Suramin sodium (BioDeep_00000706550)
代谢物信息卡片
Suramin sodium
化学式: C51H34N6Na6O23S6 (1427.9385774)
中文名称: 舒拉明钠
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]
InChI: /q
描述信息
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01C - Agents against leishmaniasis and trypanosomiasis
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C1971 - Angiogenesis Activator Inhibitor
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D000970 - Antineoplastic Agents
Suramin sodium salt (Suramin hexasodium salt) is a reversible and competitive protein-tyrosine phosphatases (PTPases) inhibitor[1]. Suramin sodium salt is a potent inhibitor of sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM)[2]. Suramin sodium salt is a competitive inhibitor of reverse transcriptase (DNA topoisomerase II: IC50=5 μM)[3][4]. Suramin sodium salt is a potent SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) inhibitor[5]. Suramin sodium salt efficiently inhibits IP5K and is an antiparasitic, anti-neoplastic and anti-angiogenic agent[6][7][8].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:9364
- KEGGdrug: D94781
- KEGGdrug: D00808
- PubChem: 8514
- ChEMBL: CHEMBL413376
- MeSH: Suramin
- CAS: 129-46-4
- medchemexpress: HY-B0879A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Hanxiao Li, Yingyue Dong, Chunmiao Han, Lisha Xia, Yue Zhang, Tongsheng Chen, Huamin Wang, Guoheng Xu. Suramin, an antiparasitic drug, stimulates adipocyte differentiation and promotes adipogenesis.
Lipids in health and disease.
2023 Dec; 22(1):222. doi:
10.1186/s12944-023-01980-3. [PMID: 38093311] - Yang-Ting Dong, Kun Cao, Jie Xiang, Xiao-Lan Qi, Yan Xiao, Wen-Feng Yu, Yan He, Wei Hong, Zhi-Zhong Guan. Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in APP/PS1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ.
Neuroscience.
2023 May; ?(?):. doi:
10.1016/j.neuroscience.2023.04.023. [PMID: 37142180] - Zhen-Ni Liu, Qian-Qian Su, Yu-Hui Wang, Xue Wu, Xiong-Wen Lv. Blockade of the P2Y2 Receptor Attenuates Alcoholic Liver Inflammation by Targeting the EGFR-ERK1/2 Signaling Pathway.
Drug design, development and therapy.
2022; 16(?):1107-1120. doi:
10.2147/dddt.s346376. [PMID: 35444406] - Martina Mravinec, Gregor Bajc, Matej Butala. Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin.
Journal of virological methods.
2021 12; 298(?):114283. doi:
10.1016/j.jviromet.2021.114283. [PMID: 34534610] - Narueporn Likhitweerawong, Chanisa Thonusin, Nonglak Boonchooduang, Orawan Louthrenoo, Intawat Nookaew, Nipon Chattipakorn, Siriporn C Chattipakorn. Profiles of urine and blood metabolomics in autism spectrum disorders.
Metabolic brain disease.
2021 10; 36(7):1641-1671. doi:
10.1007/s11011-021-00788-3. [PMID: 34338974] - Debayan Dey, Suryanarayanarao Ramakumar, Graeme L Conn. Targeted Redesign of Suramin Analogs for Novel Antimicrobial Lead Development.
Journal of chemical information and modeling.
2021 09; 61(9):4442-4454. doi:
10.1021/acs.jcim.1c00578. [PMID: 34516120] - Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S Pang. Use of Platelet-Rich Plasma Plus Suramin, an Antifibrotic Agent, to Improve Muscle Healing After Injuries.
The American journal of sports medicine.
2021 09; 49(11):3102-3112. doi:
10.1177/03635465211030295. [PMID: 34351815] - Agustina P Bertolin, Florian Weissmann, Jingkun Zeng, Viktor Posse, Jennifer C Milligan, Berta Canal, Rachel Ulferts, Mary Wu, Lucy S Drury, Michael Howell, Rupert Beale, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp12/7/8 RNA-dependent RNA polymerase.
The Biochemical journal.
2021 07; 478(13):2425-2443. doi:
10.1042/bcj20210200. [PMID: 34198323] - Jingkun Zeng, Florian Weissmann, Agustina P Bertolin, Viktor Posse, Berta Canal, Rachel Ulferts, Mary Wu, Ruth Harvey, Saira Hussain, Jennifer C Milligan, Chloe Roustan, Annabel Borg, Laura McCoy, Lucy S Drury, Svend Kjaer, John McCauley, Michael Howell, Rupert Beale, John F X Diffley. Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase.
The Biochemical journal.
2021 07; 478(13):2405-2423. doi:
10.1042/bcj20210201. [PMID: 34198322] - K Sałaga-Zaleska, P Pikul, E Kreft, S Herman, G Chyła, K Dąbkowski, A Kuchta, M Lenartowicz, M Jankowski. Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jul; 139(?):111683. doi:
10.1016/j.biopha.2021.111683. [PMID: 34243631] - Gabriela Chyła, Kornelia Sałaga-Zaleska, Kamil Dąbkowski, Agnieszka Kuchta, Maciej Jankowski. Suramin enhances the urinary excretion of VEGF-A in normoglycemic and streptozotocin-induced diabetic rats.
Pharmacological reports : PR.
2021 Jun; 73(3):841-846. doi:
10.1007/s43440-021-00236-0. [PMID: 33635529] - Raphael J Eberle, Danilo S Olivier, Marcos S Amaral, Ian Gering, Dieter Willbold, Raghuvir K Arni, Monika A Coronado. The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CLpro In Vitro.
Viruses.
2021 05; 13(5):. doi:
10.3390/v13050873. [PMID: 34068686] - Wanchao Yin, Xiaodong Luan, Zhihai Li, Ziwei Zhou, Qingxing Wang, Minqi Gao, Xiaoxi Wang, Fulai Zhou, Jingjing Shi, Erli You, Mingliang Liu, Qingxia Wang, Yi Jiang, Hualiang Jiang, Gengfu Xiao, Leike Zhang, Xuekui Yu, Shuyang Zhang, H Eric Xu. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin.
Nature structural & molecular biology.
2021 03; 28(3):319-325. doi:
10.1038/s41594-021-00570-0. [PMID: 33674802] - Zhujun Ao, Mable Chan, Maggie Jing Ouyang, Titus Abiola Olukitibi, Mona Mahmoudi, Darwyn Kobasa, Xiaojian Yao. Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry.
PloS one.
2021; 16(6):e0251649. doi:
10.1371/journal.pone.0251649. [PMID: 34106944] - Molly A Kwiatkowski, Benjamin Z Roberts, Jordy van Enkhuizen, Baohu Ji, Xianjin Zhou, Jared W Young. Chronic nicotine, but not suramin or resveratrol, partially remediates the mania-like profile of dopamine transporter knockdown mice.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2021 01; 42(?):75-86. doi:
10.1016/j.euroneuro.2020.11.004. [PMID: 33191077] - Eman Y Gohar, Malgorzata Kasztan, Shali Zhang, Edward W Inscho, David M Pollock. Role for ovarian hormones in purinoceptor-dependent natriuresis.
Biology of sex differences.
2020 09; 11(1):52. doi:
10.1186/s13293-020-00329-0. [PMID: 32928299] - Clarisse Salgado-Benvindo, Melissa Thaler, Ali Tas, Natacha S Ogando, Peter J Bredenbeek, Dennis K Ninaber, Ying Wang, Pieter S Hiemstra, Eric J Snijder, Martijn J van Hemert. Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle.
Antimicrobial agents and chemotherapy.
2020 07; 64(8):. doi:
10.1128/aac.00900-20. [PMID: 32513797] - Yuliang Wang, Shuyi Ma, Walter L Ruzzo. Spatial modeling of prostate cancer metabolic gene expression reveals extensive heterogeneity and selective vulnerabilities.
Scientific reports.
2020 02; 10(1):3490. doi:
10.1038/s41598-020-60384-w. [PMID: 32103057] - Yun Kuang, Hui Liu, Siyu Guo, Yufei Wang, Huijuan Zhang, Yanxiang Qiao. The antagonist of P2Y11 receptor NF157 ameliorates oxidized LDL-induced vascular endothelial inflammation.
Artificial cells, nanomedicine, and biotechnology.
2019 Dec; 47(1):1839-1845. doi:
10.1080/21691401.2019.1610412. [PMID: 31066305] - Ajay Dixit, Hassam Cheema, John George, Srikanth Iyer, Vikas Dudeja, Rajinder Dawra, Ashok K Saluja. Extracellular release of ATP promotes systemic inflammation during acute pancreatitis.
American journal of physiology. Gastrointestinal and liver physiology.
2019 10; 317(4):G463-G475. doi:
10.1152/ajpgi.00395.2018. [PMID: 31433214] - Mayra Quemé-Peña, Tünde Juhász, Judith Mihály, Imola Cs Szigyártó, Kata Horváti, Szilvia Bősze, Judit Henczkó, Bernadett Pályi, Csaba Németh, Zoltán Varga, Ferenc Zsila, Tamás Beke-Somfai. Manipulating Active Structure and Function of Cationic Antimicrobial Peptide CM15 with the Polysulfonated Drug Suramin: A Step Closer to in Vivo Complexity.
Chembiochem : a European journal of chemical biology.
2019 06; 20(12):1578-1590. doi:
10.1002/cbic.201800801. [PMID: 30720915] - Marianne Skals, Anne-Sofie Greve, Steen K Fagerberg, Nanna Johnsen, Mette G Christensen, Helle A Praetorius. P2X1 receptor blockers reduce the number of circulating thrombocytes and the overall survival of urosepsis with haemolysin-producing Escherichia coli.
Purinergic signalling.
2019 06; 15(2):265-276. doi:
10.1007/s11302-019-09658-1. [PMID: 31129780] - Guilherme H M Salvador, Thiago R Dreyer, Antoniel A S Gomes, Walter L G Cavalcante, Juliana I Dos Santos, César A Gandin, Mário de Oliveira Neto, Márcia Gallacci, Marcos R M Fontes. Structural and functional characterization of suramin-bound MjTX-I from Bothrops moojeni suggests a particular myotoxic mechanism.
Scientific reports.
2018 07; 8(1):10317. doi:
10.1038/s41598-018-28584-7. [PMID: 29985425] - Pharavee Jaiprasart, Bertrand Z Yeung, Ze Lu, M Guillaume Wientjes, Minjian Cui, Chien-Ming Hsieh, Sukyung Woo, Jessie L-S Au. Quantitative contributions of processes by which polyanion drugs reduce intracellular bioavailability and transfection efficiency of cationic siRNA lipoplex.
Journal of controlled release : official journal of the Controlled Release Society.
2018 01; 270(?):101-113. doi:
10.1016/j.jconrel.2017.12.001. [PMID: 29203416] - Rômulo D Novaes, Eliziária C Santos, Marli C Cupertino, Daniel S S Bastos, Andréa A S Mendonça, Eduardo de Almeida Marques-da-Silva, Sílvia A Cardoso, Juliana L R Fietto, Leandro L Oliveira. Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality by Enhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosoma cruzi-Infected Mice.
Oxidative medicine and cellular longevity.
2018; 2018(?):7385639. doi:
10.1155/2018/7385639. [PMID: 30364017] - Debasis Sahu, Shikha Sharma, Rajeev K Singla, Amulya Kumar Panda. Antioxidant activity and protective effect of suramin against oxidative stress in collagen induced arthritis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Apr; 101(?):125-139. doi:
10.1016/j.ejps.2017.02.013. [PMID: 28189815] - Peijun Ren, Yimei Zheng, Wenqi Wang, Liping Hong, Françis Delpeyroux, Fernando Arenzana-Seisdedos, Ralf Altmeyer. Suramin interacts with the positively charged region surrounding the 5-fold axis of the EV-A71 capsid and inhibits multiple enterovirus A.
Scientific reports.
2017 02; 7(?):42902. doi:
10.1038/srep42902. [PMID: 28218309] - Xiaoou Li, Yutaka Kondo, Yi Bao, Laura Staudenmaier, Albert Lee, Jingping Zhang, Carola Ledderose, Wolfgang G Junger. Systemic Adenosine Triphosphate Impairs Neutrophil Chemotaxis and Host Defense in Sepsis.
Critical care medicine.
2017 Jan; 45(1):e97-e104. doi:
10.1097/ccm.0000000000002052. [PMID: 27548819] - Honglan Piao, Yuan Chi, Xiling Zhang, Zhen Zhang, Kun Gao, Manabu Niimi, Manabu Kamiyama, Jinming Zhang, Masayuki Takeda, Jian Yao. Suramin inhibits antibody binding to cell surface antigens and disrupts complement-mediated mesangial cell lysis.
Journal of pharmacological sciences.
2016 Dec; 132(4):224-234. doi:
10.1016/j.jphs.2016.03.011. [PMID: 27103329] - You-Lin Tain, Chien-Ning Hsu, Chien-Te Lee, Yu-Ju Lin, Ching-Chou Tsai. N-Acetylcysteine Prevents Programmed Hypertension in Male Rat Offspring Born to Suramin-Treated Mothers.
Biology of reproduction.
2016 07; 95(1):8. doi:
10.1095/biolreprod.116.139766. [PMID: 27251093] - Benjamin Bailly, Larissa Dirr, Ibrahim M El-Deeb, Ralf Altmeyer, Patrice Guillon, Mark von Itzstein. A dual drug regimen synergistically blocks human parainfluenza virus infection.
Scientific reports.
2016 Apr; 6(?):24138. doi:
10.1038/srep24138. [PMID: 27053240] - Alexey Koval, Kamal Ahmed, Vladimir L Katanaev. Inhibition of Wnt signalling and breast tumour growth by the multi-purpose drug suramin through suppression of heterotrimeric G proteins and Wnt endocytosis.
The Biochemical journal.
2016 Feb; 473(4):371-81. doi:
10.1042/bj20150913. [PMID: 26604320] - Tess V Dupre, Mark A Doll, Parag P Shah, Cierra N Sharp, Alex Kiefer, Michael T Scherzer, Kumar Saurabh, Doug Saforo, Deanna Siow, Lavona Casson, Gavin E Arteel, Alfred Bennett Jenson, Judit Megyesi, Rick G Schnellmann, Levi J Beverly, Leah J Siskind. Suramin protects from cisplatin-induced acute kidney injury.
American journal of physiology. Renal physiology.
2016 Feb; 310(3):F248-58. doi:
10.1152/ajprenal.00433.2015. [PMID: 26661653] - Hung-Chang Chou, Shih-Jiuan Chiu, Teh-Min Hu. LbL Assembly of Albumin on Nitric Oxide-Releasing Silica Nanoparticles Using Suramin, a Polyanion Drug, as an Interlayer Linker.
Biomacromolecules.
2015 Aug; 16(8):2288-95. doi:
10.1021/acs.biomac.5b00534. [PMID: 26121207] - Ida Arvidsson, Anne-Lie Ståhl, Minola Manea Hedström, Ann-Charlotte Kristoffersson, Christian Rylander, Julia S Westman, Jill R Storry, Martin L Olsson, Diana Karpman. Shiga toxin-induced complement-mediated hemolysis and release of complement-coated red blood cell-derived microvesicles in hemolytic uremic syndrome.
Journal of immunology (Baltimore, Md. : 1950).
2015 Mar; 194(5):2309-18. doi:
10.4049/jimmunol.1402470. [PMID: 25637016] - Abdullah Alyoussef. Suramin attenuated inflammation and reversed skin tissue damage in experimentally induced atopic dermatitis in mice.
Inflammation & allergy drug targets.
2015; 13(6):406-10. doi:
10.2174/1871528114666150529100957. [PMID: 26021324] - Wenjin Li, Hannah Ulm, Marvin Rausch, Xue Li, Katie O'Riordan, Jean C Lee, Tanja Schneider, Christa E Müller. Analysis of the Staphylococcus aureus capsule biosynthesis pathway in vitro: characterization of the UDP-GlcNAc C6 dehydratases CapD and CapE and identification of enzyme inhibitors.
International journal of medical microbiology : IJMM.
2014 Nov; 304(8):958-69. doi:
10.1016/j.ijmm.2014.06.002. [PMID: 25023075] - Huaqing Cui, Zeeshan Kamal, Teng Ai, Yanli Xu, Swati S More, Daniel J Wilson, Liqiang Chen. Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
Journal of medicinal chemistry.
2014 Oct; 57(20):8340-57. doi:
10.1021/jm500777s. [PMID: 25275824] - Yuka Sumi, Tobias Woehrle, Yu Chen, Yi Bao, Xiaoou Li, Yongli Yao, Yoshiaki Inoue, Hiroshi Tanaka, Wolfgang G Junger. Plasma ATP is required for neutrophil activation in a mouse sepsis model.
Shock (Augusta, Ga.).
2014 Aug; 42(2):142-7. doi:
10.1097/shk.0000000000000180. [PMID: 24675414] - Ann-Kathrin Schoenfeld, Simone Vierfuß, Susanne Lühn, Susanne Alban. Testing of potential glycan-based heparanase inhibitors in a fluorescence activity assay using either bacterial heparinase II or human heparanase.
Journal of pharmaceutical and biomedical analysis.
2014 Jul; 95(?):130-8. doi:
10.1016/j.jpba.2014.02.021. [PMID: 24667567] - Peng Huang, Yuanjie Zou, Xi Zoë Zhong, Qi Cao, Kexin Zhao, Michael X Zhu, Ruth Murrell-Lagnado, Xian-Ping Dong. P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH.
The Journal of biological chemistry.
2014 Jun; 289(25):17658-67. doi:
10.1074/jbc.m114.552158. [PMID: 24817123] - J C Naviaux, M A Schuchbauer, K Li, L Wang, V B Risbrough, S B Powell, R K Naviaux. Reversal of autism-like behaviors and metabolism in adult mice with single-dose antipurinergic therapy.
Translational psychiatry.
2014 Jun; 4(?):e400. doi:
10.1038/tp.2014.33. [PMID: 24937094] - Wen Liu, Mei-Juan Cai, Chuan-Chuan Zheng, Jin-Xing Wang, Xiao-Fan Zhao. Phospholipase Cγ1 connects the cell membrane pathway to the nuclear receptor pathway in insect steroid hormone signaling.
The Journal of biological chemistry.
2014 May; 289(19):13026-41. doi:
10.1074/jbc.m113.547018. [PMID: 24692553] - Ahmed Tayel, Khaled H Abd El Galil, Mohamed A Ebrahim, Ahmed S Ibrahim, Amal M El-Gayar, Mohammed M H Al-Gayyar. Suramin inhibits hepatic tissue damage in hepatocellular carcinoma through deactivation of heparanase enzyme.
European journal of pharmacology.
2014 Apr; 728(?):151-60. doi:
10.1016/j.ejphar.2014.02.001. [PMID: 24530413] - Hans-Juergen Raatschen, Susanne Fischer, Benjamin Zsivcsec, Christian-Olaf Schoenfeld, Birgit Hotz, Heinz J Buhr, Hubert G Hotz. Non-invasive quantification of anti-angiogenic therapy by contrast-enhanced MRI in experimental pancreatic cancer.
Acta radiologica (Stockholm, Sweden : 1987).
2014 Mar; 55(2):131-9. doi:
10.1177/0284185113493776. [PMID: 23892234] - Hui-ping Zhang, Cui-ling Li, Peng Lu, Jia-cui Zheng, Li-li Yu, Wei-min Yang, Fei Xiong, Xiao-yong Zeng. The function of P2X3 receptor and NK1 receptor antagonists on cyclophosphamide-induced cystitis in rats.
World journal of urology.
2014 Feb; 32(1):91-7. doi:
10.1007/s00345-013-1098-z. [PMID: 23666265] - Nergiz Hacer Turgut, Tijen Kaya Temiz, Bülent Turgut, Baris Karadas, Mesut Parlak, Ihsan Bagcivan. Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Canadian journal of physiology and pharmacology.
2013 Oct; 91(10):797-803. doi:
10.1139/cjpp-2013-0086. [PMID: 24144050] - Pei-Rong Wang. Mouse adult renal progenitor cells in combination with erythropoietin or suramin--a potential new strategy for the treatment of acute kidney injury.
Stem cell research & therapy.
2013 Jul; 4(4):89. doi:
10.1186/scrt274. [PMID: 23899649] - Xiao Han, Li Zhao, Guodong Lu, Junke Ge, Yalin Zhao, Shulu Zu, Mingzhen Yuan, Yuqiang Liu, Feng Kong, Zhiying Xiao, Shengtian Zhao. Improving outcomes of acute kidney injury using mouse renal progenitor cells alone or in combination with erythropoietin or suramin.
Stem cell research & therapy.
2013 Jun; 4(3):74. doi:
10.1186/scrt225. [PMID: 23777889] - Camila Z El-Kik, Fabrício F A Fernandes, Marcelo Amorim Tomaz, Glauco A Gaban, Tatiane F Fonseca, Sabrina Calil-Elias, Suellen D S Oliveira, Claudia L M Silva, Ana Maria Blanco Martinez, Paulo A Melo. Neutralization of Apis mellifera bee venom activities by suramin.
Toxicon : official journal of the International Society on Toxinology.
2013 Jun; 67(?):55-62. doi:
10.1016/j.toxicon.2013.02.007. [PMID: 23474269] - Songqing He, Hasibur Rehman, Yanjun Shi, Yasodha Krishnasamy, John J Lemasters, Rick G Schnellmann, Zhi Zhong. Suramin decreases injury and improves regeneration of ethanol-induced steatotic partial liver grafts.
The Journal of pharmacology and experimental therapeutics.
2013 Feb; 344(2):417-25. doi:
10.1124/jpet.112.199919. [PMID: 23161217] - Hayato Sakaki, Mitsutoshi Tsukimoto, Hitoshi Harada, Yoshinori Moriyama, Shuji Kojima. Autocrine regulation of macrophage activation via exocytosis of ATP and activation of P2Y11 receptor.
PloS one.
2013; 8(4):e59778. doi:
10.1371/journal.pone.0059778. [PMID: 23577075] - Midhun C Korrapati, Lauren A Howell, Lauren H Howell, Brooke E Shaner, Judit K Megyesi, Leah J Siskind, Rick G Schnellmann. Suramin: a potential therapy for diabetic nephropathy.
PloS one.
2013; 8(9):e73655. doi:
10.1371/journal.pone.0073655. [PMID: 24040012] - Mohamed Izikki, Olaf Mercier, Florence Lecerf, Lauriane Lubert Guin, Eric Hoang, Peter Dorfmüller, Frédéric Perros, Marc Humbert, Gerald Simonneau, Philippe Dartevelle, Elie Fadel, Saadia Eddahibi. The beneficial effect of suramin on monocrotaline-induced pulmonary hypertension in rats.
PloS one.
2013; 8(10):e77073. doi:
10.1371/journal.pone.0077073. [PMID: 24143201] - M C Ribeiro, M S Costa-Alves, M Wengert, J R Meyer-Fernandes, P Zancan, C Caruso-Neves, A A S Pinheiro. Characterization of ecto-ATPase activity in the surface of LLC-PK1 cells and its modulation by ischemic conditions.
Biochimica et biophysica acta.
2012 Dec; 1820(12):2030-6. doi:
10.1016/j.bbagen.2012.09.009. [PMID: 23000490] - Midhun C Korrapati, Brooke E Shaner, Benjamin A Neely, Joseph L Alge, John M Arthur, Rick G Schnellmann. Diabetes-induced renal injury in rats is attenuated by suramin.
The Journal of pharmacology and experimental therapeutics.
2012 Oct; 343(1):34-43. doi:
10.1124/jpet.112.196964. [PMID: 22736507] - Maryam B Lustberg, Shubham Pant, Amy S Ruppert, Tong Shen, Yong Wei, Ling Chen, Lisa Brenner, Donna Shiels, Rhonda R Jensen, Michael Berger, Ewa Mrozek, Bhuvaneswari Ramaswamy, Michael Grever, Jessie L Au, M Guillaume Wientjes, Charles L Shapiro. Phase I/II trial of non-cytotoxic suramin in combination with weekly paclitaxel in metastatic breast cancer treated with prior taxanes.
Cancer chemotherapy and pharmacology.
2012 Jul; 70(1):49-56. doi:
10.1007/s00280-012-1887-x. [PMID: 22729159] - Jian Sun, Chun-Lan Zhang, Shu-Rong Deng, Cun-Fu Lu, Xin Shen, Xiao-Yang Zhou, Xiao-Jiang Zheng, Zan-Min Hu, Shao-Liang Chen. An ATP signalling pathway in plant cells: extracellular ATP triggers programmed cell death in Populus euphratica.
Plant, cell & environment.
2012 May; 35(5):893-916. doi:
10.1111/j.1365-3040.2011.02461.x. [PMID: 22070751] - Midhun C Korrapati, Brooke E Shaner, Rick G Schnellmann. Recovery from glycerol-induced acute kidney injury is accelerated by suramin.
The Journal of pharmacology and experimental therapeutics.
2012 Apr; 341(1):126-36. doi:
10.1124/jpet.111.190249. [PMID: 22228809] - Sam Alsford, Sabine Eckert, Nicola Baker, Lucy Glover, Alejandro Sanchez-Flores, Ka Fai Leung, Daniel J Turner, Mark C Field, Matthew Berriman, David Horn. High-throughput decoding of antitrypanosomal drug efficacy and resistance.
Nature.
2012 Jan; 482(7384):232-6. doi:
10.1038/nature10771. [PMID: 22278056] - Debasis Sahu, Ashish Saroha, Saugata Roy, Sandip Das, Prem S Srivastava, Hasi R Das. Suramin ameliorates collagen induced arthritis.
International immunopharmacology.
2012 Jan; 12(1):288-93. doi:
10.1016/j.intimp.2011.12.003. [PMID: 22178418] - Ngozichukwuka Peace Igoli, Zak Ahamefula Obanu, Alexander I Gray, Carol Clements. Bioactive diterpenes and sesquiterpenes from the rhizomes of wild ginger (Siphonochilus aethiopicus (Schweinf) B.L Burtt).
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2012; 9(1):88-93. doi:
10.4314/ajtcam.v9i1.13. [PMID: 23983325] - Na Liu, Song He, Evelyn Tolbert, Rujun Gong, George Bayliss, Shougang Zhuang. Suramin alleviates glomerular injury and inflammation in the remnant kidney.
PloS one.
2012; 7(4):e36194. doi:
10.1371/journal.pone.0036194. [PMID: 22558380] - Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Omura, Haruki Yamada. In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei.
Phytochemistry.
2011 Nov; 72(16):2024-30. doi:
10.1016/j.phytochem.2011.07.015. [PMID: 21843897] - Christian Winter, Nicole B Kampik, Luca Vedovelli, Florina Rothenberger, Teodor G Paunescu, Paul A Stehberger, Dennis Brown, Hubert John, Carsten A Wagner. Aldosterone stimulates vacuolar H(+)-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.
American journal of physiology. Cell physiology.
2011 Nov; 301(5):C1251-61. doi:
10.1152/ajpcell.00076.2011. [PMID: 21832245] - Na Liu, Evelyn Tolbert, Murugavel Ponnusamy, Haidong Yan, Shougang Zhuang. Delayed administration of suramin attenuates the progression of renal fibrosis in obstructive nephropathy.
The Journal of pharmacology and experimental therapeutics.
2011 Sep; 338(3):758-66. doi:
10.1124/jpet.111.181727. [PMID: 21622732] - Na Liu, Evelyn Tolbert, Maoyin Pang, Murugavel Ponnusamy, Haidong Yan, Shougang Zhuang. Suramin inhibits renal fibrosis in chronic kidney disease.
Journal of the American Society of Nephrology : JASN.
2011 Jun; 22(6):1064-75. doi:
10.1681/asn.2010090956. [PMID: 21617121] - Na Liu, Shougang Zhuang. Tissue protective and anti-fibrotic actions of suramin: new uses of an old drug.
Current clinical pharmacology.
2011 May; 6(2):137-42. doi:
10.2174/157488411796151174. [PMID: 21470104] - Lay-Jing Seow, Hooi-Kheng Beh, Amin Malik Shah Abdul Majid, Vikneswaran Murugaiyah, Norhayati Ismail, Mohd Zaini Asmawi. Anti-angiogenic activity of Gynura segetum leaf extracts and its fractions.
Journal of ethnopharmacology.
2011 Mar; 134(2):221-7. doi:
10.1016/j.jep.2010.12.007. [PMID: 21167271] - Cornelia Wiese, Teodora Nikolova, Ihor Zahanich, Sabine Sulzbacher, Joerg Fuchs, Satoshi Yamanaka, Eva Graf, Ursula Ravens, Kenneth R Boheler, Anna M Wobus. Differentiation induction of mouse embryonic stem cells into sinus node-like cells by suramin.
International journal of cardiology.
2011 Feb; 147(1):95-111. doi:
10.1016/j.ijcard.2009.08.021. [PMID: 19775764] - Andrew Yu, Brandon Shepherd, Meghan Wagner, Jamie Clapper, Joan M Esson. Development of polymer-membrane based electrodes for suramin.
Analytica chimica acta.
2011 Feb; 686(1-2):76-80. doi:
10.1016/j.aca.2010.11.032. [PMID: 21237310] - Jurgen Schnermann. Maintained tubuloglomerular feedback responses during acute inhibition of P2 purinergic receptors in mice.
American journal of physiology. Renal physiology.
2011 Feb; 300(2):F339-44. doi:
10.1152/ajprenal.00637.2010. [PMID: 21147842] - Leijun Hu, M Guillaume Wientjes, Jing Li, Jessie L-S Au. Bladder tissue pharmacokinetics of intravesical mitomycin C and suramin in dogs.
The AAPS journal.
2010 Dec; 12(4):586-91. doi:
10.1208/s12248-010-9219-8. [PMID: 20625863] - Elaine T Lam, Jessie L-S Au, Gregory A Otterson, M Guillaume Wientjes, Ling Chen, Tong Shen, Yong Wei, Xiaobai Li, Tanios Bekaii-Saab, Anthony J Murgo, Rhonda R Jensen, Michael Grever, Miguel A Villalona-Calero. Phase I trial of non-cytotoxic suramin as a modulator of docetaxel and gemcitabine therapy in previously treated patients with non-small cell lung cancer.
Cancer chemotherapy and pharmacology.
2010 Nov; 66(6):1019-29. doi:
10.1007/s00280-010-1252-x. [PMID: 20107799] - Markus Tölle, Mirjam Schuchardt, Annette Wiedon, Tao Huang, Lars Klöckel, Joachim Jankowski, Vera Jankowski, Walter Zidek, Markus van der Giet. Differential effects of uridine adenosine tetraphosphate on purinoceptors in the rat isolated perfused kidney.
British journal of pharmacology.
2010 Oct; 161(3):530-40. doi:
10.1111/j.1476-5381.2010.00914.x. [PMID: 20880394] - Hui Wang, Donna H Wang, James J Galligan. P2Y2 receptors mediate ATP-induced resensitization of TRPV1 expressed by kidney projecting sensory neurons.
American journal of physiology. Regulatory, integrative and comparative physiology.
2010 Jun; 298(6):R1634-41. doi:
10.1152/ajpregu.00235.2009. [PMID: 20335377] - Maksym I Harhun, Oleksandr V Povstyan, Dmitri V Gordienko. Purinoreceptor-mediated current in myocytes from renal resistance arteries.
British journal of pharmacology.
2010 Jun; 160(4):987-97. doi:
10.1111/j.1476-5381.2010.00714.x. [PMID: 20590593] - Kiymet Bozaoglu, Joanne E Curran, Claire J Stocker, Mohamed S Zaibi, David Segal, Nicky Konstantopoulos, Shona Morrison, Melanie Carless, Thomas D Dyer, Shelley A Cole, Harald H H Goring, Eric K Moses, Ken Walder, Michael A Cawthorne, John Blangero, Jeremy B M Jowett. Chemerin, a novel adipokine in the regulation of angiogenesis.
The Journal of clinical endocrinology and metabolism.
2010 May; 95(5):2476-85. doi:
10.1210/jc.2010-0042. [PMID: 20237162] - Sonja Buvinic, Gonzalo Almarza, Mario Bustamante, Mariana Casas, Javiera López, Manuel Riquelme, Juan Carlos Sáez, Juan Pablo Huidobro-Toro, Enrique Jaimovich. ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle.
The Journal of biological chemistry.
2009 Dec; 284(50):34490-505. doi:
10.1074/jbc.m109.057315. [PMID: 19822518] - Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo. Spontaneous oscillations in intracellular Ca(2+) concentration via purinergic receptors elicit transient cell swelling in rat parotid ducts.
American journal of physiology. Gastrointestinal and liver physiology.
2009 Dec; 297(6):G1198-205. doi:
10.1152/ajpgi.00168.2009. [PMID: 19779019] - H A Praetorius, J Leipziger. Released nucleotides amplify the cilium-dependent, flow-induced [Ca2+]i response in MDCK cells.
Acta physiologica (Oxford, England).
2009 Nov; 197(3):241-51. doi:
10.1111/j.1748-1716.2009.02002.x. [PMID: 19432587] - Guillermo B Silva, Jeffrey L Garvin. Extracellular ATP inhibits transport in medullary thick ascending limbs: role of P2X receptors.
American journal of physiology. Renal physiology.
2009 Nov; 297(5):F1168-73. doi:
10.1152/ajprenal.00325.2009. [PMID: 19710240] - Antonina Kolmakova, Mohanraj Rajesh, David Zang, Roberto Pili, Subroto Chatterjee. VEGF recruits lactosylceramide to induce endothelial cell adhesion molecule expression and angiogenesis in vitro and in vivo.
Glycoconjugate journal.
2009 Jul; 26(5):547-58. doi:
10.1007/s10719-008-9206-9. [PMID: 19219548] - C Sigalas, S Bent, A Kitmitto, S O'Neill, R Sitsapesan. Ca(2+)-calmodulin can activate and inactivate cardiac ryanodine receptors.
British journal of pharmacology.
2009 Mar; 156(5):794-806. doi:
10.1111/j.1476-5381.2008.00092.x. [PMID: 19220289] - Shougang Zhuang, Bo Lu, Rebecca A Daubert, Kenneth D Chavin, Liquan Wang, Rick G Schnellmann. Suramin promotes recovery from renal ischemia/reperfusion injury in mice.
Kidney international.
2009 Feb; 75(3):304-11. doi:
10.1038/ki.2008.506. [PMID: 18843260] - Akiko Shitara, Akihiko Tanimura, Atsuko Sato, Yosuke Tojyo. Spontaneous Ca2+ oscillations via purinergic receptors elicit transient cell swelling in rat parotid ducts.
The journal of medical investigation : JMI.
2009; 56 Suppl(?):377-80. doi:
10.2152/jmi.56.377. [PMID: 20224231] - M A Villalona-Calero, G A Otterson, M G Wientjes, F Weber, T Bekaii-Saab, D Young, A J Murgo, R Jensen, T-K Yeh, Y Wei, Y Zhang, C Eng, M Grever, J L-S Au. Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study.
Annals of oncology : official journal of the European Society for Medical Oncology.
2008 Nov; 19(11):1903-9. doi:
10.1093/annonc/mdn412. [PMID: 18632723] - Joan A Sim, Helen E Broomhead, R Alan North. Ectodomain lysines and suramin block of P2X1 receptors.
The Journal of biological chemistry.
2008 Oct; 283(44):29841-6. doi:
10.1074/jbc.m802523200. [PMID: 18765669] - Saby George, Robert Dreicer, Jessie J L Au, Tong Shen, Brian I Rini, Susan Roman, Matthew M Cooney, Tarek Mekhail, Paul Elson, Guillaume M Wientjes, Ram Ganapathi, Ronald M Bukowski. Phase I/II trial of 5-fluorouracil and a noncytotoxic dose level of suramin in patients with metastatic renal cell carcinoma.
Clinical genitourinary cancer.
2008 Sep; 6(2):79-85. doi:
10.3816/cgc.2008.n.012. [PMID: 18824429] - Fiona Hanner, Julia von Maltzahn, Stephan Maxeiner, Ildiko Toma, Arnold Sipos, Olaf Krüger, Klaus Willecke, János Peti-Peterdi. Connexin45 is expressed in the juxtaglomerular apparatus and is involved in the regulation of renin secretion and blood pressure.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Aug; 295(2):R371-80. doi:
10.1152/ajpregu.00468.2007. [PMID: 18579650] - Gennady G Yegutkin, Joachim Jankowski, Sirpa Jalkanen, Thomas Günthner, Walter Zidek, Vera Jankowski. Dinucleotide polyphosphates contribute to purinergic signalling via inhibition of adenylate kinase activity.
Bioscience reports.
2008 Aug; 28(4):189-94. doi:
10.1042/bsr20080052. [PMID: 18576946] - Nergiz Hacer Turgut, Tijen Kaya Temiz, Ihsan Bagcivan, Bulent Turgut, Sefa Gulturk, Baris Karadas. The effect of sildenafil on the altered thoracic aorta smooth muscle responses in rat pre-eclampsia model.
European journal of pharmacology.
2008 Jul; 589(1-3):180-7. doi:
10.1016/j.ejphar.2008.04.034. [PMID: 18538317] - Stephen A Kempson, Jason M Edwards, Alyssa Osborn, Michael Sturek. Acute inhibition of the betaine transporter by ATP and adenosine in renal MDCK cells.
American journal of physiology. Renal physiology.
2008 Jul; 295(1):F108-17. doi:
10.1152/ajprenal.00108.2008. [PMID: 18448594] - Ildikó Toma, Eric Bansal, Elliott J Meer, Jung Julie Kang, Sarah L Vargas, János Peti-Peterdi. Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Jun; 294(6):R1769-76. doi:
10.1152/ajpregu.00489.2007. [PMID: 18401004] - Caroline Martin, Soren U Nielsen, Siti Ibrahim, Margaret F Bassendine, Geoffrey L Toms. Binding of liver derived, low density hepatitis C virus to human hepatoma cells.
Journal of medical virology.
2008 May; 80(5):816-23. doi:
10.1002/jmv.21150. [PMID: 18360895] - Frank C Lanfermeijer, Marten Staal, Robert Malinowski, Johannes W Stratmann, J Theo M Elzenga. Micro-electrode flux estimation confirms that the Solanum pimpinellifolium cu3 mutant still responds to systemin.
Plant physiology.
2008 Jan; 146(1):129-39. doi:
10.1104/pp.107.110643. [PMID: 18055585] - Lishuang Cao, Mark T Young, Helen E Broomhead, Samuel J Fountain, R Alan North. Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Nov; 27(47):12916-23. doi:
10.1523/jneurosci.4036-07.2007. [PMID: 18032665] - Mercedes N Munkonda, Gilles Kauffenstein, Filip Kukulski, Sébastien A Lévesque, Charlène Legendre, Julie Pelletier, Elise G Lavoie, Joanna Lecka, Jean Sévigny. Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.
Biochemical pharmacology.
2007 Nov; 74(10):1524-34. doi:
10.1016/j.bcp.2007.07.033. [PMID: 17727821] - Shilpa Ramani, Jayabaskaran Chelliah. UV-B-induced signaling events leading to enhanced-production of catharanthine in Catharanthus roseus cell suspension cultures.
BMC plant biology.
2007 Nov; 7(?):61. doi:
10.1186/1471-2229-7-61. [PMID: 17988378]
