Dynorphin A (1-13) (BioDeep_00000707773)
代谢物信息卡片
Dynorphin A (1-13)
化学式: C75H126N24O15 (1602.9834006)
中文名称: 强啡肽 A (1-13)
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)CNC(=O)CNC(=O)C(CC3=CC=C(C=C3)O)N
InChI: InChI=1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/m0/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
D018377 - Neurotransmitter Agents > D004399 - Dynorphins
Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Edin Muratspahić, Nataša Tomašević, Shahrooz Nasrollahi-Shirazi, Jasmin Gattringer, Fabiola Susanna Emser, Michael Freissmuth, Christian W Gruber. Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling.
Journal of natural products.
2021 08; 84(8):2238-2248. doi:
10.1021/acs.jnatprod.1c00301. [PMID: 34308635] - Jia-Xu Chen, Xin Zhao, Guang-Xin Yue, Zhu-Feng Wang. Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13.
Cellular and molecular neurobiology.
2007 Feb; 27(1):1-10. doi:
10.1007/s10571-006-9110-4. [PMID: 16858636] - Jun Yang, Wen-Yan Liu, Cao-You Song, Bao-Cheng Lin. Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat.
Neuroscience research.
2006 Jan; 54(1):49-56. doi:
10.1016/j.neures.2005.10.006. [PMID: 16310878] - B Brugos, G Hochhaus. Metabolism of dynorphin A(1-13).
Die Pharmazie.
2004 May; 59(5):339-43. doi:
NULL. [PMID: 15212298] - D L Holmes, K Thibaudeau, B L'Archevêque, P G Milner, A M Ezrin, D P Bridon. Site specific 1:1 opioid:albumin conjugate with in vitro activity and long in vivo duration.
Bioconjugate chemistry.
2000 Jul; 11(4):439-44. doi:
10.1021/bc0000233. [PMID: 10898563] - S D Mikhailova, N V Glushchenko, T M Semushkina, G I Storozhakov. Peculiarities of ischemic cardiac arrhythmias in cats against the background of stimulation of sensorimotor cortex and administration of selective opiate receptor agonists.
Bulletin of experimental biology and medicine.
2000 May; 129(5):423-4. doi:
10.1007/bf02439790. [PMID: 10977939] - P Y Cheng, A V Birk, M C Gershengorn, H H Szeto. Dynorphin stimulates corticotropin release from mouse anterior pituitary AtT-20 cells through nonopioid mechanisms.
Neuroendocrinology.
2000 Mar; 71(3):170-6. doi:
10.1159/000054534. [PMID: 10729788] - S Müller, A Hutson, V Arya, G Hochhaus. Assessment of complex peptide degradation pathways via structured multicompartmental modeling approaches: the metabolism of dynorphin A1-13 and related fragments in human plasma.
Journal of pharmaceutical sciences.
1999 Sep; 88(9):938-44. doi:
10.1021/js980036d. [PMID: 10479358] - M J Kreek, J Schluger, L Borg, M Gunduz, A Ho. Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions.
The Journal of pharmacology and experimental therapeutics.
1999 Jan; 288(1):260-9. doi:
NULL. [PMID: 9862779] - H H Szeto, Y Soong, D Wu. The role of N-methyl-D-aspartate receptors in the release of adrenocorticotropin by dynorphin A1-13.
Neuroendocrinology.
1999 Jan; 69(1):28-33. doi:
10.1159/000054400. [PMID: 9892848] - X W Wan, W H Li, M Huang, Z D You, Y X Tan, C L Lu, Z H Gong. Levels of immunoreactive dynorphin A1-13 during development of morphine dependence in rats.
Zhongguo yao li xue bao = Acta pharmacologica Sinica.
1998 Nov; 19(6):560-3. doi:
NULL. [PMID: 10437147] - S Specker, W Wananukul, D Hatsukami, K Nolin, L Hooke, M J Kreek, P R Pentel. Effects of dynorphin A(1-13) on opiate withdrawal in humans.
Psychopharmacology.
1998 Jun; 137(4):326-32. doi:
10.1007/s002130050626. [PMID: 9676891] - J Chen, W Yang, R Liang, D Lu, Y Zhou. [Effects of long-term and high intensity exercise on plasma beta-endorphin, dynorphin A1-13, leucine-enkephalin and lactate in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
1997 Nov; 13(4):371. doi:
NULL. [PMID: 10322979] - A K Rattan, G A Tejwani. Effect of chronic treatment with morphine, midazolam and both together on dynorphin(1-13) levels in the rat.
Brain research.
1997 Apr; 754(1-2):239-44. doi:
10.1016/s0006-8993(97)00084-x. [PMID: 9134981] - X Lu, X Hong, C Wang. [Effect of dynorphin A1-13 on hypoxia-ischemic brain injury in neonatal rats].
Zhonghua fu chan ke za zhi.
1997 Apr; 32(4):198-201. doi:
NULL. [PMID: 9596896] - C C Taylor, D Wu, Y Soong, J S Yee, H H Szeto. Dynorphin A1-13 stimulates ovine fetal pituitary-adrenal function through a novel nonopioid mechanism.
The Journal of pharmacology and experimental therapeutics.
1997 Jan; 280(1):416-21. doi:
NULL. [PMID: 8996223] - S Müller, B L Grundy, G Hochhaus. Metabolism of dynorphin A1-13 in human CSF.
Neurochemical research.
1996 Oct; 21(10):1213-9. doi:
10.1007/bf02532398. [PMID: 8923483] - S Müller, R Dunker, G Hochhaus. Interspecies comparison of in vitro plasma degradation of dynorphin A 1-13.
Die Pharmazie.
1996 Aug; 51(8):581-5. doi:
NULL. [PMID: 8794468] - R Yin, X Tao, Z Zeng, D Zhao, S Zhu, S Xia. Changes of plasma dynorphin levels before and after percutaneous balloon mitral commissurotomy in patients with mitral stenosis.
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih.
1995 Dec; 10(4):214-9. doi:
NULL. [PMID: 8745581] - S Müller, G Hochhaus. Metabolism of dynorphin A 1-13 in human blood and plasma.
Pharmaceutical research.
1995 Aug; 12(8):1165-70. doi:
10.1023/a:1016211910107. [PMID: 7494829] - X Hong, B Li, M Li. [Effects of intrasubarachnoid space injection of anti dynorphin A1-13 serum or nor-BNI on the recovery of spinal cord injury in rats].
Zhonghua wai ke za zhi [Chinese journal of surgery].
1995 Jun; 33(6):378-81. doi:
NULL. [PMID: 8582228] - B J Van de Heijning, C Maigret, I Koekkoek-van den Herik, W F Smelik, T B van Wimersma Greidanus. Dynorphin-A and vasopressin release in the rat: a structure-activity study.
Neuropeptides.
1994 Jun; 26(6):371-8. doi:
10.1016/0143-4179(94)90021-3. [PMID: 7936124] - L Cao, P D Qian, L J Jing, Q J Liang, Z Z Zhao. Endogenous opioid-like substances in perinatal asphyxia and cerebral injury due to anoxia.
Chinese medical journal.
1993 Oct; 106(10):783-7. doi:
NULL. [PMID: 7913434] - Y C Zhang, L Huang. [A study on the effect of dynorphin A- (1-13) ICV injection on water, sodium and potassium excretion of rats].
Sheng li xue bao : [Acta physiologica Sinica].
1993 Oct; 45(5):462-9. doi:
NULL. [PMID: 7908457] - C Y Song, W Y Liu, X Y Gu, B C Lin. [Effect of anti-opioid peptide sera on oxytocin-induced enhancement of electroacupuncture analgesia].
Sheng li xue bao : [Acta physiologica Sinica].
1993 Jun; 45(3):231-6. doi:
NULL. [PMID: 7901915] - H N Bhargava, G A Matwyshyn, A K Rattan, K L Koo, G A Tejwani. The effect of U-50,488H tolerance-dependence and abstinence on the levels of dynorphin (1-13) in brain regions, spinal cord, pituitary gland and peripheral tissues of the rat.
Brain research.
1993 Jan; 600(1):151-5. doi:
10.1016/0006-8993(93)90413-h. [PMID: 8093675] - C Q Yu, D Z Wang, Z Q Wang. [Effect of endometriosis pill No. 2 on beta-endorphin and dynorphin in endometriosis].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
1993 Jan; 13(1):7-9, 3. doi:
NULL. [PMID: 8098971] - A K Rattan, K L Koo, G A Tejwani, H N Bhargava. The effect of morphine tolerance dependence and abstinence on immunoreactive dynorphin (1-13) levels in discrete brain regions, spinal cord, pituitary gland and peripheral tissues of the rat.
Brain research.
1992 Jul; 584(1-2):207-12. doi:
10.1016/0006-8993(92)90896-h. [PMID: 1355391] - S Kimura, D Erne, R Schwyzer. Interaction of glucagon with artificial lipid bilayer membranes.
International journal of peptide and protein research.
1992 May; 39(5):431-42. doi:
10.1111/j.1399-3011.1992.tb01447.x. [PMID: 1358848] - R M Kostrzewa, R Brus, D H Coy, H Criswell, P S Coogan, A J Kastin. D-Ala2,F5Phe4-dynorphin amide, an opiate with analgesic and toxic properties.
Polish journal of pharmacology and pharmacy.
1992 Mar; 44(2):109-20. doi:
NULL. [PMID: 1357636] - M H van den Berg, P L van Giersbergen, J Cox-van Put, W de Jong. Endogenous opioid peptides and blood pressure regulation during controlled, stepwise hemorrhagic hypotension.
Circulatory shock.
1991 Oct; 35(2):102-8. doi:
NULL. [PMID: 1723353] - B J Van de Heijning, I Koekkoek-Van den Herik, C Maigret, T B Van Wimersma Greidanus. Pharmacological assessment of the site of action of opioids on the release of vasopressin and oxytocin in the rat.
European journal of pharmacology.
1991 May; 197(2-3):175-80. doi:
10.1016/0014-2999(91)90518-u. [PMID: 1680708] - X Z Khawaja, I C Green, J R Thorpe, C J Bailey. Increased sensitivity to insulin-releasing and glucoregulatory effects of dynorphin A1-13 and U 50488h in ob/ob versus lean mice.
Diabetes.
1990 Oct; 39(10):1289-97. doi:
10.2337/diab.39.10.1289. [PMID: 1976559] - Z Liu, Y Shi. [Effects of Ligusticum wallichii on the plasma and CSF levels of dynorphin A1-13 in rabbits under acute experimental cerebral ischemia].
Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine.
1990 Mar; 10(3):160-1, 163, 133. doi:
NULL. [PMID: 1974173] - R B van Breemen, J C Le. Enhanced sensitivity of peptide analysis by fast-atom bombardment mass spectrometry using nitrocellulose as a substrate.
Rapid communications in mass spectrometry : RCM.
1989 Feb; 3(2):20-4. doi:
10.1002/rcm.1290030203. [PMID: 2485176] - P L Wood, H S Kim, C Cosi, S Iyengar. The endogenous kappa agonist, dynorphin(1-13), does not alter basal or morphine-stimulated dopamine metabolism in the nigrostriatal pathway of the rat.
Neuropharmacology.
1987 Nov; 26(11):1585-8. doi:
10.1016/0028-3908(87)90005-0. [PMID: 2893309] - P M Gilbeau, Y Hosobuchi, N M Lee. Consequence of dynorphin-A administration on anterior pituitary hormone concentrations in the adult male rhesus monkey.
Neuroendocrinology.
1987 Apr; 45(4):284-9. doi:
10.1159/000124742. [PMID: 2883597] - E Mühlbachová, I Janků, J Zvárová, V Krebs, M Wenke. Morphine and dynorphins in lipid mobilization in rats in vitro.
Arzneimittel-Forschung.
1987 Apr; 37(4):394-8. doi:
". [PMID: 2886130] - J A Haaf, C Maigret, E A Andringa-Bakker, T B van Wimersma Greidanus. Dynorphin-(1-13) is a potent in vivo suppressor of vasopressin levels in the rat.
Acta endocrinologica.
1987 Jan; 114(1):96-101. doi:
10.1530/acta.0.1140096. [PMID: 2880444] - O Hong, G A Young, N Khazan. Intracerebroventricular morphine produces diuresis 24 h after previous dynorphin/morphine treatment.
European journal of pharmacology.
1986 Dec; 132(1):83-5. doi:
10.1016/0014-2999(86)90015-4. [PMID: 2880730] - P M Gilbeau, Y Hosobuchi, N M Lee. Dynorphin effects on plasma concentrations of anterior pituitary hormones in the nonhuman primate.
The Journal of pharmacology and experimental therapeutics.
1986 Sep; 238(3):974-7. doi:
NULL. [PMID: 2875176] - R Schwyzer. Estimated conformation, orientation, and accumulation of dynorphin A-(1-13)-tridecapeptide on the surface of neutral lipid membranes.
Biochemistry.
1986 Jul; 25(15):4281-6. doi:
10.1021/bi00363a016. [PMID: 2875731] - L A Chahl, J S Chahl. Plasma extravasation induced by dynorphin-(1-13) in rat skin.
European journal of pharmacology.
1986 May; 124(3):343-7. doi:
10.1016/0014-2999(86)90237-2. [PMID: 2426121] - C S Wu, N M Lee, H H Loh, J T Yang. Competitive binding of dynorphin-(1-13) and beta-endorphin to cerebroside sulfate in solution.
The Journal of biological chemistry.
1986 Mar; 261(8):3687-91. doi:
10.1016/s0021-9258(17)35702-2. [PMID: 2869034] - K Jhamandas, M Sutak, S Lemaire. Comparative spinal analgesic action of dynorphin1-8, dynorphin1-13, and a kappa-receptor agonist U50,488.
Canadian journal of physiology and pharmacology.
1986 Mar; 64(3):263-8. doi:
10.1139/y86-042. [PMID: 2871911] - D Erne, D F Sargent, R Schwyzer. Preferred conformation, orientation, and accumulation of dynorphin A-(1-13)-tridecapeptide on the surface of neutral lipid membranes.
Biochemistry.
1985 Jul; 24(16):4261-3. doi:
10.1021/bi00337a001. [PMID: 2864955] - A I Faden, T P Jacobs, G P Smith, B Green, J A Zivin. Neuropeptides in spinal cord injury: comparative experimental models.
Peptides.
1983 Sep; 4(5):631-4. doi:
10.1016/0196-9781(83)90009-8. [PMID: 6657511] - B Gysin, R Schwyzer. Head group and structure specific interactions of enkephalins and dynorphin with liposomes: investigation by hydrophobic photolabeling.
Archives of biochemistry and biophysics.
1983 Sep; 225(2):467-74. doi:
10.1016/0003-9861(83)90055-3. [PMID: 6625595] - T Mitsuma, T Nogimori. Dynorphin (1-13) effects on thyrotrophin-releasing hormone and thyrotrophin secretion in rats.
Acta endocrinologica.
1983 Jul; 103(3):359-64. doi:
10.1530/acta.0.1030359. [PMID: 6410639]