10,12-TRICOSADIYNOIC ACID (BioDeep_00000704481)
代谢物信息卡片
化学式: C23H38O2 (346.28716479999997)
中文名称: 10,12-二十三联炔酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCC#CC#CCCCCCCCCC(=O)O
InChI: InChI=1S/C23H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23(24)25/h2-10,15-22H2,1H3,(H,24,25)
描述信息
10,12-Tricosadiynoic acid is a highly specific, selective, high affinity and orally active acyl-CoA oxidase-1 (ACOX1) inhibitor. 10,12-Tricosadiynoic acid can treat high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism[1]. 10,12-Tricosadiynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jia Zeng, Senwen Deng, Yiping Wang, Ping Li, Lian Tang, Yefeng Pang. Specific Inhibition of Acyl-CoA Oxidase-1 by an Acetylenic Acid Improves Hepatic Lipid and Reactive Oxygen Species (ROS) Metabolism in Rats Fed a High Fat Diet.
The Journal of biological chemistry.
2017 03; 292(9):3800-3809. doi:
10.1074/jbc.m116.763532. [PMID: 28077576] - Naing Tun Thet, William David Jamieson, Maisem Laabei, June D Mercer-Chalmers, A Toby A Jenkins. Photopolymerization of polydiacetylene in hybrid liposomes: effect of polymerization on stability and response to pathogenic bacterial toxins.
The journal of physical chemistry. B.
2014 May; 118(20):5418-27. doi:
10.1021/jp502586b. [PMID: 24806555] - Maria J Comin, Gabriella Czifra, Noemi Kedei, Andrea Telek, Nancy E Lewin, Sofiya Kolusheva, Julia F Velasquez, Ryan Kobylarz, Raz Jelinek, Peter M Blumberg, Victor E Marquez. Conformationally constrained analogues of diacylglycerol (DAG). 31. Modulation of the biological properties of diacylgycerol lactones (DAG-lactones) containing rigid-rod acyl groups separated from the core lactone by spacer units of different lengths.
Journal of medicinal chemistry.
2009 May; 52(10):3274-83. doi:
10.1021/jm900186m. [PMID: 19379015] - E C M Cabral, P T Hennies, C R D Correia, R L Zollner, M H A Santana. Preparation and characterization of diacetylene polymerized liposomes for detection of autoantibodies.
Journal of liposome research.
2003 Nov; 13(3-4):199-211. doi:
10.1081/lpr-120026387. [PMID: 14670227] - Sofiya Kolusheva, Ellen Wachtel, Raz Jelinek. Biomimetic lipid/polymer colorimetric membranes: molecular and cooperative properties.
Journal of lipid research.
2003 Jan; 44(1):65-71. doi:
10.1194/jlr.m200136-jlr200. [PMID: 12518024]