AI3-22370 (BioDeep_00000717507)
代谢物信息卡片
Ambenonium chloride
化学式: C28H42Cl4N4O2 (606.2061712)
中文名称: 安贝氯铵
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[N+](CC)(CCNC(=O)C(=O)NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)CC2=CC=CC=C2Cl.[Cl-].[Cl-]
InChI: 2*1H
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:2628
- KEGGdrug: D01001
- PubChem: 8288
- ChEMBL: CHEMBL1200541
- MeSH: Ambenonium Chloride
- CAS: 115-79-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Xiomara A Perez, J Michael McIntosh, Maryka Quik. Long-term nicotine treatment down-regulates α6β2* nicotinic receptor expression and function in nucleus accumbens.
Journal of neurochemistry.
2013 Dec; 127(6):762-71. doi:
10.1111/jnc.12442. [PMID: 23992036] - K Yamamoto, Y Sawada, T Iga. Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats.
Journal of pharmacokinetics and biopharmaceutics.
1996 Aug; 24(4):327-48. doi:
10.1007/bf02353516. [PMID: 9044164] - P Pessotto, R Liberati, O Petrella, W C Hülsmann. Quaternary nitrogen compounds affect carnitine distribution in rats. Particular emphasis on edrophonium.
Biochimica et biophysica acta.
1996 Jan; 1299(2):245-51. doi:
10.1016/0005-2760(96)00212-3. [PMID: 8555270] - K Yamamoto, Y Sawada, T Iga. Comparative pharmacokinetics of four cholinesterase inhibitors in rats.
Biological & pharmaceutical bulletin.
1995 Sep; 18(9):1292-5. doi:
10.1248/bpb.18.1292. [PMID: 8845827] - K Yamamoto, Y Sawada, T Iga. Appearance of tolerance in the increase of contractile muscle tension by ambenonium in rats.
Biological & pharmaceutical bulletin.
1994 Jul; 17(7):944-7. doi:
10.1248/bpb.17.944. [PMID: 8000383] - K Yamamoto, Y Sawada, T Iga. Sensitive determination of ambenonium in plasma using inhibitory activity to acetylcholinesterase.
Biological & pharmaceutical bulletin.
1993 Mar; 16(3):280-3. doi:
10.1248/bpb.16.280. [PMID: 8364473] - K Ohtsubo, N Fujii, S Higuchi, T Aoyama, I Goto, T Tatsuhara. Influence of food on serum ambenonium concentration in patients with myasthenia gravis.
European journal of clinical pharmacology.
1992; 42(4):371-4. doi:
10.1007/bf00280120. [PMID: 1516600] - K Yamamoto, Y Kohda, Y Sawada, T Iga. Pharmacokinetics of ambenonium, a reversible cholinesterase inhibitor, in rats.
Biopharmaceutics & drug disposition.
1991 Nov; 12(8):613-25. doi:
10.1002/bdd.2510120807. [PMID: 1801966] - C Tharasse-Bloch, C Chabenat, P Boucly, J Marchand, D Elkharrat, C Boucly-Goester, P Gajdos. Pharmacokinetic studies of ambenonium chloride in patients with myasthenia gravis.
European journal of drug metabolism and pharmacokinetics.
1991 Oct; 16(4):299-303. doi:
10.1007/bf03189975. [PMID: 1823874] - K Ohtsubo, S Higuchi, T Aoyama, N Fujii, I Goto. Sensitive determination of ambenonium chloride in serum from patients with myasthenia gravis using ion-exchange resin extraction and reversed-phase ion-pair chromatography.
Journal of chromatography.
1989 Nov; 496(2):397-406. doi:
10.1016/s0378-4347(00)82587-6. [PMID: 2613842] - C Tharasse-Bloch, C Chabenat, P Boucly, F Boismare, J Marchand. Pharmacokinetics of ambenonium chloride in dogs after intravenous and oral administration.
Arzneimittel-Forschung.
1989 Feb; 39(2):257-8. doi:
NULL. [PMID: 2730696] - K Yamamoto, Y Kohda, Y Saitoh, F Nakagawa. Determination of ambenonium in biological samples by reversed-phase ion-pair liquid chromatography.
Journal of chromatography.
1988 Dec; 433(?):167-76. doi:
10.1016/s0378-4347(00)80595-2. [PMID: 3235545] - O Pourrat, R Robert, J P Neau, P Deleplanque, D Alcalay. [Cholinergic crisis in a patient with myasthenia treated by plasma exchange and anticholinesterase agents].
Annales de medecine interne.
1988; 139 Suppl 1(?):51-2. doi:
NULL. [PMID: 3247993] - C Tharasse-Bloch, C Chabenat, P Boucly, J Marchand. Determination of ambenonium chloride in serum by reversed-phase ion-pair liquid chromatography.
Journal of chromatography.
1987 Oct; 421(2):407-11. doi:
10.1016/0378-4347(87)80426-7. [PMID: 3429595] - E P Bosch, P E Reith, D K Granner. Myasthenia gravis and Schmidt syndrome.
Neurology.
1977 Dec; 27(12):1179-80. doi:
10.1212/wnl.27.12.1179. [PMID: 563019] - V D Tonkopiĭ, V B Prozorovskiĭ, I M Suslova. [Interaction of reversible inhibitors with the catalytic centers and allosteric sites of cholinesterases].
Biulleten' eksperimental'noi biologii i meditsiny.
1976 Aug; 82(8):947-50. doi:
. [PMID: 1026294] - H Isaacs, J J Heffron, M Badenhorst. 'Picture frame' fibres in a carrier of the trait for malignant hyperpyrexia.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.
1975 Nov; 49(46):1923-6. doi:
NULL. [PMID: 795] - E Modigliani, P Charbord, C Landman, G Delzant, A Faure, L Gattegno, P Cornillot, J Sebaoun. [Myasthenia with monoclonal kappa IgM gammapathy and presence of anti-striated muscle antibodies].
Annales de medecine interne.
1973 Mar; 124(3):193-200. doi:
NULL. [PMID: 4577478] - H Iwata, A Inoue, M Tomoi. Enhancement of brain thiamine diphosphatase activity of rats by injection of cholinergic drugs.
Journal of neurochemistry.
1971 Aug; 18(8):1371-7. doi:
10.1111/j.1471-4159.1971.tb00001.x. [PMID: 4328509] - M Nakamoto. [Clinical studies on the urinary excretion of aldosterone in myasthenia gravis].
Nihon Naibunpi Gakkai zasshi.
1967 Nov; 43(8):770-84. doi:
10.1507/endocrine1927.43.8_770. [PMID: 5626257]