9(7):1499-507. doi:
10.1021/cb500177c. [PMID: 24831513] - S Zoppi, J L Madrigal, J R Caso, M S García-Gutiérrez, J Manzanares, J C Leza, B García-Bueno. Regulatory role of the cannabinoid CB2 receptor in stress-induced neuroinflammation in mice.
British journal of pharmacology.
2014 Jun; 171(11):2814-26. doi:
10.1111/bph.12607. [PMID: 24467609] - Shuxian Jiang, Meritxell Alberich-Jorda, Radoslaw Zagozdzon, Kalindi Parmar, Yigong Fu, Peter Mauch, Naheed Banu, Alexandros Makriyannis, Daniel G Tenen, Shalom Avraham, Jerome E Groopman, Hava Karsenty Avraham. Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization.
Blood.
2011 Jan; 117(3):827-38. doi:
10.1182/blood-2010-01-265082. [PMID: 21063029] - Amy Alexander, Paul F Smith, Rhonda J Rosengren. Cannabinoids in the treatment of cancer.
Cancer letters.
2009 Nov; 285(1):6-12. doi:
10.1016/j.canlet.2009.04.005. [PMID: 19442435] - Abdolamir Feizi, Mohammad-Reza Jafari, Farzaneh Hamedivafa, Pouria Tabrizian, Bijan Djahanguiri. The preventive effect of cannabinoids on reperfusion-induced ischemia of mouse kidney.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2008 Aug; 60(4-5):405-10. doi:
10.1016/j.etp.2008.04.006. [PMID: 18571910] - Yong-Yao Cui, Bruno D'Agostino, Paul-André Risse, Guiseppina Marrocco, Emmanuel Naline, Yong Zhang, Hong-Zhuan Chen, Olivier Finance, Murielle Rinaldi-Carmona, Francesco Rossi, Charles Advenier. Cannabinoid CB(2) receptor activation prevents bronchoconstriction and airway oedema in a model of gastro-oesophageal reflux.
European journal of pharmacology.
2007 Nov; 573(1-3):206-13. doi:
10.1016/j.ejphar.2007.06.040. [PMID: 17643417] - Edward S Kimball, Craig R Schneider, Nathaniel H Wallace, Pamela J Hornby. Agonists of cannabinoid receptor 1 and 2 inhibit experimental colitis induced by oil of mustard and by dextran sulfate sodium.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Aug; 291(2):G364-71. doi:
10.1152/ajpgi.00407.2005. [PMID: 16574988]