Dexpropranolol hydrochloride (BioDeep_00000718852)
代谢物信息卡片
化学式: C16H22ClNO2 (295.1338982)
中文名称: (R)-(+)-普奈洛尔 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl
InChI: /m1./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
(R)-Propranolol hydrochloride is a less active enantiomer of the?β-adrenoceptor antagonist?propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:51161
- KEGGdrug: D03729
- PubChem: 25137925
- PubChem: 66366
- ChEMBL: CHEMBL1358662
- MeSH: Propranolol
- CAS: 13071-11-9
- medchemexpress: HY-A0295
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Jirapornchai Suksaeree. Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application.
International journal of biological macromolecules.
2024 Jan; 254(Pt 2):127916. doi:
10.1016/j.ijbiomac.2023.127916
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Plant communications.
2023 Aug; ?(?):100679. doi:
10.1016/j.xplc.2023.100679
. [PMID: 37653727] - Shuming Chen, Xuekai Zhao, Junjie Huang, Na Lin, Qianhui Xu, Jianwei Chen, Jianqiang Huang, Lie Wang, Chen Lin, Zaizhong Zhang. The effects of propranolol on the biology and Notch signaling pathway of human umbilical vein endothelial cells.
Medicine.
2023 Aug; 102(32):e34672. doi:
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. [PMID: 37565874] - Dison Stracke Pfingsten Franco, Jordana Georgin, Claudete Gindri Ramos, Salma Martinez Eljaiek, Daniel Romero Badillo, Anelise Hoch Paschoalin de Oliveira, Daniel Allasia, Lucas Meili. The Synthesis and Evaluation of Porous Carbon Material from Corozo Fruit (Bactris guineensis) for Efficient Propranolol Hydrochloride Adsorption.
Molecules (Basel, Switzerland).
2023 Jul; 28(13):. doi:
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. [PMID: 37446896] - Paula Mayara Morais da Silva, Gilberto Dias de Alkimin, Natália Gabriele Camparotto, Patricia Prediger, Bruno Nunes. Toxicological effects resulting from co-exposure to nanomaterials and to a β-blocker pharmaceutical drug in the non-target macrophyte species Lemna minor.
Environmental pollution (Barking, Essex : 1987).
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International journal of phytoremediation.
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. [PMID: 35414315] - Wei-Ping He, Jin-Cheng Li, Gao-Ming Wang. [Effect of total flavonoids of buckwheat flower and leaf on myocardial cell apoptosis and Wnt/β-catenin/PPARγ pathway in arrhythmic rats].
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. [PMID: 36725274] - Mahmoud H Teaima, Moaz A Eltabeeb, Mohamed A El-Nabarawi, Menna M Abdellatif. Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation.
Drug delivery.
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Chirality.
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The Journal of dermatological treatment.
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BMC psychiatry.
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. [PMID: 34801528] - Wael S Ibrahim, Hoda M S Ahmed, Amr A A Mahmoud, Mona F Mahmoud, Islam A A E-H Ibrahim. Propranolol and low-dose isoproterenol ameliorate insulin resistance, enhance β-arrestin2 signaling, and reduce cardiac remodeling in high-fructose, high-fat diet-fed mice: Comparative study with metformin.
Life sciences.
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The Australasian journal of dermatology.
2021 Nov; 62(4):e580-e581. doi:
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. [PMID: 34293182] - Andrew K Evans, Heui Hye Park, Nay Lui Saw, Kratika Singhal, Gaku Ogawa, Ryan D Leib, Mehrdad Shamloo. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging.
2021 10; 106(?):241-256. doi:
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. [PMID: 34320462] - Georgios N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis, Haralampos Milionis. Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites.
Journal of clinical gastroenterology.
2021 09; 55(8):721-729. doi:
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. [PMID: 32991355] - Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
The journal of trauma and acute care surgery.
2021 08; 91(2S Suppl 2):S89-S98. doi:
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. [PMID: 33938511] - Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis.
Bioanalysis.
2021 Jul; 13(14):1101-1111. doi:
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. [PMID: 34275331] - Ali Hatefi, Ahmad Zare Shahneh, Zarbakht Ansari Pirsaraie, Ali Mohammad Alizadeh, Mohammad Pouya Atashnak, Reza Masoudi, Frederic Pio. The stimulation and inhibition of beta-2 adrenergic receptor on the inflammatory responses of ovary and immune system in the aged laying hens.
BMC veterinary research.
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. [PMID: 34022889] - Sultan Aydin Köker, Ahmet Ufuk Kömüroğlu, Adem Yasin Köksoy, Ülkü Gül Şiraz, Emine Tekin, Alper Köker. Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2021 May; 28(4):296-300. doi:
10.1016/j.arcped.2021.02.009
. [PMID: 33715934] - Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):704-712. doi:
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. [PMID: 33010357] - Angela Abruzzo, Alessandra Crispini, Cecilia Prata, Rosanna Adduci, Fiore Pasquale Nicoletta, Francesco Dalena, Teresa Cerchiara, Barbara Luppi, Federica Bigucci. Freeze-Dried Matrices for Buccal Administration of Propranolol in Children: Physico-Chemical and Functional Characterization.
Journal of pharmaceutical sciences.
2021 04; 110(4):1676-1686. doi:
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. [PMID: 33164786] - James C Lee, Omeed Modiri, Ryan W England, Carrie J Shawber, June K Wu. Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta.
Plastic and reconstructive surgery.
2021 04; 147(4):875-885. doi:
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. [PMID: 33776033] - Vilmos Kertesz, John F Cahill, Bernadeta R Srijanto, Charles P Collier, Marissa Vavrek, Bingming Chen. Absolute quantitation of propranolol from 200-μm regions of mouse brain and liver thin tissues using laser ablation-dropletProbe-mass spectrometry.
Rapid communications in mass spectrometry : RCM.
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. [PMID: 33232548] - Julia Walczak, Corinne Bunn, Pravesh Saini, Yuk Ming Liu, Anthony J Baldea, Kuzhali Muthumalaiappan. Transient Improvement in Erythropoiesis Is Achieved Via the Chaperone AHSP With Early Administration of Propranolol in Burn Patients.
Journal of burn care & research : official publication of the American Burn Association.
2021 03; 42(2):311-322. doi:
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. [PMID: 32842148] - Tuba Talo Yildirim, Serkan Dündar, Alihan Bozoğlan, Tahir Karaman, Samet Tekin, Onur Evren Kahraman. Evaluation of the Effects of ß-Adrenergic Receptor-Propranolol on Osseointegration of the Titanium Implants.
The Journal of craniofacial surgery.
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. [PMID: 33705036] - Doran J Satanove, Simon Rahman, T M Vanessa Chan, Suelynn Ren, Paul B S Clarke. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.
Psychopharmacology.
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. [PMID: 33150479] - Ali Zeraatkar Moghaddam, Maryam Goharjoo, Ebrahim Ghiamati, Kamal Khodaei, Hadi Tabani. Gel electro-membrane extraction of propranolol and atenolol from blood serum samples: Effect of graphene-based nanomaterials on extraction efficiency of gel membrane.
Talanta.
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. [PMID: 33167255] - Basel A Abdel-Wahab, Safaa Yousef Salem, Hala Mostafa Mohammed, Nashwa Ahmed Mohammed, Helal F Hetta. The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats.
European journal of pharmacology.
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Journal of chromatography. A.
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. [PMID: 33264700] - Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
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Rapid communications in mass spectrometry : RCM.
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PloS one.
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The journal of trauma and acute care surgery.
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International journal of biological macromolecules.
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Dermatologic therapy.
2020 11; 33(6):e13977. doi:
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Shock (Augusta, Ga.).
2020 10; 54(4):482-487. doi:
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2020 Oct; 43(10):1527-1528. doi:
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International journal of molecular sciences.
2020 Sep; 21(18):. doi:
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European journal of pharmacology.
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Experimental physiology.
2020 09; 105(9):1660-1668. doi:
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Scientific reports.
2020 08; 10(1):14160. doi:
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Analytical chemistry.
2020 07; 92(13):9214-9222. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122125. doi:
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Cells.
2020 06; 9(6):. doi:
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Pakistan journal of pharmaceutical sciences.
2020 May; 33(3):1033-1048. doi:
"
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Journal of chromatography. A.
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The Science of the total environment.
2020 Apr; 712(?):136564. doi:
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British journal of pharmacology.
2020 02; 177(3):701-712. doi:
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Food & function.
2020 Jan; 11(1):700-710. doi:
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Journal of neonatal-perinatal medicine.
2020; 13(1):135-138. doi:
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Journal of neurology.
2020 Jan; 267(1):14-25. doi:
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Drug discoveries & therapeutics.
2020; 14(2):89-92. doi:
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Journal of the American College of Surgeons.
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The Turkish journal of pediatrics.
2020; 62(6):979-985. doi:
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Current drug metabolism.
2020; 21(2):89-105. doi:
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BioMed research international.
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Journal of cellular physiology.
2019 12; 234(12):23066-23081. doi:
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Reproductive biology and endocrinology : RB&E.
2019 Nov; 17(1):95. doi:
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Scientific reports.
2019 11; 9(1):16098. doi:
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The journal of trauma and acute care surgery.
2019 11; 87(5):1140-1147. doi:
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JNMA; journal of the Nepal Medical Association.
2019 Nov; 57(220):460-463. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
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Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2019 Oct; 35(10):1083-1088. doi:
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Hypertension (Dallas, Tex. : 1979).
2019 10; 74(4):1014-1020. doi:
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Journal of the American Chemical Society.
2019 08; 141(34):13421-13433. doi:
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Pharmacology research & perspectives.
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Scientific reports.
2019 07; 9(1):10925. doi:
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Talanta.
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Journal of materials chemistry. B.
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Liver international : official journal of the International Association for the Study of the Liver.
2019 04; 39(4):705-713. doi:
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Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2019 03; 28(3):291-297. doi:
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Life sciences.
2019 Feb; 219(?):190-198. doi:
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Toxicology letters.
2019 Feb; 301(?):79-89. doi:
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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2019; 52(10):e8491. doi:
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Mediators of inflammation.
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