Frovatriptan (BioDeep_00000707100)
代谢物信息卡片
化学式: C18H25N3O6 (379.1743)
中文名称: 夫罗曲普坦琥珀酸盐水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CNC1CCC2=C(C1)C3=C(N2)C=CC(=C3)C(=O)N.C(CC(=O)O)C(=O)O.O
InChI: 1H2/t9-
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
C78272 - Agent Affecting Nervous System > C47794 - Serotonin Agonist
Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research[1][2].
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D04264
- PubChem: 152943
- ChEMBL: CHEMBL2138684
- CAS: 158930-17-7
- medchemexpress: HY-B1658A
分类词条
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lidia Savi, Selene Mogavero, Colin Gerard Egan. Efficacy and pharmacokinetic activity of frovatriptan compared to rizatriptan in patients with moderate-to-severe migraine.
Drug design, development and therapy.
2014; 8(?):983-92. doi:
10.2147/dddt.s61295. [PMID: 25092964] - Färkkilä Markus, Kallela Mikko. Frovatriptan review.
Expert opinion on pharmacotherapy.
2007 Dec; 8(17):3029-33. doi:
10.1517/14656566.8.17.3029. [PMID: 18001261] - Yvonne D'Arcy. New pain management options: drugs.
Nursing.
2007 Jan; 37(1):18-9. doi:
10.1097/00152193-200701000-00013. [PMID: 17198138] - Yvonne D'Arcy. Latest pain relief a combination of new and old.
The Nurse practitioner.
2007 Jan; 32(1):11-2. doi:
10.1097/00006205-200701000-00003. [PMID: 17198336] - Arthur H Elkind, Andrew Wade, Gary Ishkanian. Pharmacokinetics of frovatriptan in adolescent migraineurs.
Journal of clinical pharmacology.
2004 Oct; 44(10):1158-65. doi:
10.1177/0091270004268046. [PMID: 15342617] - Jerome Goldstein. Frovatriptan: a review.
Expert opinion on pharmacotherapy.
2003 Jan; 4(1):83-93. doi:
10.1517/14656566.4.1.83. [PMID: 12517245] - ". New medications show promise for migraine sufferers.
Dentistry today.
2002 Oct; 21(10):70. doi:
". [PMID: 12382492] - P Buchan, A Wade, C Ward, S D Oliver, A J Stewart, S Freestone. Frovatriptan: a review of drug-drug interactions.
Headache.
2002 Apr; 42 Suppl 2(?):S63-73. doi:
10.1046/j.1526-4610.42.s2.4.x. [PMID: 12028322] - P Buchan, C Keywood, A Wade, C Ward. Clinical pharmacokinetics of frovatriptan.
Headache.
2002 Apr; 42 Suppl 2(?):S54-62. doi:
10.1046/j.1526-4610.42.s2.3.x. [PMID: 12028321] - D Deleu, Y Hanssens. Current and emerging second-generation triptans in acute migraine therapy: a comparative review.
Journal of clinical pharmacology.
2000 Jul; 40(7):687-700. doi:
10.1177/00912700022009431. [PMID: 10883409]
