ABT-737 (BioDeep_00000719296)
代谢物信息卡片
ABT-737
化学式: C42H45ClN6O5S2 (812.2581230000001)
中文名称: 2-乙基-3-甲基戊酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCC(CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
InChI: InChI=1S/C42H45ClN6O5S2/c1-46(2)23-22-35(30-55-37-9-4-3-5-10-37)44-40-21-20-38(28-41(40)49(51)52)56(53,54)45-42(50)32-14-18-36(19-15-32)48-26-24-47(25-27-48)29-33-8-6-7-11-39(33)31-12-16-34(43)17-13-31/h3-21,28,35,44H,22-27,29-30H2,1-2H3,(H,45,50)/t35-/m1/s1
描述信息
C274 - Antineoplastic Agent > C129839 - Apoptotic Pathway-targeting Antineoplastic Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akira Koyanagi, Hitoshi Kotani, Yuichi Iida, Ryosuke Tanino, Irna D Kartika, Koji Kishimoto, Mamoru Harada. Protective roles of cytoplasmic p21Cip1 /Waf1 in senolysis and ferroptosis of lung cancer cells.
Cell proliferation.
2022 Dec; 55(12):e13326. doi:
10.1111/cpr.13326. [PMID: 36054146] - Yu-Jin Kim, Haydar Witwit, Beatrice Cubitt, Juan C de la Torre. Inhibitors of Anti-apoptotic Bcl-2 Family Proteins Exhibit Potent and Broad-Spectrum Anti-mammarenavirus Activity via Cell Cycle Arrest at G0/G1 Phase.
Journal of virology.
2021 11; 95(24):e0139921. doi:
10.1128/jvi.01399-21. [PMID: 34586865] - Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua. BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910658. [PMID: 34638998] - Natalia Rukoyatkina, Valentina Shpakova, Julia Sudnitsyna, Michael Panteleev, Stephanie Makhoul, Stepan Gambaryan, Kerstin Jurk. Curcumin at Low Doses Potentiates and at High Doses Inhibits ABT-737-Induced Platelet Apoptosis.
International journal of molecular sciences.
2021 May; 22(10):. doi:
10.3390/ijms22105405. [PMID: 34065600] - Zhizhou Xia, Xiuli Zhang, Ping Liu, Ruihong Zhang, Zhangsen Huang, Donghe Li, Xinhua Xiao, Min Wu, Nannan Ning, Qianqian Zhang, Jianmin Zhang, Mingzhu Liu, Bo Jiao, Ruibao Ren. GNA13 regulates BCL2 expression and the sensitivity of GCB-DLBCL cells to BCL2 inhibitors in a palmitoylation-dependent manner.
Cell death & disease.
2021 01; 12(1):54. doi:
10.1038/s41419-020-03311-1. [PMID: 33423045] - Hao Wei, Matthew T Harper. Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets.
Platelets.
2021 Jan; 32(1):105-112. doi:
10.1080/09537104.2020.1724276. [PMID: 32079453] - Minchen Liu, Jue Tu, Yi Feng, Jiquan Zhang, Jing Wu. Synergistic co-delivery of diacid metabolite of norcantharidin and ABT-737 based on folate-modified lipid bilayer-coated mesoporous silica nanoparticle against hepatic carcinoma.
Journal of nanobiotechnology.
2020 Aug; 18(1):114. doi:
10.1186/s12951-020-00677-4. [PMID: 32811502] - Hao Wei, Matthew T Harper. ABT-737 Triggers Caspase-Dependent Inhibition of Platelet Procoagulant Extracellular Vesicle Release during Apoptosis and Secondary Necrosis In Vitro.
Thrombosis and haemostasis.
2019 10; 119(10):1665-1674. doi:
10.1055/s-0039-1693694. [PMID: 31493778] - David Garandeau, Justine Noujarède, Justine Leclerc, Caroline Imbert, Virginie Garcia, Marie-Lise Bats, Florian Rambow, Julia Gilhodes, Thomas Filleron, Nicolas Meyer, Stéphanie Brayer, Silvia Arcucci, Sophie Tartare-Deckert, Bruno Ségui, Jean-Christophe Marine, Thierry Levade, Corine Bertolotto, Nathalie Andrieu-Abadie. Targeting the Sphingosine 1-Phosphate Axis Exerts Potent Antitumor Activity in BRAFi-Resistant Melanomas.
Molecular cancer therapeutics.
2019 02; 18(2):289-300. doi:
10.1158/1535-7163.mct-17-1141. [PMID: 30482853] - Yen-Chuan Ou, Jian-Ri Li, Jiaan-Der Wang, Wen-Ying Chen, Yu-Hsiang Kuan, Ching-Ping Yang, Su-Lan Liao, Hsi-Chi Lu, Chun-Jung Chen. Aspirin restores ABT-737-mediated apoptosis in human renal carcinoma cells.
Biochemical and biophysical research communications.
2018 07; 502(2):187-193. doi:
10.1016/j.bbrc.2018.05.142. [PMID: 29792865] - Enxiang Zhang, Shutao Yin, Xiaotong Lu, Linhu Ye, Lihong Fan, Hongbo Hu. Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.
Nutrients.
2018 Mar; 10(3):. doi:
10.3390/nu10030353. [PMID: 29543705] - Seon Min Woo, Kyoung-Jin Min, Bo Ram Seo, Young Ho Seo, Yong-Jin Jeong, Taeg Kyu Kwon. YM155 enhances ABT-737-mediated apoptosis through Mcl-1 downregulation in Mcl-1-overexpressed cancer cells.
Molecular and cellular biochemistry.
2017 May; 429(1-2):91-102. doi:
10.1007/s11010-016-2938-0. [PMID: 28120212] - Vikas A Gupta, Shannon M Matulis, Jason E Conage-Pough, Ajay K Nooka, Jonathan L Kaufman, Sagar Lonial, Lawrence H Boise. Bone marrow microenvironment-derived signals induce Mcl-1 dependence in multiple myeloma.
Blood.
2017 04; 129(14):1969-1979. doi:
10.1182/blood-2016-10-745059. [PMID: 28151428] - Xiaoning Li, Yongwei Kang, Bingxuan Jiao, Meihui Xia, Yao Wu, Liankun Sun. Autophagy eliminates ER membrane reorganization induced by Bcl-2 inhibitor in HeLa cells.
Oncology reports.
2016 Dec; 36(6):3353-3362. doi:
10.3892/or.2016.5209. [PMID: 27805250] - Ingela B Vikström, Anne Slomp, Emma M Carrington, Laura M Moesbergen, Catherine Chang, Gemma L Kelly, Stefan P Glaser, J H Marco Jansen, Jeanette H W Leusen, Andreas Strasser, David C S Huang, Andrew M Lew, Victor Peperzak, David M Tarlinton. MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.
Cell death & disease.
2016 08; 7(8):e2345. doi:
10.1038/cddis.2016.237. [PMID: 27560714] - Charlotte Gény, Gwladys Rivière, Jérome Bignon, Nicolas Birlirakis, Eric Guittet, Khaljah Awang, Marc Litaudon, Fanny Roussi, Vincent Dumontet. Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.
Journal of natural products.
2016 Apr; 79(4):838-44. doi:
10.1021/acs.jnatprod.5b00915. [PMID: 27008174] - Esther P Jane, Daniel R Premkumar, Jonathon M Cavaleri, Philip A Sutera, Thatchana Rajasekar, Ian F Pollack. Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.
The Journal of pharmacology and experimental therapeutics.
2016 Feb; 356(2):354-65. doi:
10.1124/jpet.115.230052. [PMID: 26585571] - B T Gaudette, B Dwivedi, K S Chitta, S Poulain, D Powell, P Vertino, X Leleu, S Lonial, A A Chanan-Khan, J Kowalski, L H Boise. Low expression of pro-apoptotic Bcl-2 family proteins sets the apoptotic threshold in Waldenström macroglobulinemia.
Oncogene.
2016 Jan; 35(4):479-90. doi:
10.1038/onc.2015.103. [PMID: 25893290] - Pei Yin, Jinpeng Jia, Jijun Li, Yan Song, Yiyan Zhang, Fengkun Chen. ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.
Oncology research.
2016; 24(1):65-72. doi:
10.3727/096504016x14587366983838. [PMID: 27178823] - Tanmay M Shekhar, Maja M Green, David M Rayner, Mark A Miles, Suzanne M Cutts, Christine J Hawkins. Inhibition of Bcl-2 or IAP proteins does not provoke mutations in surviving cells.
Mutation research.
2015 Jul; 777(?):23-32. doi:
10.1016/j.mrfmmm.2015.04.005. [PMID: 25916945] - S M Woo, K-J Min, B R Seo, J-O Nam, K S Choi, Y H Yoo, T K Kwon. Cafestol overcomes ABT-737 resistance in Mcl-1-overexpressed renal carcinoma Caki cells through downregulation of Mcl-1 expression and upregulation of Bim expression.
Cell death & disease.
2014 Nov; 5(?):e1514. doi:
10.1038/cddis.2014.472. [PMID: 25375379] - Brian T Gaudette, Neal N Iwakoshi, Lawrence H Boise. Bcl-xL protein protects from C/EBP homologous protein (CHOP)-dependent apoptosis during plasma cell differentiation.
The Journal of biological chemistry.
2014 Aug; 289(34):23629-40. doi:
10.1074/jbc.m114.569376. [PMID: 25023286] - Dongmin Gu, Shuhong Wang, Isere Kuiatse, Hua Wang, Jin He, Yun Dai, Richard J Jones, Chad C Bjorklund, Jing Yang, Steven Grant, Robert Z Orlowski. Inhibition of the MDM2 E3 Ligase induces apoptosis and autophagy in wild-type and mutant p53 models of multiple myeloma, and acts synergistically with ABT-737.
PloS one.
2014; 9(9):e103015. doi:
10.1371/journal.pone.0103015. [PMID: 25181509] - Asuman Mutlu, Armen V Gyulkhandanyan, John Freedman, Valery Leytin. Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface.
British journal of haematology.
2013 Nov; 163(3):377-84. doi:
10.1111/bjh.12529. [PMID: 24033315] - Stephanie Beurlet, Nader Omidvar, Petra Gorombei, Patricia Krief, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe Leboeuf, Anne Janin, Maria-Elena Noguera, Florence Hervatin, Laure Sarda-Mantel, Marina Konopleva, Michael Andreeff, Andrea W Tu, Alice C Fan, Dean W Felsher, Anthony Whetton, Marika Pla, Robert West, Pierre Fenaux, Christine Chomienne, Rose Ann Padua. BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.
Blood.
2013 Oct; 122(16):2864-76. doi:
10.1182/blood-2012-07-445635. [PMID: 23943652] - A Kmit, R van Kruchten, J Ousingsawat, N J A Mattheij, B Senden-Gijsbers, J W M Heemskerk, R Schreiber, E M Bevers, K Kunzelmann. Calcium-activated and apoptotic phospholipid scrambling induced by Ano6 can occur independently of Ano6 ion currents.
Cell death & disease.
2013 Apr; 4(?):e611. doi:
10.1038/cddis.2013.135. [PMID: 23618909] - Shudong Zhu, Matthew B Cohen, Jeffrey D Bjorge, James W Mier, Daniel C Cho. PI3K inhibition potentiates Bcl-2-dependent apoptosis in renal carcinoma cells.
Journal of cellular and molecular medicine.
2013 Mar; 17(3):377-85. doi:
10.1111/jcmm.12019. [PMID: 23387989] - Jin Akagi, Magdalena Kordon, Hong Zhao, Anna Matuszek, Jurek Dobrucki, Rachel Errington, Paul J Smith, Kazuo Takeda, Zbigniew Darzynkiewicz, Donald Wlodkowic. Real-time cell viability assays using a new anthracycline derivative DRAQ7®.
Cytometry. Part A : the journal of the International Society for Analytical Cytology.
2013 Feb; 83(2):227-34. doi:
10.1002/cyto.a.22228. [PMID: 23165976] - Hai-Dong Xu, Dan Wu, Jin-Hua Gu, Jian-Bin Ge, Jun-Chao Wu, Rong Han, Zhong-Qin Liang, Zheng-Hong Qin. The pro-survival role of autophagy depends on Bcl-2 under nutrition stress conditions.
PloS one.
2013; 8(5):e63232. doi:
10.1371/journal.pone.0063232. [PMID: 23658815] - William H Chappell, Stephen L Abrams, Richard A Franklin, Michelle M LaHair, Giuseppe Montalto, Melchiorre Cervello, Alberto M Martelli, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Jerry Polesel, Renato Talamini, Michele Milella, Agostino Tafuri, Linda S Steelman, James A McCubrey. Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine.
Cell cycle (Georgetown, Tex.).
2012 Dec; 11(23):4447-61. doi:
10.4161/cc.22786. [PMID: 23159854] - Emmanuelle Saugues, Anne-Laure Debaud, Fabrice Anizon, Nathalie Bonnefoy, Pascale Moreau. Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators.
European journal of medicinal chemistry.
2012 Nov; 57(?):112-25. doi:
10.1016/j.ejmech.2012.09.012. [PMID: 23047228] - Shuijun Zhang, Gongquan Li, Xiuxian Ma, Yu Wang, Guangzhi Liu, Liushun Feng, Yongfu Zhao, Gong Zhang, Yang Wu, Xuexiang Ye, Baoming Qin, Jianfeng Lu. Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1.
Cellular signalling.
2012 Sep; 24(9):1803-9. doi:
10.1016/j.cellsig.2012.05.009. [PMID: 22609455] - Pascaline Clerc, Gregory B Carey, Zara Mehrabian, Michael Wei, Hyehyun Hwang, Geoffrey D Girnun, Hegang Chen, Stuart S Martin, Brian M Polster. Rapid detection of an ABT-737-sensitive primed for death state in cells using microplate-based respirometry.
PloS one.
2012; 7(8):e42487. doi:
10.1371/journal.pone.0042487. [PMID: 22880001] - Linda Bodet, Patricia Gomez-Bougie, Cyrille Touzeau, Christelle Dousset, Géraldine Descamps, Sophie Maïga, Hervé Avet-Loiseau, Régis Bataille, Philippe Moreau, Steven Le Gouill, Catherine Pellat-Deceunynck, Martine Amiot. ABT-737 is highly effective against molecular subgroups of multiple myeloma.
Blood.
2011 Oct; 118(14):3901-10. doi:
10.1182/blood-2010-11-317438. [PMID: 21835956] - S A Malik, I Orhon, E Morselli, A Criollo, S Shen, G Mariño, A BenYounes, P Bénit, P Rustin, M C Maiuri, G Kroemer. BH3 mimetics activate multiple pro-autophagic pathways.
Oncogene.
2011 Sep; 30(37):3918-29. doi:
10.1038/onc.2011.104. [PMID: 21460857] - Brad E Sleebs, Peter E Czabotar, Wayne J Fairbrother, W Douglas Fairlie, John A Flygare, David C S Huang, Wilhelmus J A Kersten, Michael F T Koehler, Guillaume Lessene, Kym Lowes, John P Parisot, Brian J Smith, Morey L Smith, Andrew J Souers, Ian P Street, Hong Yang, Jonathan B Baell. Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.
Journal of medicinal chemistry.
2011 Mar; 54(6):1914-26. doi:
10.1021/jm101596e. [PMID: 21366295] - Yu-Qiang Chen, Xiao-Xia Wang, Xing-Mei Yao, Dong-Liang Zhang, Xu-Feng Yang, Shou-Fu Tian, Nian-Song Wang. MicroRNA-195 promotes apoptosis in mouse podocytes via enhanced caspase activity driven by BCL2 insufficiency.
American journal of nephrology.
2011; 34(6):549-59. doi:
10.1159/000333809. [PMID: 22123611] - Zhigang Xie, Chonglei Bi, Lip Lee Cheong, Shaw Cheng Liu, Gaofeng Huang, Jianbiao Zhou, Qiang Yu, Chien-Shing Chen, Wee Joo Chng. Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells.
PloS one.
2011; 6(6):e21583. doi:
10.1371/journal.pone.0021583. [PMID: 21720561] - Henry Zall, Arnim Weber, Robert Besch, Niko Zantl, Georg Häcker. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1.
Molecular cancer.
2010 Jun; 9(?):164. doi:
10.1186/1476-4598-9-164. [PMID: 20576107] - Emma M Carrington, Ingela B Vikstrom, Amanda Light, Robyn M Sutherland, Sarah L Londrigan, Kylie D Mason, David C S Huang, Andrew M Lew, David M Tarlinton. BH3 mimetics antagonizing restricted prosurvival Bcl-2 proteins represent another class of selective immune modulatory drugs.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Jun; 107(24):10967-71. doi:
10.1073/pnas.1005256107. [PMID: 20534453] - Jun Wei, Shinichi Kitada, Michele F Rega, John L Stebbins, Dayong Zhai, Jason Cellitti, Hongbin Yuan, Aras Emdadi, Russell Dahl, Ziming Zhang, Li Yang, John C Reed, Maurizio Pellecchia. Apogossypol derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.
Journal of medicinal chemistry.
2009 Jul; 52(14):4511-23. doi:
10.1021/jm900472s. [PMID: 19555126] - Dimitra Micha, Jeff Cummings, Alex Shoemaker, Steven Elmore, Kelly Foster, Martin Greaves, Tim Ward, Saul Rosenberg, Caroline Dive, Kathryn Simpson. Circulating biomarkers of cell death after treatment with the BH-3 mimetic ABT-737 in a preclinical model of small-cell lung cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2008 Nov; 14(22):7304-10. doi:
10.1158/1078-0432.ccr-08-0111. [PMID: 19010845] - N Tajeddine, L Galluzzi, O Kepp, E Hangen, E Morselli, L Senovilla, N Araujo, G Pinna, N Larochette, N Zamzami, N Modjtahedi, A Harel-Bellan, G Kroemer. Hierarchical involvement of Bak, VDAC1 and Bax in cisplatin-induced cell death.
Oncogene.
2008 Jul; 27(30):4221-32. doi:
10.1038/onc.2008.63. [PMID: 18362892] - Shengbing Huang, Frank A Sinicrope. BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells.
Cancer research.
2008 Apr; 68(8):2944-51. doi:
10.1158/0008-5472.can-07-2508. [PMID: 18413764]