edoxaban tosylate (BioDeep_00000701990)
代谢物信息卡片
化学式: C31H38ClN7O7S2 (719.1962548000001)
中文名称: 伊多塞班对甲苯磺酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)S(=O)(=O)O.CN1CCC2=C(C1)SC(=N2)C(=O)NC3CC(CCC3NC(=O)C(=O)NC4=NC=C(C=C4)Cl)C(=O)N(C)C
InChI: /m0./s1
描述信息
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C173067 - Direct Factor Xa Inhibitor
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent > C180619 - Direct Oral Anticoagulant
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
D006401 - Hematologic Agents > D000925 - Anticoagulants > D000991 - Antithrombins
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:85975
- KEGGdrug: D11568
- PubChem: 44610678
- ChEMBL: CHEMBL2105682
- CAS: 480449-71-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yi-Hsin Chan, Tze-Fan Chao, Shao-Wei Chen, Hsin-Fu Lee, Pei-Ru Li, Yung-Hsin Yeh, Chi-Tai Kuo, Lai-Chu See, Gregory Y H Lip. Clinical Outcomes in Elderly Atrial Fibrillation Patients at Increased Bleeding Risk Treated with Very-Low-Dose versus Regular-Dose Non-Vitamin K Antagonist Oral Anticoagulants: a Nationwide Cohort Study.
European heart journal. Cardiovascular pharmacotherapy.
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10.1093/ehjcvp/pvad058
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Journal of diabetes and its complications.
2023 08; 37(8):108512. doi:
10.1016/j.jdiacomp.2023.108512
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Clinical pharmacology in drug development.
2022 05; 11(5):666-674. doi:
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. [PMID: 34877813] - Md Abdur Rashid, Saiqa Muneer, Yahya Alhamhoom, Nazrul Islam. Rapid Assay for the Therapeutic Drug Monitoring of Edoxaban.
Biomolecules.
2022 04; 12(4):. doi:
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Physiological reports.
2022 03; 10(5):e15218. doi:
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Circulation.
2022 03; 145(9):718-720. doi:
10.1161/circulationaha.121.057190
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Circulation journal : official journal of the Japanese Circulation Society.
2022 01; 86(2):280-286. doi:
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European review for medical and pharmacological sciences.
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Medicina clinica.
2021 12; 157(11):530-534. doi:
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2021 Dec; 22(11):924-928. doi:
10.2459/jcm.0000000000001204
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International journal of pharmaceutics.
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2021 Oct; 81(6):461-468. doi:
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Clinical pharmacokinetics.
2021 08; 60(8):1061-1071. doi:
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International journal of laboratory hematology.
2021 Aug; 43(4):795-801. doi:
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. [PMID: 34092030] - Luigi Cappannoli, Mattia Galli, Raimondo De Cristofaro, Filippo Crea, Domenico D'Amario. Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration?.
Journal of the American College of Cardiology.
2021 06; 77(25):3231-3232. doi:
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. [PMID: 34167650] - Jan Steffel, Christian T Ruff, Elliott M Antman, Eugene Braunwald, Robert P Giugliano. Reply: Do We Need to Define Therapeutic Ranges for Edoxaban Plasma Concentration?.
Journal of the American College of Cardiology.
2021 06; 77(25):3232-3233. doi:
10.1016/j.jacc.2021.04.066
. [PMID: 34167651] - Akira Sezai, Makoto Taoka, Shunji Osaka, Yoshiki Kitazumi, Keito Suzuki, Keita Kamata, Masashi Tanaka. A Comparative Prospective Observational Study on the Use of Direct Oral Anticoagulants after Cardiac Surgery for the Management of Atrial Fibrillation.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia.
2021 Jun; 27(3):191-199. doi:
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. [PMID: 33208579] - Martina Havrdová, Teijo I Saari, Jouko Jalonen, Marko Peltoniemi, Mika Kurkela, Tero Vahlberg, Anri Tienhaara, Janne T Backman, Klaus T Olkkola, Alexey Schramko. Relationship of Edoxaban Plasma Concentration and Blood Coagulation in Healthy Volunteers Using Standard Laboratory Tests and Viscoelastic Analysis.
Journal of clinical pharmacology.
2021 04; 61(4):522-530. doi:
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. [PMID: 33027547] - Yoshiyuki Morishima, Chikako Kamisato, Yuko Honda. Prolongation of clot lysis time by a direct thrombin inhibitor melagatran mediated by paradoxical enhancement of thrombin generation: comparison with a direct factor Xa inhibitor edoxaban.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2021 Apr; 32(3):209-215. doi:
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International journal of pharmaceutics.
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The American journal of cardiology.
2020 12; 136(?):71-75. doi:
10.1016/j.amjcard.2020.08.047
. [PMID: 32946856] - Sameh E Younis, Sara A El-Nahass, Mohammed A W Elkhatib, Sobhi A Soliman, Rasha M Youssef. Gradient HPLC-DAD method for quantification of novel oral anticoagulant 'Edoxaban' in plasma: Its selective determination in presence of sixteen co-administered drugs.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Dec; 1160(?):122386. doi:
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. [PMID: 32947189] - Noel Chan, Magdalena Sobieraj-Teague, John W Eikelboom. Direct oral anticoagulants: evidence and unresolved issues.
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Blood transfusion = Trasfusione del sangue.
2020 11; 18(6):478-485. doi:
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Thrombosis research.
2020 10; 194(?):116-118. doi:
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. [PMID: 32788102] - Alexandra A Angheloiu, Yanglan Tan, Cristian Ruse, Scott A Shaffer, George O Angheloiu. In-Vitro Sorbent-Mediated Removal of Edoxaban from Human Plasma and Albumin Solution.
Drugs in R&D.
2020 Sep; 20(3):217-223. doi:
10.1007/s40268-020-00308-1
. [PMID: 32415538] - Yohsuke Sugiyama, Takaaki Tsuchiya, Ryota Tanaka, Aiko Ouchi, Arata Motoyama, Takeshi Takamoto, Natsumi Hara, Yoshitaka Yanagawa. Cerebral venous thrombosis in COVID-19-associated coagulopathy: A case report.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia.
2020 Sep; 79(?):30-32. doi:
10.1016/j.jocn.2020.07.038
. [PMID: 33070913] - Shun Uemura, Hironori Kobayashi, Yoshinobu Seki, Yuki Okoshi, Hirohito Sone, Nobuhiko Nomoto. Successful Treatment with Edoxaban for Disseminated Intravascular Coagulation in a Case of Aortic Dissection Complicated with Immune Thrombocytopenic Purpura.
Internal medicine (Tokyo, Japan).
2020 Aug; 59(16):2035-2039. doi:
10.2169/internalmedicine.4255-19
. [PMID: 32389942] - Basile Chrétien, Marion Sassier, Joachim Alexandre, Véronique Lelong-Boulouard, Charles Dolladille, Sophie Fedrizzi. Direct acting oral anticoagulants and alopecia: to go further with data mining in pharmacovigilance databases.
European journal of clinical pharmacology.
2020 Aug; 76(8):1197-1198. doi:
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. [PMID: 32435997] - Saki Ariizumi, Takafumi Naito, Kohei Hoshikawa, Shunta Akutsu, Masao Saotome, Yuichiro Maekawa, Junichi Kawakami. Simple LC-MS/MS method using core-shell ODS microparticles for the simultaneous quantitation of edoxaban and its major metabolites in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122121. doi:
10.1016/j.jchromb.2020.122121
. [PMID: 32361632] - Sophie Testa, Paolo Prandoni, Oriana Paoletti, Rossella Morandini, Maurizio Tala, Claudia Dellanoce, Matteo Giorgi-Pierfranceschi, Monia Betti, Gian Battista Danzi, Angelo Pan, Gualtiero Palareti. Direct oral anticoagulant plasma levels' striking increase in severe COVID-19 respiratory syndrome patients treated with antiviral agents: The Cremona experience.
Journal of thrombosis and haemostasis : JTH.
2020 06; 18(6):1320-1323. doi:
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. [PMID: 32329231] - Yating Zhao, Lewis Couchman, Karin Kipper, Roopen Arya, Jignesh P Patel. A UHPLC-MS/MS method to simultaneously quantify apixaban, edoxaban and rivaroxaban in human plasma and breast milk: For emerging lactation studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 May; 1144(?):122095. doi:
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. [PMID: 32251991] - Naoki Kiyosawa, Kenji Watanabe, Yoshiyuki Morishima, Takeshi Yamashita, Naoharu Yagi, Takuto Arita, Takayuki Otsuka, Shinya Suzuki. Exploratory Analysis of Circulating miRNA Signatures in Atrial Fibrillation Patients Determining Potential Biomarkers to Support Decision-Making in Anticoagulation and Catheter Ablation.
International journal of molecular sciences.
2020 Apr; 21(7):. doi:
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. [PMID: 32244749] - Romain Siriez, Lütfiye Alpan, Kossay Elasaad, Philippe Devel, Julie Laloy, Jean-Michel Dogné, Jonathan Douxfils. Importance of measuring pharmacologically active metabolites of edoxaban: development and validation of an ultra-high-performance liquid chromatography coupled with a tandem mass spectrometry method.
Journal of thrombosis and thrombolysis.
2020 Apr; 49(3):395-403. doi:
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. [PMID: 31925664] - Samuel S Shin, Elisabeth B Marsh, Hasan Ali, Paul A Nyquist, Daniel F Hanley, Wendy C Ziai. Comparison of Traumatic Intracranial Hemorrhage Expansion and Outcomes Among Patients on Direct Oral Anticoagulants Versus Vitamin k Antagonists.
Neurocritical care.
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Journal of pharmaceutical and biomedical analysis.
2020 Mar; 181(?):113109. doi:
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Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.
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Heart and vessels.
2020 Mar; 35(3):409-416. doi:
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Bioanalysis.
2020 Mar; 12(6):393-407. doi:
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Drug metabolism and pharmacokinetics.
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Polish archives of internal medicine.
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Journal of thrombosis and thrombolysis.
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Thrombosis and haemostasis.
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Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.
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Thrombosis and haemostasis.
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Heart and vessels.
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Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology.
2019 12; 21(12):1764-1775. doi:
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Journal of thrombosis and thrombolysis.
2019 Oct; 48(3):528-531. doi:
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Circulation journal : official journal of the Japanese Circulation Society.
2019 09; 83(10):2017-2024. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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Clinical pharmacokinetics.
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