Lazabemide (BioDeep_00000718379)
代谢物信息卡片
Lazabemide
化学式: C8H10ClN3O (199.051236)
中文名称: 拉扎贝胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=NC=C1Cl)C(=O)NCCN
InChI: InChI=1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,(H,11,13)
描述信息
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents > D000978 - Antiparkinson Agents
D004791 - Enzyme Inhibitors > D008996 - Monoamine Oxidase Inhibitors
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Arti Nile, Shivraj Hariram Nile, Carlos L Cespedes-Acuña, Jae-Wook Oh. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Aug; 154(?):112327. doi:
10.1016/j.fct.2021.112327. [PMID: 34116102] - Shiyang Zhou, Guangying Chen, Gangliang Huang. Design, synthesis and biological evaluation of lazabemide derivatives as inhibitors of monoamine oxidase.
Bioorganic & medicinal chemistry.
2018 09; 26(17):4863-4870. doi:
10.1016/j.bmc.2018.08.024. [PMID: 30143367] - Monique Hoon, Jacobus P Petzer, Francois Viljoen, Anél Petzer. The Design and Evaluation of an l-Dopa-Lazabemide Prodrug for the Treatment of Parkinson's Disease.
Molecules (Basel, Switzerland).
2017 Nov; 22(12):. doi:
10.3390/molecules22122076. [PMID: 29186917] - Celeste De Monte, Simone Carradori, Paola Chimenti, Daniela Secci, Luisa Mannina, Francesca Alcaro, Anél Petzer, Clarina I N'Da, Maria Concetta Gidaro, Giosuè Costa, Stefano Alcaro, Jacobus P Petzer. New insights into the biological properties of Crocus sativus L.: chemical modifications, human monoamine oxidases inhibition and molecular modeling studies.
European journal of medicinal chemistry.
2014 Jul; 82(?):164-71. doi:
10.1016/j.ejmech.2014.05.048. [PMID: 24904963] - Neil J Anderson, Isabelle Seif, David J Nutt, Alan L Hudson, Emma S J Robinson. Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.
Journal of neurochemistry.
2006 Mar; 96(6):1551-9. doi:
10.1111/j.1471-4159.2006.03662.x. [PMID: 16476082] - Violetta Klimek, Gary Roberson, Craig A Stockmeier, Gregory A Ordway. Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression.
Journal of psychiatric research.
2003 Sep; 37(5):387-97. doi:
10.1016/s0022-3956(03)00045-1. [PMID: 12849931] - J T Guimarães, C Vindis, P Soares-da-Silva, A Parini. Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex.
Life sciences.
2003 Jul; 73(8):955-67. doi:
10.1016/s0024-3205(03)00415-6. [PMID: 12818349] - R P Mason, E G Olmstead, R F Jacob. Antioxidant activity of the monoamine oxidase B inhibitor lazabemide.
Biochemical pharmacology.
2000 Sep; 60(5):709-16. doi:
10.1016/s0006-2952(00)00374-9. [PMID: 10927030] - P R King, A L Gundlach, W J Louis. Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.
Annals of the New York Academy of Sciences.
1999 Jun; 881(?):161-70. doi:
10.1111/j.1749-6632.1999.tb09355.x. [PMID: 10415911] - P R King, S Suzuki, A R Hosseini, D Iakovidis, T L Nero, G P Jackman, W J Louis, A L Gundlach. [3H]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [3H]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney.
Journal of the autonomic nervous system.
1998 Oct; 72(2-3):118-28. doi:
10.1016/s0165-1838(98)00096-4. [PMID: 9851560] - A R Hosseini, G P Jackman, P R King, W J Louis, A L Gundlach. Pharmacology and subcellular distribution of [3H]rilmenidine binding sites in rat brain.
Journal of the autonomic nervous system.
1998 Oct; 72(2-3):129-36. doi:
10.1016/s0165-1838(98)00097-6. [PMID: 9851561] - J T Guimarães, P Soares-da-Silva. The activity of MAO A and B in rat renal cells and tubules.
Life sciences.
1998; 62(8):727-37. doi:
10.1016/s0024-3205(97)01171-5. [PMID: 9489509] - J T Guimarães, P Soares-Da-Silva. Unusual pattern of beta-phenylethylamine deamination in the rat heart.
Biochemical Society transactions.
1997 Nov; 25(4):S622. doi:
10.1042/bst025s622. [PMID: 9450050] - J Dingemanse, N Wood, K Jorga, R Kettler. Pharmacokinetics and pharmacodynamics of single and multiple doses of the MAO-B inhibitor lazabemide in healthy subjects.
British journal of clinical pharmacology.
1997 Jan; 43(1):41-7. doi:
NULL. [PMID: 9056051] - A M Cesura, J Gottowik, H W Lahm, G Lang, R Imhof, P Malherbe, U Röthlisberger, M Da Prada. Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis.
European journal of biochemistry.
1996 Mar; 236(3):996-1002. doi:
10.1111/j.1432-1033.1996.00996.x. [PMID: 8665924] - J Saura, E Nadal, B van den Berg, M Vila, J A Bombi, N Mahy. Localization of monoamine oxidases in human peripheral tissues.
Life sciences.
1996; 59(16):1341-9. doi:
10.1016/0024-3205(96)00459-6. [PMID: 8876663] - P P Davis, T Crews, J J Bradford, R W Edom. Determination of Ro 19-6327 (Lazabemide) in human plasma and urine by gas chromatography-negative chemical ionization mass spectrometry.
Journal of chromatography. B, Biomedical applications.
1995 Mar; 665(2):327-35. doi:
10.1016/0378-4347(94)00531-9. [PMID: 7795812] - M Pestana, P Soares-da-Silva. Effect of type A and B monoamine oxidase selective inhibition by Ro 41-1049 and Ro 19-6327 on dopamine outflow in rat kidney slices.
British journal of pharmacology.
1994 Dec; 113(4):1269-74. doi:
10.1111/j.1476-5381.1994.tb17135.x. [PMID: 7889283] - N H Holford, T W Guentert, J Dingemanse, R Kettler. Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B.
British journal of clinical pharmacology.
1994 Jun; 37(6):553-7. doi:
10.1111/j.1365-2125.1994.tb04303.x. [PMID: 7917773] - T W Guentert, N H Holford, J P Pfefen, J Dingemanse. Mixed linear and non-linear disposition of lazabemide, a reversible and selective inhibitor of monoamine oxidase B.
British journal of clinical pharmacology.
1994 Jun; 37(6):545-51. doi:
10.1111/j.1365-2125.1994.tb04302.x. [PMID: 7917772] - M A Vieira-Coelho, M H Fernandes, P Soares-da-Silva. In vivo effects of the monoamine oxidase inhibitors Ro 41-1049 and Ro 19-6327 on the production and fate of renal dopamine.
Journal of neural transmission. Supplementum.
1994; 41(?):365-70. doi:
10.1007/978-3-7091-9324-2_48. [PMID: 7931252] - A A Lammertsma, C J Bench, G W Price, J E Cremer, S K Luthra, D Turton, N D Wood, R S Frackowiak. Measurement of cerebral monoamine oxidase B activity using L-[11C]deprenyl and dynamic positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1991 Jul; 11(4):545-56. doi:
10.1038/jcbfm.1991.103. [PMID: 1904879] - M H Fernandes, M Pestana, P Soares-da-Silva. Deamination of newly-formed dopamine in rat renal tissues.
British journal of pharmacology.
1991 Mar; 102(3):778-82. doi:
10.1111/j.1476-5381.1991.tb12250.x. [PMID: 1364853] - M H Fernandes, P Soares-da-Silva. Effects of MAO-A and MAO-B selective inhibitors Ro 41-1049 and Ro 19-6327 on the deamination of newly formed dopamine in the rat kidney.
The Journal of pharmacology and experimental therapeutics.
1990 Dec; 255(3):1309-13. doi:
NULL. [PMID: 2124622] - R Wyss, W Philipp. Determination of the monoamine oxidase B inhibitor Ro 19-6327 in plasma by high-performance liquid chromatography using precolumn derivatization with fluorescamine and fluorescence detection.
Journal of chromatography.
1990 May; 507(?):187-98. doi:
10.1016/s0021-9673(01)84195-9. [PMID: 2380287] - M H Fernandes, P Soares-da-Silva. Role of monoamine oxidase A and B in the deamination of newly-formed dopamine in the rat kidney.
Journal of neural transmission. Supplementum.
1990; 32(?):155-9. doi:
10.1007/978-3-7091-9113-2_22. [PMID: 2089083]