SB-269970 (BioDeep_00000706523)

   


代谢物信息卡片


(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol

化学式: C18H28N2O3S (352.18205380000006)
中文名称: SB 269970盐酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCN(CC1)CCC2CCCN2S(=O)(=O)C3=CC=CC(=C3)O
InChI: InChI=1S/C18H28N2O3S/c1-15-7-11-19(12-8-15)13-9-16-4-3-10-20(16)24(22,23)18-6-2-5-17(21)14-18/h2,5-6,14-16,21H,3-4,7-13H2,1H3/t16-/m1/s1

描述信息

同义名列表

2 个代谢物同义名

(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol; SB-269970



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • I Cinar, Z Halici, B Dincer, B Sirin, E Cadirci. The role of 5-HT7 receptors on isoproterenol-induced myocardial infarction in rats with high-fat diet exacerbated coronary endothelial dysfunction. Human & experimental toxicology. 2020 Aug; 39(8):1005-1018. doi: 10.1177/0960327120916821. [PMID: 32329363]
  • Marwa Ahmed Amin Atallah, Samah M Elaidy, Mona K Tawfik. Assessment of the possible roles of SB-269970 versus ketanserin on carbon tetrachloride-induced liver fibrosis in rats: Oxidative stress/TGF-β1-induced HSCs activation pathway. Pharmacological reports : PR. 2018 Jun; 70(3):509-518. doi: 10.1016/j.pharep.2017.11.017. [PMID: 29660654]
  • Hyun Jung Kim, Guem San Lee, Hyungwoo Kim, Byung Joo Kim. Hwangryunhaedok-tang induces the depolarization of pacemaker potentials through 5-HT3 and 5-HT4 receptors in cultured murine small intestine interstitial cells of Cajal. World journal of gastroenterology. 2017 Aug; 23(29):5313-5323. doi: 10.3748/wjg.v23.i29.5313. [PMID: 28839431]
  • Konstantinos N Tzirogiannis, Kalliopi T Kourentzi, Sofia Zyga, Vassiliki Papalimneou, Maria Tsironi, Agni D Grypioti, Ioannis Protopsaltis, Dimitrios Panidis, Georgios I Panoutsopoulos. Effect of 5-HT7 receptor blockade on liver regeneration after 60-70\% partial hepatectomy. BMC gastroenterology. 2014 Nov; 14(?):201. doi: 10.1186/s12876-014-0201-2. [PMID: 25433672]
  • Lee Jae Dam, Lin Hai, Yoon Myung Ha. Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. Neuroscience letters. 2014 Apr; 566(?):50-4. doi: 10.1016/j.neulet.2014.02.021. [PMID: 24561091]
  • Elif Cadirci, Zekai Halici, Yasin Bayir, Abdulmecit Albayrak, Emre Karakus, Beyzagul Polat, Deniz Unal, Sabri S Atamanalp, Selina Aksak, Cemal Gundogdu. Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats. Immunobiology. 2013 Oct; 218(10):1271-83. doi: 10.1016/j.imbio.2013.04.012. [PMID: 23694713]
  • Kerry A Waters, Tania O Stean, Beverley Hammond, David J Virley, Neil Upton, James N C Kew, Ishrut Hussain. Effects of the selective 5-HT(7) receptor antagonist SB-269970 in animal models of psychosis and cognition. Behavioural brain research. 2012 Mar; 228(1):211-8. doi: 10.1016/j.bbr.2011.12.009. [PMID: 22189656]
  • Pascal Bonaventure, Leah Aluisio, James Shoblock, Jamin D Boggs, Ian C Fraser, Brian Lord, Timothy W Lovenberg, Ruggero Galici. Pharmacological blockade of serotonin 5-HT₇ receptor reverses working memory deficits in rats by normalizing cortical glutamate neurotransmission. PloS one. 2011; 6(6):e20210. doi: 10.1371/journal.pone.0020210. [PMID: 21701689]
  • Xiaojuan Wang, Yannan Fang, Jianbo Liang, Zhao Yin, Jiayin Miao, Ning Luo. Selective inhibition of 5-HT7 receptor reduces CGRP release in an experimental model for migraine. Headache. 2010 Apr; 50(4):579-87. doi: 10.1111/j.1526-4610.2010.01632.x. [PMID: 20236348]
  • Meredith A Fox, Catherine L Jensen, Helen T French, Alison R Stein, Su-Jan Huang, Teresa J Tolliver, Dennis L Murphy. Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. Psychopharmacology. 2008 Dec; 201(2):203-18. doi: 10.1007/s00213-008-1268-7. [PMID: 18712364]
  • E Louiset, K Isvi, J M Gasc, C Duparc, B Cauliez, A Laquerrière, J M Kuhn, H Lefebvre. Ectopic expression of serotonin7 receptors in an adrenocortical carcinoma co-secreting renin and cortisol. Endocrine-related cancer. 2008 Dec; 15(4):1025-34. doi: 10.1677/erc-08-0085. [PMID: 18708508]
  • Marcello Leopoldo, Enza Lacivita, Paola De Giorgio, Claudia Fracasso, Sara Guzzetti, Silvio Caccia, Marialessandra Contino, Nicola A Colabufo, Francesco Berardi, Roberto Perrone. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III. Journal of medicinal chemistry. 2008 Sep; 51(18):5813-22. doi: 10.1021/jm800615e. [PMID: 18800769]
  • Pascal Bonaventure, Lisa Kelly, Leah Aluisio, Jonathan Shelton, Brian Lord, Ruggero Galici, Kirsten Miller, John Atack, Timothy W Lovenberg, Christine Dugovic. Selective blockade of 5-hydroxytryptamine (5-HT)7 receptors enhances 5-HT transmission, antidepressant-like behavior, and rapid eye movement sleep suppression induced by citalopram in rodents. The Journal of pharmacology and experimental therapeutics. 2007 May; 321(2):690-8. doi: 10.1124/jpet.107.119404. [PMID: 17314195]
  • Benita Sjögren, Mark W Hamblin, Per Svenningsson. Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. European journal of pharmacology. 2006 Dec; 552(1-3):1-10. doi: 10.1016/j.ejphar.2006.08.069. [PMID: 17064686]
  • Céline Faure, Ouissame Mnie-Filali, Hélène Scarna, Guy Debonnel, Nasser Haddjeri. Effects of the 5-HT7 receptor antagonist SB-269970 on rat hormonal and temperature responses to the 5-HT1A/7 receptor agonist 8-OH-DPAT. Neuroscience letters. 2006 Aug; 404(1-2):122-6. doi: 10.1016/j.neulet.2006.05.023. [PMID: 16759802]
  • M Lai, J A McCormick, K E Chapman, P A T Kelly, J R Seckl, J L W Yau. Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture. Neuroscience. 2003; 118(4):975-84. doi: 10.1016/s0306-4522(03)00038-1. [PMID: 12732243]