18-hydroxy-11-deoxy Corticosterone (BioDeep_00000707177)
代谢物信息卡片
18,21-Dihydroxypregn-4-ene-3,20-dione
化学式: C21H30O4 (346.214398)
中文名称: 18-羟基-11-脱氧皮质酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C=C1CCC3C2CCC4(C3CCC4C(=O)CO)CO
InChI: InChI=1S/C21H30O4/c1-20-8-6-14(24)10-13(20)2-3-15-16(20)7-9-21(12-23)17(15)4-5-18(21)19(25)11-22/h10,15-18,22-23H,2-9,11-12H2,1H3/t15-,16+,17+,18-,20+,21-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- G P Vinson. Glomerulosa function and aldosterone synthesis in the rat.
Molecular and cellular endocrinology.
2004 Mar; 217(1-2):59-65. doi:
10.1016/j.mce.2003.10.010. [PMID: 15134802] - G Békési, K Rácz, A Hrabák, R Kakucs, S Várbíró, Z Magyar, J Fehér, E Dinya, T Pázmány, S Paku, B Székács. Systematic investigation of different steroid precursors with respect to their effect on superoxide anion production by human neutrophil granulocytes.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2004 Mar; 36(3):155-63. doi:
10.1055/s-2004-814339. [PMID: 15057668] - Seiki Wada, Shinji Kitahama, Atsuhito Togashi, Kiyoaki Inoue, Makoto Iitaka, Shigehiro Katayama. Preclinical Cushing's syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone.
Internal medicine (Tokyo, Japan).
2002 Apr; 41(4):304-8. doi:
10.2169/internalmedicine.41.304. [PMID: 11993792] - D Pignatelli, P Pinto, M M Magalhães, M C Magalhães. The development of the adrenal gland zona glomerulosa in the rat. A morphological, immunohistochemical and biochemical study.
Molecular and cellular endocrinology.
1998 May; 140(1-2):163-8. doi:
10.1016/s0303-7207(98)00045-8. [PMID: 9722185] - W C Boon, J G McDougall, J P Coghlan. Hypothesis: aldosterone is synthesized by an alternative pathway during severe sodium depletion. 'A new wine in an old bottle'.
Clinical and experimental pharmacology & physiology.
1998 May; 25(5):369-78. doi:
10.1111/j.1440-1681.1998.tb02365.x. [PMID: 9612665] - B Aupetit-Faisant, C Battaglia, M Zenatti, N Emeric-Blanchouin, J C Legrand. Hypoaldosteronism accompanied by normal or elevated mineralocorticosteroid pathway steroid: a marker of adrenal carcinoma.
The Journal of clinical endocrinology and metabolism.
1993 Jan; 76(1):38-43. doi:
10.1210/jcem.76.1.8421100. [PMID: 8421100] - M K Birmingham, L Solyom, P Vecsei. Cortisol/18-OH-DOC in menstrual cycle.
Biological psychiatry.
1993 Jan; 33(1):58-60. doi:
10.1016/0006-3223(93)90281-h. [PMID: 8420598] - G T Griffing, J C Melby, M Holbrook, T C Wilson, M J Wyss. Adrenocorticosteroid excretion in salt-sensitive and salt-resistant spontaneously hypertensive rats.
Steroids.
1992 Feb; 57(2):90-4. doi:
10.1016/0039-128x(92)90036-9. [PMID: 1621263] - G P Vinson, S M Laird, B J Whitehouse, R Teja, J P Hinson. The biosynthesis of aldosterone.
The Journal of steroid biochemistry and molecular biology.
1991 Nov; 39(5B):851-8. doi:
10.1016/0960-0760(91)90035-4. [PMID: 1954174] - M J Matilla, M M Jiménez, M Montiel. Deoxycorticosterone, 18-OH-deoxycorticosterone and corticosterone determination by high performance liquid chromatography in monolayer adrenal cell culture.
Biochemistry international.
1991 Jul; 24(5):951-7. doi:
NULL. [PMID: 1776959] - G Neri, P G Andreis, L K Malendowicz, G G Nussdorfer. Acute action of polypeptide YY (PYY) on rat adrenocortical cells: in vivo versus in vitro effects.
Neuropeptides.
1991 Jun; 19(2):73-6. doi:
10.1016/0143-4179(91)90135-6. [PMID: 1658675] - G T Griffing, J C Melby, M Holbrook, T Wilson, S Azar, M Delaney, S Weiss. Elevated 18-hydroxy-corticosterone in inbred salt-sensitive rats.
Clinical and experimental hypertension. Part A, Theory and practice.
1991; 13(3):371-82. doi:
10.3109/10641969109045057. [PMID: 1893610] - N Hazon, I W Henderson. Effects of altered dietary sodium intake on hormonal profiles in salt-sensitive hypertensive rats.
The Journal of endocrinology.
1990 Nov; 127(2):243-8. doi:
10.1677/joe.0.1270243. [PMID: 2250149] - T Kinouchi, N Shimizu, H Yoshida. [Clinical significance of serum 11-deoxycorticosterone analysis in endocrine tests of the adrenal cortex].
Nihon rinsho. Japanese journal of clinical medicine.
1989 Dec; 48 Suppl(?):1211-6. doi:
NULL. [PMID: 2560067] - S M Laird, G P Vinson, B J Whitehouse. Steroid sequestration within the rat adrenal zona glomerulosa.
The Journal of endocrinology.
1988 May; 117(2):191-6. doi:
10.1677/joe.0.1170191. [PMID: 3379353] - O B Holland, H Brown, M Risk, R Paone, P Dube, C Gomez-Sanchez. Simplified method for the determination of plasma 18-hydroxycorticosterone.
Journal of chromatography.
1988 Apr; 426(1):148-54. doi:
10.1016/s0378-4347(00)81936-2. [PMID: 3384867] - E P Gomez-Sanchez, C E Gomez-Sanchez. 19-Nordeoxycorticosterone excretion in male and female inbred salt-sensitive (S/JR) and salt-resistant (R/JR) Dahl rats.
Endocrinology.
1988 Mar; 122(3):1110-3. doi:
10.1210/endo-122-3-1110. [PMID: 3342746] - J A Rodríguez Portales, E Arteaga, J M López Moreno, E G Biglieri. Zona glomerulosa function after life-long suppression in two siblings with the hypertensive virilizing form of congenital adrenal hyperplasia.
The Journal of clinical endocrinology and metabolism.
1988 Feb; 66(2):349-54. doi:
10.1210/jcem-66-2-349. [PMID: 3276723] - L Membreno, I Irony, W Dere, R Klein, E G Biglieri, E Cobb. Adrenocortical function in acquired immunodeficiency syndrome.
The Journal of clinical endocrinology and metabolism.
1987 Sep; 65(3):482-7. doi:
10.1210/jcem-65-3-482. [PMID: 3040796] - A K Kuang, C X Wang, G Li, D H Xu, Y S Qian, M L Huang. Effect of Qigong therapy on plasma 18-OH-DOC level in hypertensives.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
1987 Sep; 7(3):169-70. doi:
NULL. [PMID: 3444346] - G T Griffing, T E Wilson, E A Alexander, H H Bengele, R D Perrone, J C Melby. Biphasic 19-nor-deoxycorticosterone excretion after adrenal enucleation is associated with altered adrenal mitochondrial cytochrome P450 11 beta-, 18-, and 19-hydroxylase activities.
Endocrinology.
1987 Aug; 121(2):645-9. doi:
10.1210/endo-121-2-645. [PMID: 3496214] - K Makino, K Yasuda, M Okuyama, M Ojima, N Sasano, K Miura. An adrenocortical tumor secreting weak mineralocorticoids.
Endocrinologia japonica.
1987 Feb; 34(1):65-72. doi:
10.1507/endocrj1954.34.65. [PMID: 3608914] - H Bultasová, A Veselková, V Brodan, P Pinsker. Circadian rhythms of urinary sodium, potassium and some agents influencing their excretion in young borderline hypertensives.
Endocrinologia experimentalis.
1986 Dec; 20(4):359-69. doi:
NULL. [PMID: 3492363]