GBR 12783 dihydrochloride (BioDeep_00000706568)

   


代谢物信息卡片


1-(2-(Diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine

化学式: C28H32N2O (412.25145019999997)
中文名称: 1-[2-(二苯基甲氧基)乙基]-4-(3-苯基-2-丙苯基)-哌嗪
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(CCN1CCOC(C2=CC=CC=C2)C3=CC=CC=C3)CC=CC4=CC=CC=C4
InChI: InChI=1S/C28H32N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-17,28H,18-24H2/b13-10+

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018765 - Dopamine Uptake Inhibitors
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
D049990 - Membrane Transport Modulators

同义名列表

2 个代谢物同义名

1-(2-(Diphenylmethoxy)ethyl)-4-(3-phenyl-2-propenyl)piperazine; GBR 12783 dihydrochloride



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • J C Do-Régo, H Hue, J Costentin, J J Bonnet. Evidence for the sequential formation of two complexes between an uptake inhibitor, GBR 12783 [1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine], and the neuronal transporter of dopamine. Journal of neurochemistry. 1999 Jan; 72(1):396-404. doi: 10.1046/j.1471-4159.1999.0720396.x. [PMID: 9886093]
  • A T Corera, J C Do Régo, J J Bonnet. Specificity and ion dependence of binding of GBR analogs. Methods in enzymology. 1998; 296(?):203-19. doi: 10.1016/s0076-6879(98)96016-5. [PMID: 9779450]
  • D Boulay, D Duterte-Boucher, I Leroux-Nicollet, L Naudon, J Costentin. Locomotor sensitization and decrease in [3H]mazindol binding to the dopamine transporter in the nucleus accumbens are delayed after chronic treatments by GBR12783 or cocaine. The Journal of pharmacology and experimental therapeutics. 1996 Jul; 278(1):330-7. doi: NULL. [PMID: 8764367]
  • C Héron, G Billaud, J Costentin, J J Bonnet. Complex ionic control of [3H]GBR 12783 binding to the dopamine neuronal carrier. European journal of pharmacology. 1996 Apr; 301(1-3):195-202. doi: 10.1016/0014-2999(96)00050-7. [PMID: 8773464]
  • C Ramassamy, F Girbe, Y Christen, J Costentin. Peroxidation of synaptosomes alters the dopamine uptake complex but spares the exocytotic release of dopamine. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. 1995 Jun; 4(2):155-60. doi: 10.1006/neur.1995.0019. [PMID: 7583679]
  • F Refahi-Lyamani, S Saadouni, J Costentin, J J Bonnet. Interaction of two sulfhydryl reagents with a cation recognition site on the neuronal dopamine carrier evidences small differences between [3H]GBR 12783 and [3H]cocaine binding sites. Naunyn-Schmiedeberg's archives of pharmacology. 1995 Feb; 351(2):136-45. doi: 10.1007/bf00169327. [PMID: 7770096]
  • C Héron, J Costentin, J J Bonnet. Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier. European journal of pharmacology. 1994 Nov; 264(3):391-8. doi: 10.1016/0014-2999(94)00502-8. [PMID: 7698180]
  • G Billaud, J F Menard, N Marcellin, J M Kamenka, J Costentin, J J Bonnet. Thermodynamics of the binding of BTCP (GK 13) and related derivatives on the dopamine neuronal carrier. European journal of pharmacology. 1994 Aug; 268(3):357-63. doi: 10.1016/0922-4106(94)90060-4. [PMID: 7805759]
  • S Saadouni, F Refahi-Lyamani, J Costentin, J J Bonnet. Cocaine and GBR 12783 recognize nonidentical, overlapping binding domains on the dopamine neuronal carrier. European journal of pharmacology. 1994 Jul; 268(2):187-97. doi: 10.1016/0922-4106(94)90188-0. [PMID: 7957640]
  • I Leroux-Nicollet, J Costentin. Comparison of the subregional distributions of the monoamine vesicular transporter and dopamine uptake complex in the rat striatum and changes during aging. Journal of neural transmission. General section. 1994; 97(2):93-106. doi: 10.1007/bf01277946. [PMID: 7873127]
  • J J Bonnet, S Benmansour, N Amejdki-Chab, J Costentin. Effect of CH3HgCl and several transition metals on the dopamine neuronal carrier; peculiar behaviour of Zn2+. European journal of pharmacology. 1994 Jan; 266(1):87-97. doi: 10.1016/0922-4106(94)90213-5. [PMID: 8137886]
  • G Billaud, J Costentin, J J Bonnet. Specific binding of [3H]GBR 12783 to the dopamine neuronal carrier included in polarized membranes. European journal of pharmacology. 1993 Nov; 247(3):333-40. doi: 10.1016/0922-4106(93)90203-l. [PMID: 8307105]
  • J M Vaugeois, J J Bonnet, D Duterte-Boucher, J Costentin. In vivo occupancy of the striatal dopamine uptake complex by various inhibitors does not predict their effects on locomotion. European journal of pharmacology. 1993 Jan; 230(2):195-201. doi: 10.1016/0014-2999(93)90802-o. [PMID: 8422901]
  • T Maurice, G Barbanel, J Vignon. Endogenous dopamine differently affects N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine and cocaine binding to the dopamine uptake complex. General pharmacology. 1993 Jan; 24(1):191-4. doi: 10.1016/0306-3623(93)90033-t. [PMID: 8482495]
  • L Naudon, I Leroux-Nicollet, J Costentin. Consequences of an intrastriatal injection of kainic acid on the dopaminergic neuronal and vesicular uptake systems. Brain research. 1992 Oct; 593(1):32-8. doi: 10.1016/0006-8993(92)91259-h. [PMID: 1360863]
  • J M Vaugeois, J J Bonnet, J Costentin. In vivo labelling of the neuronal dopamine uptake complex in the mouse striatum by [3H]GBR 12783. European journal of pharmacology. 1992 Jan; 210(1):77-84. doi: 10.1016/0014-2999(92)90654-m. [PMID: 1350989]
  • T Maurice, G Barbanel, J M Kamenka, J Vignon. Modulation by dopamine of [3H]N-[1-(2-benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP, a phencyclidine derivative) binding to the dopamine uptake complex. Neuropharmacology. 1991 Jun; 30(6):591-8. doi: 10.1016/0028-3908(91)90078-p. [PMID: 1681444]
  • T Maurice, J Vignon, J M Kamenka, R Chicheportiche. Differential interaction of phencyclidine-like drugs with the dopamine uptake complex in vivo. Journal of neurochemistry. 1991 Feb; 56(2):553-9. doi: 10.1111/j.1471-4159.1991.tb08185.x. [PMID: 1671086]
  • C Ramassamy, F Clostre, Y Christen, J Costentin. Prevention by a Ginkgo biloba extract (GBE 761) of the dopaminergic neurotoxicity of MPTP. The Journal of pharmacy and pharmacology. 1990 Nov; 42(11):785-9. doi: 10.1111/j.2042-7158.1990.tb07021.x. [PMID: 1982302]
  • F Thibaut, J J Bonnet, J Costentin. Time course of postmortem modifications in synaptosomal [3H]dopamine uptake and [3H]GBR 12783 binding to the dopamine uptake complex in the rat striatum. Neuroscience letters. 1989 Jan; 96(3):335-9. doi: 10.1016/0304-3940(89)90401-1. [PMID: 2717059]