Irsogladine Maleate (BioDeep_00000710556)
代谢物信息卡片
化学式: C13H11Cl2N5O4 (371.01880660000006)
中文名称: 6-(2,5-二氯苯基)-1,3,5-三嗪-2,4-二胺马来酸盐, 马来酸伊索拉定
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1Cl)C2=NC(=NC(=N2)N)N)Cl.C(=CC(=O)O)C(=O)O
InChI: 2-1-
描述信息
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:31721
- KEGGdrug: D01658
- PubChem: 5282435
- ChEMBL: CHEMBL1712923
- CAS: 57381-28-9
- CAS: 84504-69-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seong Chun Kwon, Ji Hoon Kim. Gastroprotective effects of irsogladine maleate on ethanol/hydrochloric acid induced gastric ulcers in mice.
The Korean journal of internal medicine.
2021 01; 36(1):67-75. doi:
10.3904/kjim.2018.290. [PMID: 31852177] - Takanori Kuramoto, Eiji Umegaki, Sadaharu Nouda, Ken Narabayashi, Yuichi Kojima, Yukiko Yoda, Kumi Ishida, Ken Kawakami, Yosuke Abe, Toshihisa Takeuchi, Takuya Inoue, Mitsuyuki Murano, Satoshi Tokioka, Kazuhide Higuchi. Preventive effect of irsogladine or omeprazole on non-steroidal anti-inflammatory drug-induced esophagitis, peptic ulcers, and small intestinal lesions in humans, a prospective randomized controlled study.
BMC gastroenterology.
2013 May; 13(?):85. doi:
10.1186/1471-230x-13-85. [PMID: 23672202] - Tsuyoshi Matsumoto, Kenichi Sakurai, Asami Tanaka, Takayuki Ishibashi, Kaori Tachibana, Ko Ishikawa, Koutaro Yokote. The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells.
European journal of pharmacology.
2012 Jun; 685(1-3):213-7. doi:
10.1016/j.ejphar.2012.04.005. [PMID: 22542662] - Akio Nakamura, Katsuhiko Tougou, Hiroko Kitazumi, Tetsuhiro Yamada, Kumikto Honjou, Kiyoko Nonaka, Hideya Mukai. Effects of irsogladine on P450-isoform specific activities in human hepatic microsomes.
Arzneimittel-Forschung.
2006; 56(7):547-52. doi:
10.1055/s-0031-1296750. [PMID: 16927538] - T Ito, K Ogoshi, I Nakano, F Ueda, H Sakai, M Kinjo, H Nawata. Effect of Irsogladine on gap junctions in cerulein-induced acute pancreatitis in rats.
Pancreas.
1997 Oct; 15(3):297-303. doi:
10.1097/00006676-199710000-00013. [PMID: 9336795] - Y Mizoguchi, N Kawada, Y Ichikawa, K Kobayashi, S Morisawa. Effects of irsoglandine maleate in an experimentally-induced acute hepatic failure model using mice.
Gastroenterologia Japonica.
1991 Apr; 26(2):177-81. doi:
10.1007/bf02811077. [PMID: 2040400] - T Ando, K Momota, M Sugiyama. Absorption, distribution and excretion of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate in rats, dogs and monkeys.
Arzneimittel-Forschung.
1986 Aug; 36(8):1221-8. doi:
NULL. [PMID: 3778559] - M Sugiyama, T Ando, Y Okuyama, T Sugimoto, S Choukai. Metabolism of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate in rats, guinea pigs, dogs and monkeys.
Arzneimittel-Forschung.
1986 Aug; 36(8):1229-36. doi:
NULL. [PMID: 3778560] - M Nakashima, T Uematsu, Y Takiguchi, T Hayashi. Phase I study of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695), a new anti-ulcer agent.
Arzneimittel-Forschung.
1984; 34(4):492-8. doi:
NULL. [PMID: 6540108]