Roflumilast N-oxide (BioDeep_00000715318)
代谢物信息卡片
Roflumilast N-oxide
化学式: C17H14Cl2F2N2O4 (418.0299)
中文名称: 罗氟司特d4 N-氧化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC1COC2=C(C=CC(=C2)C(=O)N=C3C(=CN(C=C3Cl)O)Cl)OC(F)F
InChI: InChI=1S/C17H14Cl2F2N2O4/c18-11-6-23(25)7-12(19)15(11)22-16(24)10-3-4-13(27-17(20)21)14(5-10)26-8-9-1-2-9/h3-7,9,17,25H,1-2,8H2
描述信息
D004791 - Enzyme Inhibitors > D010726 - Phosphodiesterase Inhibitors > D058988 - Phosphodiesterase 4 Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
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文献列表
- Haijun Qu, Keyu Zhang, Chunqing Fu, Feng Qiu. Simultaneous quantification and pharmacokinetic evaluation of roflumilast and its N-oxide in cynomolgus monkey plasma by LC-MS/MS method.
Biomedical chromatography : BMC.
2021 Feb; 35(2):e4973. doi:
10.1002/bmc.4973. [PMID: 32840886] - Martin Kertys, Anna Urbanova, Juraj Mokry. Determination of Phosphodiesterase Inhibitors Tadalafil, Roflumilast and Roflumilast N-Oxide Using LC-MS in Guinea Pig Plasma.
Journal of chromatographic science.
2018 Nov; 56(10):948-954. doi:
10.1093/chromsci/bmy072. [PMID: 29992297] - Qian Li, Yiya Wang, Lingye Liu, Pengcheng Ma, Li Ding. Pharmacokinetics of Roflumilast and Its Active Metabolite Roflumilast N-Oxide in Healthy Chinese Subjects After Single and Multiple Oral Doses.
European journal of drug metabolism and pharmacokinetics.
2017 Jun; 42(3):371-381. doi:
10.1007/s13318-016-0343-4. [PMID: 27306372] - Ezigbobiara N Umejiego, Yanhua Wang, Mark A Knepper, Chung-Lin Chou. Roflumilast and aquaporin-2 regulation in rat renal inner medullary collecting duct.
Physiological reports.
2017 Jan; 5(2):. doi:
10.14814/phy2.13121. [PMID: 28108651] - Xinge Cui, Jie Huang, Xin Zheng, Ji Jiang, Yun Kuang, Pei Hu. Simultaneous determination of roflumilast and its metabolite in human plasma by LC-MS/MS: Application for a pharmacokinetic study.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Sep; 1029-1030(?):60-67. doi:
10.1016/j.jchromb.2016.06.001. [PMID: 27423044] - S Sugin Lal Jabaris, Haridass Sumathy, Ramesh Girish, Shridhar Narayanan, Mani Sugumar, Chidambaram Saravana Babu, Sadagopan Thanikachalam, Mohan Thanikachalam. Phosphodiesterase-4 inhibitors ameliorates cognitive deficits in deoxycorticosterone acetate induced hypertensive rats via cAMP/CREB signaling system.
Brain research.
2015 Oct; 1622(?):279-91. doi:
10.1016/j.brainres.2015.07.003. [PMID: 26168894] - Sobhana George Sugin Lal Jabaris, Haridass Sumathy, Ramadass Satiesh Kumar, Shridhar Narayanan, Sadagopan Thanikachalam, Chidambaram Saravana Babu. Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats.
European journal of pharmacology.
2015 Jan; 746(?):138-47. doi:
10.1016/j.ejphar.2014.10.039. [PMID: 25446433] - Satheeshmanikandan R S Thappali, Kanthikiran V S Varanasi, Sridhar Veeraraghavan, Swaroop Kumar V S Vakkalanka, K Mukkanti. Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic study.
Journal of mass spectrometry : JMS.
2012 Dec; 47(12):1612-9. doi:
10.1002/jms.3103. [PMID: 23280750] - S Vollert, N Kaessner, A Heuser, G Hanauer, A Dieckmann, D Knaack, H P Kley, R Beume, C Weiss-Haljiti. The glucose-lowering effects of the PDE4 inhibitors roflumilast and roflumilast-N-oxide in db/db mice.
Diabetologia.
2012 Oct; 55(10):2779-2788. doi:
10.1007/s00125-012-2632-z. [PMID: 22790061] - Norbert G Knebel, Rolf Herzog, Felix Reutter, Karl Zech. Sensitive quantification of roflumilast and roflumilast N-oxide in human plasma by LC-MS/MS employing parallel chromatography and electrospray ionisation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Apr; 893-894(?):82-91. doi:
10.1016/j.jchromb.2012.02.038. [PMID: 22425388] - T D Bethke, M Hartmann, A Hünnemeyer, G Lahu, C H Gleiter. Influence of renal impairment on the pharmacokinetics of oral roflumilast: an open-label, parallel-group, single-center study.
International journal of clinical pharmacology and therapeutics.
2011 Aug; 49(8):491-9. doi:
10.5414/cp201556. [PMID: 21781649] - Gabriele M Böhmer, Christoph H Gleiter, Klaus Mörike, Nassr Nassr, Antje Walz, Gezim Lahu. No dose adjustment on coadministration of the PDE4 inhibitor roflumilast with a weak CYP3A, CYP1A2, and CYP2C19 inhibitor: an investigation using cimetidine.
Journal of clinical pharmacology.
2011 Apr; 51(4):594-602. doi:
10.1177/0091270010368282. [PMID: 20484614] - Gezim Lahu, Andreas Hünnemeyer, Edgar Diletti, Martin Elmlinger, Peter Ruth, Karl Zech, Nigel McCracken, Axel Facius. Population pharmacokinetic modelling of roflumilast and roflumilast N-oxide by total phosphodiesterase-4 inhibitory activity and development of a population pharmacodynamic-adverse event model.
Clinical pharmacokinetics.
2010 Sep; 49(9):589-606. doi:
10.2165/11536600-000000000-00000. [PMID: 20690782] - Nassr Nassr, Andreas Huennemeyer, Rolf Herzog, Oliver von Richter, Robert Hermann, Manuela Koch, Kevin Duffy, Karl Zech, Gezim Lahu. Effects of rifampicin on the pharmacokinetics of roflumilast and roflumilast N-oxide in healthy subjects.
British journal of clinical pharmacology.
2009 Oct; 68(4):580-7. doi:
10.1111/j.1365-2125.2009.03478.x. [PMID: 19843061] - Oliver von Richter, Gezim Lahu, Andreas Huennemeyer, Rolf Herzog, Karl Zech, Robert Hermann. Effect of fluvoxamine on the pharmacokinetics of roflumilast and roflumilast N-oxide.
Clinical pharmacokinetics.
2007; 46(7):613-22. doi:
10.2165/00003088-200746070-00006. [PMID: 17596106] - Robert Hermann, Nassr Nassr, Gezim Lahu, Eva Péterfai, Dietrich Knoerzer, Rolf Herzog, Karl Zech, Christian de Mey. Steady-state pharmacokinetics of roflumilast and roflumilast N-oxide in patients with mild and moderate liver cirrhosis.
Clinical pharmacokinetics.
2007; 46(5):403-16. doi:
10.2165/00003088-200746050-00003. [PMID: 17465639]
