Tacrine hydrochloride (BioDeep_00000706595)
代谢物信息卡片
Tacrine hydrochloride
化学式: C13H15ClN2 (234.09237)
中文名称: 9-氨基-1,2,3,4-四氢吖啶盐酸盐水合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC2=NC3=CC=CC=C3C(=C2C1)N.Cl
InChI: 1H
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D004791 - Enzyme Inhibitors
Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- KEGGdrug: D02068
- PubChem: 2723754
- ChEMBL: CHEMBL1677
- MeSH: Tacrine
- CAS: 1684-40-8
- medchemexpress: HY-B1488
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Fanxin Zeng, Tao Lu, Jie Wang, Xuliang Nie, Wanming Xiong, Zhongping Yin, Dayong Peng. Design, Synthesis and Bioactivity Evaluation of Coumarin-BMT Hybrids as New Acetylcholinesterase Inhibitors.
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072142. [PMID: 35408542] - Beenita Saikia, Lipika Buragohain, Chandana Choudhury Barua, Jadav Sarma, Sarojini Mahanta Tamuli, Dhruba Jyoti Kalita, Acheenta Gohain Barua, Iswar Chandra Barua, Ramakrishna Elancheran. Evaluation of anti-amnesic effect of Conyza bonariensis in rats.
Indian journal of pharmacology.
2022 Mar; 54(2):102-109. doi:
10.4103/ijp.ijp_201_19. [PMID: 35546461] - Prayasee Baruah, Debojit Paul, Jitesh Doshi, Sivaprasad Mitra. Elevated Fibrinogen Level Reduces Therapeutic Efficiency of AD Drugs: Biophysical Insights into the Interaction of FDA-Approved Cholinesterase Inhibitors with Human Fibrinogen.
The journal of physical chemistry. B.
2022 01; 126(1):30-43. doi:
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Cells.
2021 12; 10(12):. doi:
10.3390/cells10123533. [PMID: 34944045] - Etta Y L Liu, Shinghung Mak, Xiangpeng Kong, Yingjie Xia, Kenneth K L Kwan, Miranda L Xu, Karl W K Tsim. Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells.
Molecular pharmacology.
2021 11; 100(5):456-469. doi:
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Bioorganic chemistry.
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ACS chemical neuroscience.
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European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
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ACS chemical neuroscience.
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Life sciences.
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Bioorganic & medicinal chemistry.
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ACS chemical neuroscience.
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