ospemifene (BioDeep_00000713673)
代谢物信息卡片
ospemifene
化学式: C24H23ClO2 (378.1386)
中文名称: 奥培米芬
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C(=C(C2=CC=CC=C2)C3=CC=C(C=C3)OCCO)CCCl
InChI: InChI=1S/C24H23ClO2/c25-16-15-23(19-7-3-1-4-8-19)24(20-9-5-2-6-10-20)21-11-13-22(14-12-21)27-18-17-26/h1-14,26H,15-18H2/b24-23-
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03X - Other sex hormones and modulators of the genital system > G03XC - Selective estrogen receptor modulators
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
C1892 - Chemopreventive Agent
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:73275
- KEGGdrug: D08958
- PubChem: 3036505
- DrugBank: DB04938
- ChEMBL: CHEMBL2105395
- CAS: 128607-22-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Robert L Reid, Denise Black, Christine Derzko, David Portman. Ospemifene: A Novel Oral Therapy for Vulvovaginal Atrophy of Menopause.
Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC.
2020 Mar; 42(3):301-303. doi:
10.1016/j.jogc.2019.10.039. [PMID: 31932249] - Siva Sankara Rao Yadlapalli, Naresh Kumar Katari, Surendra Babu Manabolu Surya. Determination of ospemifene in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
Biomedical chromatography : BMC.
2019 Apr; 33(4):e4451. doi:
10.1002/bmc.4451. [PMID: 30536649] - Michele Carlo Schiavi, Anna Di Pinto, Valentina Sciuga, Pierangelo Faiano, Chiara Di Tucci, Ottavia D'oria, Angela Martoccia, Giovanni Prata, Carlo Carraro, Rosa Ostuni, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici. Prevention of recurrent lower urinary tract infections in postmenopausal women with genitourinary syndrome: outcome after 6 months of treatment with ospemifene.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Feb; 34(2):140-143. doi:
10.1080/09513590.2017.1370645. [PMID: 28853624] - David F Archer, Corrado Altomare, Wei Jiang, Susannah Cort. Ospemifene's effects on lipids and coagulation factors: a post hoc analysis of phase 2 and 3 clinical trial data.
Menopause (New York, N.Y.).
2017 Oct; 24(10):1167-1174. doi:
10.1097/gme.0000000000000900. [PMID: 28509812] - Ryuji Kubota, Sayaka Matsumoto, Toshihiro Wajima. Population pharmacokinetics of ospemifene and safety evaluation of pharmacokinetic alterations caused by intrinsic and extrinsic factors
.
International journal of clinical pharmacology and therapeutics.
2017 Apr; 55(4):339-347. doi:
10.5414/cp202821. [PMID: 28128722] - G Constantine, S Graham, D J Portman, R C Rosen, S A Kingsberg. Female sexual function improved with ospemifene in postmenopausal women with vulvar and vaginal atrophy: results of a randomized, placebo-controlled trial.
Climacteric : the journal of the International Menopause Society.
2015 Apr; 18(2):226-32. doi:
10.3109/13697137.2014.954996. [PMID: 25252699] - Michael W DeGregorio, Robert L Zerbe, Gregory T Wurz. Ospemifene: a first-in-class, non-hormonal selective estrogen receptor modulator approved for the treatment of dyspareunia associated with vulvar and vaginal atrophy.
Steroids.
2014 Nov; 90(?):82-93. doi:
10.1016/j.steroids.2014.07.012. [PMID: 25087944] - Pasi Koskimies, Jari Turunen, Risto Lammintausta, Mika Scheinin. Single-dose and steady-state pharmacokinetics of ospemifene, a selective estrogen receptor modulator, in postmenopausal women.
International journal of clinical pharmacology and therapeutics.
2013 Nov; 51(11):861-7. doi:
10.5414/cp201925. [PMID: 24075094] - Terhi Lehtinen, Ari Tolonen, Miia Turpeinen, Jouko Uusitalo, Jouni Vuorinen, Risto Lammintausta, Olavi Pelkonen, Mika Scheinin. Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene.
Biopharmaceutics & drug disposition.
2013 Oct; 34(7):387-95. doi:
10.1002/bdd.1853. [PMID: 23852652] - Miia Turpeinen, Jouko Uusitalo, Terhi Lehtinen, Marita Kailajärvi, Olavi Pelkonen, Jouni Vuorinen, Pasi Tapanainen, Camilla Stjernschantz, Risto Lammintausta, Mika Scheinin. Effects of ospemifene on drug metabolism mediated by cytochrome P450 enzymes in humans in vitro and in vivo.
International journal of molecular sciences.
2013 Jul; 14(7):14064-75. doi:
10.3390/ijms140714064. [PMID: 23880855] - Ari Tolonen, Pasi Koskimies, Miia Turpeinen, Jouko Uusitalo, Risto Lammintausta, Olavi Pelkonen. Ospemifene metabolism in humans in vitro and in vivo: metabolite identification, quantitation, and CYP assignment of major hydroxylations.
Drug metabolism and drug interactions.
2013; 28(3):153-61. doi:
10.1515/dmdi-2013-0016. [PMID: 23729558] - Rebekah A Burich, Neelima Rakesh Mehta, Gregory T Wurz, Jamie Lee McCall, Brittany E Greenberg, Katie E Bell, Stephen M Griffey, Michael W DeGregorio. Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model.
Menopause (New York, N.Y.).
2012 Jan; 19(1):96-103. doi:
10.1097/gme.0b013e318223e82a. [PMID: 21926925] - Noelia A-González, Antonio Castrillo. Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.
Biochimica et biophysica acta.
2011 Aug; 1812(8):982-94. doi:
10.1016/j.bbadis.2010.12.015. [PMID: 21193033] - Gregory T Wurz, Utha Hellmann-Blumberg, Michael W DeGregorio. Pharmacologic effects of ospemifene in rhesus macaques: a pilot study.
Basic & clinical pharmacology & toxicology.
2008 Jun; 102(6):552-8. doi:
10.1111/j.1742-7843.2008.00235.x. [PMID: 18346046] - G E Christodoulakos, I V Lambrinoudaki, D C Botsis. The cardiovascular effects of selective estrogen receptor modulators.
Annals of the New York Academy of Sciences.
2006 Dec; 1092(?):374-84. doi:
10.1196/annals.1365.034. [PMID: 17308162] - Janne Komi, Kari S Lankinen, Michael DeGregorio, Jorma Heikkinen, Seppo Saarikoski, Marjo Tuppurainen, Kaija Halonen, Risto Lammintausta, Kalervo Väänänen, Olavi Ylikorkala, Risto Erkkola. Effects of ospemifene and raloxifene on biochemical markers of bone turnover in postmenopausal women.
Journal of bone and mineral metabolism.
2006; 24(4):314-8. doi:
10.1007/s00774-006-0689-9. [PMID: 16816926] - Gregory T Wurz, Cristina Marchisano-Karpman, Michael W DeGregorio. Ineffectiveness of American ginseng in the prevention of dimethylbenzanthracene-induced mammary tumors in mice.
Oncology research.
2006; 16(6):251-60. doi:
10.3727/000000006783981017. [PMID: 17476970] - Janne Komi, Kari S Lankinen, Pirkko Härkönen, Michael W DeGregorio, Sari Voipio, Seppo Kivinen, Risto Tuimala, Tarja Vihtamäki, Kimmo Vihko, Olavi Ylikorkala, Risto Erkkola. Effects of ospemifene and raloxifene on hormonal status, lipids, genital tract, and tolerability in postmenopausal women.
Menopause (New York, N.Y.).
2005 Mar; 12(2):202-9. doi:
10.1097/00042192-200512020-00015. [PMID: 15772568] - J Komi, J Heikkinen, E M Rutanen, K Halonen, R Lammintausta, O Ylikorkala. Effects of ospemifene, a novel SERM, on biochemical markers of bone turnover in healthy postmenopausal women.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2004 Mar; 18(3):152-8. doi:
10.1080/09513590410001672197. [PMID: 15255284] - Olavi Ylikorkala, Bruno Cacciatore, Kaija Halonen, Riitta Lassila, Risto Lammintausta, Eeva-Marja Rutanen, Jorma Heikkinen, Janne Komi. Effects of ospemifene, a novel SERM, on vascular markers and function in healthy, postmenopausal women.
Menopause (New York, N.Y.).
2003 Sep; 10(5):440-7. doi:
10.1097/01.gme.0000063566.84134.98. [PMID: 14501606] - S K Voipio, J Komi, L Kangas, K Halonen, M W DeGregorio, R U Erkkola. Effects of ospemifene (FC-1271a) on uterine endometrium, vaginal maturation index, and hormonal status in healthy postmenopausal women.
Maturitas.
2002 Nov; 43(3):207-14. doi:
10.1016/s0378-5122(02)00206-2. [PMID: 12443837] - U Hellmann-Blumberg, T L Taras, G T Wurz, M W DeGregorio. Genotoxic effects of the novel mixed antiestrogen FC-1271a in comparison to tamoxifen and toremifene.
Breast cancer research and treatment.
2000 Mar; 60(1):63-70. doi:
10.1023/a:1006311214152. [PMID: 10845810] - Q Qu, H Zheng, J Dahllund, A Laine, N Cockcroft, Z Peng, M Koskinen, K Hemminki, L Kangas, K Väänänen, P Härkönen. Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats.
Endocrinology.
2000 Feb; 141(2):809-20. doi:
10.1210/endo.141.2.7342. [PMID: 10650964] - T L Taras, G T Wurz, U Hellmann-Blumberg, M W DeGregorio. Quantitative analysis of Z-2-[4-(4-chloro-1,2-diphenyl-but-1-enyl)phenoxy]ethanol in human plasma using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1999 Mar; 724(1):163-71. doi:
10.1016/s0378-4347(98)00571-4. [PMID: 10202969]
