Ambroxol HCl (BioDeep_00000718422)
代谢物信息卡片
cis-4-[(2-Amino-3,5-dibromobenzyl)amino]cyclohexanol hydrochloride (1:1)
化学式: C13H19Br2ClN2O (411.9553)
中文名称: 氨溴索碱杂质3, 盐酸氨溴索
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC(CCC1NCC2=C(C(=CC(=C2)Br)Br)N)O.Cl
InChI: 1H
描述信息
C78273 - Agent Affecting Respiratory System > C74536 - Mucolytic Agent
D019141 - Respiratory System Agents > D005100 - Expectorants
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31198
- KEGGdrug: D01479
- PubChem: 108013
- ChEMBL: CHEMBL1514634
- MeSH: Ambroxol
- CAS: 1146648-86-3
- CAS: 1384955-66-1
- CAS: 23828-92-4
- CAS: 15942-05-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Zubing Zhou, Lele Yang, Chao Hu, Rui Gao, Xiaobo Zhang, Tao Shen. The combination of astragalus injection and ambroxol hydrochloride in the adjuvant treatment of COPD: a systematic review and meta-analysis.
Scientific reports.
2023 12; 13(1):22077. doi:
10.1038/s41598-023-49421-6. [PMID: 38087032] - Dongli Qi, Bei Jia, Hui Peng, Jiachen He, Jiaxin Pi, Pan Guo, Ying Zhang, Xiuping Deng, Jiawei Li, Zhidong Liu. Baicalin/ambroxol hydrochloride combined dry powder inhalation formulation targeting lung delivery for treatment of idiopathic pulmonary fibrosis: Fabrication, characterization, pharmacokinetics, and pharmacodynamics.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2023 Jul; 188(?):243-253. doi:
10.1016/j.ejpb.2023.05.017. [PMID: 37224929] - Idowu A Kehinde, Anu Egbejimi, Manvir Kaur, Collins Onyenaka, Tolulope Adebusuyi, Omonike A Olaleye. Inhibitory mechanism of Ambroxol and Bromhexine Hydrochlorides as potent blockers of molecular interaction between SARS-CoV-2 spike protein and human angiotensin-converting Enzyme-2.
Journal of molecular graphics & modelling.
2022 07; 114(?):108201. doi:
10.1016/j.jmgm.2022.108201. [PMID: 35487151] - Zixuan Wang, Li Yu, Shaochong Zhang, Zhenhan Wang, Mingwu Wang. An animal study on the effect of topically administered ambroxol for dry eye.
Frontiers in bioscience (Landmark edition).
2022 01; 27(1):4. doi:
10.31083/j.fbl2701004. [PMID: 35090309] - Cagri Gultekin, Ahmet Ozer Sehirli, Sule Cetinel, Serkan Sayiner. Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats?.
Bratislavske lekarske listy.
2022; 123(5):381-384. doi:
10.4149/bll_2022_060. [PMID: 35420884] - Hao Zhou, Min Zhang, Ling Sun, Wenfang Li, Qian Liu. A simple LC-MS/MS method for simultaneous determination of cilostazol and ambroxol in Sprague-Dawley rat plasma and its application to drug-drug pharmacokinetic interaction study following oral delivery in rats.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Aug; 1179(?):122766. doi:
10.1016/j.jchromb.2021.122766. [PMID: 34247102] - Lisa O'Byrne, Katie E Webster, Samuel MacKeith, Carl Philpott, Claire Hopkins, Martin J Burton. Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.
The Cochrane database of systematic reviews.
2021 07; 7(?):CD013876. doi:
10.1002/14651858.cd013876.pub2. [PMID: 34291813] - Bojan F Hörnich, Anna K Großkopf, Sarah Schlagowski, Matthias Tenbusch, Hannah Kleine-Weber, Frank Neipel, Christiane Stahl-Hennig, Alexander S Hahn. SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation.
Journal of virology.
2021 04; 95(9):. doi:
10.1128/jvi.00002-21. [PMID: 33608407] - Chao-Nan Yang, Wen-Ya Peng, Lie-Chwen Lin, Tung-Hu Tsai. Protein unbound pharmacokinetics of ambroxol in the blood and brains of rats and the interaction of ambroxol with Polygala tenuifolia by multiple microdialysis.
Journal of ethnopharmacology.
2021 Apr; 269(?):113764. doi:
10.1016/j.jep.2020.113764. [PMID: 33383115] - Christin Walther, Kristin Döring, Michaela Schmidtke. Comparative in vitro analysis of inhibition of rhinovirus and influenza virus replication by mucoactive secretolytic agents and plant extracts.
BMC complementary medicine and therapies.
2020 Dec; 20(1):380. doi:
10.1186/s12906-020-03173-2. [PMID: 33357221] - Myasar Alkotaji. Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2.
International journal of antimicrobial agents.
2020 Dec; 56(6):106192. doi:
10.1016/j.ijantimicag.2020.106192. [PMID: 33045350] - Tawfik Khoury, Yuval Ishay, Devorah Rotnemer-Golinkin, Lidya Zolotarovya, David Arkadir, Ari Zimran, Yaron Ilan. A synergistic effect of Ambroxol and Beta-Glucosylceramide in alleviating immune-mediated hepatitis: A novel immunomodulatory non-immunosuppressive formulation for treatment of immune-mediated disorders.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Dec; 132(?):110890. doi:
10.1016/j.biopha.2020.110890. [PMID: 33080465] - H-Y Li, C-M Zhang, Y-Y Lv, W-Q Dai, B Xu, X-M Qi. Value of chest imaging in the newborn with suspected COVID-19.
European review for medical and pharmacological sciences.
2020 11; 24(22):11971-11976. doi:
10.26355/eurrev_202011_23859. [PMID: 33275274] - Hideyuki Takano. Pulmonary surfactant itself must be a strong defender against SARS-CoV-2.
Medical hypotheses.
2020 Nov; 144(?):110020. doi:
10.1016/j.mehy.2020.110020. [PMID: 32590326] - Sara Elgamasy, Mohamed G Kamel, Sherief Ghozy, Adham Khalil, Mostafa E Morra, Sheikh M S Islam. First case of focal epilepsy associated with SARS-coronavirus-2.
Journal of medical virology.
2020 10; 92(10):2238-2242. doi:
10.1002/jmv.26113. [PMID: 32484990] - Alexandra Bouscary, Cyril Quessada. [Therapeutic potential of ambroxol for motor neuron diseases].
Medecine sciences : M/S.
2020 May; 36(5):447-448. doi:
10.1051/medsci/2020071. [PMID: 32452362] - Yoon-Myung Kim, Mi-Sun Yum, Sun Hee Heo, Taeho Kim, Hee Kyung Jin, Jae-Sung Bae, Go Hun Seo, Arum Oh, Hee Mang Yoon, Hyun Taek Lim, Hyo-Won Kim, Tae-Sung Ko, Hyeong-Seok Lim, Mark J Osborn, Jakub Tolar, Claudia Cozma, Arndt Rolfs, Ari Zimran, Beom Hee Lee, Han-Wook Yoo. Pharmacologic properties of high-dose ambroxol in four patients with Gaucher disease and myoclonic epilepsy.
Journal of medical genetics.
2020 02; 57(2):124-131. doi:
10.1136/jmedgenet-2019-106132. [PMID: 31649052] - Fanhua Meng, Jing Cheng, Peng Sang, Jianhui Wang. Effects of Bronchoalveolar Lavage with Ambroxol Hydrochloride on Treating Pulmonary Infection in Patients with Cerebral Infarction and on Serum Proinflammatory Cytokines, MDA and SOD.
Computational and mathematical methods in medicine.
2020; 2020(?):7984565. doi:
10.1155/2020/7984565. [PMID: 33133226] - Priyanka Lohar, Manish Kumar Sharma, Amit Kumar Sahu, Rajeswari Rathod, Pinaki Sengupta. Simultaneous bioanalysis and pharmacokinetic interaction study of acebrophylline, levocetirizine and pranlukast in Sprague-Dawley rats.
Biomedical chromatography : BMC.
2019 Dec; 33(12):e4672. doi:
10.1002/bmc.4672. [PMID: 31386207] - Dongmei Wang, Shu Sun, Songxue Hu. The therapeutic efficacy of high-dose ambroxol and the nursing effects in the treatment of severe pneumonia.
Pakistan journal of pharmaceutical sciences.
2019 May; 32(3 Special):1409-1413. doi:
". [PMID: 31551222] - C R A Silveira, J MacKinley, K Coleman, Z Li, E Finger, R Bartha, S A Morrow, J Wells, M Borrie, R G Tirona, C A Rupar, G Zou, R A Hegele, D Mahuran, P MacDonald, M E Jenkins, M Jog, S H Pasternak. Ambroxol as a novel disease-modifying treatment for Parkinson's disease dementia: protocol for a single-centre, randomized, double-blind, placebo-controlled trial.
BMC neurology.
2019 Feb; 19(1):20. doi:
10.1186/s12883-019-1252-3. [PMID: 30738426] - Abeer Bishr, Nada Sallam, Mahmoud Nour El-Din, Azza S Awad, Sanaa A Kenawy. Ambroxol attenuates cisplatin-induced hepatotoxicity and nephrotoxicity via inhibition of p-JNK/p-ERK.
Canadian journal of physiology and pharmacology.
2019 Jan; 97(1):55-64. doi:
10.1139/cjpp-2018-0528. [PMID: 30383980] - Yan Wang, Jin Lu, Tengfei Li, Shunbo Zhao, Wen Yang, Lingye Liu, Xing Shi, Mtalimanja Michael, Li Ding. Pharmacokinetics and safety of salbutamol/ambroxol fixed-dose combination granules in healthy Chinese subjects
.
International journal of clinical pharmacology and therapeutics.
2018 Dec; 56(12):597-603. doi:
10.5414/cp203212. [PMID: 30232958] - Meilian He, Changchuan Guo, Jiawei Leng, Xunjie Zhang, Ruiqing Xian, Liping Gong, Feng Shi, Wei Jiang. [Determination of ambroxol hydrochloride in human plasma by ultra high performance liquid chromatography-tandem mass spectrometry and bioequivalence evaluation of its preparation].
Se pu = Chinese journal of chromatography.
2018 Nov; 36(11):1099-1104. doi:
10.3724/sp.j.1123.2018.07021. [PMID: 30378372] - Haoyang Zhang, Jing Liu, Tianhao Liu, Yu Wang, Weidan Dai. Antenatal maternal medication administration in preventing respiratory distress syndrome of premature infants: A network meta-analysis.
The clinical respiratory journal.
2018 Oct; 12(10):2480-2490. doi:
10.1111/crj.12923. [PMID: 30074296] - Qiu Han, Chun Chen, Hai-Qin Hu, Jun Shen, Guang Yang, Bin Chen, Lei Xia. Effect evaluation on use of bedside fiber bronchoscope in treating stroke-associated pneumonia.
Topics in stroke rehabilitation.
2018 09; 25(6):459-466. doi:
10.1080/10749357.2018.1469712. [PMID: 29785872] - Yan Wang, Jin Lu, Tengfei Li, Shunbo Zhao, Wen Yang, Lingye Liu, Xing Shi, Li Ding. Investigation of a potential drug-drug interaction between salbutamol and ambroxol and bioequivalence of a new fixed-dose combination containing these two drugs in healthy Chinese subjects.
International journal of clinical pharmacology and therapeutics.
2018 May; 56(5):247-254. doi:
10.5414/cp203188. [PMID: 29595123] - J D Hull, R A Lyon. In vitro pharmacology of ambroxol: Potential serotonergic sites of action.
Life sciences.
2018 Mar; 197(?):67-72. doi:
10.1016/j.lfs.2018.02.002. [PMID: 29412172] - Zhengsheng Mao, Xin Wang, Xin DI, Yangdan Liu, Yanan Zang, Dongke Ma, Youping Liu, Xin DI. Quantitative Detection of Ambroxol in Human Plasma Using HPLC-APCI-MS/MS: Application to a Pharmacokinetic Study.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2017; 33(10):1099-1103. doi:
10.2116/analsci.33.1099. [PMID: 28993581] - Zhening Guo, Yangsheng Chen, Xiaoliang Ding, Chenrong Huang, Liyan Miao. Simultaneous determination of ambroxol and salbutamol in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2016 Nov; 30(11):1789-1795. doi:
10.1002/bmc.3754. [PMID: 27129716] - Yaojun Ni, Lili Hou, Liang Chen, Jiang Fan. Bioequivalence assessment of ambroxol orally-disintegrating tablet after a single oral-dose administration to healthy volunteers.
International journal of clinical pharmacology and therapeutics.
2016 May; 54(5):399-404. doi:
10.5414/cp202527. [PMID: 27007998] - Giorgio Fois, Nina Hobi, Edward Felder, Andreas Ziegler, Pika Miklavc, Paul Walther, Peter Radermacher, Thomas Haller, Paul Dietl. A new role for an old drug: Ambroxol triggers lysosomal exocytosis via pH-dependent Ca²⁺ release from acidic Ca²⁺ stores.
Cell calcium.
2015 Dec; 58(6):628-37. doi:
10.1016/j.ceca.2015.10.002. [PMID: 26560688] - Yunhui Zhang, Yakun Fu, Jialin Yu, Qing Ai, Junshuai Li, Ningning Peng, Sijie Song, Yu He, Zhengli Wang. Synergy of ambroxol with vancomycin in elimination of catheter-related Staphylococcus epidermidis biofilm in vitro and in vivo.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2015 Nov; 21(11):808-15. doi:
10.1016/j.jiac.2015.08.017. [PMID: 26423688] - Nao Oda, Koji Tamai, Yujiro Suzuki, Harukazu Yoshimatsu, Hirofumi Matsuoka, Yusuke Matsumoto, Nobuhiko Okada. Marked improvement in autoimmune pulmonary alveolar proteinosis with severe hypoxemia in a patient treated with ambroxol: a case report.
Journal of medical case reports.
2015 May; 9(?):100. doi:
10.1186/s13256-015-0588-6. [PMID: 25943363] - Andrzej M Fal, Karina Schönknecht. [Efficacy and safety of acute bronchitis treatment in adults--a comparison of Bronchosol® syrup and synthetic preparations with ambroxol. Results of observational study].
Wiadomosci lekarskie (Warsaw, Poland : 1960).
2015; 68(2):139-44. doi:
". [PMID: 26181148] - Xiangdong Wu, Suwei Li, Jiuzhi Zhang, Yongli Zhang, Lili Han, Qiuming Deng, Xianyao Wan. Meta-analysis of high doses of ambroxol treatment for acute lung injury/acute respiratory distress syndrome based on randomized controlled trials.
Journal of clinical pharmacology.
2014 Nov; 54(11):1199-206. doi:
10.1002/jcph.389. [PMID: 25174313] - Yan-Qing Yao, Zi-Wei Wang, Ying-Xue Ding, Yang Yu, Wen-Xing Jiang, Xiao-Hong Liu, Zhong-Hao Zhang, Hong Cui. [Effect of Zhifei mixture combined western drugs on symptoms and signs of children with mycoplasma pneumonia].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2014 May; 34(5):522-5. doi:
". [PMID: 24941836] - Jin Huang, Jianying Xu, Lin Tian, Liangwei Zhong. A thioredoxin reductase and/or thioredoxin system-based mechanism for antioxidant effects of ambroxol.
Biochimie.
2014 Feb; 97(?):92-103. doi:
10.1016/j.biochi.2013.09.024. [PMID: 24103200] - N A Geppe, E G Kondyurina, A N Galustyan, T E Pak, N B Baltserovich, O V Zhiglinskaya, A V Kamaev, S G Lazareva, S L Laleko, I M Melnikova, E V Mikhalkova, O A Perminova, A U Sabitov, Yu M Spivakovsky. [Rengalin, a novel drug for treatment of cough in children. Intermediate data on multicentre, comparative randomized clinical trial].
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].
2014; 59(7-8):16-24. doi:
NULL. [PMID: 25975103] - K Jiang, X Wang, X Mao, H Lao, J Zhang, G Wang, Y Cao, I Tong, F Zhang. Ambroxol alleviates hepatic ischemia reperfusion injury by antioxidant and antiapoptotic pathways.
Transplantation proceedings.
2013 Jul; 45(6):2439-45. doi:
10.1016/j.transproceed.2013.04.007. [PMID: 23953561] - Xin Dong, Li Ding, Xiaomei Cao, Liyuan Jiang, Shuisheng Zhong. A sensitive LC-MS/MS method for the simultaneous determination of amoxicillin and ambroxol in human plasma with segmental monitoring.
Biomedical chromatography : BMC.
2013 Apr; 27(4):520-6. doi:
10.1002/bmc.2824. [PMID: 23027506] - Zhuo Luan, Linjing Li, Katsumi Higaki, Eiji Nanba, Yoshiyuki Suzuki, Kousaku Ohno. The chaperone activity and toxicity of ambroxol on Gaucher cells and normal mice.
Brain & development.
2013 Apr; 35(4):317-22. doi:
10.1016/j.braindev.2012.05.008. [PMID: 22682976] - Ji Li, Youwei Bi, Li Wang, Fanlu Sun, Zhao Chen, Guili Xu, Guorong Fan. β-Cyclodextrin enhanced on-line organic solvent field-amplified sample stacking in capillary zone electrophoresis for analysis of ambroxol in human plasma, following liquid-liquid extraction in the 96-well format.
Journal of pharmaceutical and biomedical analysis.
2012 Jul; 66(?):218-24. doi:
10.1016/j.jpba.2012.02.026. [PMID: 22464560] - Samy Emara, Maha Kamal, Mohamed Abdel Kawi. On-line sample cleanup and enrichment chromatographic technique for the determination of ambroxol in human serum.
Journal of chromatographic science.
2012 Feb; 50(2):91-6. doi:
10.1093/chromsci/bmr033. [PMID: 22298756] - J Dharuman, M Vasudhevan, T Ajithlal. High performance liquid chromatographic method for the determination of cetirizine and ambroxol in human plasma and urine--a boxcar approach.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Sep; 879(25):2624-31. doi:
10.1016/j.jchromb.2011.07.024. [PMID: 21840269] - Yang Wang, Fang-Yan Wang, Zhan Pan, Yong-Yue Dai, He-Jing Xu, Ke-Ke Jin, Wan-Tie Wang. [Effects of ambroxol combined with low-dose heparin on TNF-alpha and IL-1beta in rabbits with acute lung injury].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2011 May; 27(2):231-5. doi:
NULL. [PMID: 21845882] - Jing Liang, Su-Ling Feng. [Interaction between ambroxol hydrochloride and human serum albumin studied by spectroscopic and molecular modeling methods].
Guang pu xue yu guang pu fen xi = Guang pu.
2011 Apr; 31(4):1020-4. doi:
NULL. [PMID: 21714251] - De-Hong Xia, Lei Xi, Chen Xv, Wei-Dong Mao, Wei-Sheng Shen, Zhong-Qin Shu, Hong-Zhi Yang, Min Dai. The protective effects of ambroxol on radiation lung injury and influence on production of transforming growth factor beta1 and tumor necrosis factor alpha.
Medical oncology (Northwood, London, England).
2010 Sep; 27(3):697-701. doi:
10.1007/s12032-009-9271-3. [PMID: 19636975] - P S Jain. Stability-indicating HPTLC determination of ambroxol hydrochloride in bulk drug and pharmaceutical dosage form.
Journal of chromatographic science.
2010 Jan; 48(1):45-8. doi:
10.1093/chromsci/48.1.45. [PMID: 20056035] - Joanna A Wiktorska, Andrzej Lewinski, Michal Stuss, Dariusz Nowak, Tadeusz Pietras, Ewa Sewerynek. Effects of certain antioxidants on lipid peroxidation process in lung homogenates of L thyroxine-receiving rats.
Neuro endocrinology letters.
2010; 31(1):137-46. doi:
". [PMID: 20150865] - Jian-Hua Liu, Cai-Jiao Xie, Li Li. [Effects of ambroxol on renal function in children undergoing cardiopulmonary bypass].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2009 Aug; 11(8):656-8. doi:
NULL. [PMID: 19695194] - Y C Ren, L Wang, H B He, X Tang. Pulmonary selectivity and local pharmacokinetics of ambroxol hydrochloride dry powder inhalation in rat.
Journal of pharmaceutical sciences.
2009 May; 98(5):1797-803. doi:
10.1002/jps.21529. [PMID: 18837427] - K M Beeh, J Beier, A Esperester, L D Paul. Antiinflammatory properties of ambroxol.
European journal of medical research.
2008 Dec; 13(12):557-62. doi:
". [PMID: 19073395] - Aidong Wen, Taijun Hang, Suning Chen, Zhirui Wang, Likun Ding, Yun Tian, Meng Zhang, Xinxin Xu. Simultaneous determination of amoxicillin and ambroxol in human plasma by LC-MS/MS: validation and application to pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2008 Nov; 48(3):829-34. doi:
10.1016/j.jpba.2008.05.032. [PMID: 18603398] - Wanqun Hu, Yu Xu, Fei Liu, Aixiang Liu, Qingxiang Guo. Rapid and sensitive liquid chromatography tandem mass spectrometry method for the quantification of ambroxol in human plasma.
Biomedical chromatography : BMC.
2008 Oct; 22(10):1108-14. doi:
10.1002/bmc.1032. [PMID: 18506738] - Weng Li, Bing Mao, Gang Wang, Lei Wang, Jing Chang, Ying Zhang, Mei-hua Wan, Jia Guo. [A study of the mechanism of Qingre Huatan therapy in treatment of acute exacerbation of chronic obstructive pulmonary disease by improving airway inflammation and mucus hypersecretion].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2008 Aug; 6(8):799-805. doi:
10.3736/jcim20080806. [PMID: 18664347] - Thomas Weiser. Ambroxol: a CNS drug?.
CNS neuroscience & therapeutics.
2008; 14(1):17-24. doi:
10.1111/j.1527-3458.2007.00032.x. [PMID: 18482096] - Tomasz Drewa, Zbigniew Wolski, Marzena Gruszka, Bartosz Misterek, Joanna Lysik. Uric acid plasma level and urine pH in rats treated with ambroxol.
Acta poloniae pharmaceutica.
2007 Nov; 64(6):565-7. doi:
NULL. [PMID: 18323253] - Yu-teng Ma, Ying-ping Tian, Han-wen Shi, Cui-huan Lv, Jian-hui Liu, Zhi-ping Sun. [Effects of high dose ambroxol on lung injury induced by paraquat in rats].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2007 Sep; 25(9):523-6. doi:
NULL. [PMID: 17997885] - Tai-Jun Hang, Meng Zhang, Min Song, Jian-Ping Shen, Yin-di Zhang. Simultaneous determination and pharmacokinetic study of roxithromycin and ambroxol hydrochloride in human plasma by LC-MS/MS.
Clinica chimica acta; international journal of clinical chemistry.
2007 Jul; 382(1-2):20-4. doi:
10.1016/j.cca.2007.03.015. [PMID: 17462615] - Fenli Su, Feng Wang, Wei Gao, Huande Li. Determination of ambroxol in human plasma by high performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-MS/ESI).
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 853(1-2):364-8. doi:
10.1016/j.jchromb.2007.03.015. [PMID: 17446147] - Nan Lin, Xiao-Yan Chen, Bo Song, Da-Fang Zhong. [Determination of ambroxol and clenbuterol in human plasma by LC-MS/MS method].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Mar; 42(3):308-13. doi:
NULL. [PMID: 17520832] - Thomas Weiser. Comparison of the effects of four Na+ channel analgesics on TTX-resistant Na+ currents in rat sensory neurons and recombinant Nav1.2 channels.
Neuroscience letters.
2006 Mar; 395(3):179-84. doi:
10.1016/j.neulet.2005.10.058. [PMID: 16293367] - Wolfram Gaida, Klaus Klinder, Kirsten Arndt, Thomas Weiser. Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.
Neuropharmacology.
2005 Dec; 49(8):1220-7. doi:
10.1016/j.neuropharm.2005.08.004. [PMID: 16182323] - V Stetinová, V Herout, J Kvetina. In vitro and in vivo antioxidant activity of ambroxol.
Clinical and experimental medicine.
2004 Dec; 4(3):152-8. doi:
10.1007/s10238-004-0050-3. [PMID: 15599665] - Shuang-ping Zhao, Qu-lian Guo, Rui-ke Wang, E Wang. [Oxidative and anti-oxidative effects of ambroxol on acute hydrochloric acid-induced lung injury in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2004 Oct; 29(5):586-8. doi:
". [PMID: 16137054] - Iwao Koyama, Toshiyuki Matsunaga, Tsuyoshi Harada, Akira Kikuno, Shigeru Hokari, Tsugikazu Komoda. Ambroxol reduces LPS toxicity mediated by induction of alkaline phosphatases in rat lung.
Clinical biochemistry.
2004 Aug; 37(8):688-93. doi:
10.1016/j.clinbiochem.2004.02.004. [PMID: 15302612] - Wataru Kubo, Shozo Miyazaki, Masatake Dairaku, Mitsuo Togashi, Ryozo Mikami, David Attwood. Oral sustained delivery of ambroxol from in situ-gelling pectin formulations.
International journal of pharmaceutics.
2004 Mar; 271(1-2):233-40. doi:
10.1016/j.ijpharm.2003.11.027. [PMID: 15129990] - Hee Joo Lee, Sun Koung Joung, Yoon Gyoon Kim, Jeong-Yeon Yoo, Sang Beom Han. Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers.
Pharmacological research.
2004 Jan; 49(1):93-8. doi:
10.1016/j.phrs.2003.07.011. [PMID: 14597158] - José Villacampa, Fernando Alcántar, Juan Manuel Rodríguez, Jóse Manuel Morales, Jorge Herrera, Rosa Rosete. Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men.
Clinical therapeutics.
2003 Aug; 25(8):2225-32. doi:
10.1016/s0149-2918(03)80215-1. [PMID: 14512130] - Hohyun Kim, Jeong-Yeon Yoo, Sang Beom Han, Hee Joo Lee, Kyung Ryul Lee. Determination of ambroxol in human plasma using LC-MS/MS.
Journal of pharmaceutical and biomedical analysis.
2003 Jun; 32(2):209-16. doi:
10.1016/s0731-7085(03)00059-1. [PMID: 12763530] - D Chlubek, J Zawierta, M Olszewska, A Kaźmierczyk, M Sikora. [Effect of ambroxol on lipid peroxidation in homogenates of the human placenta].
Ginekologia polska.
2001 Oct; 72(10):804-8. doi:
". [PMID: 11848017] - M Schmolz, D Ottendorfer, R W März, C Sieder. Enhanced resistance to Sendai virus infection in DBA/2J mice with a botanical drug combination (Sinupret).
International immunopharmacology.
2001 Sep; 1(9-10):1841-8. doi:
10.1016/s1567-5769(01)00108-4. [PMID: 11562075] - T Perez-Ruiz, C Martínez-Lozano, A Sanz, E Bravo. Sensitive method for the determination of ambroxol in body fluids by capillary electrophoresis and fluorescence detection.
Journal of chromatography. B, Biomedical sciences and applications.
2000 May; 742(1):205-10. doi:
10.1016/s0378-4347(00)00150-x. [PMID: 10892600] - Y Matsuda, S Hobo, H Naito. Transferability of cephalothin to the alveolar cavity in thoroughbreds.
The Journal of veterinary medical science.
1999 Mar; 61(3):209-12. doi:
10.1292/jvms.61.209. [PMID: 10331190] - J Röhrich, S Zörntlein, J Lotz, J Becker, T Kern, C Rittner. False-positive LSD testing in urine samples from intensive care patients.
Journal of analytical toxicology.
1998 Sep; 22(5):393-5. doi:
10.1093/jat/22.5.393. [PMID: 9737335] - J Lotz, G Hafner, J Röhrich, S Zörntlein, T Kern, W Prellwitz. False-positive LSD drug screening induced by a mucolytic medication.
Clinical chemistry.
1998 Jul; 44(7):1580-1. doi:
NULL. [PMID: 9665451] - T Pérez-Ruiz, C Martínez-Lozano, A Sanz, E Bravo. Determination of bromhexine and ambroxol in pharmaceutical dosage forms, urine and blood serum.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Apr; 692(1):199-205. doi:
10.1016/s0378-4347(96)00482-3. [PMID: 9187400] - E Mira, M Benazzo, F De Paoli, A Casasco, A Calligaro. [Surfactants of the airways. Critical review and personal research].
Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.
1997 Feb; 17(1 Suppl 56):3-16. doi:
NULL. [PMID: 9304345] - W J Piotrowski, T Pietras, Z Kurmanowska, D Nowak, J Marczak, J Marks-Kończalik, P Mazerant. Effect of paraquat intoxication and ambroxol treatment on hydrogen peroxide production and lipid peroxidation in selected organs of rat.
Journal of applied toxicology : JAT.
1996 Nov; 16(6):501-7. doi:
10.1002/(sici)1099-1263(199611)16:6<501::aid-jat379>3.0.co;2-z. [PMID: 8956096] - D Nowak, G Pierscinski, J Drzewoski. Ambroxol inhibits doxorubicin-induced lipid peroxidation in heart of mice.
Free radical biology & medicine.
1995 Nov; 19(5):659-63. doi:
10.1016/0891-5849(95)00028-v. [PMID: 8529925] - F Paganin, O Bouvet, P Chanez, D Fabre, M Galtier, P Godard, F B Michel, F Bressolle. Evaluation of the effects of ambroxol on the ofloxacin concentrations in bronchial tissues in COPD patients with infectious exacerbation.
Biopharmaceutics & drug disposition.
1995 Jul; 16(5):393-401. doi:
10.1002/bdd.2510160504. [PMID: 8527688] - D Nowak, A Antczak, T Pietras, P Bialasiewicz, M Krol. Protective effect of ambroxol against heat- and hydrogen peroxide-induced damage to lung lipids in mice.
The European respiratory journal.
1994 Sep; 7(9):1629-34. doi:
10.1183/09031936.94.07091629. [PMID: 7995392] - D Nowak, A Antczak, M Król, P Bialasiewicz, T Pietras. Antioxidant properties of Ambroxol.
Free radical biology & medicine.
1994 Apr; 16(4):517-22. doi:
10.1016/0891-5849(94)90130-9. [PMID: 8005537] - D Nowak, T Pietras, A Antczak, M Król, G Piasecka. Ambroxol inhibits endotoxin-induced lipid peroxidation in mice.
Polish journal of pharmacology.
1993 May; 45(3):317-22. doi:
". [PMID: 8220663] - B Oosterhuis, G Storm, P J Cornelissen, C A Su, F A Sollie, J H Jonkman. Dose-dependent uricosuric effect of ambroxol.
European journal of clinical pharmacology.
1993; 44(3):237-41. doi:
10.1007/bf00271364. [PMID: 8491237] - M Nobilis, J Pastera, D Svoboda, J Kvêtina, K Macek. High-performance liquid chromatographic determination of ambroxol in human plasma.
Journal of chromatography.
1992 Oct; 581(2):251-5. doi:
10.1016/0378-4347(92)80278-x. [PMID: 1452615] - K Winsel. [The antioxidative and inflammation inhibiting properties of ambroxol].
Pneumologie (Stuttgart, Germany).
1992 Sep; 46(9):461-75. doi:
". [PMID: 1438126] - S Jabłonka, A Ledwozyw, W Kadziołka, A Jabłonka, A Nestorowicz. The influence of Ambroxol on peroxidative processes in lung and plasma in dogs after pulmonectomy.
Archivum veterinarium Polonicum.
1992; 32(1-2):57-66. doi:
NULL. [PMID: 1308708] - M Kitsos, C Gandini, G Massolini, E De Lorenzi, G Caccialanza. High-performance liquid chromatography post-column derivatization with fluorescence detection to study the influence of ambroxol on dipalmitoylphosphatidylcholine levels in rabbit eustachian tube washings.
Journal of chromatography.
1991 Aug; 553(1-2):1-6. doi:
10.1016/s0021-9673(01)88464-8. [PMID: 1787145] - C E Uboh, J A Rudy, L R Soma, M Fennell, L May, R Sams, F A Railing, J Shellenberger, M Kahler. Characterization of bromhexine and ambroxol in equine urine: effect of furosemide on identification and confirmation.
Journal of pharmaceutical and biomedical analysis.
1991; 9(1):33-9. doi:
10.1016/0731-7085(91)80234-z. [PMID: 2043720] - A Ledwozyw, S Jabłonka, E Tusińska. [The effect of ambroxol on peroxidative processes in dog lung mitochondria].
Polskie archiwum weterynaryjne.
1991; 31(3-4):105-13. doi:
". [PMID: 1842611] - L Colombo, F Marcucci, G M Marini, P Pierfederici, E Mussini. Determination of ambroxol in biological material by gas chromatography with electron-capture detection.
Journal of chromatography.
1990 Aug; 530(1):141-7. doi:
10.1016/s0378-4347(00)82313-0. [PMID: 2277104] - W Couet, J Girault, B G Reigner, I Ingrand, J Bizouard, D Acerbi, P Chiesi, J B Fourtillan. Steady-state bioavailability and pharmacokinetics of ambroxol and clenbuterol administered alone and combined in a new oral formulation.
International journal of clinical pharmacology, therapy, and toxicology.
1989 Sep; 27(9):467-72. doi:
NULL. [PMID: 2807621] - Z Novák, S I Varga, L Kovács, A Pál, L Pataki, B Matkovics. The effects of Oradexone and Ambroxol pretreatment of the oxidative sensitivity of the red blood cells in preterm infants.
Clinica chimica acta; international journal of clinical chemistry.
1989 Jul; 182(3):241-5. doi:
10.1016/0009-8981(89)90101-0. [PMID: 2766548] - F J Flores-Murrieta, C Hoyo-Vadillo, E Hong, G Castañeda-Hernandez. Assay of ambroxol in human plasma by high-performance liquid chromatography with amperometric detection.
Journal of chromatography.
1989 May; 490(2):464-9. doi:
10.1016/s0378-4347(00)82807-8. [PMID: 2768418] - P C Curti, M Genghini. Role of surfactant in alveolar defence against inhaled particles.
Respiration; international review of thoracic diseases.
1989; 55 Suppl 1(?):60-7. doi:
10.1159/000195753. [PMID: 2682871] - T J Janssen, P J Guelen, T B Vree, M H Botterblom, R Valducci. Bioavailability of ambroxol sustained release preparations. Part II: Single and multiple oral dose studies in man.
Arzneimittel-Forschung.
1988 Jan; 38(1):95-7. doi:
NULL. [PMID: 3365282] - T Alighieri, S Avanessian, S Berlini, S G Bianchi, P Deluigi, R Valducci, P J Guelen. Bioavailability of ambroxol sustained release preparations. Part I: In vitro dissolution studies.
Arzneimittel-Forschung.
1988 Jan; 38(1):92-4. doi:
". [PMID: 3365281]
