Dexloxiglumide (BioDeep_00000718353)

   


代谢物信息卡片


Dexloxiglumide

化学式: C21H30Cl2N2O5 (460.1532)
中文名称: 右氯谷胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCN(CCCOC)C(=O)C(CCC(=O)O)NC(=O)C1=CC(=C(C=C1)Cl)Cl
InChI: InChI=1S/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)/t18-/m1/s1

描述信息

C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Dexloxiglumide is a selective cholecystokinin type A (CCKA) receptor antagonist[1]. Dexloxiglumide, the active enantiomer of Loxiglumide, inhibits smooth muscle cell contractions induced by cholecystokinin-octapeptide (CCK-8)[2].

同义名列表

1 个代谢物同义名

Dexloxiglumide



数据库引用编号

6 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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PlantCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Beatriz Lobo, Jordi Serra, Massimo D'Amato, Lucio Rovati, Juan-R Malagelada, Javier Santos, Fernando Azpiroz. Effect of selective CCK1 receptor antagonism on accommodation and tolerance of intestinal gas in functional gut disorders. Journal of gastroenterology and hepatology. 2016 Feb; 31(2):288-93. doi: 10.1111/jgh.13177. [PMID: 26416485]
  • Daniel J Lassman, Shane McKie, Lloyd J Gregory, Simon Lal, Massimo D'Amato, Islay Steele, Andrea Varro, Graham J Dockray, Steven C R Williams, David George Thompson. Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology. 2010 Apr; 138(4):1514-24. doi: 10.1053/j.gastro.2009.12.060. [PMID: 20080096]
  • Svetlana Beglinger, Juergen Drewe, Joerg Schirra, Burkhard Göke, Massimo D'Amato, Christoph Beglinger. Role of fat hydrolysis in regulating glucagon-like Peptide-1 secretion. The Journal of clinical endocrinology and metabolism. 2010 Feb; 95(2):879-86. doi: 10.1210/jc.2009-1062. [PMID: 19837920]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • A K Purhonen, K H Herzig, H J Gabius, S André, S Ketterer, D Matzinger, C Beglinger, P Hildebrand. Duodenal phytohaemagglutinin (red kidney bean lectin) stimulates gallbladder contraction in humans. Acta physiologica (Oxford, England). 2008 Jul; 193(3):241-7. doi: 10.1111/j.1748-1716.2008.01839.x. [PMID: 18248661]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • T D Barrett, W Yan, J M Freedman, G J Lagaud, J G Breitenbucher, N P Shankley. Role of CCK and potential utility of CCK1 receptor antagonism in the treatment of pancreatitis induced by biliary tract obstruction. British journal of pharmacology. 2008 Apr; 153(8):1650-8. doi: 10.1038/bjp.2008.44. [PMID: 18297100]
  • Lukas Degen, Juergen Drewe, Franziska Piccoli, Karin Gräni, Sibylle Oesch, Raluca Bunea, Massimo D'Amato, Christoph Beglinger. Effect of CCK-1 receptor blockade on ghrelin and PYY secretion in men. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 Apr; 292(4):R1391-9. doi: 10.1152/ajpregu.00734.2006. [PMID: 17138722]
  • Nam Q Nguyen, Robert J Fraser, Laura K Bryant, Marianne J Chapman, Judith Wishart, Richard H Holloway, Ross Butler, Michael Horowitz. The relationship between gastric emptying, plasma cholecystokinin, and peptide YY in critically ill patients. Critical care (London, England). 2007; 11(6):R132. doi: 10.1186/cc6205. [PMID: 18154642]
  • Derek J Roberts, Hoan Linh Banh, Richard I Hall. Use of novel prokinetic agents to facilitate return of gastrointestinal motility in adult critically ill patients. Current opinion in critical care. 2006 Aug; 12(4):295-302. doi: 10.1097/01.ccx.0000235205.54579.5d. [PMID: 16810038]
  • Stefano Persiani, Massimo D'Amato, Abhijeet Jakate, Partha Roy, Julie Wangsa, Ram Kapil, Lucio C Rovati. Pharmacokinetic profile of dexloxiglumide. Clinical pharmacokinetics. 2006; 45(12):1177-88. doi: 10.2165/00003088-200645120-00003. [PMID: 17112294]
  • Abhijeet S Jakate, Partha Roy, Alpita Patel, Wattanaporn Abramowitz, Stefano Persiani, Julie Wangsa, Ram Kapil. Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide. British journal of clinical pharmacology. 2005 Nov; 60(5):498-507. doi: 10.1111/j.1365-2125.2005.02465.x. [PMID: 16236040]
  • J J Galligan, S Vanner. Basic and clinical pharmacology of new motility promoting agents. Neurogastroenterology and motility. 2005 Oct; 17(5):643-53. doi: 10.1111/j.1365-2982.2005.00675.x. [PMID: 16185302]
  • P Roy, J Wangsa, A Patel, A Nolting, St Persiani, W Abramowitz, R Kapil. The single-dose pharmacokinetics of the novel CCK1 receptor antagonist, dexloxiglumide, are not influenced by age and gender. International journal of clinical pharmacology and therapeutics. 2005 Sep; 43(9):444-51. doi: 10.5414/cpp43444. [PMID: 16163898]
  • Magda F Morton, Pei-Qi Liu, Andreas Reik, Ragan de la Rosa, Matthew Mendel, Xiao-Yong Li, Casey Case, Carl Pabo, Veronica Moreno, Jayashree Pyati, Nigel P Shankley. Pharmacological analysis of CCK2 receptors up-regulated using engineered transcription factors. Regulatory peptides. 2005 Jul; 129(1-3):227-32. doi: 10.1016/j.regpep.2005.02.013. [PMID: 15927720]
  • Partha Roy, Abhijeet S Jakate, Alpita Patel, Wattanaporn Abramowitz, Julie Wangsa, Stefano Persiani, Ram Kapil. Effect of multiple-dose dexloxiglumide on the pharmacokinetics of oral contraceptives in healthy women. Journal of clinical pharmacology. 2005 Mar; 45(3):329-36. doi: 10.1177/0091270004272732. [PMID: 15703367]
  • Simon Lal, John McLaughlin, Josephine Barlow, Massimo D'Amato, Giampaolo Giacovelli, Andrea Varro, Graham J Dockray, David G Thompson. Cholecystokinin pathways modulate sensations induced by gastric distension in humans. American journal of physiology. Gastrointestinal and liver physiology. 2004 Jul; 287(1):G72-9. doi: 10.1152/ajpgi.00351.2003. [PMID: 14764444]
  • Michael Hall, Stefano Persiani, Yen-Ling Cheung, Anne Matthews, Z Richard Cybulski, Jeremy D Holding, Ram Kapil, Massimo D'Amato, Francesco Makovec, Lucio C Rovati. Interaction of dexloxiglumide, a cholecystokinin type-1 receptor antagonist, with human cytochromes P450. Biopharmaceutics & drug disposition. 2004 May; 25(4):163-76. doi: 10.1002/bdd.397. [PMID: 15108219]
  • C Webber, C A Stokes, S Persiani, F Makovec, A McBurney, R P Kapil, B A John, M D'Amato, L F Chasseaud. Absorption, distribution, metabolism and excretion of the cholecystokinin-1 antagonist dexloxiglumide in the dog. European journal of drug metabolism and pharmacokinetics. 2004 Jan; 29(1):15-23. doi: 10.1007/bf03190569. [PMID: 15151166]
  • Sanna Tolle-Sander, Andreas Grill, Hemant Joshi, Ram Kapil, Stefano Persiani, James E Polli. Characterization of dexloxiglumide in vitro biopharmaceutical properties and active transport. Journal of pharmaceutical sciences. 2003 Oct; 92(10):1968-80. doi: 10.1002/jps.10428. [PMID: 14502537]
  • C Webber, C A Stokes, S Persiani, F Makovec, A McBurney, R P Kapil, B A John, T L Houchen, M D'Amato, L F Chasseaud. Absorption, distribution, metabolism and excretion of the cholecystokinin-1 antagonist dexloxiglumide in the rat. European journal of drug metabolism and pharmacokinetics. 2003 Jul; 28(3):201-12. doi: 10.1007/bf03190486. [PMID: 14527093]
  • C Webber, A Roth, S Persiani, A J Peard, F Makovec, R P Kapil, B A John, J D Holding, M D'amato, Z R Cybulski, L F Chasseaud, L C Rovati. Pharmacokinetics and metabolism of the cholecystokinin antagonist dexloxiglumide in male human subjects. Xenobiotica; the fate of foreign compounds in biological systems. 2003 Jun; 33(6):625-41. doi: 10.1080/0049825031000089137. [PMID: 12851039]
  • R Brodie, A Peard, A Roth, S Persiani, F Makovec, M D'Amato. Development and validation of a bioanalytical method for the determination of the cholecystokinin type-1 (CCK(1)) receptor antagonist dexloxiglumide in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 784(1):91-100. doi: 10.1016/s1570-0232(02)00760-2. [PMID: 12504186]
  • S Persiani, M D'Amato, F Makovec, I A Tavares, P M Bishai, L C Rovati. Pharmacokinetics of dexloxiglumide after administration of single and repeat oral escalating doses in healthy young males. International journal of clinical pharmacology and therapeutics. 2002 May; 40(5):198-206. doi: 10.5414/cpp40198. [PMID: 12051571]
  • C Feinle, O Meier, B Otto, M D'Amato, M Fried. Role of duodenal lipid and cholecystokinin A receptors in the pathophysiology of functional dyspepsia. Gut. 2001 Mar; 48(3):347-55. doi: 10.1136/gut.48.3.347. [PMID: 11171824]