4-DAMP (BioDeep_00000706590)
代谢物信息卡片
4-Damp methiodide
化学式: C21H26INO2 (451.1008)
中文名称: 4-二苯乙酰氧基-N-甲基-哌啶甲碘化物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1(CCC(CC1)OC(=O)C(C2=CC=CC=C2)C3=CC=CC=C3)C.[I-]
InChI: /p-1
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
同义名列表
2 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mohammad Zarei, Saeed Mohammadi, Sajjad Jabbari, Siamak Shahidi. Intracerebroventricular microinjection of kaempferol on memory retention of passive avoidance learning in rats: involvement of cholinergic mechanism(s).
The International journal of neuroscience.
2019 Dec; 129(12):1203-1212. doi:
10.1080/00207454.2019.1653867. [PMID: 31393204] - Luke R Odell, Mohammed K Abdel-Hamid, Timothy A Hill, Ngoc Chau, Kelly A Young, Fiona M Deane, Jennette A Sakoff, Sofia Andersson, James A Daniel, Phillip J Robinson, Adam McCluskey. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.
Journal of medicinal chemistry.
2017 01; 60(1):349-361. doi:
10.1021/acs.jmedchem.6b01422. [PMID: 27997171] - Masaki Ogoda, Yoshihiko Ito, Yusuke Fuchihata, Satomi Onoue, Shizuo Yamada. Characterization of muscarinic and P2X receptors in the urothelium and detrusor muscle of the rat bladder.
Journal of pharmacological sciences.
2016 May; 131(1):58-63. doi:
10.1016/j.jphs.2016.04.020. [PMID: 27174863] - Marcelo J Alfonzo, Ramona González De Alfonzo, Marcelo A Alfonzo-González, Itala Lippo De Becemberg. Cyclic GMP regulates M₃AChR activity at plasma membranes from airway smooth muscle.
Molecular membrane biology.
2013 Dec; 30(8):403-17. doi:
10.3109/09687688.2013.851419. [PMID: 24175711] - Shankar P Parajuli, Georgi V Petkov. Activation of muscarinic M3 receptors inhibits large-conductance voltage- and Ca2+-activated K+ channels in rat urinary bladder smooth muscle cells.
American journal of physiology. Cell physiology.
2013 Jul; 305(2):C207-14. doi:
10.1152/ajpcell.00113.2013. [PMID: 23703523] - Jing Hu, Wen-Yuan Gao, Lin Ma, Shu-Li Man, Lu-Qi Huang, Chang-Xiao Liu. Activation of M3 muscarinic receptor and Ca²⁺ influx by crude fraction from Crotonis Fructus in isolated rabbit jejunum.
Journal of ethnopharmacology.
2012 Jan; 139(1):136-41. doi:
10.1016/j.jep.2011.10.041. [PMID: 22107834] - T T Yang, S-M Ling, C-W Tsao, J-T Cheng. Opening of ATP-sensitive potassium channel by insulin in the brain-induced insulin secretion in Wistar rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2010 Feb; 42(2):110-4. doi:
10.1055/s-0029-1241822. [PMID: 19890806] - Keum Young So, Sang Hun Kim, Hong Moon Sohn, Soo Jin Choi, Shankar Prasad Parajuli, Seok Choi, Cheol Ho Yeum, Pyung Jin Yoon, Jae Yeoul Jun. Carbachol regulates pacemaker activities in cultured interstitial cells of Cajal from the mouse small intestine.
Molecules and cells.
2009 May; 27(5):525-31. doi:
10.1007/s10059-009-0076-1. [PMID: 19466600] - Tetsuya Asari, Kazuyasu Maruyama, Hiroshi Kusama. Salivation triggered by pilocarpine involves aquaporin-5 in normal rats but not in irradiated rats.
Clinical and experimental pharmacology & physiology.
2009 May; 36(5-6):531-8. doi:
10.1111/j.1440-1681.2008.05104.x. [PMID: 19673936] - Ko Yu Liu, Yang-Chang Wu, I-Min Liu, Wen Chen Yu, Juei-Tang Cheng. Release of acetylcholine by syringin, an active principle of Eleutherococcus senticosus, to raise insulin secretion in Wistar rats.
Neuroscience letters.
2008 Mar; 434(2):195-9. doi:
10.1016/j.neulet.2008.01.054. [PMID: 18304730] - Paul Mitrani, Malathi Srinivasan, Catherine Dodds, Mulchand S Patel. Autonomic involvement in the permanent metabolic programming of hyperinsulinemia in the high-carbohydrate rat model.
American journal of physiology. Endocrinology and metabolism.
2007 May; 292(5):E1364-77. doi:
10.1152/ajpendo.00672.2006. [PMID: 17227957] - R Sugawara, Y Takai, M Miyazu, H Ohinata, A Yoshida, A Takai. Agonist and antagonist sensitivity of non-selective cation channel currents evoked by muscarinic receptor stimulation in bovine ciliary muscle cells.
Autonomic & autacoid pharmacology.
2006 Jul; 26(3):285-92. doi:
10.1111/j.1474-8673.2006.00347.x. [PMID: 16879494] - Wen-Kung Lee, Shung-Te Kao, I-Min Liu, Juei-Tang Cheng. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats.
Clinical and experimental pharmacology & physiology.
2006 Jan; 33(1-2):27-32. doi:
10.1111/j.1440-1681.2006.04319.x. [PMID: 16445695] - T R Renuka, Das V Ani, C S Paulose. Alterations in the muscarinic M1 and M3 receptor gene expression in the brain stem during pancreatic regeneration and insulin secretion in weanling rats.
Life sciences.
2004 Sep; 75(19):2269-80. doi:
10.1016/j.lfs.2004.03.034. [PMID: 15350825] - Yan Liu, Yu-hong Jing, Hong-li Sun, Hu-lun Li, Bao-feng Yang. [Relationship between M3 receptor and myocyte apoptosis induced by acute myocardial infarction].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 May; 39(5):338-41. doi:
NULL. [PMID: 15338874] - Ender Tekes, Banu Bayar, Selda Emre-Aydingoz, Meral Tuncer. Mechanism of action of the cisapride-induced vasodilatation in renal vasculature of rat.
The Indian journal of medical research.
2004 Mar; 119(3):115-20. doi:
. [PMID: 15115163] - Shorong-Shii Liou, I-Min Liu, Jen-Hao Hsu, Yang-Chang Wu, Sheng-Fa Hsu, Juei-Tang Chen. Release of acetylcholine by Die-Huang-Wan to enhance insulin secretion for lowering plasma glucose in Wistar rats.
Autonomic neuroscience : basic & clinical.
2002 Sep; 100(1-2):21-6. doi:
10.1016/s1566-0702(02)00138-8. [PMID: 12422956] - J Wang, P S Krysiak, L G Laurier, S M Sims, H G Preiksaitis. Human esophageal smooth muscle cells express muscarinic receptor subtypes M(1) through M(5).
American journal of physiology. Gastrointestinal and liver physiology.
2000 Nov; 279(5):G1059-69. doi:
10.1152/ajpgi.2000.279.5.g1059. [PMID: 11053004] - R W Mitchell, A J Halayko, S Kahraman, J Solway, M E Wylam. Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
American journal of physiology. Lung cellular and molecular physiology.
2000 May; 278(5):L1091-100. doi:
10.1152/ajplung.2000.278.5.l1091. [PMID: 10781442] - H Shi, H Wang, Y Lu, B Yang, Z Wang. Choline modulates cardiac membrane repolarization by activating an M3 muscarinic receptor and its coupled K+ channel.
The Journal of membrane biology.
1999 May; 169(1):55-64. doi:
10.1007/pl00005901. [PMID: 10227852] - T J Visser, A van Waarde, T J Jansen, G M Visser, T W van der Mark, J Kraan, K Ensing, W Vaalburg. Stereoselective synthesis and biodistribution of potent [11C]-labeled antagonists for positron emission tomography imaging of muscarinic receptors in the airways.
Journal of medicinal chemistry.
1997 Jan; 40(1):117-24. doi:
10.1021/jm960374w. [PMID: 9016336] - T Yamada, A Mizumoto, M Satoh, N Haga, Z Itoh. Muscarinic control of phase III contractions and motilin release in dogs.
Peptides.
1997; 18(5):673-80. doi:
10.1016/s0196-9781(97)00132-0. [PMID: 9213360] - S Bacman, L Sterin-Borda, J J Camusso, R Arana, O Hubscher, E Borda. Circulating antibodies against rat parotid gland M3 muscarinic receptors in primary Sjögren's syndrome.
Clinical and experimental immunology.
1996 Jun; 104(3):454-9. doi:
10.1046/j.1365-2249.1996.42748.x. [PMID: 9099930] - A M Chapa, J M Fernandez, D L Thompson, R J Tempelman, L F Berrio, W J Croom, W M Hagler. Endocrine and metabolic response to muscarinic stimulation and inhibition in the ruminant: effects of slaframine.
Journal of animal science.
1995 Dec; 73(12):3673-80. doi:
10.2527/1995.73123673x. [PMID: 8655443] - K Blüml, E Mutschler, J Wess. Insertion mutagenesis as a tool to predict the secondary structure of a muscarinic receptor domain determining specificity of G-protein coupling.
Proceedings of the National Academy of Sciences of the United States of America.
1994 Aug; 91(17):7980-4. doi:
10.1073/pnas.91.17.7980. [PMID: 8058746] - Y Fukomoto, M Yoshida, R M Weiss, J Latifpour. Reversibility of diabetes- and diuresis-induced alterations in rat bladder dome muscarinic receptors.
Diabetes.
1994 Jun; 43(6):819-26. doi:
10.2337/diab.43.6.819. [PMID: 8194669] - M Tanikawa, T Hayakawa, T Kondo, S Naruse, T Shibata, M Kitagawa. Regulation of pancreatic polypeptide release is mediated through M3 muscarinic receptors.
Digestion.
1994; 55(6):374-9. doi:
10.1159/000201168. [PMID: 7705550] - A van Waarde, G M Visser, T J Visser, J Bouwer, A M Paans, W Vaalburg. Rodent biodistribution and metabolism of tritiated 4-DAMP, a M3 subtype-selective cholinoceptor ligand.
Nuclear medicine and biology.
1994 Jan; 21(1):41-7. doi:
10.1016/0969-8051(94)90127-9. [PMID: 9234262] - J S Aguilar, J J Ballesta, J A Reig, M Palmero, S Viniegra, M Criado. Muscarinic receptor subtypes in bovine adrenal medulla.
Neurochemical research.
1992 Dec; 17(12):1235-9. doi:
10.1007/bf00968406. [PMID: 1461370] - J M Wilkes, M Kajimura, D R Scott, S J Hersey, G Sachs. Muscarinic responses of gastric parietal cells.
The Journal of membrane biology.
1991 Jun; 122(2):97-110. doi:
10.1007/bf01872634. [PMID: 1895339] - C Polidori, P L Pompei, M Perfumi, C Melchiorre, M Massi. Natriuresis, kaliuresis and antidiuresis induced by central carbachol injection are mediated by muscarinic M1 receptors.
European journal of pharmacology.
1991 Mar; 195(1):139-43. doi:
10.1016/0014-2999(91)90391-3. [PMID: 2065708]
