Acepromazine maleate (BioDeep_00000708721)

   


代谢物信息卡片


AceproMazine-d6 Maleate

化学式: C23H26N2O5S (442.1562)
中文名称: 乙酰丙嗪-d6马来酸酯, 马来酸乙酰丙嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2CCCN(C)C.C(=CC(=O)O)C(=O)O
InChI: 2-1-

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist

同义名列表

2 个代谢物同义名

AceproMazine-d6 Maleate; Acepromazine maleate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Tithipong Plangsangmas, Hathaipat Rattanathanya, Wanlaya Tipkantha, Saowaphang Sanannu, Umaporn Maikaew, Jessada Thaeonoen, Bencharong Sangkharak, Pornpiroon Chinson, Watcharin Hin-On, Nathavut Kanatiyanont, Boripat Siriaroonrat, Nantarika Chansue, Parntep Ratanakorn. Immobilization of captive plains zebras (Equus quagga) with a combination of etorphine hydrochloride, acepromazine, and xylazine hydrochloride. The Journal of veterinary medical science. 2022 Jan; 84(1):181-185. doi: 10.1292/jvms.21-0458. [PMID: 34866094]
  • Robert J Brosnan, Bruno H Pypendop. Evaluation of whether acepromazine maleate causes fentanyl to decrease the minimum alveolar concentration of isoflurane in cats. American journal of veterinary research. 2021 May; 82(5):352-357. doi: 10.2460/ajvr.82.5.352. [PMID: 33904805]
  • Andrea Cattai, Roberto Rabozzi, Heidi Ferasin, Maurizio Isola, Paolo Franci. Haemodynamic changes during propofol induction in dogs: new findings and approach of monitoring. BMC veterinary research. 2018 Sep; 14(1):282. doi: 10.1186/s12917-018-1608-8. [PMID: 30208893]
  • H K Knych, K Seminoff, D S McKemie, P H Kass. Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses. Journal of veterinary pharmacology and therapeutics. 2018 Aug; 41(4):522-535. doi: 10.1111/jvp.12494. [PMID: 29457257]
  • M C Niimura Del Barrio, Rachel C Bennett, J M Lynne Hughes. Effect of detomidine or romifidine constant rate infusion on plasma lactate concentration and inhalant requirements during isoflurane anaesthesia in horses. Veterinary anaesthesia and analgesia. 2017 May; 44(3):473-482. doi: 10.1016/j.vaa.2016.01.002. [PMID: 28462846]
  • K Bujold, M Hauer-Jensen, O Donini, A Rumage, D Hartman, H P Hendrickson, J Stamatopoulos, H Naraghi, M Pouliot, A Ascah, M Sebastian, M K Pugsley, K Wong, S Authier. Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects. Radiation research. 2016 07; 186(1):71-8. doi: 10.1667/rr14305.1. [PMID: 27351760]
  • Stephanie Keating, Carolyn Kerr, Wayne McDonell, Alexander Valverde, Ron Johnson, Heather Knych, Andrea Edginton. Effects of acepromazine or dexmedetomidine on fentanyl disposition in dogs during recovery from isoflurane anesthesia. Veterinary anaesthesia and analgesia. 2016 Jan; 43(1):35-43. doi: 10.1111/vaa.12271. [PMID: 25943714]
  • Ayla Solmaz Avcikurt, Selma Sinan, Feray Kockar. Antidepressant and antipsychotic drugs differentially affect PON1 enzyme activity. Journal of enzyme inhibition and medicinal chemistry. 2015 Apr; 30(2):245-9. doi: 10.3109/14756366.2014.913038. [PMID: 24934243]
  • D Adam Algren, Amber Ashworth. Acute acepromazine overdose: clinical effects and toxicokinetic evaluation. Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2015 Mar; 11(1):121-3. doi: 10.1007/s13181-014-0416-1. [PMID: 25059809]
  • Andrea Schwarz, Karin Kalchofner, Julia Palm, Stephanie Picek, Sonja Hartnack, Regula Bettschart-Wolfensberger. Minimum infusion rate of alfaxalone for total intravenous anaesthesia after sedation with acepromazine or medetomidine in cats undergoing ovariohysterectomy. Veterinary anaesthesia and analgesia. 2014 Sep; 41(5):480-90. doi: 10.1111/vaa.12144. [PMID: 24575797]
  • Bruno H Pypendop, Jan E Ilkiw. Relationship between plasma dexmedetomidine concentration and sedation score and thermal threshold in cats. American journal of veterinary research. 2014 May; 75(5):446-52. doi: 10.2460/ajvr.75.5.446. [PMID: 24762016]
  • J M McGree, G Noble, F Schneiders, A J Dunstan, A R McKinney, R Boston, M Sillence. A Bayesian approach for estimating detection times in horses: exploring the pharmacokinetics of a urinary acepromazine metabolite. Journal of veterinary pharmacology and therapeutics. 2013 Feb; 36(1):31-42. doi: 10.1111/j.1365-2885.2013.01389.x. [PMID: 23317425]
  • Maki Ishibashi, Hideo Akiyoshi, Toshie Iseri, Fumihito Ohashi. Skin conductance reflects drug-induced changes in blood levels of cortisol, adrenaline and noradrenaline in dogs. The Journal of veterinary medical science. 2013; 75(6):809-13. doi: 10.1292/jvms.12-0478. [PMID: 23358494]
  • Melissa D Sinclair, Doris H Dyson. The impact of acepromazine on the efficacy of crystalloid, dextran or ephedrine treatment in hypotensive dogs under isoflurane anesthesia. Veterinary anaesthesia and analgesia. 2012 Nov; 39(6):563-73. doi: 10.1111/j.1467-2995.2012.00766.x. [PMID: 23035903]
  • Marina Verena Hoffmann, Sabine Beate Rita Kästner, Manfred Kietzmann, Sabine Kramer. Contact heat thermal threshold testing in beagle dogs: baseline reproducibility and the effect of acepromazine, levomethadone and fenpipramide. BMC veterinary research. 2012 Oct; 8(?):206. doi: 10.1186/1746-6148-8-206. [PMID: 23110740]
  • Fiona I Schneiders, Glenys K Noble, Raymond C Boston, Anthony J Dunstan, Martin N Sillence, Andrew R McKinney. Acepromazine pharmacokinetics: a forensic perspective. Veterinary journal (London, England : 1997). 2012 Oct; 194(1):48-54. doi: 10.1016/j.tvjl.2012.03.017. [PMID: 22534188]
  • Akari Kamine, Michito Shimozuru, Haruki Shibata, Toshio Tsubota. Effects of intramuscular administration of tiletamine-zolazepam with and without sedative pretreatment on plasma and serum biochemical values and glucose tolerance test results in Japanese black bears (Ursus thibetanus japonicus). American journal of veterinary research. 2012 Aug; 73(8):1282-9. doi: 10.2460/ajvr.73.8.1282. [PMID: 22849689]
  • Encarna Casas-Díaz, Ignasi Marco, Jorge Ramón López-Olvera, Gregorio Mentaberre, Emmanuel Serrano, Santiago Lavín. Effect of acepromazine and haloperidol in male Iberian Ibex (Capra pyrenaica) captured by box-trap. Journal of wildlife diseases. 2012 Jul; 48(3):763-7. doi: 10.7589/0090-3558-48.3.763. [PMID: 22740543]
  • D C Williams, M Aleman, B Tharp, D J Fletcher, P H Kass, E P Steffey, R A LeCouteur, T A Holliday. Qualitative and quantitative characteristics of the electroencephalogram in normal horses after sedation. Journal of veterinary internal medicine. 2012 May; 26(3):645-53. doi: 10.1111/j.1939-1676.2012.00921.x. [PMID: 22489924]
  • Helen Valentine, Wendy O Williams, Kirk J Maurer. Sedation or inhalant anesthesia before euthanasia with CO2 does not reduce behavioral or physiologic signs of pain and stress in mice. Journal of the American Association for Laboratory Animal Science : JAALAS. 2012 Jan; 51(1):50-7. doi: NULL. [PMID: 22330868]
  • Matthew D Winter, Kristina G Miles, Dean H Riedesel. Effect of sedation protocol on glomerular filtration rate in cats as determined by use of quantitative renal scintigraphy. American journal of veterinary research. 2011 Sep; 72(9):1222-5. doi: 10.2460/ajvr.72.9.1222. [PMID: 21879980]
  • André Martins Gimenes, Antonio José de Araujo Aguiar, Sílvia Helena Venturoli Perri, Guilherme de Paula Nogueira. Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs. Veterinary anaesthesia and analgesia. 2011 Jan; 38(1):54-62. doi: 10.1111/j.1467-2995.2010.00579.x. [PMID: 21214710]
  • Isabelle Aubert, Anthony C G Abrams-Ogg, Anne M Sylvestre, Doris H Dyson, Dana G Allen, Ian B Johnstone. The use of vascular access ports for blood collection in feline blood donors. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2011 Jan; 75(1):25-34. doi: NULL. [PMID: 21461192]
  • I Kiefer, K Becker, C Haarstrick, G Oechtering, M Alef. [Effects of a neuroleptic analgesia with acepromazine on the blood perfusion of the canine kidney. Examination using the sonographic recordable blood circulation parameters of resistance index and pulsatility index]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere. 2011; 39(3):154-62. doi: NULL. [PMID: 22143624]
  • Songqing He, Carl Atkinson, Fei Qiao, Xiaoping Chen, Stephen Tomlinson. Ketamine-xylazine-acepromazine compared with isoflurane for anesthesia during liver transplantation in rodents. Journal of the American Association for Laboratory Animal Science : JAALAS. 2010 Jan; 49(1):45-51. doi: NULL. [PMID: 20122316]
  • L M Ribeiro, D A Ferreira, S Brás, A Castro, C A Nunes, P Amorim, L M Antunes. Correlation between clinical signs of depth of anaesthesia and cerebral state index responses in dogs during induction of anaesthesia with propofol. Research in veterinary science. 2009 Oct; 87(2):287-91. doi: 10.1016/j.rvsc.2009.02.010. [PMID: 19339028]
  • K Pasloske, B Sauer, N Perkins, T Whittem. Plasma pharmacokinetics of alfaxalone in both premedicated and unpremedicated Greyhound dogs after single, intravenous administration of Alfaxan at a clinical dose. Journal of veterinary pharmacology and therapeutics. 2009 Oct; 32(5):510-3. doi: 10.1111/j.1365-2885.2009.01070.x. [PMID: 19754921]
  • Stephen A Felt, Fady I Guirguis, Momtaz O Wasfy, Jim S Howard, Neil V Domingo, Hussein I Hussein. An effective venipuncture technique and normal serum biochemistry parameters of the captive fat-tailed jird (Pachyuromys duprasi). Journal of the American Association for Laboratory Animal Science : JAALAS. 2009 Jan; 48(1):57-60. doi: NULL. [PMID: 19245752]
  • L C R Meyer, R S Hetem, L G Fick, A Matthee, D Mitchell, A Fuller. Thermal, cardiorespiratory and cortisol responses of impala (Aepyceros melampus) to chemical immobilisation with 4 different drug combinations. Journal of the South African Veterinary Association. 2008 Sep; 79(3):121-9. doi: 10.4102/jsava.v79i3.258. [PMID: 19244820]
  • Mohammad Reza Seddighi, Mehrdad Mohri. Anesthesia in Caspian ponies. Veterinary anaesthesia and analgesia. 2008 May; 35(3):237-41. doi: 10.1111/j.1467-2995.2007.00366.x. [PMID: 17927676]
  • Marcello Tontodonati, Nicola Fasdelli, Elena Moscardo, Alessandra Giarola, Roberto Dorigatti. A canine model used to simultaneously assess potential neurobehavioural and cardiovascular effects of candidate drugs. Journal of pharmacological and toxicological methods. 2007 Sep; 56(2):265-75. doi: 10.1016/j.vascn.2007.03.005. [PMID: 17587603]
  • J Montané, I Marco, J R López-Olvera, L Rossi, X Manteca, S Lavín. Effect of acepromazine on the signs of capture stress in captive and free-ranging roe deer (Capreolus capreolus). The Veterinary record. 2007 May; 160(21):730-8. doi: 10.1136/vr.160.21.730. [PMID: 17526895]
  • Jorge R López-Olvera, Ignasi Marco, Jordi Montané, Encarna Casas-Díaz, Santiago Lavín. Effects of acepromazine on the stress response in Southern chamois (Rupicapra pyrenaica) captured by means of drive-nets. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2007 Jan; 71(1):41-51. doi: NULL. [PMID: 17193881]
  • Jorge Ramón López-Olvera, Ignasi Marco, Jordi Montané, Santiago Lavín. Transport stress in Southern chamois (Rupicapra pyrenaica) and its modulation by acepromazine. Veterinary journal (London, England : 1997). 2006 Sep; 172(2):347-55. doi: 10.1016/j.tvjl.2005.06.007. [PMID: 16154370]
  • K J Stafford, J P Chambers, S P Sylvester, P R Kenyon, S T Morris, I Lizarraga, G de Nicolo. The stress caused by laparoscopy in sheep and its alleviation. New Zealand veterinary journal. 2006 Jun; 54(3):109-13. doi: 10.1080/00480169.2006.36621. [PMID: 16751840]
  • Ingrid M Boström, Görel Nyman, Astrid Hoppe, Peter Lord. Effects of meloxicam on renal function in dogs with hypotension during anaesthesia. Veterinary anaesthesia and analgesia. 2006 Jan; 33(1):62-9. doi: 10.1111/j.1467-2995.2005.00208.x. [PMID: 16412133]
  • L S St-Pierre, M A Persinger. Extreme obesity in female rats following prepuberal induction of lithium-pilocarpine seizures and a single injection of acepromazine. Epilepsy & behavior : E&B. 2005 Nov; 7(3):411-8. doi: 10.1016/j.yebeh.2005.06.009. [PMID: 16103018]
  • Irina R Miksa, Margaret R Cummings, Robert H Poppenga. Determination of acepromazine, ketamine, medetomidine, and xylazine in serum: multi-residue screening by liquid chromatography-mass spectrometry. Journal of analytical toxicology. 2005 Sep; 29(6):544-51. doi: 10.1093/jat/29.6.544. [PMID: 16168177]
  • Terry N Thrasher. Effects of chronic baroreceptor unloading on blood pressure in the dog. American journal of physiology. Regulatory, integrative and comparative physiology. 2005 Apr; 288(4):R863-71. doi: 10.1152/ajpregu.00489.2004. [PMID: 15563576]
  • Viorica Ionut, Erlinda L Kirkman, Richard N Bergman. Investigation of the effect of acepromazine on intravenous glucose tolerance tests in dogs. American journal of veterinary research. 2004 Aug; 65(8):1124-7. doi: 10.2460/ajvr.2004.65.1124. [PMID: 15334847]
  • Deborah V Wilson, A Thomas Evans, Rachael A Carpenter, David R Mullineaux. The effect of four anesthetic protocols on splenic size in dogs. Veterinary anaesthesia and analgesia. 2004 Apr; 31(2):102-8. doi: 10.1111/j.1467-2987.2004.00152.x. [PMID: 15053748]
  • Ingrid Boström, Görel Nyman, Naurepon Kampa, Jens Häggström, Peter Lord. Effects of acepromazine on renal function in anesthetized dogs. American journal of veterinary research. 2003 May; 64(5):590-8. doi: 10.2460/ajvr.2003.64.590. [PMID: 12755300]
  • Kevin R Crooks, D K Garcelon, Cheryl A Scott, Jeffery T Wilcox, Steven F Timm, Dirk H Van Vuren. Hematology and serum chemistry of the island spotted skunk on Santa Cruz Island. Journal of wildlife diseases. 2003 Apr; 39(2):460-6. doi: 10.7589/0090-3558-39.2.460. [PMID: 12910779]
  • J Montané, I Marco, J López-Olvera, D Perpiñán, X Manteca, S Lavín. Effects of acepromazine on capture stress in roe deer (Capreolus capreolus). Journal of wildlife diseases. 2003 Apr; 39(2):375-86. doi: 10.7589/0090-3558-39.2.375. [PMID: 12910765]
  • Misse Väisänen, Marja Raekallio, Erja Kuusela, Pirkko Huttunen, Juhani Leppäluoto, Petra Kirves, Outi Vainio. Evaluation of the perioperative stress response in dogs administered medetomidine or acepromazine as part of the preanesthetic medication. American journal of veterinary research. 2002 Jul; 63(7):969-75. doi: 10.2460/ajvr.2002.63.969. [PMID: 12118677]
  • Renée Bergeron, Shannon L Scott, Jean-Pierre Emond, Florent Mercier, Nigel J Cook, Al L Schaefer. Physiology and behavior of dogs during air transport. Canadian journal of veterinary research = Revue canadienne de recherche veterinaire. 2002 Jul; 66(3):211-6. doi: NULL. [PMID: 12146895]
  • Ingrid M Boström, Görel C Nyman, Peter E Lord, Jens Häggström, Bernt E V Jones, Henrik P Bohlin. Effects of carprofen on renal function and results of serum biochemical and hematologic analyses in anesthetized dogs that had low blood pressure during anesthesia. American journal of veterinary research. 2002 May; 63(5):712-21. doi: 10.2460/ajvr.2002.63.712. [PMID: 12013473]
  • Anthony P Carr. Concerned with protocol used in urine production study. American journal of veterinary research. 2002 Mar; 63(3):314. doi: 10.2460/ajvr.2002.63.314. [PMID: 11911563]
  • S A Robertson, J G Hauptman, R F Nachreiner, M A Richter. Effects of acetylpromazine or morphine on urine production in halothane-anesthetized dogs. American journal of veterinary research. 2001 Dec; 62(12):1922-7. doi: 10.2460/ajvr.2001.62.1922. [PMID: 11763182]
  • R B Atwell, F E Campbell, E A Evans. Prospective survey of tick paralysis in dogs. Australian veterinary journal. 2001 Jun; 79(6):412-8. doi: 10.1111/j.1751-0813.2001.tb12986.x. [PMID: 11491220]
  • L J Smith, J K Yu, D E Bjorling, K Waller. Effects of hydromorphone or oxymorphone, with or without acepromazine, on preanesthetic sedation, physiologic values, and histamine release in dogs. Journal of the American Veterinary Medical Association. 2001 Apr; 218(7):1101-5. doi: 10.2460/javma.2001.218.1101. [PMID: 11318359]
  • C A Mastronardi, W H Yu, S M McCann. Comparisons of the effects of anesthesia and stress on release of tumor necrosis factor-alpha, leptin, and nitric oxide in adult male rats. Experimental biology and medicine (Maywood, N.J.). 2001 Apr; 226(4):296-300. doi: 10.1177/153537020122600405. [PMID: 11368420]
  • H Hackbarth, N Küppers, W Bohnet. Euthanasia of rats with carbon dioxide--animal welfare aspects. Laboratory animals. 2000 Jan; 34(1):91-6. doi: 10.1258/002367700780578055. [PMID: 10759372]
  • T J Doherty, F M Andrews, M K Provenza, D L Frazier. The effect of sedation on gastric emptying of a liquid marker in ponies. Veterinary surgery : VS. 1999 Sep; 28(5):375-9. doi: 10.1111/j.1532-950x.1999.00375.x. [PMID: 10493642]
  • S P Elliott, K A Hale. A previously unidentified acepromazine metabolite in humans: implications for the measurement of acepromazine in blood. Journal of analytical toxicology. 1999 Sep; 23(5):367-71. doi: 10.1093/jat/23.5.367. [PMID: 10488925]
  • P M Taylor. Effects of hypertonic saline infusion on the adrenocortical response to thiopental-halothane anesthesia in sheep after premedication with acepromazine. Veterinary surgery : VS. 1999 Jan; 28(1):77-82. doi: 10.1053/jvet.1999.0077. [PMID: 10025644]
  • S M Newell, L Neuwirth, P E Ginn, G D Roberts, L S Prime, J M Harrison. Doppler ultrasound of the prostate in normal dogs and in dogs with chronic lymphocytic-lymphoplasmocytic prostatitis. Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association. 1998 Jul; 39(4):332-6. doi: 10.1111/j.1740-8261.1998.tb01616.x. [PMID: 9710137]
  • C C Chou, C L Chen, A C Asbury, A I Webb, T W Vickroy. Development and use of an enzyme-linked immunosorbent assay to monitor serum and urine acepromazine concentrations in thoroghbreds, and possible changes associated with exercise. American journal of veterinary research. 1998 May; 59(5):593-7. doi: NULL. [PMID: 9582962]
  • S M Newell, J C Ko, P E Ginn, T G Heaton-Jones, D A Hyatt, A L Cardwell, D F Mauragis, J M Harrison. Effects of three sedative protocols on glomerular filtration rate in clinically normal dogs. American journal of veterinary research. 1997 May; 58(5):446-50. doi: NULL. [PMID: 9140548]
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  • H P Lefebvre, J P Jaeg, A G Rico, P L Toutain, J P Braun. Variations of plasma creatine kinase in rabbits following repetitive blood sampling effects of pretreatment with acepromazine, carazolol and dantrolene. European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. 1992 Jul; 30(7):425-8. doi: NULL. [PMID: 1356023]
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