meprednisone (BioDeep_00000719586)

   


代谢物信息卡片


meprednisone

化学式: C22H28O5 (372.1936638)
中文名称: 甲基泼尼松
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3C(=O)CC2(C1(C(=O)CO)O)C)C
InChI: InChI=1S/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19+,20-,21-,22-/m0/s1

描述信息

H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid

同义名列表

1 个代谢物同义名

meprednisone



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tajudheen Kunhamu Karatt, M Anwar Sathiq, Saraswathy Laya. Is 9β-dehydrohalogenation of betamethasone and dexamethasone hindering the detection of banned co-eluting meprednisone? A reverse-phase chiral liquid chromatography high-resolution mass spectrometry approach. Steroids. 2020 03; 155(?):108572. doi: 10.1016/j.steroids.2019.108572. [PMID: 31904376]
  • Fernando A Camporro, Exequiel Bulacio, Ignacio Gutierrez Magaldi. Systemic Immunoglobulin G4-Related Disease in an Asymptomatic Patient. The American journal of medicine. 2017 Dec; 130(12):e546-e547. doi: 10.1016/j.amjmed.2017.07.029. [PMID: 28807714]
  • Xiaoli Ma, Jiawei He, Jin Yan, Qing Wang, Hui Li. Comparative analysis the binding affinity of mycophenolic sodium and meprednisone with human serum albumin: Insight by NMR relaxation data and docking simulation. Chemico-biological interactions. 2016 Mar; 248(?):52-9. doi: 10.1016/j.cbi.2016.02.009. [PMID: 26892221]
  • Subhashis Pal, Kainat Khan, Shyamsundar Pal China, Monika Mittal, Konica Porwal, Richa Shrivastava, Isha Taneja, Zakir Hossain, Dhanaraju Mandalapu, Jiaur R Gayen, Muhammad Wahajuddin, Vishnu Lal Sharma, Arun K Trivedi, Sabyasachi Sanyal, Smrati Bhadauria, Madan M Godbole, Sushil K Gupta, Naibedya Chattopadhyay. Theophylline, a methylxanthine drug induces osteopenia and alters calciotropic hormones, and prophylactic vitamin D treatment protects against these changes in rats. Toxicology and applied pharmacology. 2016 Mar; 295(?):12-25. doi: 10.1016/j.taap.2016.02.002. [PMID: 26851681]
  • Paulino Antonio Alvarez, Jose Egozcue, Jihan Sleiman, Lucas Moretti, Guillermo Di Girolamo, Guillermo Alberto Keller. Severe neutropenia in a renal transplant patient suggesting an interaction between mycophenolate and fenofibrate. Current drug safety. 2012 Feb; 7(1):24-9. doi: 10.2174/157488612800492708. [PMID: 22663953]
  • Marcelo E Katz, Fernando Margulis, Rubén Schiavelli, Pablo Arias, Geoffrey A Head, Diego A Golombek. Disruption of Transitional Stages in 24-h Blood Pressure Recording in Renal Transplant Recipients. Frontiers in neurology. 2012; 3(?):35. doi: 10.3389/fneur.2012.00035. [PMID: 22438849]
  • Lei Yang, Yong-Feng Liu, Shu-Rong Liu, Gang Wu, Jia-Lin Zhang, Yi-Man Meng, Shao-Wei Shong, Gui-Chen Li. Prevention and treatment of rejection after simultaneous pancreas-kidney transplantation. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. 2005 Sep; 20(3):210-3. doi: NULL. [PMID: 16261897]
  • J R Ferraris, M L Tambutti, M Redal, J A Ramirez, M C Carlin, M C Samaniego, N Prigoshin. Immunosuppressive activity of deflazacort in pediatric renal transplantation. Transplantation. 1996 Aug; 62(3):417-20. doi: 10.1097/00007890-199608150-00021. [PMID: 8779694]
  • J R Ferraris, T Pasqualini. Therapy with a new glucocorticoid: effect of deflazacort on linear growth and growth hormone secretion in renal transplantation. The Journal of rheumatology. Supplement. 1993 Apr; 37(?):43-6. doi: NULL. [PMID: 8501752]
  • D B Haughey, W J Jusko. Effect of ketoconazole on methylprednisolone pharmacokinetics and receptor/gene-mediated pharmacodynamics. The Journal of pharmacology and experimental therapeutics. 1991 Nov; 259(2):826-32. doi: NULL. [PMID: 1941630]
  • L N Contreras, L Rizzo, R M Gómez, J R Zanchetta, M A Rossi, M Kral, A M Masini, O D Bruno. Long-term low-dose glucocorticoid therapy in hyperandrogenized women: utility and effects on bone mineral content and hypothalamic-pituitary-adrenocortical function. Hormone research. 1991; 35(3-4):142-5. doi: 10.1159/000181890. [PMID: 1839628]
  • H Y Cheng, W J Jusko. Mean interconversion times and distribution rate parameters for drugs undergoing reversible metabolism. Pharmaceutical research. 1990 Oct; 7(10):1003-10. doi: 10.1023/a:1015930831024. [PMID: 2281028]
  • M A Castro Ríos, D O Kniznik. [POEMS syndrome: report of a case and review of the literature]. Medicina. 1990; 50(2):149-52. doi: NULL. [PMID: 2101848]
  • D B Haughey, W J Jusko. Analysis of methylprednisolone, methylprednisone and corticosterone for assessment of methylprednisolone disposition in the rat. Journal of chromatography. 1988 Sep; 430(2):241-8. doi: 10.1016/s0378-4347(00)83159-x. [PMID: 3235500]
  • W F Ebling, S A Rich, S J Szefler, W J Jusko. Troleandomycin effects on methylprednisolone and methylprednisone interconversion and disposition in the rabbit. European journal of drug metabolism and pharmacokinetics. 1987 Jan; 12(1):50-7. doi: 10.1007/bf03189861. [PMID: 3497038]
  • J S Cheigh, K H Stenzel, A L Rubin. Low-dose immunosuppressive therapy in kidney transplantation. Transplantation. 1982 Oct; 34(4):232-3. doi: NULL. [PMID: 6755837]
  • P VITALE, R BUONINCONTI, O DEDIVITIIS. [COMPARATIVE EVALUATION OF THE EFFECTS OF PREDNISONE AND 16-BETA-METHYL-PREDNISONE ON WATER AND ELECTROLYTE BALANCE IN ENDEMIGENIC SYNDROMES]. La Riforma medica. 1964 Jun; 78(?):705-11. doi: NULL. [PMID: 14172593]