Landiolol (BioDeep_00000705648)

   


代谢物信息卡片


Landiolol

化学式: C25H39N3O8 (509.2737014)
中文名称: 羊毛二醇D4
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(OCC(O1)COC(=O)CCC2=CC=C(C=C2)OCC(CNCCNC(=O)N3CCOCC3)O)C
InChI: InChI=1S/C25H39N3O8/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31)/t20-,22+/m0/s1

描述信息

C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AB - Beta blocking agents, selective
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

1 个代谢物同义名

Landiolol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ranjit Lall, Dipesh Mistry, Emma Skilton, Nafisa Boota, Scott Regan, Julian Bion, Simon Gates, Anthony C Gordon, Janet Lord, Daniel Francis McAuley, Gavin Perkins, Mervyn Singer, Duncan Young, Tony Whitehouse. Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial. BMJ open. 2021 02; 11(2):e043194. doi: 10.1136/bmjopen-2020-043194. [PMID: 33593781]
  • Geoffroy Hariri, Tomas Urbina, Sandie Mazerand, Naike Bige, Jean-Luc Baudel, Hafid Ait-Oufella. Rate control in atrial fibrillation using Landiolol is safe in critically ill Covid-19 patients. Critical care (London, England). 2021 01; 25(1):33. doi: 10.1186/s13054-021-03470-3. [PMID: 33482867]
  • Günther Krumpl, Ivan Ulč, Michaela Trebs, Pavla Kadlecová, Juri Hodisch. Pharmacodynamic and pharmacokinetic behavior of landiolol during dobutamine challenge in healthy adults. BMC pharmacology & toxicology. 2020 11; 21(1):82. doi: 10.1186/s40360-020-00462-x. [PMID: 33239108]
  • Masayoshi Kiyokuni, Masaaki Konishi, Yusuke Saigusa, Kiwamu Iwata, Naoki Nakayama, Naohiro Komura, Teruyasu Sugano, Tomoaki Ishigami, Toshiyuki Ishikawa, Takeharu Yamanaka, Kouichi Tamura, Kazuo Kimura. Randomized controlled trial of landiolol, a short-acting beta-1 adrenergic receptor blocker, illustrating changes in high-molecular weight adiponectin levels after elective percutaneous coronary intervention. Heart and vessels. 2020 Nov; 35(11):1510-1517. doi: 10.1007/s00380-020-01637-6. [PMID: 32533314]
  • Teruhiko Imamura, Koichiro Kinugawa. Novel rate control strategy with landiolol in patients with cardiac dysfunction and atrial fibrillation. ESC heart failure. 2020 10; 7(5):2208-2213. doi: 10.1002/ehf2.12879. [PMID: 32666693]
  • Yujiro Matsuishi, Bryan J Mathis, Nobutake Shimojo, Satoru Kawano, Yoshiaki Inoue. Evaluating the Therapeutic Efficacy and Safety of Landiolol Hydrochloride for Management of Arrhythmia in Critical Settings: Review of the Literature. Vascular health and risk management. 2020; 16(?):111-123. doi: 10.2147/vhrm.s210561. [PMID: 32308404]
  • Natsue Kiyonaga, Takahiro Moriyama, Yuichi Kanmura. Effects of Landiolol in Lipopolysaccharide-Induced Acute Kidney Injury in Rats and In Vitro. Shock (Augusta, Ga.). 2019 11; 52(5):e117-e123. doi: 10.1097/shk.0000000000001306. [PMID: 30585987]
  • Yuta Horikoshi, Toru Goyagi, Ryohei Kudo, Sahoko Kodama, Takashi Horiguchi, Toshiaki Nishikawa. The suppressive effects of landiolol administration on the occurrence of postoperative atrial fibrillation and tachycardia, and plasma IL-6 elevation in patients undergoing esophageal surgery: A randomized controlled clinical trial. Journal of clinical anesthesia. 2017 May; 38(?):111-116. doi: 10.1016/j.jclinane.2017.01.036. [PMID: 28372647]
  • Yujiro Matsuishi, Subrina Jesmin, Satoru Kawano, Sakuramoto Hideaki, Nobutake Shimojo, Chishimba Nathan Mowa, Shila Akhtar, Sohel Zaedi, Tanzila Khatun, Yoshiya Tsunoda, Takumi Kiwamoto, Nobuyuki Hizawa, Yoshiaki Inoue, Taro Mizutani. Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1. Life sciences. 2016 Dec; 166(?):27-33. doi: 10.1016/j.lfs.2016.10.010. [PMID: 27742253]
  • Shahrooz Nasrollahi-Shirazi, Sonja Sucic, Qiong Yang, Michael Freissmuth, Christian Nanoff. Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions. The Journal of pharmacology and experimental therapeutics. 2016 10; 359(1):73-81. doi: 10.1124/jpet.116.232884. [PMID: 27451411]
  • Günther Krumpl, Ivan Ulc, Michaela Trebs, Pavla Kadlecová, Juri Hodisch. Pharmacokinetics and pharmacodynamics of two different landiolol formulations in a healthy Caucasian group. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 Sep; 92(?):64-73. doi: 10.1016/j.ejps.2016.06.022. [PMID: 27373605]
  • Keitaro Tachi, Shinji Takahashi, Makoto Tanaka. [Relationship between the Landiolol Dose and Urinary Catecholamine Metabolites in the Perioperative Management of Patients Undergoing Pheochromocytoma Resection]. Masui. The Japanese journal of anesthesiology. 2015 Dec; 64(12):1234-8. doi: . [PMID: 26790322]
  • Takayuki Kunisawa, Akio Yamagishi, Manabu Suno, Susumu Nakade, Ryunosuke Higashi, Atsushi Kurosawa, Ami Sugawara, Kazuo Matsubara, Hiroshi Iwasaki. Target-controlled infusion and population pharmacokinetics of landiolol hydrochloride in gynecologic patients. Journal of anesthesia. 2015 Apr; 29(2):198-205. doi: 10.1007/s00540-014-1908-5. [PMID: 25186494]
  • Yoshiyasu Ogura, Subrina Jesmin, Naoto Yamaguchi, Masami Oki, Nobutake Shimojo, Md Majedul Islam, Tanzila Khatun, Junko Kamiyama, Hideaki Sakuramoto, Keiichi Hagiya, Satoru Kawano, Taro Mizutani. Potential amelioration of upregulated renal HIF-1alpha-endothelin-1 system by landiolol hydrochloride in a rat model of endotoxemia. Life sciences. 2014 Nov; 118(2):347-56. doi: 10.1016/j.lfs.2014.05.007. [PMID: 24846832]
  • Yoshimoto Seki, Subrina Jesmin, Nobutake Shimojo, Md Majedul Islam, Md Arifur Rahman, Tanzila Khatun, Hideaki Sakuramoto, Masami Oki, Aiko Sonobe, Junko Kamiyama, Keiichi Hagiya, Satoru Kawano, Taro Mizutani. Significant reversal of cardiac upregulated endothelin-1 system in a rat model of sepsis by landiolol hydrochloride. Life sciences. 2014 Nov; 118(2):357-63. doi: 10.1016/j.lfs.2014.04.005. [PMID: 24735957]
  • Manabu Kitano, Nobuyasu Komasawa, Toshiyuki Sawai, Toshiaki Minami. [Successful anesthetic management of a patient with giant pheochromocytoma using high-dose landiolol hydrochloride]. Masui. The Japanese journal of anesthesiology. 2014 Aug; 63(8):898-900. doi: NULL. [PMID: 25199327]
  • Manabu Yoshimura, Takayuki Kunisawa, Takafumi Iida, Megumi Matsumoto, Hayato Takakai, Hirotsugu Kanda, Atsushi Kurosawa, Osamu Takahata, Hiroshi Iwasaki. Preoperative morphological analysis by transesophageal echocardiography and predictive value of plasma landiolol concentration during systolic anterior motion mitral valve repair : a report of three cases. Journal of anesthesia. 2014 Jun; 28(3):452-5. doi: 10.1007/s00540-013-1731-4. [PMID: 24162450]
  • Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J Paul Fawcett, Jingkai Gu, Limei Zhao. Determination of landiolol, an ultra-short-acting β₁-receptor antagonist, in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 891-892(?):7-11. doi: 10.1016/j.jchromb.2011.12.024. [PMID: 22418070]
  • Naoki Matsumoto, Tohru Aomori, Masafumi Kanamoto, Tadashi Usui, Tatsuya Shiga, Koujirou Yamamoto, Shigeru Saito. Influence of hemodynamic variations on the pharmacokinetics of landiolol in patients undergoing cardiovascular surgery. Biological & pharmaceutical bulletin. 2012; 35(10):1655-60. doi: 10.1248/bpb.b110727. [PMID: 22864018]
  • Satoki Inoue, Ryuichi Abe, Masahiko Kawaguchi, Hiroshi Kobayashi, Hitoshi Furuya. Metoclopramide does not prolong duration of action of landiolol attenuating the hemodynamic response to induction of anesthesia and tracheal intubation. Journal of anesthesia. 2010 Aug; 24(4):649-52. doi: 10.1007/s00540-010-0945-y. [PMID: 20454811]
  • Masahiko Kawaguchi, Kouji Utada, Kenji Yoshitani, Hiroyuki Uchino, Yoshimasa Takeda, Kenichi Masui, Takefumi Sakabe. Effects of a short-acting [beta]1 receptor antagonist landiolol on hemodynamics and tissue injury markers in patients with subarachnoid hemorrhage undergoing intracranial aneurysm surgery. Journal of neurosurgical anesthesiology. 2010 Jul; 22(3):230-9. doi: 10.1097/ana.0b013e3181d0c2e4. [PMID: 20118792]
  • Masahiro Uraoka, Yoshiki Nakajima, Tadayoshi Kurita, Akira Suzuki, Kotaro Takata, Shigehito Sato. Landiolol, an ultra short acting beta1-blocker, improves pulmonary edema after cardiopulmonary resuscitation with epinephrine in rats. Journal of anesthesia. 2010 Feb; 24(1):67-72. doi: 10.1007/s00540-009-0834-4. [PMID: 20039077]
  • Nao Tamada, Yohei Kasuya, Tomoko Yorozu, Takehiko Iijima, Yasuhide Iwao. [Case of thyroid crisis with persistent tachycardia diagnosed postoperatively]. Masui. The Japanese journal of anesthesiology. 2009 Dec; 58(12):1541-4. doi: NULL. [PMID: 20055204]
  • Manabu Suno, Takayuki Kunisawa, Akio Yamagishi, Takashi Ono, Joe Yamamoto, Takehiro Yamada, Yoshikazu Tasaki, Keiko Shimizu, Hiroshi Iwasaki, Kazuo Matsubara. Detection of landiolol using high-performance liquid chromatography/fluorescence: a blood esterase-sensitive ultra-short-acting beta(1)-receptor antagonist. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Jun; 877(16-17):1705-8. doi: 10.1016/j.jchromb.2009.04.017. [PMID: 19409865]
  • Satoshi Hagiwara, Hideo Iwasaka, Hayato Maeda, Takayuki Noguchi. Landiolol, an ultrashort-acting beta1-adrenoceptor antagonist, has protective effects in an LPS-induced systemic inflammation model. Shock (Augusta, Ga.). 2009 May; 31(5):515-20. doi: 10.1097/shk.0b013e3181863689. [PMID: 18791493]
  • Saori Kimura-Kurosawa, Noriaki Kanaya, Noriko Kamada, Naoyuki Hirata, Masayasu Nakayama, Akiyoshi Namiki. Cardioprotective effect and mechanism of action of landiolol on the ischemic reperfused heart. Journal of anesthesia. 2007; 21(4):480-9. doi: 10.1007/s00540-007-0558-2. [PMID: 18008115]
  • Makiko Sakanashi, Mayuko Sakanashi, Kazuhiro Sugahara, Matao Sakanashi. Effects of landiolol on mechanical and metabolic changes in rat reperfused ischaemic hearts. Clinical and experimental pharmacology & physiology. 2007 Jan; 34(1-2):55-60. doi: 10.1111/j.1440-1681.2007.04543.x. [PMID: 17201736]
  • Daisuke Takizawa, Shigeru Saito, Eri Sato, Haruhiko Hiraoka, Fumio Kunimoto, Fumio Goto. Influence of landiolol on the dose requirement of propofol for induction of anesthesia. Fundamental & clinical pharmacology. 2005 Oct; 19(5):597-9. doi: 10.1111/j.1472-8206.2005.00351.x. [PMID: 16176340]
  • Takenori Takahata, Norio Yasui-Furukori, Juichi Sakamoto, Koji Suto, Toshiyuki Suto, Tomonori Tateishi, Akihiro Munakata. Influence of hepatic impairment on the pharmacokinetics and pharmacodynamics of landiolol hydrochloride, an ultra-short-acting beta1-blocker. Drugs in R&D. 2005; 6(6):385-94. doi: 10.2165/00126839-200506060-00006. [PMID: 16274261]
  • Sachiko Imamura, Kyung-ho Chang, Yuuichiro Saitoh, Erika Sano, Tooru Akune, Kazuo Hanaoka. [The successful anesthetic management of a patient with pheochromocytoma using prostaglandin E1 and a novel, short-acting beta-adrenergic blocker: landiolol hydrochloride]. Masui. The Japanese journal of anesthesiology. 2004 Jul; 53(7):806-9. doi: . [PMID: 15298253]
  • S Takahashi, Y Fujii, T Hoshi, S Inomata, M Miyabe, H Toyooka. Modifications of the hemodynamic consequences of theophylline intoxication with landiolol in halothane-anesthetized dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2000 Mar; 47(3):265-72. doi: 10.1007/bf03018925. [PMID: 10730740]
  • S Takahashi, Y Fujii, S Inomata, M Miyabe, H Toyooka. Landiolol decreases a dysrhythmogenic dose of epinephrine in dogs during halothane anesthesia. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1999 Jun; 46(6):599-604. doi: 10.1007/bf03013554. [PMID: 10391611]
  • I Ahmet, N Fukushima, Y Sawa, T Masai, K Kadoba, K Kagisaki, J C Chang, T Yamaguchi, H Matsuda. The effects of a new ultra-short-acting beta-adrenergic blocker, ONO-1101, on cardiac function during and after cardiopulmonary bypass. Surgery today. 1999; 29(3):248-54. doi: 10.1007/bf02483015. [PMID: 10192736]
  • K Yamaguchi, H Yanagi, Y Shichino, K Shimizu, H Ueda, H Oida, M Tanaka, Y Suzuki, H Yonezawa, T Fujita. [Toxicity studies of landiolol hydrochloride (ONO-1101) (3). 4-week repeated dose intravenous toxicity study in dogs with 4-week recovery test]. The Journal of toxicological sciences. 1997 Dec; 22 Suppl 3(?):463-87. doi: 10.2131/jts.22.supplementiii_463. [PMID: 9483476]
  • K Yamaguchi, T Kasahara, Y Yanagisawa, T Nanba, Y Aze, K Shinomiya, H Yonezawa, T Fujita. [Toxicity studies of landiolol hydrochloride (ONO-1101) (1). Single intravenous toxicity study in rats and dogs]. The Journal of toxicological sciences. 1997 Dec; 22 Suppl 3(?):437-41. doi: 10.2131/jts.22.supplementiii_437. [PMID: 9483474]
  • K Yamaguchi, H Yanagi, K Shimizu, M Sakai, K Nishibata, H Oida, K Shinomiya, Y Suzuki, H Yonezawa, T Fujita. [Toxicity studies of landiolol hydrochloride (ONO-1101) (2). 4-week repeated dose intravenous toxicity study in rats with 4-week recovery test]. The Journal of toxicological sciences. 1997 Dec; 22 Suppl 3(?):443-61. doi: 10.2131/jts.22.supplementiii_443. [PMID: 9483475]