Cyclobenzaprine hydrochloride (BioDeep_00000717857)
代谢物信息卡片
Cyclobenzaprine hydrochloride
化学式: C20H22ClN (311.14406820000005)
中文名称: 环苯扎林盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13.Cl
InChI: 1H
描述信息
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant with activity on the central nervous system.
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:3997
- KEGGdrug: D00772
- PubChem: 22576
- ChEMBL: CHEMBL1200636
- CAS: 6202-23-9
- medchemexpress: HY-B0740
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Cihangir Buyukgoz, Shantaveer Gangu, Faaria Gowani, Dai Kimura. Treatment of comatose patient from cyclobenzaprine overdose with therapeutic plasma exchange.
Journal of clinical apheresis.
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International journal of pharmaceutics.
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine.
Journal of clinical pharmacy and therapeutics.
2020 Aug; 45(4):774-782. doi:
10.1111/jcpt.13165. [PMID: 32390248] - Mehran Haidari, Sravan Mansani, Dezaray Ponds, Lissett Romero, Christine Cobb, Saad Alsaab. Storage of urine specimens in point of care (POC) urine drug testing cups reduces concentrations of many drugs.
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - M I Walash, S A El Abass Mohamed. Green analytical chromatographic assay method for quantitation of cyclobenzaprine in tablets, spiked human urine and in-vitro dissolution test.
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10.1016/j.pharma.2019.06.004. [PMID: 31296331] - Mohammad Hassan Baig, Safikur Rahman, Gulam Rabbani, Mohd Imran, Khurshid Ahmad, Inho Choi. Multi-Spectroscopic Characterization of Human Serum Albumin Binding with Cyclobenzaprine Hydrochloride: Insights from Biophysical and In Silico Approaches.
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BioMed research international.
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10.1155/2013/281392. [PMID: 24151591] - Yi Xiang, Liping Zhou, Zhenyu Qian, Kelong Peng, Dongyan Li, Xiaomei Chen, Hongliang Jiang, Heng Zheng. Determination of cyclobenzaprine in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.
Biomedical chromatography : BMC.
2012 Sep; 26(9):1083-8. doi:
10.1002/bmc.1751. [PMID: 22120786] - Ney Carter Borges, Vinicius Marcondes Rezende, Jose Marcos Santana, Ricardo Pereira Moreira, Roberto Fernandes Moreira, Patrícia Moreno, Diego Carter Borges, José Luiz Donato, Ronilson Agnaldo Moreno. Chlorpromazine quantification in human plasma by UPLC-electrospray ionization tandem mass spectrometry. Application to a comparative pharmacokinetic study.
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Clinical pharmacology and therapeutics.
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2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Mona Darwish, Edward T Hellriegel. Steady-state pharmacokinetics of once-daily cyclobenzaprine extended release: a randomized, double-blind, 2-period crossover study in healthy volunteers.
Clinical therapeutics.
2011 Jun; 33(6):746-53. doi:
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Expert opinion on drug metabolism & toxicology.
2010 Nov; 6(11):1425-36. doi:
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2009 Apr; 47(4):269-74. doi:
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Clinical therapeutics.
2009 Jan; 31(1):108-14. doi:
10.1016/j.clinthera.2009.01.014. [PMID: 19243711] - Mona Darwish, Fang Xie. Comparison of the single-dose pharmacokinetics of once-daily cyclobenzaprine extended-release 30 mg and cyclobenzaprine immediate-release 10 mg three times daily in the elderly: a randomized, open-label, crossover study.
Drugs & aging.
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