dexamethasone isonicotinate (BioDeep_00000717079)
代谢物信息卡片
化学式: C28H32FNO6 (497.2213544)
中文名称: 地塞米松异烟酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)COC(=O)C5=CC=NC=C5)O)C)O)F)C
InChI: InChI=1S/C28H32FNO6/c1-16-12-21-20-5-4-18-13-19(31)6-9-25(18,2)27(20,29)22(32)14-26(21,3)28(16,35)23(33)15-36-24(34)17-7-10-30-11-8-17/h6-11,13,16,20-22,32,35H,4-5,12,14-15H2,1-3H3/t16-,20+,21+,22+,25+,26+,27+,28+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
D018926 - Anti-Allergic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:177639
- KEGGdrug: D07797
- PubChem: 16752
- DrugBank: DB11487
- ChEMBL: CHEMBL3186453
- MeSH: Dexamethasone Isonicotinate
- CAS: 2265-64-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Saskia G A van der Drift, Martin Houweling, Marina Bouman, Ad P Koets, Aloysius G M Tielens, Mirjam Nielen, Ruurd Jorritsma. Effects of a single glucocorticoid injection on propylene glycol-treated cows with clinical ketosis.
Veterinary journal (London, England : 1997).
2015 May; 204(2):144-9. doi:
10.1016/j.tvjl.2015.01.016. [PMID: 25841896] - M Kusenda, M Kaske, M Piechotta, L Locher, A Starke, K Huber, J Rehage. Effects of dexamethasone-21-isonicotinate on peripheral insulin action in dairy cows 5 days after surgical correction of abomasal displacement.
Journal of veterinary internal medicine.
2013 Jan; 27(1):200-6. doi:
10.1111/jvim.12010. [PMID: 23194055] - Thomas Wittek, Kathleen Wittek, Manfred Fürll. [Effects of a single dose of dexamethasone-21-isonicotinate on the phagocytosis performance of neutrophilic granulocytes and monocytes in periparturient dairy cows].
Berliner und Munchener tierarztliche Wochenschrift.
2005 Mar; 118(3-4):140-9. doi:
". [PMID: 15803762] - R Jorritsma, J Thanasak, M Houweling, J P T M Noordhuizen, K E Müller. Effects of a single dose of dexamethasone-21-isonicotinate on the metabolism of heifers in early lactation.
The Veterinary record.
2004 Oct; 155(17):521-3. doi:
10.1136/vr.155.17.521. [PMID: 15551926] - A C Moreira, A M Leal, M Castro. Adrenocorticotropin-corticosterone relationship during dexamethasone therapy in 17 alpha-hydroxylase deficiency.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
1992 Jul; 24(7):339-41. doi:
10.1055/s-2007-1003328. [PMID: 1325404] - G Hochhaus, H Derendorf, H Möllmann, J Barth. A selective LC/RIA for dexamethasone and its prodrug dexamethasone-21-isonicotinate in biological fluids.
Journal of pharmaceutical and biomedical analysis.
1991; 9(9):761-7. doi:
10.1016/0731-7085(91)80218-x. [PMID: 1821154] - P J Lane, P Lees, J Fink-Gremmels. Action of dexamethasone in an equine model of acute non-immune inflammation.
Research in veterinary science.
1990 Jan; 48(1):87-95. doi:
10.1016/s0034-5288(18)31515-7. [PMID: 2300722] - P L Toutain, R A Brandon, H de Pomyers, M Alvinerie, J D Baggot. Dexamethasone and prednisolone in the horse: pharmacokinetics and action on the adrenal gland.
American journal of veterinary research.
1984 Sep; 45(9):1750-6. doi:
NULL. [PMID: 6497132] - L Andersson, T Olsson. The effect of two glucocorticoids on plasma glucose and milk production in healthy cows and the therapeutic effect in ketosis.
Nordisk veterinaermedicin.
1984 Jan; 36(1-2):13-8. doi:
NULL. [PMID: 6547229] - D Tainturier, M Alvinerie, R A Brandon, P L Toutain. Dexamethasone concentrations in bovine blood plasma and milk after intravenous injection.
Journal of dairy science.
1982 Oct; 65(10):1921-4. doi:
10.3168/jds.s0022-0302(82)82439-9. [PMID: 7174961] - L Andersson, M Engel, V Mattesson. Glucose concentrations in plasma and urine after glucocorticoid injection in healthy cows.
Nordisk veterinaermedicin.
1982 Apr; 34(4-5):143-6. doi:
NULL. [PMID: 6184673] - P L Toutain, R A Brandon, M Alvinerie, R Garcia-Villar, Y Ruckebusch. Dexamethasone in cattle: pharmacokinetics and action on the adrenal gland.
Journal of veterinary pharmacology and therapeutics.
1982 Mar; 5(1):33-43. doi:
10.1111/j.1365-2885.1982.tb00496.x. [PMID: 7097848] - H Goeth, U Lechner. [The effect of Voren on the progress of experimental bacterial infections and their therapy using antibiotics and sulfonamides as well as on the phagocytosis activity of the reticuloendothelial system (RES) and on the serum protein composition in mice].
Berliner und Munchener tierarztliche Wochenschrift.
1978 Mar; 91(5):87-93. doi:
NULL. [PMID: 637833] - A Ouredník, J Humhal, A Jindra. [Plasma cortisol in asthmatics treated with aerosol inhalations of dexametazon-21-isonicotinate (author's transl)].
Casopis lekaru ceskych.
1978; 117(44-45):1405-8. doi:
NULL. [PMID: 728929] - C G Sparkes. Plasma cortisol levels in normal subjects after inhaled corticosteroids.
Postgraduate medical journal.
1974 Sep; 50 suppl 4(?):9-11. doi:
NULL. [PMID: 4467157]