LY2811376 (BioDeep_00000709692)

   


代谢物信息卡片


(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine

化学式: C15H14F2N4S (320.09071880000005)
中文名称: (4S)-4-[2,4-二氟-5-(5-嘧啶)苯基]-5,6-二氢-4-甲基-4H-1,3-噻嗪-2-胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
InChI: InChI=1S/C15H14F2N4S/c1-15(2-3-22-14(18)21-15)11-4-10(12(16)5-13(11)17)9-6-19-8-20-7-9/h4-8H,2-3H2,1H3,(H2,18,21)/t15-/m0/s1

描述信息

同义名列表

2 个代谢物同义名

(S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine; LY2811376



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Changxing Qi, Mengting Liu, Qun Zhou, Weixi Gao, Chunmei Chen, Yongji Lai, Zhengxi Hu, Yongbo Xue, Jinwen Zhang, Dongyan Li, Xiao-Nian Li, Qing Zhang, Jianping Wang, Hucheng Zhu, Yonghui Zhang. BACE1 Inhibitory Meroterpenoids from Aspergillus terreus. Journal of natural products. 2018 09; 81(9):1937-1945. doi: 10.1021/acs.jnatprod.7b01050. [PMID: 30207465]
  • Shuangshuang Xie, Ye Wu, Yuben Qiao, Yi Guo, Jianping Wang, Zhengxi Hu, Qing Zhang, Xiaonian Li, Jinfeng Huang, Qun Zhou, Zengwei Luo, Junjun Liu, Hucheng Zhu, Yongbo Xue, Yonghui Zhang. Protoilludane, Illudalane, and Botryane Sesquiterpenoids from the Endophytic Fungus Phomopsis sp. TJ507A. Journal of natural products. 2018 06; 81(6):1311-1320. doi: 10.1021/acs.jnatprod.7b00889. [PMID: 29771527]
  • Severin Filser, Saak V Ovsepian, Mercè Masana, Lidia Blazquez-Llorca, Anders Brandt Elvang, Christiane Volbracht, Marianne B Müller, Christian K E Jung, Jochen Herms. Pharmacological inhibition of BACE1 impairs synaptic plasticity and cognitive functions. Biological psychiatry. 2015 Apr; 77(8):729-39. doi: 10.1016/j.biopsych.2014.10.013. [PMID: 25599931]
  • Xingrong Liu, Harvey Wong, Kimberly Scearce-Levie, Ryan J Watts, Melis Coraggio, Young G Shin, Kun Peng, Kristin R Wildsmith, Jasvinder K Atwal, Jason Mango, Stephen P Schauer, Kelly Regal, Kevin W Hunt, Allen A Thomas, Michael Siu, Joseph Lyssikatos, Gauri Deshmukh, Cornelis E C A Hop. Mechanistic pharmacokinetic-pharmacodynamic modeling of BACE1 inhibition in monkeys: development of a predictive model for amyloid precursor protein processing. Drug metabolism and disposition: the biological fate of chemicals. 2013 Jul; 41(7):1319-28. doi: 10.1124/dmd.112.050864. [PMID: 23584887]
  • D Richard Lachno, Julie K Emerson, Hugo Vanderstichele, Celedon Gonzales, Ferenc Martényi, Robert J Konrad, Jayne A Talbot, Stephen L Lowe, Paul E Oefinger, Robert A Dean. Validation of a multiplex assay for simultaneous quantification of amyloid-β peptide species in human plasma with utility for measurements in studies of Alzheimer's disease therapeutics. Journal of Alzheimer's disease : JAD. 2012; 32(4):905-18. doi: 10.3233/jad-2012-121075. [PMID: 22886018]