SL-327 (BioDeep_00000706542)
代谢物信息卡片
化学式: C16H12F3N3S (335.0703988)
中文名称: SL327
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F
InChI: InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+
描述信息
SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively.
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:92211
- PubChem: 9549284
- CAS: 297744-39-9
- CAS: 305350-87-2
- medchemexpress: HY-15437
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Charles-Andrew Vande Catsyne, Sufyan Ali Sayyed, Patricia Molina-Ortiz, Bastien Moes, David Communi, Joséphine Muller, Roy Heusschen, Jo Caers, Abdelhalim Azzi, Christophe Erneux, Stéphane Schurmans. Altered chondrocyte differentiation, matrix mineralization and MEK-Erk1/2 signaling in an INPPL1 catalytic knock-out mouse model of opsismodysplasia.
Advances in biological regulation.
2020 05; 76(?):100651. doi:
10.1016/j.jbior.2019.100651. [PMID: 31519471] - Ji-Woon Kim, Mee Jung Ko, Edson Luck Gonzales, Ri Jin Kang, Do Gyeong Kim, Yujeong Kim, Hana Seung, Hyun A Oh, Pyeong Hwa Eun, Chan Young Shin. Social support rescues acute stress-induced cognitive impairments by modulating ERK1/2 phosphorylation in adolescent mice.
Scientific reports.
2018 08; 8(1):12003. doi:
10.1038/s41598-018-30524-4. [PMID: 30104581] - Cheng-Fu Li, Shao-Mei Chen, Xue-Mei Chen, Rong-Hao Mu, Shuang-Shuang Wang, Di Geng, Qing Liu, Li-Tao Yi. ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress.
Brain research bulletin.
2016 06; 124(?):40-7. doi:
10.1016/j.brainresbull.2016.03.016. [PMID: 27018164] - E Martínez-Laorden, M A Hurle, M V Milanés, M L Laorden, P Almela. Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.
The Journal of pharmacology and experimental therapeutics.
2012 Sep; 342(3):665-75. doi:
10.1124/jpet.112.193581. [PMID: 22647273] - Robert S Bitner, William H Bunnelle, David J Anderson, Clark A Briggs, Jerry Buccafusco, Peter Curzon, Michael W Decker, Jennifer M Frost, Jens Halvard Gronlien, Earl Gubbins, Jinhe Li, John Malysz, Stella Markosyan, Kennan Marsh, Michael D Meyer, Arthur L Nikkel, Richard J Radek, Holly M Robb, Daniel Timmermann, James P Sullivan, Murali Gopalakrishnan. Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2007 Sep; 27(39):10578-87. doi:
10.1523/jneurosci.2444-07.2007. [PMID: 17898229]
