benzethonium chloride (BioDeep_00000715910)

   

Volatile Flavor Compounds


代谢物信息卡片


benzethonium chloride

化学式: C27H42ClNO2 (447.29039020000005)
中文名称: 苄索氯铵
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)(C)CC(C)(C)C1=CC=C(C=C1)OCCOCC[N+](C)(C)CC2=CC=CC=C2.[Cl-]
InChI: /p-1

描述信息

D - Dermatologicals > D08 - Antiseptics and disinfectants > D08A - Antiseptics and disinfectants > D08AJ - Quaternary ammonium compounds
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
D000890 - Anti-Infective Agents
Benzethonium chloride inhibits nicotinic acetylcholine receptors in human recombinant α7 and α4β2 neurons in Xenopus laevis oocytes.

同义名列表

3 个代谢物同义名

benzethonium chloride; Benzethonium (chloride); Benzethonium chloride



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Patrycja Czerwoniec, Rafal Kukawka, Maciej Spychalski, Ryszard Koczura, Joanna Mokracka, Marcin Smiglak. New biologically active ionic liquids with benzethonium cation-efficient SAR inducers and antimicrobial agents. Pest management science. 2024 Jun; 80(6):3047-3055. doi: 10.1002/ps.8014. [PMID: 38319125]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • S Zhang, M Jain, L A Fleites, P A Rayside, D W Gabriel. Identification and Characterization of Menadione and Benzethonium Chloride as Potential Treatments of Pierce's Disease of Grapevines. Phytopathology. 2019 Feb; 109(2):233-239. doi: 10.1094/phyto-07-18-0244-fi. [PMID: 30407880]
  • Usein M Dzhemilev, Vladimir A D'yakonov, Regina A Tuktarova, Lilya U Dzhemileva, Svetlana R Ishmukhametova, Milyausha M Yunusbaeva, Armin de Meijere. Short Route to the Total Synthesis of Natural Muricadienin and Investigation of Its Cytotoxic Properties. Journal of natural products. 2016 08; 79(8):2039-44. doi: 10.1021/acs.jnatprod.6b00335. [PMID: 27533261]
  • Nasli Rafsanjany, Jandirk Sendker, Matthias Lechtenberg, Frank Petereit, Birte Scharf, Andreas Hensel. Traditionally used medicinal plants against uncomplicated urinary tract infections: Are unusual, flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L. against uropathogenic E. coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities?. Fitoterapia. 2015 Sep; 105(?):246-53. doi: 10.1016/j.fitote.2015.07.014. [PMID: 26210697]
  • John Takyi-Williams, Xueming Dong, Haiqing Gong, Yang Wang, Wenying Jian, Chuan-Fa Liu, Kai Tang. Application of paper spray-MS in PK studies using sunitinib and benzethonium as model compounds. Bioanalysis. 2015; 7(4):413-23. doi: 10.4155/bio.14.288. [PMID: 25747761]
  • S L Curtis, N B Roberts, L R Ranganath. Interferences of homogentisic acid (HGA) on routine clinical chemistry assays in serum and urine and the implications for biochemical monitoring of patients with alkaptonuria. Clinical biochemistry. 2014 May; 47(7-8):640-7. doi: 10.1016/j.clinbiochem.2013.12.016. [PMID: 24373924]
  • Hatice Sürer, Tuba Özgün, Fatma Meriç Yilmaz, Gülsen Yilmaz. The effect of centrifugation on three urine protein assays: benzethonium chloride, benzalkonium chloride and pyrogallol red. Clinical chemistry and laboratory medicine. 2014 Apr; 52(4):e71-3. doi: 10.1515/cclm-2013-0868. [PMID: 24280287]
  • Liang Guo, Luke Coyle, Rory M C Abrams, Raymond Kemper, Eric T Chiao, Kyle L Kolaja. Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):581-94. doi: 10.1093/toxsci/kft205. [PMID: 24052561]
  • John G Stoffolano, Laura Danai, James Chambers. Effect of channel blockers on the smooth muscle of the adult crop of the queen blowfly, Phormia regina. Journal of insect science (Online). 2013; 13(?):97. doi: 10.1673/031.013.9701. [PMID: 24205919]
  • Yuying Xue, Shanshan Zhang, Meng Tang, Ting Zhang, Yiqing Wang, Yoko Hieda, Haruo Takeshita. Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats. Journal of applied toxicology : JAT. 2012 Jul; 32(7):480-7. doi: 10.1002/jat.1662. [PMID: 21387348]
  • Brandon Findlay, George G Zhanel, Frank Schweizer. Neomycin-phenolic conjugates: polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding. Bioorganic & medicinal chemistry letters. 2012 Feb; 22(4):1499-503. doi: 10.1016/j.bmcl.2012.01.025. [PMID: 22285320]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Somer Bekiroglu, Olle Myrberg, Kristina Ostman, Marianne Ek, Torbjörn Arvidsson, Torgny Rundlöf, Birgit Hakkarainen. Validation of a quantitative NMR method for suspected counterfeit products exemplified on determination of benzethonium chloride in grapefruit seed extracts. Journal of pharmaceutical and biomedical analysis. 2008 Aug; 47(4-5):958-61. doi: 10.1016/j.jpba.2008.03.021. [PMID: 18456447]
  • Fatma Meriç Yilmaz, Gülsen Yilmaz, Doğan Yücel. Is secondary wavelength always necessary in turbidimetric urine protein measurements?. Clinical biochemistry. 2008 May; 41(7-8):645-7. doi: 10.1016/j.clinbiochem.2008.01.011. [PMID: 18249194]
  • Mei-Hui Li. Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian. Chemosphere. 2008 Feb; 70(10):1796-803. doi: 10.1016/j.chemosphere.2007.08.032. [PMID: 17905407]
  • Naoki Sugimoto, Atsuko Tada, Masanori Kuroyanagi, Yuko Yoneda, Young Sook Yun, Akira Kunugi, Kyoko Sato, Takeshi Yamazaki, Ken-Ichi Tanamoto. [Survey of synthetic disinfectants in grapefruit seed extract and its compounded products]. Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan. 2008 Feb; 49(1):56-62. doi: 10.3358/shokueishi.49.56. [PMID: 18344660]
  • B Avula, S Dentali, I A Khan. Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract. Die Pharmazie. 2007 Aug; 62(8):593-6. doi: ". [PMID: 17867553]
  • Helena Brandin, Olle Myrberg, Torgny Rundlöf, Ann-Kristin Arvidsson, Gunilla Brenning. Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy. European journal of clinical pharmacology. 2007 Jun; 63(6):565-70. doi: 10.1007/s00228-007-0289-1. [PMID: 17468864]
  • A Sengun, S Buyukbas, S S Hakki. Cytotoxic effects of dental desensitizers on human gingival fibroblasts. Journal of biomedical materials research. Part B, Applied biomaterials. 2006 Jul; 78(1):131-7. doi: 10.1002/jbm.b.30464. [PMID: 16470823]
  • Fatma Meriç Yilmaz, Dogan Yücel. Effect of addition of hemolysate on urine and cerebrospinal fluid assays for protein. Clinical chemistry. 2006 Jan; 52(1):152-3. doi: 10.1373/clinchem.2005.057547. [PMID: 16391333]
  • G Takeoka, L Dao, R Y Wong, R Lundin, N Mahoney. Identification of benzethonium chloride in commercial grapefruit seed extracts. Journal of agricultural and food chemistry. 2001 Jul; 49(7):3316-20. doi: 10.1021/jf010222w. [PMID: 11453769]
  • Z Zaman, E Speeleveld, L Sneyers, K Desmet. Inhibition of acetylcholine esterase and choline esterase by benzethonium chloride and avoidance of the benzethonium chloride carry-over inhibitory effect. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1997 Aug; 35(8):603-7. doi: 10.1515/cclm.1997.35.8.603. [PMID: 9298350]
  • E Sykes, M Gibson, C Dmuchowski. Homogentisic acid interference in the measurement of urinary protein using benzethonium chloride. Annals of clinical biochemistry. 1996 Jan; 33 ( Pt 1)(?):86-8. doi: 10.1177/000456329603300117. [PMID: 8929077]
  • J P Beilby, B A O'Leary. Alpha 1-acid glycoprotein decreases recovery of total protein in urine when trichloroacetic acid is used to precipitate the proteins. Clinical chemistry. 1990 Mar; 36(3):565-7. doi: . [PMID: 2311234]
  • K Beilby, B O'Leary. Are the positive interferences in the benzethonium chloride method for urine protein real?. Annals of clinical biochemistry. 1990 Jan; 27 ( Pt 1)(?):88-9. doi: 10.1177/000456329002700121. [PMID: 2310164]
  • P M Crofton. Positive and negative interference in the benzethonium chloride method for urine protein. Annals of clinical biochemistry. 1989 Jan; 26 ( Pt 1)(?):104-5. doi: 10.1177/000456328902600117. [PMID: 2735743]
  • D R Nurse, M J Hallworth. More on errors in estimating urinary protein by use of benzethonium chloride. Clinical chemistry. 1988 Sep; 34(9):1944-5. doi: NULL. [PMID: 3416474]
  • F H Wians, J I Heald, N Staples. More on quantification of urinary protein with benzethonium chloride. Clinical chemistry. 1988 Mar; 34(3):645-6. doi: NULL. [PMID: 3349629]
  • I Watson, L Jenkins. Errors in estimating urinary protein by use of benzethonium chloride. Clinical chemistry. 1987 Nov; 33(11):2127-8. doi: NULL. [PMID: 3677399]
  • Z H Siddik, F E Boxall, K R Harrap. Flameless atomic absorption spectrophotometric determination of platinum in tissues solubilized in hyamine hydroxide. Analytical biochemistry. 1987 May; 163(1):21-6. doi: 10.1016/0003-2697(87)90087-x. [PMID: 3039867]
  • N O'Leary, K Brophy, P F Duggan. Benzethonium chloride interference with subsequent assays involving heparinized plasma in a centrifugal analyzer. Clinical chemistry. 1987 Apr; 33(4):615-6. doi: 10.1093/clinchem/33.4.615a. [PMID: 3829407]
  • K Lorentz, T Weiss. [Protein determination in urine--a critical review]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1986 May; 24(5):309-23. doi: . [PMID: 3734701]
  • R Lehmitz. [Turbidimetric protein determination with benzethonium chloride and sulfosalicylic acid]. Zeitschrift fur medizinische Laboratoriumsdiagnostik. 1986; 27(2):89-91. doi: NULL. [PMID: 3705706]
  • T L McDowell. Benzethonium chloride method for proteins adapted to centrifugal analysis. Clinical chemistry. 1985 Jun; 31(6):864-6. doi: NULL. [PMID: 3995765]
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  • J Iwata, O Nishikaze. New micro-turbidimetric method for determination of protein in cerebrospinal fluid and urine. Clinical chemistry. 1979 Jul; 25(7):1317-9. doi: 10.1093/clinchem/25.7.1317. [PMID: 88281]
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