SB 239063 (BioDeep_00000706607)

   


代谢物信息卡片


Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-

化学式: C20H21FN4O2 (368.1648)
中文名称: SB 239063
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=NC=CC(=N1)C2=C(N=CN2C3CCC(CC3)O)C4=CC=C(C=C4)F
InChI: InChI=1S/C20H21FN4O2/c1-27-20-22-11-10-17(24-20)19-18(13-2-4-14(21)5-3-13)23-12-25(19)15-6-8-16(26)9-7-15/h2-5,10-12,15-16,26H,6-9H2,1H3

描述信息

D004791 - Enzyme Inhibitors > D047428 - Protein Kinase Inhibitors

同义名列表

2 个代谢物同义名

Cyclohexanol, 4-(4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl)-, trans-; SB 239063



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Xiang Li, Xun Cui, Shuai Zhou, Da-Lin Xing, Hu-Ri Piao, Qing-Gao Zhang, Yu-Qing Zhao, Li-Ping Liu. The novel ginsenoside AD2 prevents angiotensin II-induced connexin 40 and connexin 43 dysregulation by activating AMP kinase signaling in perfused beating rat atria. Chemico-biological interactions. 2021 Apr; 339(?):109430. doi: 10.1016/j.cbi.2021.109430. [PMID: 33676887]
  • Jianwei Yuan, Jinghua Zhang, Juan Cao, Guangxing Wang, Hansheng Bai. Geniposide Alleviates Traumatic Brain Injury in Rats Via Anti-Inflammatory Effect and MAPK/NF-kB Inhibition. Cellular and molecular neurobiology. 2020 May; 40(4):511-520. doi: 10.1007/s10571-019-00749-6. [PMID: 31677006]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • S Pereira, W Q Yu, J Moore, Y Mori, E Tsiani, A Giacca. Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo. Nutrition & diabetes. 2016 May; 6(?):e210. doi: 10.1038/nutd.2016.11. [PMID: 27136448]
  • Xue-Mei Zhang, Li Zhang, Guili Wang, Wenxiu Niu, Zhijie He, Li Ding, Jie Jia. Suppression of mitochondrial fission in experimental cerebral ischemia: The potential neuroprotective target of p38 MAPK inhibition. Neurochemistry international. 2015 Nov; 90(?):1-8. doi: 10.1016/j.neuint.2015.06.010. [PMID: 26116440]
  • Kai-yang Lv, Xi-ya Yu, Yu-shu Bai, Shi-hui Zhu, Hong-tai Tang, Dao-feng Ben, Shi-chu Xiao, Guang-yi Wang, Bing Ma, Zhao-fan Xia. Role of inhibition of p38 mitogen-activated protein kinase in liver dysfunction after hemorrhagic shock and resuscitation. The Journal of surgical research. 2012 Dec; 178(2):827-32. doi: 10.1016/j.jss.2012.04.006. [PMID: 22560853]
  • Tsun-Yung Kuo, Chuen-Lin Huang, Jung-Mou Yang, Wei-Jung Huang, Nai-Kuei Huang, Yue-Wen Chen, Ren-Jye Lin, Ying-Chen Yang. The role of ribosylated-BSA in regulating PC12 cell viability. Cell biology and toxicology. 2012 Aug; 28(4):255-67. doi: 10.1007/s10565-012-9220-3. [PMID: 22543687]
  • Ana Agusti, Omar Cauli, Regina Rodrigo, Marta Llansola, Vicente Hernández-Rabaza, Vicente Felipo. p38 MAP kinase is a therapeutic target for hepatic encephalopathy in rats with portacaval shunts. Gut. 2011 Nov; 60(11):1572-9. doi: 10.1136/gut.2010.236083. [PMID: 21636647]
  • Silvia Bison, Maria Razzoli, Roberto Arban, Francesca Michielin, Simone Bertani, Lucia Carboni. Effect of the p38 MAPK inhibitor SB-239063 on Lipopolysaccharide-induced psychomotor retardation and peripheral biomarker alterations in rats. European journal of pharmacology. 2011 Jul; 661(1-3):49-56. doi: 10.1016/j.ejphar.2011.04.020. [PMID: 21545800]
  • Kakulavarapu V Rama Rao, Arumugam R Jayakumar, Pichili V B Reddy, Xiaoying Tong, Kevin M Curtis, M D Norenberg. Aquaporin-4 in manganese-treated cultured astrocytes. Glia. 2010 Sep; 58(12):1490-9. doi: 10.1002/glia.21023. [PMID: 20648640]
  • Cang-Bao Xu, Jian-Pu Zheng, Wei Zhang, Yaping Zhang, Lars Edvinsson. Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Dec; 106(2):546-55. doi: 10.1093/toxsci/kfn173. [PMID: 18718921]
  • Xiaomin Deng, Jingtao Lu, Lois D Lehman-McKeeman, Ernst Malle, David L Crandall, Patricia E Ganey, Robert A Roth. p38 mitogen-activated protein kinase-dependent tumor necrosis factor-alpha-converting enzyme is important for liver injury in hepatotoxic interaction between lipopolysaccharide and ranitidine. The Journal of pharmacology and experimental therapeutics. 2008 Jul; 326(1):144-52. doi: 10.1124/jpet.108.137497. [PMID: 18390808]
  • Martin H de Borst, Gerjan Navis, Rudolf A de Boer, Sippie Huitema, Lotte M Vis, Wiek H van Gilst, Harry van Goor. Specific MAP-kinase blockade protects against renal damage in homozygous TGR(mRen2)27 rats. Laboratory investigation; a journal of technical methods and pathology. 2003 Dec; 83(12):1761-70. doi: 10.1097/01.lab.0000101731.11015.f6. [PMID: 14691294]
  • Stephen C Lenhard, Sandhya S Nerurkar, Thomas R Schaeffer, Rosanna C Mirabile, Rogely W Boyce, David F Adams, Beat M Jucker, Robert N Willette. p38 MAPK inhibitors ameliorate target organ damage in hypertension: Part 2. Improved renal function as assessed by dynamic contrast-enhanced magnetic resonance imaging. The Journal of pharmacology and experimental therapeutics. 2003 Dec; 307(3):939-46. doi: 10.1124/jpet.103.057398. [PMID: 14561850]
  • T M Behr, S S Nerurkar, A H Nelson, R W Coatney, T N Woods, A Sulpizio, S Chandra, D P Brooks, S Kumar, J C Lee, E H Ohlstein, C E Angermann, J L Adams, J Sisko, J D Sackner-Bernstein, R N Willette. Hypertensive end-organ damage and premature mortality are p38 mitogen-activated protein kinase-dependent in a rat model of cardiac hypertrophy and dysfunction. Circulation. 2001 Sep; 104(11):1292-8. doi: 10.1161/hc3601.094275. [PMID: 11551882]
  • F C Barone, E A Irving, A M Ray, J C Lee, S Kassis, S Kumar, A M Badger, J J Legos, J A Erhardt, E H Ohlstein, A J Hunter, D C Harrison, K Philpott, B R Smith, J L Adams, A A Parsons. Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia. Medicinal research reviews. 2001 Mar; 21(2):129-45. doi: 10.1002/1098-1128(200103)21:2<129::aid-med1003>3.0.co;2-h. [PMID: 11223862]
  • F C Barone, E A Irving, A M Ray, J C Lee, S Kassis, S Kumar, A M Badger, R F White, M J McVey, J J Legos, J A Erhardt, A H Nelson, E H Ohlstein, A J Hunter, K Ward, B R Smith, J L Adams, A A Parsons. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. The Journal of pharmacology and experimental therapeutics. 2001 Feb; 296(2):312-21. doi: NULL. [PMID: 11160612]