Carumonam (BioDeep_00000705529)
代谢物信息卡片
化学式: C12H14N6O10S2 (466.0213)
中文名称: 卡芦莫南
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(N=C(S1)N)C(=NOCC(=O)O)C(=O)NC2C(N(C2=O)S(=O)(=O)O)COC(=O)N
InChI: InChI=1S/C12H14N6O10S2/c13-11-15-4(3-29-11)7(17-28-2-6(19)20)9(21)16-8-5(1-27-12(14)23)18(10(8)22)30(24,25)26/h3,5,8H,1-2H2,(H2,13,15)(H2,14,23)(H,16,21)(H,19,20)(H,24,25,26)/b17-7-/t5-,8+/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DF - Monobactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
An N-sulfonated monobactam antibiotic.
同义名列表
2 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:55486
- KEGGdrug: D07625
- PubChem: 6540466
- DrugBank: DB13553
- ChEMBL: CHEMBL1614658
- CAS: 87638-04-8
- MetaboLights: MTBLC55486
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Nuggehally R Srinivas. Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Sep; 46(9):784-92. doi:
10.3109/00498254.2015.1121554. [PMID: 26711252] - Jürgen B Bulitta, Stephen B Duffull, Cornelia B Landersdorfer, Martina Kinzig, Ulrike Holzgrabe, Ulrich Stephan, George L Drusano, Fritz Sörgel. Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.
Diagnostic microbiology and infectious disease.
2009 Oct; 65(2):130-41. doi:
10.1016/j.diagmicrobio.2009.06.018. [PMID: 19748423] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - K Konishi, H Suzuki, T Saruta, N Deguchi, T Fugono. Pharmacokinetics of carumonam (AMA-1080) in patients with impaired renal function and in those undergoing hemodialysis.
Antimicrobial agents and chemotherapy.
1991 Jun; 35(6):1048-52. doi:
10.1128/aac.35.6.1048. [PMID: 1929242] - T Sonoda, E Nakano, T Seguchi, H Yano, H Kuroda, Y Ihara, T Kishimoto, H Takatera, S Mizutani, N Iwao. [Clinical evaluation of the combination of carumonam and cefotiam in the treatment of complicated urinary tract infection].
Hinyokika kiyo. Acta urologica Japonica.
1991 Feb; 37(2):203-9. doi:
NULL. [PMID: 2048503] - H Kakizaki, N Ishii, S Murakami, K Suzuki, A Takamizawa, J Hirano, K Mitobe, M Saito, K Hirano, A Imamura. [Clinical evaluation of the combination of carumonam and fosfomycin in the treatment of complicated urinary tract infection].
Hinyokika kiyo. Acta urologica Japonica.
1990 Jun; 36(6):731-5. doi:
NULL. [PMID: 2239570] - M Whitby, J Hempenstall, C Gilpin, L Weir, G Nimmo. Penetration of monobactam antibiotics (aztreonam, carumonam) into human prostatic tissue.
Chemotherapy.
1989; 35(1):7-11. doi:
10.1159/000238629. [PMID: 2721291] - I H Patel, P P Soni, R Portmann, K Suter, L Banken, E Weidekamm. Multiple intravenous dose pharmacokinetic study of carumonam in healthy subjects.
The Journal of antimicrobial chemotherapy.
1989 Jan; 23(1):107-11. doi:
10.1093/jac/23.1.107. [PMID: 2745245] - D Bérubé, F Vallée, A C Panneton, M G Bergeron, M LeBel. Pharmacokinetics of carumonam after single and multiple 1- and 2-g dosage regimens.
Antimicrobial agents and chemotherapy.
1988 Mar; 32(3):354-7. doi:
10.1128/aac.32.3.354. [PMID: 3364953] - E Veringa, A Box, M Rozenberg-Arska, J Verhoef. Monobactam antibiotics in subinhibitory concentrations enhance opsonophagocytosis and serum bacteriolysis in certain Escherichia coli strains.
Drugs under experimental and clinical research.
1988; 14(1):1-8. doi:
NULL. [PMID: 3292179] - Y Kita, A Imada. Mechanism of renal excretion of carumonam in rats, rabbits, dogs, and monkeys.
Antimicrobial agents and chemotherapy.
1987 Nov; 31(11):1692-6. doi:
10.1128/aac.31.11.1692. [PMID: 3435117] - H J Egger, G Fischer. Determination of the monocyclic beta-lactam antibiotic carumonam in plasma and urine by ion-pair and ion-suppression reversed-phase high-performance liquid chromatography.
Journal of chromatography.
1987 Sep; 420(2):357-72. doi:
10.1016/0378-4347(87)80191-3. [PMID: 3693507] - P Koeppe, D Höffler, K Strobel. Pharmacokinetics and dose recommendations of carumonam in renal failure.
Arzneimittel-Forschung.
1987 Jan; 37(1):65-9. doi:
NULL. [PMID: 3566860] - K Yoshida, M Mitani, I Naeshiro, H Torii, S Tanayama. Disposition of carumonam (AMA-1080/Ro 17-2301), a new N-sulfonated monocyclic beta-lactam, in rats and dogs.
Antimicrobial agents and chemotherapy.
1986 Jun; 29(6):1017-24. doi:
10.1128/aac.29.6.1017. [PMID: 3729358] - Y Kita, T Fugono, A Imada. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys.
Antimicrobial agents and chemotherapy.
1986 Jan; 29(1):127-34. doi:
10.1128/aac.29.1.127. [PMID: 3729325] - F Horber, H J Egger, E Weidekamm, U C Dubach, F J Frey, P J Probst, K Stoeckel. Pharmacokinetics of carumonam in patients with renal insufficiency.
Antimicrobial agents and chemotherapy.
1986 Jan; 29(1):116-21. doi:
10.1128/aac.29.1.116. [PMID: 3729324] - C A McNulty, G M Garden, J Ashby, R Wise. Pharmacokinetics and tissue penetration of carumonam, a new synthetic monobactam.
Antimicrobial agents and chemotherapy.
1985 Sep; 28(3):425-7. doi:
10.1128/aac.28.3.425. [PMID: 4073864] - R Wise, J M Andrews, L J Piddock. The in-vitro activity of Ro 17-2301, a new monobactam, compared with other antimicrobial agents.
The Journal of antimicrobial chemotherapy.
1985 Feb; 15(2):193-200. doi:
10.1093/jac/15.2.193. [PMID: 3980309] - P Angehrn. Antibacterial properties of carumonam (Ro 17-2301, AMA-1080), a new sulfonated monocyclic beta-lactam antibiotic.
Chemotherapy.
1985; 31(6):440-50. doi:
10.1159/000238372. [PMID: 3935396] - E Weidekamm, K Stoeckel, H J Egger, W H Ziegler. Single-dose pharmacokinetics of Ro 17-2301 (AMA-1080), a monocyclic beta-lactam, in humans.
Antimicrobial agents and chemotherapy.
1984 Dec; 26(6):898-902. doi:
10.1128/aac.26.6.898. [PMID: 6395801]
