LGK 974 (BioDeep_00000712949)
代谢物信息卡片
化学式: C23H20N6O (396.169851)
中文名称: 2,3-二甲基-N-[5-(2-吡嗪基)-2-吡啶基]-[2,4-联吡啶]-5-乙酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4
InChI: InChI=1S/C23H20N6O/c1-15-9-17(12-28-23(15)18-5-6-25-16(2)10-18)11-22(30)29-21-4-3-19(13-27-21)20-14-24-7-8-26-20/h3-10,12-14H,11H2,1-2H3,(H,27,29,30)
描述信息
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:78030
- PubChem: 46926973
- DrugBank: DB12561
- ChEMBL: CHEMBL3188386
- CAS: 1243244-14-5
分类词条
相关代谢途径
Reactome(2)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jaewoong Jang, Jaewon Song, Hyunji Lee, Inae Sim, Young V Kwon, Eek-Hoon Jho, Yoosik Yoon. LGK974 suppresses lipopolysaccharide-induced endotoxemia in mice by modulating the crosstalk between the Wnt/β-catenin and NF-κB pathways.
Experimental & molecular medicine.
2021 03; 53(3):407-421. doi:
10.1038/s12276-021-00577-z. [PMID: 33692475] - Jianyi Li, Guangzhen Wu, Yingkun Xu, Jiatong Li, Ningke Ruan, Yougen Chen, Qi Zhang, Qinghua Xia. Porcupine Inhibitor LGK974 Downregulates the Wnt Signaling Pathway and Inhibits Clear Cell Renal Cell Carcinoma.
BioMed research international.
2020; 2020(?):2527643. doi:
10.1155/2020/2527643. [PMID: 32104684] - Thomas Funck-Brentano, Karin H Nilsson, Robert Brommage, Petra Henning, Ulf H Lerner, Antti Koskela, Juha Tuukkanen, Martine Cohen-Solal, Sofia Movérare-Skrtic, Claes Ohlsson. Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice.
The Journal of endocrinology.
2018 07; 238(1):13-23. doi:
10.1530/joe-18-0153. [PMID: 29720540] - Ao Li, Yuchen Xu, Song Fan, Jialin Meng, Xufeng Shen, Qian Xiao, Yuan Li, Li Zhang, Xiansheng Zhang, Guanqing Wu, Chaozhao Liang, Dianqing Wu. Canonical Wnt inhibitors ameliorate cystogenesis in a mouse ortholog of human ADPKD.
JCI insight.
2018 03; 3(5):. doi:
10.1172/jci.insight.95874. [PMID: 29515026] - Zhixiang Xu, Xiangxiang Xu, Ruadhan O'Laoi, Haikuo Ma, Jiyue Zheng, Shuaishuai Chen, Lusong Luo, Zhilin Hu, Sudan He, Jiajun Li, Hongjian Zhang, Xiaohu Zhang. Design, synthesis, and evaluation of novel porcupine inhibitors featuring a fused 3-ring system based on the 'reversed' amide scaffold.
Bioorganic & medicinal chemistry.
2016 11; 24(22):5861-5872. doi:
10.1016/j.bmc.2016.09.041. [PMID: 27692509] - Zhixiang Xu, Jiajun Li, Yiyuan Wu, Zhijian Sun, Lusong Luo, Zhilin Hu, Sudan He, Jiyue Zheng, Hongjian Zhang, Xiaohu Zhang. Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system.
European journal of medicinal chemistry.
2016 Jan; 108(?):154-165. doi:
10.1016/j.ejmech.2015.11.026. [PMID: 26647303] - Yan Dong, Kehuang Li, Zhixiang Xu, Haikuo Ma, Jiyue Zheng, Zhilin Hu, Sudan He, Yiyuan Wu, Zhijian Sun, Lusong Luo, Jiajun Li, Hongjian Zhang, Xiaohu Zhang. Exploration of the linkage elements of porcupine antagonists led to potent Wnt signaling pathway inhibitors.
Bioorganic & medicinal chemistry.
2015 Nov; 23(21):6855-68. doi:
10.1016/j.bmc.2015.09.048. [PMID: 26455655] - G Y Lii, J D Garlich, G C Rock. Protein and energy utilization by the insect, Argyrotaenia velutinana (Walker), fed diets containing graded levels of an amino acid mixture.
Comparative biochemistry and physiology. A, Comparative physiology.
1975 Dec; 52(4):615-8. doi:
10.1016/s0300-9629(75)80011-9. [PMID: 1184]