Trimipramine maleate (BioDeep_00000717597)

   


代谢物信息卡片


Trimipramine maleate

化学式: C24H30N2O4 (410.220546)
中文名称: 马来酸三甲丙咪嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN(C)C)CN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.O=C(O)/C=C\C(O)=O
InChI: 2-1-

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D049990 - Membrane Transport Modulators
Trimipramine maleate is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively[1]. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively[2]. Trimipramine maleate has vascular activity and anxiolytic efficacy[3].

同义名列表

3 个代谢物同义名

Trimipramine maleate; Trimipramine (maleate); Trimipramine maleate



数据库引用编号

14 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Yasamin Nasiri Khonsari, Shiguo Sun. A novel MIP-ECL sensor based on RGO-CeO2NP/Ru(bpy)32+-chitosan for ultratrace determination of trimipramine. Journal of materials chemistry. B. 2021 01; 9(2):471-478. doi: 10.1039/d0tb01666g. [PMID: 33289771]
  • Anssi Lipponen, Teemu Natunen, Mika Hujo, Robert Ciszek, Elina Hämäläinen, Jussi Tohka, Mikko Hiltunen, Jussi Paananen, David Poulsen, Emilia Kansanen, Xavier Ekolle Ndode-Ekane, Anna-Liisa Levonen, Asla Pitkänen. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. International journal of molecular sciences. 2019 Oct; 20(21):. doi: 10.3390/ijms20215395. [PMID: 31671916]
  • Christoph Kowalewski, Ekkehard Haen, Christoph Hiemke, Florian Ridders, Katharina Endres, Gerhard Gründer, Michael Paulzen, Georgios Schoretsanitis. Cytochrome P450-mediated inhibition of venlafaxine metabolism by trimipramine. International clinical psychopharmacology. 2019 09; 34(5):241-246. doi: 10.1097/yic.0000000000000268. [PMID: 31094902]
  • Hadi Tabani, Ali Shokri, Shakila Tizro, Saeed Nojavan, Pakorn Varanusupakul, Michal Alexovič. Evaluation of dispersive liquid-liquid microextraction by coupling with green-based agarose gel-electromembrane extraction: An efficient method to the tandem extraction of basic drugs from biological fluids. Talanta. 2019 Jul; 199(?):329-335. doi: 10.1016/j.talanta.2019.02.078. [PMID: 30952267]
  • Maedeh Akhoundian, Taher Alizadeh, Mohammad Reza Ganjali, Faride Rafiei. A new carbon paste electrode modified with MWCNTs and nano-structured molecularly imprinted polymer for ultratrace determination of trimipramine: The crucial effect of electrode components mixing on its performance. Biosensors & bioelectronics. 2018 Jul; 111(?):27-33. doi: 10.1016/j.bios.2018.03.061. [PMID: 29631160]
  • Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Elham Memarian, Saeed Nojavan. Electromembrane extraction through a virtually rotating supported liquid membrane. Electrophoresis. 2016 Jan; 37(2):339-46. doi: 10.1002/elps.201500296. [PMID: 26462723]
  • Mojtaba Shamsipur, Mehrosadat Mirmohammadi. High performance liquid chromatographic determination of ultra traces of two tricyclic antidepressant drugs imipramine and trimipramine in urine samples after their dispersive liquid-liquid microextraction coupled with response surface optimization. Journal of pharmaceutical and biomedical analysis. 2014 Nov; 100(?):271-278. doi: 10.1016/j.jpba.2014.08.008. [PMID: 25178259]
  • Bankim J Sanghavi, Ashwini K Srivastava. Adsorptive stripping voltammetric determination of imipramine, trimipramine and desipramine employing titanium dioxide nanoparticles and an Amberlite XAD-2 modified glassy carbon paste electrode. The Analyst. 2013 Mar; 138(5):1395-404. doi: 10.1039/c2an36330e. [PMID: 23324861]
  • Ali R Fakhari, Hadi Tabani, Saeed Nojavan, Hamid Abedi. Electromembrane extraction combined with cyclodextrin-modified capillary electrophoresis for the quantification of trimipramine enantiomers. Electrophoresis. 2012 Feb; 33(3):506-15. doi: 10.1002/elps.201100426. [PMID: 22287179]
  • Britta Haenisch, Christoph Hiemke, Heinz Bönisch. Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters. Psychopharmacology. 2011 Sep; 217(2):289-95. doi: 10.1007/s00213-011-2281-9. [PMID: 21484238]
  • M T Jafari, M Saraji, H Sherafatmand. Electrospray ionization-ion mobility spectrometry as a detection system for three-phase hollow fiber microextraction technique and simultaneous determination of trimipramine and desipramine in urine and plasma samples. Analytical and bioanalytical chemistry. 2011 Apr; 399(10):3555-64. doi: 10.1007/s00216-011-4730-z. [PMID: 21298415]
  • Judith Neuwoehner, Beate I Escher. The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model. Aquatic toxicology (Amsterdam, Netherlands). 2011 Jan; 101(1):266-75. doi: 10.1016/j.aquatox.2010.10.008. [PMID: 21084122]
  • Emin Aghayev, Christian Jackowski, Andreas Christe, Michael Thali. Radiopaque stomach contents in postmortem CT in suicidal oral medication intoxication: report of three cases. Journal of forensic and legal medicine. 2010 Apr; 17(3):164-8. doi: 10.1016/j.jflm.2009.10.001. [PMID: 20211459]
  • M Flechtner-Mors, C P Jenkinson, A Alt, G Adler, H H Ditschuneit. Metabolism in adipose tissue in response to citalopram and trimipramine treatment--an in situ microdialysis study. Journal of psychiatric research. 2008 Jun; 42(7):578-86. doi: 10.1016/j.jpsychires.2007.06.003. [PMID: 17692337]
  • Annette Thierauf, Reinhard Dettmeyer, Heike Wollersen, Burkhard Madea. Aplastic right coronary artery and left coronary artery with a separate origin of the circumflex branch in a 31-year-old woman. Forensic science international. 2007 Dec; 173(2-3):178-81. doi: 10.1016/j.forsciint.2007.01.001. [PMID: 17317059]
  • Donald F Smith, Bo S Stork, Gregers Wegener, Steen Jakobsen, Dirk Bender, Hélène Audrain, Svend B Jensen, Søren B Hansen, Anders Rodell, Raben Rosenberg. Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Psychopharmacology. 2007 Nov; 195(1):131-8. doi: 10.1007/s00213-007-0877-x. [PMID: 17653532]
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  • M Wolfsperger, W Greil. Galactorrhea during treatment with trimipramine. A case report. Pharmacopsychiatry. 2005 Nov; 38(6):326-7. doi: 10.1055/s-2005-916189. [PMID: 16342006]
  • Manfred Uhr, Markus T Grauer. abcb1ab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice. Journal of psychiatric research. 2003 May; 37(3):179-85. doi: 10.1016/s0022-3956(03)00022-0. [PMID: 12650738]
  • U Hemmeter, B Annen, R Bischof, U Brüderlin, M Hatzinger, U Rose, E Holsboer-Trachsler. Polysomnographic effects of adjuvant ginkgo biloba therapy in patients with major depression medicated with trimipramine. Pharmacopsychiatry. 2001 Mar; 34(2):50-9. doi: 10.1055/s-2001-15182. [PMID: 11302564]
  • C Hébert, A Habimana, R Elie, T A Reader. Effects of chronic antidepressant treatments on 5-HT and NA transporters in rat brain: an autoradiographic study. Neurochemistry international. 2001 Jan; 38(1):63-74. doi: 10.1016/s0197-0186(00)00043-7. [PMID: 10913689]
  • C B Eap, S Bender, M Gastpar, W Fischer, C Haarmann, K Powell, M Jonzier-Perey, N Cochard, P Baumann. Steady state plasma levels of the enantiomers of trimipramine and of its metabolites in CYP2D6-, CYP2C19- and CYP3A4/5-phenotyped patients. Therapeutic drug monitoring. 2000 Apr; 22(2):209-14. doi: 10.1097/00007691-200004000-00012. [PMID: 10774635]
  • J Liu, J T Stewart. Quantitation of trimipramine enantiomers in human serum by enantioselective high-performance liquid chromatography and mixed-mode disc solid-phase extraction. Journal of chromatography. B, Biomedical sciences and applications. 1997 Oct; 700(1-2):175-82. doi: 10.1016/s0378-4347(97)00324-1. [PMID: 9390727]
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  • N Jourdil, B Pinteur, F Vincent, C Marka, G Bessard. Simultaneous determination of trimipramine and desmethyl- and hydroxytrimipramine in plasma and red blood cells by capillary gas chromatography with nitrogen-selective detection. Journal of chromatography. 1993 Mar; 613(1):59-65. doi: 10.1016/0378-4347(93)80197-c. [PMID: 8458903]
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  • C B Eap, L Koeb, E Holsboer-Trachsler, P Baumann. Plasma levels of trimipramine and metabolites in four patients: determination of the enantiomer concentrations of the hydroxy metabolites. Therapeutic drug monitoring. 1992 Oct; 14(5):380-5. doi: 10.1097/00007691-199210000-00007. [PMID: 1448845]
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  • C B Eap, S Laurian, A Souche, L Koeb, P Reymond, T Buclin, P Baumann. Influence of quinidine on the pharmacokinetics of trimipramine and on its effect on the waking EEG of healthy volunteers. A pilot study on two subjects. Neuropsychobiology. 1992; 25(4):214-20. doi: 10.1159/000118840. [PMID: 1454163]
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