SKF 86002 (BioDeep_00000706528)
代谢物信息卡片
6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
化学式: C16H12FN3S (297.07359240000005)
中文名称: 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChI: InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
D004791 - Enzyme Inhibitors
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Liangxian Cao, Marla Weetall, Christopher Trotta, Katherine Cintron, Jiyuan Ma, Min Jung Kim, Bansri Furia, Charles Romfo, Jason D Graci, Wencheng Li, Joshua Du, Josephine Sheedy, Jean Hedrick, Nicole Risher, Shirley Yeh, Hongyan Qi, Tamil Arasu, Seongwoo Hwang, William Lennox, Ronald Kong, Janet Petruska, Young-Choon Moon, John Babiak, Thomas W Davis, Allan Jacobson, Neil G Almstead, Art Branstrom, Joseph M Colacino, Stuart W Peltz. Targeting of Hematologic Malignancies with PTC299, A Novel Potent Inhibitor of Dihydroorotate Dehydrogenase with Favorable Pharmaceutical Properties.
Molecular cancer therapeutics.
2019 01; 18(1):3-16. doi:
10.1158/1535-7163.mct-18-0863. [PMID: 30352802] - Marla Weetall, Thomas Davis, Gary Elfring, Valerie Northcutt, Liangxian Cao, Young-Choon Moon, Peter Riebling, Mandar Dali, Samit Hirawat, John Babiak, Joseph Colacino, Neil Almstead, Robert Spiegel, Stuart W Peltz. Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation.
Clinical pharmacology in drug development.
2016 Jul; 5(4):296-305. doi:
10.1002/cpdd.240. [PMID: 27310330] - Rachel A Bender Ignacio, Jeannette Y Lee, Michelle A Rudek, Dirk P Dittmer, Richard F Ambinder, Susan E Krown. Brief Report: A Phase 1b/Pharmacokinetic Trial of PTC299, a Novel PostTranscriptional VEGF Inhibitor, for AIDS-Related Kaposi's Sarcoma: AIDS Malignancy Consortium Trial 059.
Journal of acquired immune deficiency syndromes (1999).
2016 May; 72(1):52-7. doi:
10.1097/qai.0000000000000918. [PMID: 26689971] - Jin Lee, Kye-Taek Lim. Expression of TNF-alpha and IL-6 in HMC-1 cells treated with bisphenol A is attenuated by plant-originating glycoprotein (75 kDa) by blocking p38 MAPK.
Naunyn-Schmiedeberg's archives of pharmacology.
2010 Jul; 382(1):51-61. doi:
10.1007/s00210-010-0527-4. [PMID: 20499049] - Ganesan Ramesh, W Brian Reeves. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice.
American journal of physiology. Renal physiology.
2005 Jul; 289(1):F166-74. doi:
10.1152/ajprenal.00401.2004. [PMID: 15701814] - B Schnyder, P C Meunier, B D Car. Inhibition of kinases impairs neutrophil activation and killing of Staphylococcus aureus.
The Biochemical journal.
1998 Apr; 331 ( Pt 2)(?):489-95. doi:
10.1042/bj3310489. [PMID: 9531489] - M Pouliot, J Baillargeon, J C Lee, L G Cleland, M J James. Inhibition of prostaglandin endoperoxide synthase-2 expression in stimulated human monocytes by inhibitors of p38 mitogen-activated protein kinase.
Journal of immunology (Baltimore, Md. : 1950).
1997 May; 158(10):4930-7. doi:
NULL. [PMID: 9144511] - E A Triplett, K T Kruse-Elliott, A P Hart, B R Schram, P S MacWilliams, A J Cooley, M K Clayton, B J Darien. SK&F 86002, a dual cytokine and eicosanoid inhibitor, attenuates endotoxin-induced cardiopulmonary dysfunction in the pig.
Shock (Augusta, Ga.).
1996 Nov; 6(5):357-64. doi:
10.1097/00024382-199611000-00010. [PMID: 8946652] - K B Glaser, Y W Lock. Regulation of prostaglandin H synthase 2 expression in human monocytes by the marine natural products manoalide and scalaradial. Novel effects independent of inhibition of lipid mediator production.
Biochemical pharmacology.
1995 Sep; 50(7):913-22. doi:
10.1016/0006-2952(95)00211-h. [PMID: 7575673] - D L Olivera, J T Laydon, L Hillegass, A M Badger, J C Lee. Effects of pyridinyl imidazole compounds on murine TNF-alpha production.
Agents and actions.
1993; 39 Spec No(?):C55-7. doi:
10.1007/bf01972719. [PMID: 8273586] - E F Smith, M J Slivjak, J O Bartus, K M Esser. SK&F 86002 inhibits tumor necrosis factor formation and improves survival in endotoxemic rats.
Journal of cardiovascular pharmacology.
1991 Nov; 18(5):721-8. doi:
10.1097/00005344-199111000-00010. [PMID: 1723769] - D E Griswold, E F Webb, L M Hillegass. Induction of plasma exudation and inflammatory cell infiltration by leukotriene C4 and leukotriene B4 in mouse peritonitis.
Inflammation.
1991 Aug; 15(4):251-8. doi:
10.1007/bf00917310. [PMID: 1663083] - B E Barton, L C James. The effect of dual inhibitor, SK&F 86002, on helper T cell functions.
Immunopharmacology and immunotoxicology.
1990; 12(1):105-21. doi:
10.3109/08923979009006464. [PMID: 2141033] - J F Newton, L P Yodis, D Keohane, R Eckardt, R Dewey, J Dent, B Mico. Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats.
Drug metabolism and disposition: the biological fate of chemicals.
1989 Mar; 17(2):174-9. doi:
NULL. [PMID: 2565207] - A M Badger, D Olivera, J E Talmadge, N Hanna. Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.
Circulatory shock.
1989 Jan; 27(1):51-61. doi:
NULL. [PMID: 2492908] - D E Griswold, L M Hillegass, P C Meunier, M J DiMartino, N Hanna. Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis.
Arthritis and rheumatism.
1988 Nov; 31(11):1406-12. doi:
10.1002/art.1780311110. [PMID: 3142488] - R F Walker, L W Schwartz, J M Manson. Ovarian effects of an anti-inflammatory-immunomodulatory drug in the rat.
Toxicology and applied pharmacology.
1988 Jun; 94(2):266-75. doi:
10.1016/0041-008x(88)90268-2. [PMID: 3388423] - R F Walker, L W Schwartz, T J Torphy, J F Newton, J M Manson. Ovarian effects of SK&F 86002-A2 in the rat: site of action.
Toxicology and applied pharmacology.
1988 Jun; 94(2):276-86. doi:
10.1016/0041-008x(88)90269-4. [PMID: 3388424]