pyrazolo(1,5-a)pyrimidine (BioDeep_00000710730)
代谢物信息卡片
化学式: C6H5N3 (119.0483)
中文名称: 吡唑并[1,5-a]嘧啶
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CN2C(=CC=N2)N=C1
InChI: InChI=1S/C6H5N3/c1-3-7-6-2-4-8-9(6)5-1/h1-5H
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Ling-Ling He, Qi Qi, Xin Wang, Yu Li, Yao Zhu, Xiao-Fang Wang, Liang Xu. Synthesis of two novel pyrazolo[1,5-a]pyrimidine compounds with antibacterial activity and biophysical insights into their interactions with plasma protein.
Bioorganic chemistry.
2020 06; 99(?):103833. doi:
10.1016/j.bioorg.2020.103833. [PMID: 32305694] - Mingmin Ding, Hongbo Wang, Chunrong Qu, Fuchun Xu, Yingmin Zhu, Guangyao Lv, Yungang Lu, Qingjun Zhou, Hui Zhou, Xiaodong Zeng, Jingwen Zhang, Chunhong Yan, Jiacheng Lin, Huai-Rong Luo, Zixing Deng, Yuling Xiao, Jinbin Tian, Michael X Zhu, Xuechuan Hong. Pyrazolo[1,5-a]pyrimidine TRPC6 antagonists for the treatment of gastric cancer.
Cancer letters.
2018 09; 432(?):47-55. doi:
10.1016/j.canlet.2018.05.041. [PMID: 29859875] - Wolfgang Klein, Claudia Rutz, Jamina Eckhard, Becky Provinciael, Edgar Specker, Martin Neuenschwander, Gunnar Kleinau, Patrick Scheerer, Jens-Peter von Kries, Marc Nazaré, Kurt Vermeire, Ralf Schülein. Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway.
PloS one.
2018; 13(12):e0208641. doi:
10.1371/journal.pone.0208641. [PMID: 30543669] - David A Griffith, Diane M Hargrove, Tristan S Maurer, Charles A Blum, Stéphane De Lombaert, John K Inthavongsay, Lee E Klade, Christine M Mack, Colin R Rose, Martin J Sanders, Philip A Carpino. Discovery and evaluation of pyrazolo[1,5-a]pyrimidines as neuropeptide Y1 receptor antagonists.
Bioorganic & medicinal chemistry letters.
2011 May; 21(9):2641-5. doi:
10.1016/j.bmcl.2010.12.116. [PMID: 21295475] - Gregory D Cuny, Paul B Yu, Joydev K Laha, Xuechao Xing, Ji-Feng Liu, Carol S Lai, Donna Y Deng, Chetana Sachidanandan, Kenneth D Bloch, Randall T Peterson. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Bioorganic & medicinal chemistry letters.
2008 Aug; 18(15):4388-92. doi:
10.1016/j.bmcl.2008.06.052. [PMID: 18621530]
