Tiotidine (BioDeep_00000719644)

   


代谢物信息卡片


Tiotidine

化学式: C10H16N8S2 (312.0939)
中文名称: 硫替丁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN/C(NC#N)=N\CCSCC1=CSC(NC(N)=N)=N1
InChI: InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent > C29702 - Histamine-2 Receptor Antagonist
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors[1][2].

同义名列表

2 个代谢物同义名

Tiotidine; ICI 125211



数据库引用编号

7 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Satoshi Osawa, Masayoshi Kajimura, Seiji Yamamoto, Mutsuhiro Ikuma, Chihiro Mochizuki, Hirohiko Iwasaki, Akira Hishida, Susumu Terakawa. Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced upregulation. American journal of physiology. Gastrointestinal and liver physiology. 2005 Nov; 289(5):G880-9. doi: 10.1152/ajpgi.00536.2004. [PMID: 15961859]
  • M W Beukers, C H Klaassen, W J De Grip, D Verzijl, H Timmerman, R Leurs. Heterologous expression of rat epitope-tagged histamine H2 receptors in insect Sf9 cells. British journal of pharmacology. 1997 Nov; 122(5):867-74. doi: 10.1038/sj.bjp.0701466. [PMID: 9384502]
  • Y Fukushima, T Asano, K Takata, M Funaki, T Ogihara, M Anai, K Tsukuda, T Saitoh, H Katagiri, M Aihara, N Matsuhashi, Y Oka, Y Yazaki, K Sugano. Role of the C terminus in histamine H2 receptor signaling, desensitization, and agonist-induced internalization. The Journal of biological chemistry. 1997 Aug; 272(31):19464-70. doi: 10.1074/jbc.272.31.19464. [PMID: 9235948]
  • Y Fukushima, Y Oka, T Saitoh, H Katagiri, T Asano, N Matsuhashi, K Takata, E van Breda, Y Yazaki, K Sugano. Structural and functional analysis of the canine histamine H2 receptor by site-directed mutagenesis: N-glycosylation is not vital for its action. The Biochemical journal. 1995 Sep; 310 ( Pt 2)(?):553-8. doi: 10.1042/bj3100553. [PMID: 7544576]
  • P Dobson, T O Yellin. A radioimmunoassay for the histamine H2-antagonist, tiotidine. Agents and actions. 1984 Oct; 15(3-4):162-6. doi: 10.1007/bf01972343. [PMID: 6151804]
  • C T Richardson, M Feldman, C Brater, J Welborn. Tiotidine, a new long-acting histamine H2-receptor antagonist: comparison with cimetidine. Gastroenterology. 1981 Feb; 80(2):301-6. doi: 10.1016/0016-5085(81)90718-6. [PMID: 6108895]
  • S Kaojarern, M Feldman, C T Richardson, D C Brater. Tiotidine and cimetidine--kinetics and dynamics. Clinical pharmacology and therapeutics. 1981 Feb; 29(2):198-202. doi: 10.1038/clpt.1981.31. [PMID: 6109588]
  • K Monson, R K Simon, J O Malbica. Quantitative high-performance liquid chromatography determination of ICI 125,211 in plasma. Journal of analytical toxicology. 1980 Sep; 4(5):244-9. doi: 10.1093/jat/4.5.244. [PMID: 6108390]