Methenamine hippurate (BioDeep_00000710545)
代谢物信息卡片
Methenamine hippurate
化学式: C15H21N5O3 (319.1644)
中文名称: 马尿酸乌洛托品
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1N2CN3CN1CN(C2)C3.C1=CC=C(C=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C9H9NO3.C6H12N4/c11-8(12)6-10-9(13)7-4-2-1-3-5-7
描述信息
C254 - Anti-Infective Agent > C255 - Urinary Anti-Infective Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:6825
- KEGGdrug: D81437
- KEGGdrug: D00855
- PubChem: 21945
- ChEMBL: CHEMBL1201104
- CAS: 5714-73-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Jessica L Sawhill, Amy Mora, Kendall McDaniel, Marianne M Ligon, Jerry L Lowder, Indira U Mysorekar, Christine M Chu. The Impact of Methenamine Hippurate Treatment on Urothelial Integrity and Bladder Inflammation in Aged Female Mice and Women With Urinary Tract Infections.
Female pelvic medicine & reconstructive surgery.
2022 Jun; 28(6):e205-e210. doi:
10.1097/spv.0000000000001185. [PMID: 35536668] - Chris Harding, Thomas Chadwick, Tara Homer, Jan Lecouturier, Helen Mossop, Sonya Carnell, Will King, Alaa Abouhajar, Luke Vale, Gillian Watson, Rebecca Forbes, Stephanie Currer, Robert Pickard, Ian Eardley, Ian Pearce, Nikesh Thiruchelvam, Karen Guerrero, Katherine Walton, Zahid Hussain, Henry Lazarowicz, Ased Ali. Methenamine hippurate compared with antibiotic prophylaxis to prevent recurrent urinary tract infections in women: the ALTAR non-inferiority RCT.
Health technology assessment (Winchester, England).
2022 05; 26(23):1-172. doi:
10.3310/qoiz6538. [PMID: 35535708] - Orlando Quintero Cardona, Vagish S Hemmige, Yoram A Puius. Methenamine hippurate may have particular benefit in preventing recurrent urinary tract infections in diabetic renal transplant recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 04; 22(2):e13247. doi:
10.1111/tid.13247. [PMID: 31957150] - Ian Hollyer, Francesca Varias, Bing Ho, Michael G Ison. Safety and efficacy of methenamine hippurate for the prevention of recurrent urinary tract infections in adult renal transplant recipients: A single center, retrospective study.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Jun; 21(3):e13063. doi:
10.1111/tid.13063. [PMID: 30776166] - Néha Sihra, Anna Goodman, Rhana Zakri, Arun Sahai, Sachin Malde. Nonantibiotic prevention and management of recurrent urinary tract infection.
Nature reviews. Urology.
2018 12; 15(12):750-776. doi:
10.1038/s41585-018-0106-x. [PMID: 30361493] - Rebecca Forbes, Ased Ali, Alaa Abouhajar, Catherine Brennand, Heather Brown, Sonya Carnell, Thomas Chadwick, Ian Eardley, Jan Lecouturier, Helen Mossop, Ian Pearce, Robert Pickard, Nikesh Thiruchelvam, Katherine Walton, Jennifer Wilkinson, Chris Harding. ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial.
Trials.
2018 Nov; 19(1):616. doi:
10.1186/s13063-018-2998-4. [PMID: 30413181] - Cathy Davis, Angie Rantell. Lower urinary tract infections in women.
British journal of nursing (Mark Allen Publishing).
2017 May; 26(9):S12-S19. doi:
10.12968/bjon.2017.26.9.s12. [PMID: 28493770] - Philip R A Webber, Aasne K Aarsand, Arne K Sandvik, Øyvind Skadberg, Morten Lindberg, Sverre Sandberg. Acute porphyrias may be overlooked in patients taking methenamine hippurate.
Clinical chemistry and laboratory medicine.
2010 Sep; 48(9):1355-7. doi:
10.1515/cclm.2010.253. [PMID: 20557279] - B B Lee, M J Haran, L M Hunt, J M Simpson, O Marial, S B Rutkowski, J W Middleton, G Kotsiou, M Tudehope, I D Cameron. Spinal-injured neuropathic bladder antisepsis (SINBA) trial.
Spinal cord.
2007 Aug; 45(8):542-50. doi:
10.1038/sj.sc.3101974. [PMID: 17043681] - J G Strom, H W Jun. Effect of urine pH and ascorbic acid on the rate of conversion of methenamine to formaldehyde.
Biopharmaceutics & drug disposition.
1993 Jan; 14(1):61-9. doi:
10.1002/bdd.2510140106. [PMID: 8427945] - I Wall, H G Tiselius. Long-term acidification of urine in patients treated for infected renal stones.
Urologia internationalis.
1990; 45(6):336-41. doi:
10.1159/000281732. [PMID: 2288050] - B Pettersson, H G Tiselius. Are prophylactic antibiotics necessary during extracorporeal shockwave lithotripsy?.
British journal of urology.
1989 May; 63(5):449-52. doi:
10.1111/j.1464-410x.1989.tb05932.x. [PMID: 2659132] - V Spustová, A Krechnáková, M Geryková, K Schmidtová, E Timková. [Pharmacokinetic aspects of therapy with methenamine hippurate].
Casopis lekaru ceskych.
1987 Jul; 126(29):914-7. doi:
NULL. [PMID: 3652145] - B Fellström, M Butz, B G Danielson, S Ljunghall. The effects of methenamine-hippurate upon urinary risk factors for renal stone formation.
Scandinavian journal of urology and nephrology.
1985; 19(2):125-7. doi:
10.3109/00365598509180239. [PMID: 4059874] - S Räisänen, P Ylitalo, A Toponen, J Seppänen. Trimethoprim and methenamine hippurate. A new theoretical combination for the treatment of urinary tract infections.
Scandinavian journal of infectious diseases.
1985; 17(2):211-8. doi:
10.3109/inf.1985.17.issue-2.13. [PMID: 3895402] - J K Devenport, J R Swenson, G E Dukes, P K Sonsalla. Formaldehyde generation from methenamine salts in spinal cord injury.
Archives of physical medicine and rehabilitation.
1984 May; 65(5):257-9. doi:
NULL. [PMID: 6712452] - A A Kostiala, P Nyrén, L Runeberg. Effect of nitrofurantoin and methenamine hippurate prophylaxis on bacteria and yeasts in the urine of patients with an indwelling catheter.
The Journal of hospital infection.
1982 Dec; 3(4):357-64. doi:
10.1016/0195-6701(82)90068-8. [PMID: 6190868] - D Greenwood, R C Slack. The antibacterial activity of hexamine (methenamine), hexamine hippurate and hexamine mandelate.
Infection.
1981; 9(5):223-7. doi:
10.1007/bf01640720. [PMID: 7028634] - O O Barriga. Depression of cell-mediated immunity following inoculation of Trichinella spiralis extract in the mouse.
Immunology.
1978 Jan; 34(1):167-73. doi:
NULL. [PMID: 23994] - K Carlström, N O Lunell. Interference of antiseptics containing hexamethylene tetraamine (Hiprex) with the estimation of urinary oestriol excretion during pregnancy.
Acta obstetricia et gynecologica Scandinavica.
1975; 54(4):387-8. doi:
10.3109/00016347509156773. [PMID: 1199707]
