Quinocetone (BioDeep_00000713635)
代谢物信息卡片
Deciquam Solution
化学式: C18H14N2O3 (306.10043740000003)
中文名称: 喹烯酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C([N+](=O)C2=CC=CC=C2N1[O-])C(=O)C=CC3=CC=CC=C3
InChI: InChI=1S/C18H14N2O3/c1-13-18(17(21)12-11-14-7-3-2-4-8-14)20(23)16-10-6-5-9-15(16)19(13)22/h2-12H,1H3/b12-11+
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lirui Hou, Fang Liu, Chong Zhao, Lihong Fan, Hongbo Hu, Shutao Yin. Combination of oxytetracycline and quinocetone synergistically induces hepatotoxicity via generation of reactive oxygen species and activation of mitochondrial pathway.
Toxicology mechanisms and methods.
2022 Jan; 32(1):49-57. doi:
10.1080/15376516.2021.1965273. [PMID: 34348565] - M Qiu, Z Hao, R Zhang, L Cui, C Wang, S Qu, S Yuan, Y Bai. Plasma pharmacokinetics of quinocetone in ducks after oral and intravenous administration.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):142-147. doi:
10.1111/jvp.12426. [PMID: 28730638] - Xudong Zhu, Lingli Huang, Yamei Xu, Shuyu Xie, Yuanhu Pan, Dongmei Chen, Zhenli Liu, Zonghui Yuan. Physiologically based pharmacokinetic model for quinocetone in pigs and extrapolation to mequindox.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2017 Feb; 34(2):192-210. doi:
10.1080/19440049.2016.1258121. [PMID: 28001497] - Y Liu, X Ai, F Wang, H Yang, N Xu, Q Yang. Comparative pharmacokinetics and tissue distribution of quinocetone in crucian carp (Carassius auratus), common carp (Cyprinus carpio L.), and grass carp (Ctenopharyngodon idella) following the same experimental conditions.
Journal of veterinary pharmacology and therapeutics.
2015 Aug; 38(4):383-91. doi:
10.1111/jvp.12195. [PMID: 25515188] - Wenjuan Xun, Liguang Shi, Hanlin Zhou, Guanyu Hou, Ting Cao, Chunping Zhao. Effects of curcumin on growth performance, jejunal mucosal membrane integrity, morphology and immune status in weaned piglets challenged with enterotoxigenic Escherichia coli.
International immunopharmacology.
2015 Jul; 27(1):46-52. doi:
10.1016/j.intimp.2015.04.038. [PMID: 25937483] - Juan Li, Lingli Huang, Yuanhu Pan, Dongmei Chen, Xu Wang, Ijaz Ahmad, Yanfei Tao, Zhenli Liu, Zonghui Yuan. Tissue depletion of quinocetone and its five major metabolites in pigs, broilers, and carp fed quinocetone premix.
Journal of agricultural and food chemistry.
2014 Oct; 62(42):10348-56. doi:
10.1021/jf5042867. [PMID: 25280481] - Juan Li, Lingli Huang, Xu Wang, Yuanhu Pan, Zhaoying Liu, Dongmei Chen, Yanfei Tao, Qinghua Wu, Zonghui Yuan. Metabolic disposition and excretion of quinocetone in rats, pigs, broilers, and carp.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Jul; 69(?):109-19. doi:
10.1016/j.fct.2014.04.004. [PMID: 24727229] - Miao Yu, Di Wang, Mengjing Xu, Yang Liu, Xia Wang, Jun Liu, Xuefeng Yang, Ping Yao, Hong Yan, Liegang Liu. Quinocetone-induced Nrf2/HO-1 pathway suppression aggravates hepatocyte damage of Sprague-Dawley rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 Jul; 69(?):210-9. doi:
10.1016/j.fct.2014.04.026. [PMID: 24795230] - Miao Yu, Mengjing Xu, Yang Liu, Wei Yang, Ying Rong, Ping Yao, Hong Yan, Di Wang, Liegang Liu. Nrf2/ARE is the potential pathway to protect Sprague-Dawley rats against oxidative stress induced by quinocetone.
Regulatory toxicology and pharmacology : RTP.
2013 Aug; 66(3):279-85. doi:
10.1016/j.yrtph.2013.04.005. [PMID: 23624349] - Yan Yong, Yahong Liu, Limin He, Lixiao Xu, Yaping Zhang, Binghu Fang. Simultaneous determination of quinocetone and its major metabolites in chicken tissues by high-performance liquid chromatography tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2013 Mar; 919-920(?):30-7. doi:
10.1016/j.jchromb.2012.12.038. [PMID: 23411016] - Jiaheng Zhang, Min Li, Linxia Li, Yubo Li, Bing Peng, Suxia Zhang, Haixiang Gao, Wenfeng Zhou. Investigation of the ultrasound effect and target analyte selectivity of dispersive liquid-liquid microextraction and its application to a quinocetone pharmacokinetic study.
Journal of chromatography. A.
2012 Dec; 1268(?):1-8. doi:
10.1016/j.chroma.2012.10.028. [PMID: 23122995] - Haixia Wu, Chunyan Yang, Zhanhui Wang, Jianzhong Shen, Suxia Zhang, Peisheng Feng, Linxia Li, Linli Cheng. Metabolism profile of quinocetone in swine by ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry.
European journal of drug metabolism and pharmacokinetics.
2012 Jun; 37(2):141-54. doi:
10.1007/s13318-011-0067-4. [PMID: 21932157] - Di Wang, Xiao Luo, Ying Zhong, Wei Yang, Mengjing Xu, Yang Liu, Jie Meng, Ping Yao, Hong Yan, Liegang Liu. Pu-erh black tea extract supplementation attenuates the oxidative DNA damage and oxidative stress in Sprague-Dawley rats with renal dysfunction induced by subchronic 3-methyl-2-quinoxalin benzenevinylketo-1,4-dioxide exposure.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Feb; 50(2):147-54. doi:
10.1016/j.fct.2011.10.069. [PMID: 22079314] - Di Wang, Ying Zhong, Xiao Luo, Shuang Wu, Rong Xiao, Wei Bao, Wei Yang, Hong Yan, Ping Yao, Liegang Liu. Pu-erh black tea supplementation decreases quinocetone-induced ROS generation and oxidative DNA damage in Balb/c mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Feb; 49(2):477-84. doi:
10.1016/j.fct.2010.11.028. [PMID: 21112366] - Xu Wang, Wei Zhang, Yulian Wang, Dapeng Peng, Awais Ihsan, Xianju Huang, Lingli Huang, Zhenli Liu, Menghong Dai, Wen Zhou, Zong-Hui Yuan. Acute and sub-chronic oral toxicological evaluations of quinocetone in Wistar rats.
Regulatory toxicology and pharmacology : RTP.
2010 Dec; 58(3):421-7. doi:
10.1016/j.yrtph.2010.08.008. [PMID: 20713111] - Jianzhong Shen, Chunyan Yang, Congming Wu, Peisheng Feng, Zhanhui Wang, Yan Li, Yanshen Li, Suxia Zhang. Identification of the major metabolites of quinocetone in swine urine using ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2010 Feb; 24(3):375-83. doi:
10.1002/rcm.4399. [PMID: 20054845] - Yong Li, ZhiXian Gao, FangTing Dong, YiYong Cheng. Quantitative determination of quinocetone and its metabolites in chicken plasma by liquid chromatography/tandem mass spectrometry.
Journal of AOAC International.
2008 Nov; 91(6):1494-8. doi:
10.1093/jaoac/91.6.1494. [PMID: 19202814] - Lingli Huang, Aiguo Xiao, Shengxian Fan, Juyi Yin, Pin Chen, Dengcai Liu, Yinsheng Qiu, Yulian Wang, Zonghui Yuan. Development of liquid chromatographic methods for determination of quinocetone and its main metabolites in edible tissues of swine and chicken.
Journal of AOAC International.
2005 Mar; 88(2):472-8. doi:
10.1093/jaoac/88.2.472. [PMID: 15859074]