MRS 1220 (BioDeep_00000706514)

   


代谢物信息卡片


N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide

化学式: C21H14ClN5O2 (403.0836)
中文名称: N-[9-CHLORO-2-(2-FURANYL)[1,2,4]-TRIAZOLO[1,5-C]QUINAZOLIN-5-YL]BENZENE ACETAMIDE
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(=O)NC2=NC3=C(C=C(C=C3)Cl)C4=NC(=NN42)C5=CC=CO5
InChI: InChI=1S/C21H14ClN5O2/c22-14-8-9-16-15(12-14)20-25-19(17-7-4-10-29-17)26-27(20)21(23-16)24-18(28)11-13-5-2-1-3-6-13/h1-10,12H,11H2,(H,23,24,28)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058914 - Purinergic Antagonists
MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system[1]. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo[2].

同义名列表

3 个代谢物同义名

N-(9-chloro-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-yl)-2-phenylacetamide; MRS 1220; MRS1220



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Eszter Kozma, P Suresh Jayasekara, Lucia Squarcialupi, Silvia Paoletta, Stefano Moro, Stephanie Federico, Giampiero Spalluto, Kenneth A Jacobson. Fluorescent ligands for adenosine receptors. Bioorganic & medicinal chemistry letters. 2013 Jan; 23(1):26-36. doi: 10.1016/j.bmcl.2012.10.112. [PMID: 23200243]
  • Zhan-Guo Gao, Soo-Kyung Kim, Thibaud Biadatti, Wangzhong Chen, Kyeong Lee, Dov Barak, Seong Gon Kim, Carl R Johnson, Kenneth A Jacobson. Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary. Journal of medicinal chemistry. 2002 Sep; 45(20):4471-84. doi: 10.1021/jm020211+. [PMID: 12238926]
  • Zhan-guo Gao, Kenneth A Jacobson. 2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor. European journal of pharmacology. 2002 May; 443(1-3):39-42. doi: 10.1016/s0014-2999(02)01552-2. [PMID: 12044789]
  • Seong Gon Kim, Gnana Ravi, Carsten Hoffmann, Yun Jin Jung, Min Kim, Aishe Chen, Kenneth A Jacobson. p53-Independent induction of Fas and apoptosis in leukemic cells by an adenosine derivative, Cl-IB-MECA. Biochemical pharmacology. 2002 Mar; 63(5):871-80. doi: 10.1016/s0006-2952(02)00839-0. [PMID: 11911839]
  • M S Mozaffari, W Abebe, B K Warren. Renal adenosine A3 receptors in the rat: assessment of functional role. Canadian journal of physiology and pharmacology. 2000 May; 78(5):428-32. doi: NULL. [PMID: 10841439]
  • R A Mittal, C H Tan, H E Khoo. Adenosine modulates cell growth in baby hamster kidney (BHK) cells. BioFactors (Oxford, England). 2000; 11(4):247-56. doi: 10.1002/biof.5520110403. [PMID: 11270505]
  • Y C Kim, M de Zwart, L Chang, S Moro, J K von Frijtag Drabbe Künzel, N Melman, A P IJzerman, K A Jacobson. Derivatives of the triazoloquinazoline adenosine antagonist (CGS 15943) having high potency at the human A2B and A3 receptor subtypes. Journal of medicinal chemistry. 1998 Jul; 41(15):2835-45. doi: 10.1021/jm980094b. [PMID: 9667972]
  • K A Jacobson, K S Park, J L Jiang, Y C Kim, M E Olah, G L Stiles, X D Ji. Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Neuropharmacology. 1997 Sep; 36(9):1157-65. doi: 10.1016/s0028-3908(97)00104-4. [PMID: 9364471]
  • J Jiang, A M van Rhee, L Chang, A Patchornik, X D Ji, P Evans, N Melman, K A Jacobson. Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists. Journal of medicinal chemistry. 1997 Aug; 40(16):2596-608. doi: 10.1021/jm970091j. [PMID: 9258367]
  • Y C Kim, X D Ji, K A Jacobson. Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype. Journal of medicinal chemistry. 1996 Oct; 39(21):4142-8. doi: 10.1021/jm960482i. [PMID: 8863790]