Edatrexate (BioDeep_00000706866)

   


代谢物信息卡片


2-[[4-[1-(2,4-diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid

化学式: C22H25N7O5 (467.191708)
中文名称: 依达曲沙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C22H25N7O5/c1-2-11(9-14-10-25-19-17(26-14)18(23)28-22(24)29-19)12-3-5-13(6-4-12)20(32)27-15(21(33)34)7-8-16(30)31/h3-6,10-11,15H,2,7-9H2,1H3,(H,27,32)(H,30,31)(H,33,34)(H4,23,24,25,28,29)

描述信息

C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
C471 - Enzyme Inhibitor > C2153 - Dihydrofolate Reductase Inhibitor
D004791 - Enzyme Inhibitors > D005493 - Folic Acid Antagonists
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

2-[[4-[1-(2,4-diaminopteridin-6-yl)butan-2-yl]benzoyl]amino]pentanedioic acid; Edatrexate



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Bipinchandra Mistry, Paul L Kimmel, Paul C Hetzel, Terence M Phillips, Gregory L Braden. The role of circulating immune complexes and biocompatibility of staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2004 Oct; 44(4):e50-8. doi: 10.1016/s0272-6386(04)00985-0. [PMID: 15384034]
  • M J Edelman, D R Gandara, E A Perez, D Lau, I Lauder, C Turrell, M Uhrich, F Meyers. Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy. Investigational new drugs. 1998; 16(1):69-75. doi: 10.1023/a:1006026928733. [PMID: 9740546]
  • C H Takimoto. Antifolates in clinical development. Seminars in oncology. 1997 Oct; 24(5 Suppl 18):S18-40. doi: ". [PMID: 9420020]
  • R Dreicer, K J Propert, T Kuzel, J M Kirkwood, P J O'Dwyer, P J Loehrer. A phase II trial of edatrexate in patients with advanced renal cell carcinoma. An Eastern Cooperative Oncology Group study. American journal of clinical oncology. 1997 Jun; 20(3):251-3. doi: 10.1097/00000421-199706000-00008. [PMID: 9167747]
  • K M Pisters, L B Tyson, W Tong, M Fleisher, V A Miller, S C Grant, D G Pfister, J R Rigas, C L Densmore, G Krol, R T Heelan, F M Sirotnak, J R Bertino, M G Kris. High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 1996 Nov; 2(11):1819-24. doi: NULL. [PMID: 9816135]
  • G R Westerhof, S Rijnboutt, J H Schornagel, H M Pinedo, G J Peters, G Jansen. Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein. Cancer research. 1995 Sep; 55(17):3795-802. doi: . [PMID: 7641196]
  • R Pazdur, D F Moore, B Bready, L Giannone, A Maldonado, Y G Lin, R H Fueger, R J Winn, B Levin. Phase II trial of edatrexate in patients with advanced hepatocellular carcinoma. Annals of oncology : official journal of the European Society for Medical Oncology. 1994 Sep; 5(7):646-8. doi: 10.1093/oxfordjournals.annonc.a058939. [PMID: 7527654]
  • K J Skeith, C Ramos-Remus, A S Russell. Comparative efficacy and toxicity of 10-ethyl-10-deazaaminopterin and methotrexate in a mycobacterial rat arthritis model. The Journal of rheumatology. 1994 Mar; 21(3):473-5. doi: NULL. [PMID: 8006891]
  • E A Perez, F M Hack, T S Fletcher, T C Chou. Modulation of intrinsic in vitro resistance to carboplatin by edatrexate in the A549 human nonsmall cell lung cancer cell line. Oncology research. 1994; 6(3):151-6. doi: NULL. [PMID: 7994086]
  • M A Malone, A Costa Garcia, P Tunon Blanco, M R Smyth. Phase-selective AC adsorptive stripping voltammetric assay for aminopterin and 10-Edam in human serum. Journal of pharmaceutical and biomedical analysis. 1993 Oct; 11(10):939-46. doi: 10.1016/0731-7085(93)80053-4. [PMID: 8305599]
  • S Tsukagoshi. [Recent development of new anticancer drugs in Japan]. Nihon rinsho. Japanese journal of clinical medicine. 1993 Jul; 51(7):1923-9. doi: ". [PMID: 8103565]
  • J M Hartley, P W Nicholson, R Allen, P Lamond, S J Harland, R L Souhami. Pharmacokinetics of 10-ethyl-10-deaza-aminopterin, edatrexate, given weekly for non-small-cell lung cancer. Cancer chemotherapy and pharmacology. 1993; 31(4):328-32. doi: 10.1007/bf00685680. [PMID: 8380758]
  • G F Fleming, R L Schilsky. Antifolates: the next generation. Seminars in oncology. 1992 Dec; 19(6):707-19. doi: ". [PMID: 1462168]
  • W W Li, J T Lin, W P Tong, T M Trippett, M F Brennan, J R Bertino. Mechanisms of natural resistance to antifolates in human soft tissue sarcomas. Cancer research. 1992 Mar; 52(6):1434-8. doi: NULL. [PMID: 1371715]
  • O van Tellingen, J H Beijnen, H R van der Woude, P F Bruning, W J Nooyen. High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma. Journal of chromatography. 1990 Jul; 529(1):135-43. doi: 10.1016/s0378-4347(00)83814-1. [PMID: 2211926]
  • M G Kris, J J Kinahan, R J Gralla, M P Fanucchi, M S Wertheim, J P O'Connell, L D Marks, L Williams, F Farag, C W Young. Phase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer. Cancer research. 1988 Oct; 48(19):5573-9. doi: NULL. [PMID: 3416310]
  • M G Nair, N T Nanavati, P Kumar, Y Gaumont, R L Kisliuk. Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin. Journal of medicinal chemistry. 1988 Jan; 31(1):181-5. doi: 10.1021/jm00396a029. [PMID: 2447278]
  • M P Fanucchi, J J Kinahan, L L Samuels, C Hancock, T C Chou, D Niedzwiecki, F Farag, P M Vidal, J I DeGraw, S S Sternberg. Toxicity, elimination, and metabolism of 10-ethyl-10-deazaaminopterin in rats and dogs. Cancer research. 1987 May; 47(9):2334-9. doi: NULL. [PMID: 2436760]
  • J J Kinahan, L L Samuels, F Farag, M P Fanucchi, P M Vidal, F M Sirotnak, C W Young. Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites. Analytical biochemistry. 1985 Oct; 150(1):203-13. doi: 10.1016/0003-2697(85)90460-9. [PMID: 2417507]