Ranitidine bismuth citrate (BioDeep_00000713620)
代谢物信息卡片
化学式: C19H27BiN4O10S (712.1251702000001)
中文名称: 枸橼酸铋雷尼替丁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C.C(C(=O)[O-])C(CC(=O)[O-])(C(=O)[O-])O.[Bi+3]
InChI: /q
描述信息
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord) > A02BA - H2-receptor antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuofeng Yuan, Runming Wang, Jasper Fuk-Woo Chan, Anna Jinxia Zhang, Tianfan Cheng, Kenn Ka-Heng Chik, Zi-Wei Ye, Suyu Wang, Andrew Chak-Yiu Lee, Lijian Jin, Hongyan Li, Dong-Yan Jin, Kwok-Yung Yuen, Hongzhe Sun. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters.
Nature microbiology.
2020 11; 5(11):1439-1448. doi:
10.1038/s41564-020-00802-x. [PMID: 33028965] - Agnete Larsen, Nargot Martiny, Meredin Stoltenberg, Gorm Danscher, Jørgen Rungby. Gastrointestinal and systemic uptake of bismuth in mice after oral exposure.
Pharmacology & toxicology.
2003 Aug; 93(2):82-90. doi:
NULL. [PMID: 12899670] - A S Loginov, V I Reshetnyak, T V Dudik, G N Vostroknutova, A A Il'chenko, A S Kaprel'yants. Diagnostic methods for detecting forms and strains of Helicobacter pylori and evaluation of its eradication.
Bulletin of experimental biology and medicine.
2001 Aug; 132(2):802-6. doi:
10.1023/a:1013006717904. [PMID: 11713571] - T Alarcón, D Domingo, N Prieto, M López-Brea. Bacteriostatic and bactericidal activity of ranitidine bismuth citrate in Helicobacter pylori clinical isolates.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
1999 Mar; 12(1):64-8. doi:
NULL. [PMID: 10209056] - H Gudjonsson, K D Bardhan, O Hoie, E S Kristensen, E Schuetz, C Kliebe-Frisch, G A Pipkin, A E Duggan. High Helicobacter pylori eradication rate with a 1-week regimen containing ranitidine bismuth citrate.
Alimentary pharmacology & therapeutics.
1998 Nov; 12(11):1113-9. doi:
10.1046/j.1365-2036.1998.00413.x. [PMID: 9845401] - J Canena, J Reis, A S Pinto, A M Santos, J Leitão, T Pinheiro, M G Quina. Distribution of bismuth in the rat after oral dosing with ranitidine bismuth citrate and bismuth subcitrate.
The Journal of pharmacy and pharmacology.
1998 Mar; 50(3):279-83. doi:
10.1111/j.2042-7158.1998.tb06861.x. [PMID: 9600719] - K D Bardhan, C Dallaire, H Eisold, A E Duggan. Ranitidine bismuth citrate with clarithromycin for the treatment of duodenal ulcer.
Gut.
1997 Aug; 41(2):181-6. doi:
10.1136/gut.41.2.181. [PMID: 9301496] - J E Bennett, J C Wakefield, L F Lacey. Modeling of trough plasma bismuth concentrations.
Journal of pharmacokinetics and biopharmaceutics.
1997 Feb; 25(1):79-106. doi:
10.1023/a:1025771811143. [PMID: 9353695] - A A Ciociola, D D Webb, A Heath, J H Walsh. Effects of ranitidine bismuth citrate on gastric acid secretion and gastrin release in subjects with and without Helicobacter pylori infection.
Alimentary pharmacology & therapeutics.
1996 Dec; 10(6):905-12. doi:
10.1046/j.1365-2036.1996.83255000.x. [PMID: 8971287] - K M Koch, B M Kerr, A E Gooding, I M Davis. Pharmacokinetics of bismuth and ranitidine following multiple doses of ranitidine bismuth citrate.
British journal of clinical pharmacology.
1996 Aug; 42(2):207-11. doi:
10.1046/j.1365-2125.1996.39310.x. [PMID: 8864319] - L A Tillman, F M Drake, J S Dixon, J R Wood. Review article: safety of bismuth in the treatment of gastrointestinal diseases.
Alimentary pharmacology & therapeutics.
1996 Aug; 10(4):459-67. doi:
10.1046/j.1365-2036.1996.22163000.x. [PMID: 8853750] - K M Koch, I M Davis, A E Gooding, Y Yin. Pharmacokinetics of bismuth and ranitidine following single doses of ranitidine bismuth citrate.
British journal of clinical pharmacology.
1996 Aug; 42(2):201-5. doi:
10.1046/j.1365-2125.1996.03929.x. [PMID: 8864318] - K D Bardhan, C P Dekkers, S K Lam, A Nowak, O B Schaffalitzky de Muckadell, K Schutze, G Tildesley, L Kler, J K Forster, L F Lacey. GR122311X (ranitidine bismuth citrate), a new drug for the treatment of duodenal ulcer.
Alimentary pharmacology & therapeutics.
1995 Oct; 9(5):497-506. doi:
10.1111/j.1365-2036.1995.tb00412.x. [PMID: 8580269] - L F Lacey, N M Frazer, O N Keene, J T Smith. Comparative pharmacokinetics of bismuth from ranitidine bismuth citrate (GR122311X), a novel anti-ulcerant and tripotassium dicitrato bismuthate (TDB).
European journal of clinical pharmacology.
1994; 47(2):177-80. doi:
10.1007/bf00194969. [PMID: 7859806] - A G Fraser, W M Lam, Y W Luk, J Sercombe, A M Sawyerr, M Hudson, I M Samloff, R E Pounder. Effect of ranitidine bismuth citrate on postprandial plasma gastrin and pepsinogens.
Gut.
1993 Mar; 34(3):338-42. doi:
10.1136/gut.34.3.338. [PMID: 8472980] - E J Prewett, C U Nwokolo, M Hudson, A M Sawyerr, A Fraser, R E Pounder. The effect of GR122311X, a bismuth compound with H2-antagonist activity, on 24-hour intragastric acidity.
Alimentary pharmacology & therapeutics.
1991 Oct; 5(5):481-90. doi:
10.1111/j.1365-2036.1991.tb00517.x. [PMID: 1686562]