Dexpropranolol hydrochloride (BioDeep_00000718852)
代谢物信息卡片
(R)-Propranolol hydrochloride
化学式: C16H22ClNO2 (295.1338982)
中文名称: (R)-(+)-普奈洛尔 盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl
InChI: /m1./s1
描述信息
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
(R)-Propranolol hydrochloride is a less active enantiomer of the?β-adrenoceptor antagonist?propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:51161
- KEGGdrug: D03729
- PubChem: 25137925
- PubChem: 66366
- ChEMBL: CHEMBL1358662
- MeSH: Propranolol
- CAS: 13071-11-9
- medchemexpress: HY-A0295
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Pattwat Maneewattanapinyo, Chaowalit Monton, Wiwat Pichayakorn, Jirapornchai Suksaeree. Plant leaf mucilage/carrageenan/Eudragit® NE30D blended films: Optimization, characterization, and pharmaceutical application.
International journal of biological macromolecules.
2024 Jan; 254(Pt 2):127916. doi:
10.1016/j.ijbiomac.2023.127916. [PMID: 37944740] - Juan Zhao, Yu Chen, Zhifen Ding, Yaru Zhou, Ruiqing Bi, Ziting Qin, Lei Yang, Peng Sun, Qiping Sun, Guang Chen, Daiyuan Sun, Xianya Jiang, Lu Zheng, Xiao-Lin Chen, Hu Wan, Guanghui Wang, Qiang Li, Huailong Teng, Guotian Li. Identification of propranolol and derivatives that are chemical inhibitors of phosphatidate phosphatase as potential broad-spectrum fungicides.
Plant communications.
2023 Aug; ?(?):100679. doi:
10.1016/j.xplc.2023.100679. [PMID: 37653727] - Shuming Chen, Xuekai Zhao, Junjie Huang, Na Lin, Qianhui Xu, Jianwei Chen, Jianqiang Huang, Lie Wang, Chen Lin, Zaizhong Zhang. The effects of propranolol on the biology and Notch signaling pathway of human umbilical vein endothelial cells.
Medicine.
2023 Aug; 102(32):e34672. doi:
10.1097/md.0000000000034672. [PMID: 37565874] - Dison Stracke Pfingsten Franco, Jordana Georgin, Claudete Gindri Ramos, Salma Martinez Eljaiek, Daniel Romero Badillo, Anelise Hoch Paschoalin de Oliveira, Daniel Allasia, Lucas Meili. The Synthesis and Evaluation of Porous Carbon Material from Corozo Fruit (Bactris guineensis) for Efficient Propranolol Hydrochloride Adsorption.
Molecules (Basel, Switzerland).
2023 Jul; 28(13):. doi:
10.3390/molecules28135232. [PMID: 37446896] - Paula Mayara Morais da Silva, Gilberto Dias de Alkimin, Natália Gabriele Camparotto, Patricia Prediger, Bruno Nunes. Toxicological effects resulting from co-exposure to nanomaterials and to a β-blocker pharmaceutical drug in the non-target macrophyte species Lemna minor.
Environmental pollution (Barking, Essex : 1987).
2023 Apr; 322(?):121166. doi:
10.1016/j.envpol.2023.121166. [PMID: 36738879] - Ming Yi, Jinxiu Lou, Wanlu Zhu, Dan Li, Pingfeng Yu, Huijie Lu. Mechanism of β-blocker biodegradation by wastewater microorganisms.
Journal of hazardous materials.
2023 02; 444(Pt A):130338. doi:
10.1016/j.jhazmat.2022.130338. [PMID: 36417780] - Yu Lei, Livio Carlucci, Huub Rijnaarts, Alette Langenhoff. Phytoremediation of micropollutants by Phragmites australis, Typha angustifolia, and Juncus effuses.
International journal of phytoremediation.
2023; 25(1):82-88. doi:
10.1080/15226514.2022.2057422. [PMID: 35414315] - Wei-Ping He, Jin-Cheng Li, Gao-Ming Wang. [Effect of total flavonoids of buckwheat flower and leaf on myocardial cell apoptosis and Wnt/β-catenin/PPARγ pathway in arrhythmic rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(1):220-225. doi:
10.19540/j.cnki.cjcmm.20221014.701. [PMID: 36725274] - Mahmoud H Teaima, Moaz A Eltabeeb, Mohamed A El-Nabarawi, Menna M Abdellatif. Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation.
Drug delivery.
2022 Dec; 29(1):2549-2560. doi:
10.1080/10717544.2022.2100514. [PMID: 35912869] - Pandeng Miao, Jie Gan, Jian Zhang, Mingxuan Ma, Xiaoqi Li, Yingxiang Du, Zijie Feng, Liu Zhang. Carboxymethyl-β-cyclodextrin and histidine-zeolitic imidazolate framework-8 used for enantioseparation of three basic drugs in open-tubular capillary electrochromatography.
Chirality.
2022 09; 34(9):1209-1218. doi:
10.1002/chir.23480. [PMID: 35678370] - Farzaneh Feizi, Ajit K Sarmah, Ropru Rangsivek, Kapish Gobindlal. Adsorptive removal of propranolol under fixed-bed column using magnetic tyre char: Effects of wastewater effluent organic matter and ball milling.
Environmental pollution (Barking, Essex : 1987).
2022 Jul; 305(?):119283. doi:
10.1016/j.envpol.2022.119283. [PMID: 35421549] - Abdolhamid Esmaeeli, Zahra Keshavarz, Firoozeh Dehdar, Majid Assadi, Mohammad Seyedabadi. The effects of carvedilol, metoprolol and propranolol on cisplatin-induced kidney injury.
Drug and chemical toxicology.
2022 Jul; 45(4):1558-1564. doi:
10.1080/01480545.2020.1846551. [PMID: 33198524] - Ramasamy Manikandan, Balamuralikrishnan Balasubramanian, Panneerselvam Punniyakotti, Arumugam Vijaya Anand, Arun Meyyazhagan, Shanmugam Velayuthaprabhu, Rengasamy Lakshminarayanan Rengarajan, Utthapon Issara, Wen-Chao Liu. Cardio-protective effects of terminalia catappa leaves and terminalia chebula fruit extract in doxorubicin-induced cardiomyopathy in rats.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2022 Jul; 27(5):488-495. doi:
10.1080/1354750x.2022.2064550. [PMID: 35400254] - Edward S Wragg, Patrizia Pannucci, Stephen J Hill, Jeanette Woolard, Samantha L Cooper. Involvement of β-adrenoceptors in the cardiovascular responses induced by selective adenosine A2A and A2B receptor agonists.
Pharmacology research & perspectives.
2022 06; 10(3):e00975. doi:
10.1002/prp2.975. [PMID: 35643970] - Yuefei Ruan, Hongwen Sun, Yichun Lu, Yanwei Zhang, Jiayao Xu, Hongkai Zhu, Yuhe He. Evaluating phospholipid- and protein-water partitioning of two groups of chemicals of emerging concern: Diastereo- and enantioselectivity.
Journal of hazardous materials.
2022 05; 430(?):128499. doi:
10.1016/j.jhazmat.2022.128499. [PMID: 35739679] - Rozelle Corda, Sophia Chrisomalis-Dring, Sarah Crook, Carrie J Shawber, June K Wu, Paul J Chai. Propranolol treatment for chylothorax after congenital cardiac surgery.
The Journal of thoracic and cardiovascular surgery.
2022 05; 163(5):1630-1641.e2. doi:
10.1016/j.jtcvs.2021.09.007. [PMID: 34583843] - Debashish Chowdhury, Luv Bansal, Ashish Duggal, Debabrata Datta, Ankit Mundra, Anand Krishnan, Arun Koul, Anu Gupta. TOP-PRO study: A randomized double-blind controlled trial of topiramate versus propranolol for prevention of chronic migraine.
Cephalalgia : an international journal of headache.
2022 04; 42(4-5):396-408. doi:
10.1177/03331024211047454. [PMID: 34579560] - Nicole Arguelles, Janielle Richards, Ahmed A El-Sherbeni, Sharon Miksys, Rachel F Tyndale. Sex, estrous cycle, and hormone regulation of CYP2D in the brain alters oxycodone metabolism and analgesia.
Biochemical pharmacology.
2022 04; 198(?):114949. doi:
10.1016/j.bcp.2022.114949. [PMID: 35143755] - E Bäckström, T Erngren, B-M Fihn, M W Sadiq, W Lindberg, M Fridén, K Grime. Possible Extraction of Drugs from Lung Tissue During Broncho-alveolar Lavage Suggest Uncertainty in the Procedure's Utility for Quantitative Assessment of Airway Drug Exposure.
Journal of pharmaceutical sciences.
2022 03; 111(3):852-858. doi:
10.1016/j.xphs.2021.12.004. [PMID: 34890629] - Darren M Roberts, Haddijatou K Hughes, Paul S Haber, Graham R D Jones. Variability in insulin pharmacokinetics following high-dose insulin therapy.
Clinical toxicology (Philadelphia, Pa.).
2022 Mar; 60(3):389-391. doi:
10.1080/15563650.2021.1967372. [PMID: 34521309] - Hagar Bessar, Abdalla Hassan Kandil, Noha Mohammed Nasr, Fathia Khattab. Itraconazole versus propranolol: therapeutic and pharmacologic effect on serum angiopoietin-2 in patients with infantile hemangioma.
The Journal of dermatological treatment.
2022 Feb; 33(1):105-110. doi:
10.1080/09546634.2019.1687822. [PMID: 31668109] - Hae-Jung Yang, Seung-Gon Kim, Eun Hyun Seo, Hyung-Jun Yoon. Amisulpride withdrawal akathisia responding to aripiprazole with propranolol in first-onset psychosis: a case report.
BMC psychiatry.
2022 01; 22(1):74. doi:
10.1186/s12888-022-03721-9. [PMID: 35093063] - Virginia Albiñana, Lucía Recio-Poveda, Pilar González-Peramato, Luis Martinez-Piñeiro, Luisa María Botella, Angel M Cuesta. Blockade of β2-Adrenergic Receptor Reduces Inflammation and Oxidative Stress in Clear Cell Renal Cell Carcinoma.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031325. [PMID: 35163250] - Seong-Ho Ok, Seung Hyun Ahn, Soo Hee Lee, Hyun-Jin Kim, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Lipid emulsion attenuates propranolol-induced early apoptosis in rat cardiomyoblasts.
Human & experimental toxicology.
2022 Jan; 41(?):9603271221110852. doi:
10.1177/09603271221110852. [PMID: 35738838] - Ivana Kurćubić, Una-Jovana Vajić, Sandra Cvijić, Milkica Crevar-Sakač, Nataša Bogavac-Stanojević, Zoran Miloradović, Nevena Mihajlović-Stanojević, Milan Ivanov, Danijela Karanović, Đurđica Jovović, Jelena Djuriš. Mucoadhesive buccal tablets with propranolol hydrochloride: Formulation development and in vivo performances in experimental essential hypertension.
International journal of pharmaceutics.
2021 Dec; 610(?):121266. doi:
10.1016/j.ijpharm.2021.121266. [PMID: 34752918] - Tomoko Kodama, Satoshi Kameshima, Kosuke Otani, Muneyoshi Okada, Hideyuki Yamawaki. Eukaryotic elongation factor 2 kinase inhibitor, A484954 induces diuretic effect via renal vasorelaxation in spontaneously hypertensive rats.
European journal of pharmacology.
2021 Dec; 913(?):174637. doi:
10.1016/j.ejphar.2021.174637. [PMID: 34801528] - Wael S Ibrahim, Hoda M S Ahmed, Amr A A Mahmoud, Mona F Mahmoud, Islam A A E-H Ibrahim. Propranolol and low-dose isoproterenol ameliorate insulin resistance, enhance β-arrestin2 signaling, and reduce cardiac remodeling in high-fructose, high-fat diet-fed mice: Comparative study with metformin.
Life sciences.
2021 Dec; 286(?):120055. doi:
10.1016/j.lfs.2021.120055. [PMID: 34662551] - Deshan F Sebaratnam, Ana L Rodríguez Bandera, Li-Chuen F Wong, Orli Wargon. Infantile hemangioma. Part 2: Management.
Journal of the American Academy of Dermatology.
2021 12; 85(6):1395-1404. doi:
10.1016/j.jaad.2021.08.020. [PMID: 34419523] - Mehdi Farshchian, Geoffrey A Potts. Transient hypertriglyceridaemia associated with propranolol for treatment of infantile hemangioma.
The Australasian journal of dermatology.
2021 Nov; 62(4):e580-e581. doi:
10.1111/ajd.13669. [PMID: 34293182] - Andrew K Evans, Heui Hye Park, Nay Lui Saw, Kratika Singhal, Gaku Ogawa, Ryan D Leib, Mehrdad Shamloo. Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.
Neurobiology of aging.
2021 10; 106(?):241-256. doi:
10.1016/j.neurobiolaging.2021.06.012. [PMID: 34320462] - Georgios N Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Sempastien Fillipas-Ntekouan, Andreas Fotopoulos, Spyridon Tsiouris, Xanthi Xourgia, Lampros Lakkas, Konstantinos Pappas, Lampros K Michalis, Fotini Sergianiti, Gerasimos Baltayiannis, Dimitrios Christodoulou, Christina Koustousi, Nikolaos Aggelis, Haralampos Milionis. Conversion of Propranolol to Carvedilol Improves Renal Perfusion and Outcome in Patients With Cirrhosis and Ascites.
Journal of clinical gastroenterology.
2021 09; 55(8):721-729. doi:
10.1097/mcg.0000000000001431. [PMID: 32991355] - Kathleen E Singer, Taylor E Wallen, Mackenzie C Morris, Emily McGlone, Sabre Stevens-Topie, Ryan Earnest, Michael D Goodman. Postinjury treatments to make early tactical aeromedical evacuation practical for the brain after TBI.
The journal of trauma and acute care surgery.
2021 08; 91(2S Suppl 2):S89-S98. doi:
10.1097/ta.0000000000003259. [PMID: 33938511] - Sheelan Ahmad, Daniel Baker, Darragh Murnane, Neil Spooner, Ute Gerhard. Solid-phase microextraction for assessment of plasma protein binding, a complement to rapid equilibrium dialysis.
Bioanalysis.
2021 Jul; 13(14):1101-1111. doi:
10.4155/bio-2021-0109. [PMID: 34275331] - Ali Hatefi, Ahmad Zare Shahneh, Zarbakht Ansari Pirsaraie, Ali Mohammad Alizadeh, Mohammad Pouya Atashnak, Reza Masoudi, Frederic Pio. The stimulation and inhibition of beta-2 adrenergic receptor on the inflammatory responses of ovary and immune system in the aged laying hens.
BMC veterinary research.
2021 May; 17(1):195. doi:
10.1186/s12917-021-02892-z. [PMID: 34022889] - Sultan Aydin Köker, Ahmet Ufuk Kömüroğlu, Adem Yasin Köksoy, Ülkü Gül Şiraz, Emine Tekin, Alper Köker. Evaluation of GLUT1, IGF-2, VEGF, FGF 1, and angiopoietin 2 in infantile hemangioma.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2021 May; 28(4):296-300. doi:
10.1016/j.arcped.2021.02.009. [PMID: 33715934] - Hui Zhou, John J Sim, Jiaxiao Shi, Sally F Shaw, Ming-Sum Lee, Jonathan R Neyer, Csaba P Kovesdy, Kamyar Kalantar-Zadeh, Steven J Jacobsen. β-Blocker Use and Risk of Mortality in Heart Failure Patients Initiating Maintenance Dialysis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2021 05; 77(5):704-712. doi:
10.1053/j.ajkd.2020.07.023. [PMID: 33010357] - Angela Abruzzo, Alessandra Crispini, Cecilia Prata, Rosanna Adduci, Fiore Pasquale Nicoletta, Francesco Dalena, Teresa Cerchiara, Barbara Luppi, Federica Bigucci. Freeze-Dried Matrices for Buccal Administration of Propranolol in Children: Physico-Chemical and Functional Characterization.
Journal of pharmaceutical sciences.
2021 04; 110(4):1676-1686. doi:
10.1016/j.xphs.2020.10.033. [PMID: 33164786] - James C Lee, Omeed Modiri, Ryan W England, Carrie J Shawber, June K Wu. Propranolol Therapy in Infantile Hemangioma: It Is Not Just About the Beta.
Plastic and reconstructive surgery.
2021 04; 147(4):875-885. doi:
10.1097/prs.0000000000007699. [PMID: 33776033] - Vilmos Kertesz, John F Cahill, Bernadeta R Srijanto, Charles P Collier, Marissa Vavrek, Bingming Chen. Absolute quantitation of propranolol from 200-μm regions of mouse brain and liver thin tissues using laser ablation-dropletProbe-mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2021 Mar; 35(5):e9010. doi:
10.1002/rcm.9010. [PMID: 33232548] - Julia Walczak, Corinne Bunn, Pravesh Saini, Yuk Ming Liu, Anthony J Baldea, Kuzhali Muthumalaiappan. Transient Improvement in Erythropoiesis Is Achieved Via the Chaperone AHSP With Early Administration of Propranolol in Burn Patients.
Journal of burn care & research : official publication of the American Burn Association.
2021 03; 42(2):311-322. doi:
10.1093/jbcr/iraa150. [PMID: 32842148] - Tuba Talo Yildirim, Serkan Dündar, Alihan Bozoğlan, Tahir Karaman, Samet Tekin, Onur Evren Kahraman. Evaluation of the Effects of ß-Adrenergic Receptor-Propranolol on Osseointegration of the Titanium Implants.
The Journal of craniofacial surgery.
2021 Mar; 32(2):783-786. doi:
10.1097/scs.0000000000006857. [PMID: 33705036] - Doran J Satanove, Simon Rahman, T M Vanessa Chan, Suelynn Ren, Paul B S Clarke. Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects.
Psychopharmacology.
2021 Feb; 238(2):475-486. doi:
10.1007/s00213-020-05696-5. [PMID: 33150479] - Ali Zeraatkar Moghaddam, Maryam Goharjoo, Ebrahim Ghiamati, Kamal Khodaei, Hadi Tabani. Gel electro-membrane extraction of propranolol and atenolol from blood serum samples: Effect of graphene-based nanomaterials on extraction efficiency of gel membrane.
Talanta.
2021 Jan; 222(?):121557. doi:
10.1016/j.talanta.2020.121557. [PMID: 33167255] - Basel A Abdel-Wahab, Safaa Yousef Salem, Hala Mostafa Mohammed, Nashwa Ahmed Mohammed, Helal F Hetta. The role of vimentin, Connexin-43 proteins, and oxidative stress in the protective effect of propranolol against clozapine-induced myocarditis and apoptosis in rats.
European journal of pharmacology.
2021 Jan; 890(?):173645. doi:
10.1016/j.ejphar.2020.173645. [PMID: 33098837] - Lenka Michalcová, Hana Nevídalová, Zdeněk Glatz. Toward an automated workflow for the study of plasma protein-drug interactions based on capillary electrophoresis-frontal analysis combined with in-capillary mixing of interacting partners.
Journal of chromatography. A.
2021 Jan; 1635(?):461734. doi:
10.1016/j.chroma.2020.461734. [PMID: 33264700] - Ayoub Amssayef, Mohammed Ajebli, Mohamed Eddouks. Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Jan; 43(1):49-55. doi:
10.1080/10641963.2020.1797087. [PMID: 32706597] - Edin Botan, Tanıl Kendirli, Emrah Gün, Serdar Balsak, Mehmet Ramoğlu, Ercan Tutar. Cardiac arrest due to a fatal dose of propranolol successfully treated with intravenous lipid infusion.
The Turkish journal of pediatrics.
2021 ; 63(5):913-916. doi:
10.24953/turkjped.2021.05.020. [PMID: 34738374] - Vilmos Kertesz, John F Cahill, Bernadeta R Srijanto, Charles P Collier, Marissa Vavrek, Bingming Chen. Integrated laser ablation-dropletProbe-mass spectrometry for absolute drug quantitation, metabolite detection, and distribution in tissue.
Rapid communications in mass spectrometry : RCM.
2021; 35(23):e9202. doi:
10.1002/rcm.9202. [PMID: 34545636] - Abdulaziz A Alzahrani, Lily L Cao, Hayyaf S Aldossary, Demitris Nathanael, Jiarong Fu, Clare J Ray, Keith L Brain, Prem Kumar, Andrew M Coney, Andrew P Holmes. β-Adrenoceptor blockade prevents carotid body hyperactivity and elevated vascular sympathetic nerve density induced by chronic intermittent hypoxia.
Pflugers Archiv : European journal of physiology.
2021 01; 473(1):37-51. doi:
10.1007/s00424-020-02492-0. [PMID: 33210151] - Muhammad Nasir Kalam, Muhammad Fawad Rasool, Faleh Alqahtani, Imran Imran, Asim Ur Rehman, Naveed Ahmed. Development and Evaluation of a Physiologically Based Pharmacokinetic Drug-Disease Model of Propranolol for Suggesting Model Informed Dosing in Liver Cirrhosis Patients.
Drug design, development and therapy.
2021; 15(?):1195-1211. doi:
10.2147/dddt.s297981. [PMID: 33762817] - Manabu Murakami, Agnieszka M Murakami, Yasushi Matsuzaki, Daisuke Sawamura, Takayoshi Ohba, Ichirou Miyoshi, Shirou Itagaki, Hiroyuki Sakagami. Attenuated β-adrenergic response in calcium/calmodulin-dependent protein kinase IV-knockout mice.
PloS one.
2021; 16(4):e0249932. doi:
10.1371/journal.pone.0249932. [PMID: 33857227] - Samer Asmar, Letitia Bible, Mohamad Chehab, Andrew Tang, Muhammad Khurrum, Lourdes Castanon, Michael Ditillo, Molly Douglas, Bellal Joseph. Traumatic brain injury induced temperature dysregulation: What is the role of β blockers?.
The journal of trauma and acute care surgery.
2021 01; 90(1):177-184. doi:
10.1097/ta.0000000000002975. [PMID: 33332783] - Hala Salah Abdel-Kawy. Effect of carvedilol versus propranolol on acute and chronic liver toxicity in rats.
Drug and chemical toxicology.
2021 Jan; 44(1):101-111. doi:
10.1080/01480545.2019.1576718. [PMID: 30810389] - Maja D Nešić, Tanja Dučić, Xinyue Liang, Manuel Algarra, Lan Mi, Lela Korićanac, Jelena Žakula, Tatjana J Kop, Mira S Bjelaković, Aleksandra Mitrović, Gordana D Gojgić Cvijović, Milutin Stepić, Marijana Petković. SR-FTIR spectro-microscopic interaction study of biochemical changes in HeLa cells induced by Levan-C60, Pullulan-C60, and their cholesterol-derivatives.
International journal of biological macromolecules.
2020 Dec; 165(Pt B):2541-2549. doi:
10.1016/j.ijbiomac.2020.10.141. [PMID: 33736274] - Sanjiv K Hyoju, Olga Zaborina, Harry van Goor. SARS-CoV-2 and the sympathetic immune response: Dampening inflammation with antihypertensive drugs (Clonidine and Propranolol).
Medical hypotheses.
2020 Nov; 144(?):110039. doi:
10.1016/j.mehy.2020.110039. [PMID: 32758881] - Carli Weyers, Laura M K Dingle, Brendan S Wilhelmi, Adrienne L Edkins, Clinton G L Veale. Use of a non-hepatic cell line highlights limitations associated with cell-based assessment of metabolically induced toxicity.
Drug and chemical toxicology.
2020 Nov; 43(6):656-662. doi:
10.1080/01480545.2019.1585869. [PMID: 30880486] - Meerim Park, Hye Lim Jung, Ye Jee Shim, Heung Sik Kim, Hoi Soo Yoon, Sang Kyu Park, Hee Won Cheuh, Mee Jeong Lee, Jae Min Lee, Eun Sil Park, Jae Hee Lee, Yeon-Jung Lim, Young Bae Choi. Serum cytokine profiles in infants with infantile hemangiomas on oral propranolol treatment: VEGF and bFGF, potential biomarkers predicting clinical outcomes.
Pediatric research.
2020 11; 88(5):749-755. doi:
10.1038/s41390-020-0862-1. [PMID: 32311699] - Elizabeth S Miller, Camille G Apple, Kolenkode B Kannan, Zackary M Funk, Philip A Efron, Alicia M Mohr. The effects of selective beta-adrenergic blockade on bone marrow dysfunction following severe trauma and chronic stress.
American journal of surgery.
2020 11; 220(5):1312-1318. doi:
10.1016/j.amjsurg.2020.06.058. [PMID: 32741547] - Andrea Bassi, Andrea Azzarelli, Angelina Vaccaro, Carlo Mazzatenta. At-home dose escalation of propranolol for infantile hemangiomas during the COVID-19 pandemic.
Dermatologic therapy.
2020 11; 33(6):e13977. doi:
10.1111/dth.13977. [PMID: 32633450] - Tyler J Loftus, Kolenkode B Kannan, Juan C Mira, Scott C Brakenridge, Philip A Efron, Alicia M Mohr. Modulation of the HGF/c-Met Axis Impacts Prolonged Hematopoietic Progenitor Mobilization Following Trauma and Chronic Stress.
Shock (Augusta, Ga.).
2020 10; 54(4):482-487. doi:
10.1097/shk.0000000000001506. [PMID: 31904616] - M Mateu-Salat, E Urgell, A Chico. SARS-COV-2 as a trigger for autoimmune disease: report of two cases of Graves' disease after COVID-19.
Journal of endocrinological investigation.
2020 Oct; 43(10):1527-1528. doi:
10.1007/s40618-020-01366-7. [PMID: 32686042] - Marián Masár, Jasna Hradski, Martin G Schmid, Roman Szucs. Advantages and Pitfalls of Capillary Electrophoresis of Pharmaceutical Compounds and Their Enantiomers in Complex Samples: Comparison of Hydrodynamically Opened and Closed Systems.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186852. [PMID: 32961980] - Sonia Maccari, Valentina Pace, Federica Barbagallo, Tonino Stati, Caterina Ambrosio, Maria Cristina Grò, Paola Molinari, Vanessa Vezzi, Liviana Catalano, Paola Matarrese, Mario Patrizio, Roberto Rizzi, Giuseppe Marano. Intermittent β-adrenergic blockade downregulates the gene expression of β-myosin heavy chain in the mouse heart.
European journal of pharmacology.
2020 Sep; 882(?):173287. doi:
10.1016/j.ejphar.2020.173287. [PMID: 32585157] - Qiaorong Ji, Yu Zhang, Huan Zhang, Jie Liu, Chengzhu Cao, Zhouyang Yuan, Qianqian Ma, Wei Zhang. Effects of β-adrenoceptor activation on haemodynamics during hypoxic stress in rats.
Experimental physiology.
2020 09; 105(9):1660-1668. doi:
10.1113/ep088669. [PMID: 32706493] - Yuan Gao, Yixin Han, Xiaoyu Zhang, Qiaoling Fei, Ruijuan Qi, Rui Hou, Runlan Cai, Cheng Peng, Yun Qi. Penicillin causes non-allergic anaphylaxis by activating the contact system.
Scientific reports.
2020 08; 10(1):14160. doi:
10.1038/s41598-020-71083-x. [PMID: 32843685] - Di-Qiong Jin, Shao-Wen Shi, Yan Ma, Qun Fang. LC-Swan Probe: An Integrated In Situ Sampling Interface for Liquid Chromatography Separation and Mass Spectrometry Analysis.
Analytical chemistry.
2020 07; 92(13):9214-9222. doi:
10.1021/acs.analchem.0c01555. [PMID: 32496041] - Zeid A ALOthman, Khalid M Alsheetan, Hassan Y Aboul-Enein, Imran Ali. Applications of shun shell column and nanocomposite sorbent for analysis of eleven anti-hypertensive in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122125. doi:
10.1016/j.jchromb.2020.122125. [PMID: 32371329] - Shih-Yi Lin, Ya-Yu Wang, Cheng-Yi Chang, Chih-Cheng Wu, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Chun-Jung Chen. Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke.
Cells.
2020 06; 9(6):. doi:
10.3390/cells9061373. [PMID: 32492962] - Jin Qi Li, Shu-Han Zhang, Rong-Sheng Tong, Dan He, Zhen-Dong Zhong, Shu-Ya She. Curcuma's extraction attenuates propranolol-induced psoriasis like in mice by inhibition of keratin, proliferating cell nuclear antigen and toll-like receptor expression.
Pakistan journal of pharmaceutical sciences.
2020 May; 33(3):1033-1048. doi:
". [PMID: 33191227] - Lukas C Harps, Sonja Schipperges, Felix Bredendiek, Bernhard Wuest, Andreas Borowiak, Maria Kristina Parr. Two dimensional chromatography mass spectrometry: Quantitation of chiral shifts in metabolism of propranolol in bioanalysis.
Journal of chromatography. A.
2020 Apr; 1617(?):460828. doi:
10.1016/j.chroma.2019.460828. [PMID: 31911001] - Irina A Duarte, Patrick Reis-Santos, Sara C Novais, Lénia D Rato, Marco F L Lemos, Andreia Freitas, Ana Sofia Vila Pouca, Jorge Barbosa, Henrique N Cabral, Vanessa F Fonseca. Depressed, hypertense and sore: Long-term effects of fluoxetine, propranolol and diclofenac exposure in a top predator fish.
The Science of the total environment.
2020 Apr; 712(?):136564. doi:
10.1016/j.scitotenv.2020.136564. [PMID: 31945523] - Edgor Cole Tolledo, Sharon Miksys, Frank J Gonzalez, Rachel F Tyndale. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.
British journal of pharmacology.
2020 02; 177(3):701-712. doi:
10.1111/bph.14884. [PMID: 31648367] - Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen, Ping Wang. Vanillin enhances the passive transport rate and absorption of drugs with moderate oral bioavailability in vitro and in vivo by affecting the membrane structure.
Food & function.
2020 Jan; 11(1):700-710. doi:
10.1039/c9fo02846c. [PMID: 31909774] - S Suga, S Araki, S Aramaki, E Shibata, K Kusuhara. Giant placental chorioangioma followed by circulatory failure of the newborn and infantile hemangioma: Case report.
Journal of neonatal-perinatal medicine.
2020; 13(1):135-138. doi:
10.3233/npm-180118. [PMID: 32280067] - Yao-Yao Chen, Juan Li, Min Chen, Ling Yue, Tian-Wei She, Hui Zheng. Acupuncture versus propranolol in migraine prophylaxis: an indirect treatment comparison meta-analysis.
Journal of neurology.
2020 Jan; 267(1):14-25. doi:
10.1007/s00415-019-09510-x. [PMID: 31435770] - Sayaka Tani, Kayo Kunimoto, Yutaka Inaba, Naoya Mikita, Chikako Kaminaka, Nobuo Kanazawa, Yuki Yamamoto, Nobuyuki Kakimoto, Tomohiro Suenaga, Takashi Takeuchi, Hiroyuki Suzuki, Masatoshi Jinnin. Change of serum cytokine profiles by propranolol treatment in patients with infantile hemangioma.
Drug discoveries & therapeutics.
2020; 14(2):89-92. doi:
10.5582/ddt.2020.03014. [PMID: 32378651] - Camille G Apple, Elizabeth S Miller, Tyler J Loftus, Kolenkode B Kannan, Chase W Thompson, Maria Cecilia Lopez, Henry V Baker, Lyle L Moldawer, Philip A Efron, Alicia M Mohr. Effect of Beta-Blockade on the Expression of Regulatory MicroRNA after Severe Trauma and Chronic Stress.
Journal of the American College of Surgeons.
2020 01; 230(1):121-129. doi:
10.1016/j.jamcollsurg.2019.09.011. [PMID: 31672639] - Hilal Susam Şen, Bilgehan Yalçın, Hande Canpınar, Süheyla Ocak, Canan Akyüz. Serum levels of VEGF and bFGF in infantile hemangiomas treated with propranolol.
The Turkish journal of pediatrics.
2020; 62(6):979-985. doi:
10.24953/turkjped.2020.06.009. [PMID: 33372436] - Muhammad Nasir Kalam, Muhammad Fawad Rasool, Asim Ur Rehman, Naveed Ahmed. Clinical Pharmacokinetics of Propranolol Hydrochloride: A Review.
Current drug metabolism.
2020; 21(2):89-105. doi:
10.2174/1389200221666200414094644. [PMID: 32286940] - Lidan Wang, Kai Zheng, Xinlin Li, Yang Wang, Qiong Xu. Influence of Cytochrome P450 2D6 Polymorphisms on the Efficacy of Oral Propranolol in Treating Infantile Hemangioma.
BioMed research international.
2020; 2020(?):8732871. doi:
10.1155/2020/8732871. [PMID: 32219146] - Alice Lee, Scott P Fraser, Mustafa B A Djamgoz. Propranolol inhibits neonatal Nav1.5 activity and invasiveness of MDA-MB-231 breast cancer cells: Effects of combination with ranolazine.
Journal of cellular physiology.
2019 12; 234(12):23066-23081. doi:
10.1002/jcp.28868. [PMID: 31222761] - Berenice Venegas, Lizzbeth Yureli De León Gordillo, Gabriela Rosas, Julieta A Espinoza, Carolina Morán, Roberto Domínguez, Leticia Morales-Ledesma. In rats with estradiol valerate-induced polycystic ovary syndrome, the acute blockade of ovarian β-adrenoreceptors improve ovulation.
Reproductive biology and endocrinology : RB&E.
2019 Nov; 17(1):95. doi:
10.1186/s12958-019-0539-y. [PMID: 31744506] - Ana B Segarra, Isabel Prieto-Gomez, Inmaculada Banegas, Magdalena Martínez-Cañamero, Juan de Dios Luna, Marc de Gasparo, Manuel Ramírez-Sánchez. Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments.
Scientific reports.
2019 11; 9(1):16098. doi:
10.1038/s41598-019-52658-9. [PMID: 31695104] - Muhammad Zeeshan, Mohammad Hamidi, Terence OʼKeeffe, Esther H Bae, Kamil Hanna, Randall S Friese, Narong Kulvatunyou, El Rasheid Zakaria, Lynn Gries, Andrew Tang, Bellal Joseph. Propranolol attenuates cognitive, learning, and memory deficits in a murine model of traumatic brain injury.
The journal of trauma and acute care surgery.
2019 11; 87(5):1140-1147. doi:
10.1097/ta.0000000000002484. [PMID: 31425494] - Sabina Khadka, Indu K C, Rabindra Jang Rayamajhi, Pravakar Dawadi, Pravash Budhathoki. Thyrotoxic Periodic Paralysis with Hypokalemia in an Adult Male from Nepal: A Case Report.
JNMA; journal of the Nepal Medical Association.
2019 Nov; 57(220):460-463. doi:
10.31729/jnma.4763. [PMID: 32335663] - Bart van Domburg, Bart C H van der Nagel, Louise M Andrews, Birgit C P Koch. High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Oct; 1129(?):121793. doi:
10.1016/j.jchromb.2019.121793. [PMID: 31629310] - Rana Shariati, Behzad Rezaei, Hamid Reza Jamei, Ali Asghar Ensafi. Manufacturing of a Sensitive and Selective Optical Sensor Based on Molecularly Imprinted Polymers and Green Carbon Dots Synthesized from Cedrus Plant for Trace Analysis of Propranolol.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2019 Oct; 35(10):1083-1088. doi:
10.2116/analsci.19p133. [PMID: 31130581] - Eva Gatineau, Ming C Gong, Frédérique Yiannikouris. Soluble Prorenin Receptor Increases Blood Pressure in High Fat-Fed Male Mice.
Hypertension (Dallas, Tex. : 1979).
2019 10; 74(4):1014-1020. doi:
10.1161/hypertensionaha.119.12906. [PMID: 31378099] - Zhi Yue, Chenghan Li, Gregory A Voth, Jessica M J Swanson. Dynamic Protonation Dramatically Affects the Membrane Permeability of Drug-like Molecules.
Journal of the American Chemical Society.
2019 08; 141(34):13421-13433. doi:
10.1021/jacs.9b04387. [PMID: 31382734] - Frederik N Ågesen, Peter E Weeke, Peer Tfelt-Hansen, Jacob Tfelt-Hansen. Pharmacokinetic variability of beta-adrenergic blocking agents used in cardiology.
Pharmacology research & perspectives.
2019 08; 7(4):e00496. doi:
10.1002/prp2.496. [PMID: 31338197] - Andy Hsien Wei Koh, Russ Chess-Williams, Anna Elizabeth Lohning. Differential mechanisms of action of the trace amines octopamine, synephrine and tyramine on the porcine coronary and mesenteric artery.
Scientific reports.
2019 07; 9(1):10925. doi:
10.1038/s41598-019-46627-5. [PMID: 31358768] - Ahmed A Khorshed, Mohamed Khairy, Craig E Banks. Electrochemical determination of antihypertensive drugs by employing costless and portable unmodified screen-printed electrodes.
Talanta.
2019 Jun; 198(?):447-456. doi:
10.1016/j.talanta.2019.01.117. [PMID: 30876585] - Yujuan Ma, Jianfeng Gao, Congguang Zheng, Huiqi Zhang. Well-defined biological sample-compatible molecularly imprinted polymer microspheres by combining RAFT polymerization and thiol-epoxy coupling chemistry.
Journal of materials chemistry. B.
2019 04; 7(15):2474-2483. doi:
10.1039/c9tb00056a. [PMID: 32255124] - Enric Reverter, Juan J Lozano, Cristina Alonso, Annalisa Berzigotti, Susana Seijo, Fanny Turon, Anna Baiges, Mari L Martínez-Chantar, José M Mato, Ibon Martínez-Arranz, Vincenzo La Mura, Virginia Hernández-Gea, Jaume Bosch, Juan C García-Pagán. Metabolomics discloses potential biomarkers to predict the acute HVPG response to propranolol in patients with cirrhosis.
Liver international : official journal of the International Association for the Study of the Liver.
2019 04; 39(4):705-713. doi:
10.1111/liv.14042. [PMID: 30637923] - Ezgi Özyılmaz, Hacer Sinem Göktürk Büyüknacar, Emine Kılıç Bağır, Leman Sencar, Özlem Görüroğlu Öztürk, Ismail Cem Eray, Yusuf Kenan Dağlıoğlu, Oya Baydar, Gülşah Seydaoğlu, Ufuk Özgü Mete, Derya Gümürdülü, Ali Kocabaş. Early propranolol treatment ameliorates endothelial dysfunction in experimental septic lung.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2019 03; 28(3):291-297. doi:
10.17219/acem/78248. [PMID: 29969202] - Nadezhda M Zakharova, Yury S Tarahovsky, Irina S Fadeeva, Natalia P Komelina, Maxim O Khrenov, Olga V Glushkova, Dmitry A Prokhorov, Viktor P Kutyshenko, Anatoly L Kovtun. A pharmacological composition for induction of a reversible torpor-like state and hypothermia in rats.
Life sciences.
2019 Feb; 219(?):190-198. doi:
10.1016/j.lfs.2019.01.023. [PMID: 30658098] - Lilian H J Richter, Andreas Beck, Veit Flockerzi, Hans H Maurer, Markus R Meyer. Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay.
Toxicology letters.
2019 Feb; 301(?):79-89. doi:
10.1016/j.toxlet.2018.11.007. [PMID: 30465810] - F A C Seara, I G Araujo, G E Império, M P Marassi, A C M Silva, A S Mecawi, L C Reis, E L Olivares. Propranolol inhibits myocardial infarction-induced brown adipose tissue D2 activation and maintains a low thyroid hormone state in rats.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2019; 52(10):e8491. doi:
10.1590/1414-431x20198491. [PMID: 31618368] - Xiao-Jing Ji, Ji-Wei Hao, Guang-Lei Li, Ning Dong, Xin-Qi Wang, Min Zhou, Qing-Hong Zhang, Yong-Ming Yao. Exendin-4 Exacerbates Burn-Induced Morbidity in Mice by Activation of the Sympathetic Nervous System.
Mediators of inflammation.
2019; 2019(?):2750528. doi:
10.1155/2019/2750528. [PMID: 30800001]