Aroclor 1254 (BioDeep_00000701866)

   

Industrial Pollutants


代谢物信息卡片


2,2,3,3,4-pentachlorobiphenyl

化学式: C12H5Cl5 (323.8834)
中文名称: 多氯联苯 1254溶液, 五氯联苯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C(=C1)Cl)Cl)C2=C(C(=C(C=C2)Cl)Cl)Cl
InChI: InChI=1S/C12H5Cl5/c13-8-3-1-2-6(10(8)15)7-4-5-9(14)12(17)11(7)16/h1-5H

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D013956 - Antithyroid Agents
D004785 - Environmental Pollutants > D011078 - Polychlorinated Biphenyls
D004785 - Environmental Pollutants > D001140 - Aroclors

同义名列表

2 个代谢物同义名

2,2,3,3,4-pentachlorobiphenyl; Aroclor 1254



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Muhammad Kaleem, Abdul Samad Mumtaz, Muhammad Zaffar Hashmi, Aamer Saeed, Farooq Inam, Rooma Waqar, Amber Jabeen. Myco- and phyco-remediation of polychlorinated biphenyls in the environment: a review. Environmental science and pollution research international. 2023 Feb; 30(6):13994-14007. doi: 10.1007/s11356-022-24902-9. [PMID: 36550253]
  • Anneline Pinson, Elena Sevrin, Christina Chatzi, Benjamin Le Gac, Marc Thiry, Gary L Westbrook, Anne-Simone Parent. Induction of Oxidative Stress and Alteration of Synaptic Gene Expression in Newborn Hippocampal Granule Cells after Developmental Exposure to Aroclor 1254. Neuroendocrinology. 2023; 113(12):1248-1261. doi: 10.1159/000527576. [PMID: 36257292]
  • Mehmet Kocabaş, Filiz Kutluyer Kocabaş, Önder Aksu, Fulya Benzer, Mine Erişir, Yeliz Çakir Sahilli. Aroclor 1254 impairs sperm quality, fertilization ability, and embryo development of rainbow trout (Oncorhynchus mykiss). Environmental science and pollution research international. 2022 Dec; 29(56):84581-84589. doi: 10.1007/s11356-022-21789-4. [PMID: 35781661]
  • Yu Chen, Yuwei Cai, Chunxiang Chen, Mengting Li, Lingdan Lu, Zhongxiang Yu, Shuqiang Wang, Lei Fang, Shengming Xu. Aroclor 1254 induced inhibitory effects on osteoblast differentiation in murine MC3T3-E1 cells through oxidative stress. Frontiers in endocrinology. 2022; 13(?):940624. doi: 10.3389/fendo.2022.940624. [PMID: 36353240]
  • Marwa A A Ibrahim, Heba H Elkaliny, Marwa M Abd-Elsalam. Lycopene ameliorates the effect of Aroclor 1254 on morphology, proliferation, and angiogenesis of the thyroid gland in rat. Toxicology. 2021 03; 452(?):152722. doi: 10.1016/j.tox.2021.152722. [PMID: 33592256]
  • Naciye Dilara Zeybek, Ünzile Sur, Ofcan Oflaz, Pınar Erkekoğlu, Aylin Balcı, Gizem Özkemahlı, Ali Aşçı, Murat Kızılgün, Oğuz Han Edebal, Belma Koçer-Gümüşel. Renal changes and apoptosis caused by subacute exposure to Aroclor 1254 in selenium-deficient and selenium-supplemented rats. Arhiv za higijenu rada i toksikologiju. 2020 Jun; 71(2):110-120. doi: 10.2478/aiht-2020-71-3360. [PMID: 32975097]
  • Jinpeng Ruan, Jiaojiao Guo, Yameng Huang, Yunzi Mao, Zhenggang Yang, Zhenghong Zuo. Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. Environmental research. 2020 02; 181(?):108909. doi: 10.1016/j.envres.2019.108909. [PMID: 31776016]
  • Lu Fang, Shiqi Zhang, Kunlin Ou, Zhenghong Zuo, Ang Yu, Chonggang Wang. Exposure to Aroclor 1254 differentially affects the survival of pancreatic β-cells and α-cells in the male mice and the potential reason. Ecotoxicology and environmental safety. 2020 Jan; 188(?):109875. doi: 10.1016/j.ecoenv.2019.109875. [PMID: 31706244]
  • Arleta Krystyna Skrzynska, Gonzalo Martínez-Rodríguez, Magdalena Gozdowska, Ewa Kulczykowska, Juan Miguel Mancera, Juan Antonio Martos-Sitcha. Aroclor 1254 inhibits vasotocinergic pathways related to osmoregulatory and stress functions in the gilthead sea bream (Sparus aurata, Linnaeus 1758). Aquatic toxicology (Amsterdam, Netherlands). 2019 Jul; 212(?):98-109. doi: 10.1016/j.aquatox.2019.04.019. [PMID: 31082703]
  • Zhihui Xi, Lu Fang, Jing Xu, Bingshui Li, Zhenghong Zuo, Liangju Lv, Chonggang Wang. Exposure to Aroclor 1254 persistently suppresses the functions of pancreatic β-cells and deteriorates glucose homeostasis in male mice. Environmental pollution (Barking, Essex : 1987). 2019 Jun; 249(?):822-830. doi: 10.1016/j.envpol.2019.03.101. [PMID: 30953944]
  • Halef Okan Doğan, Mehmet Eray Alçiğir. Assessment of epigenetic changes and oxidative DNA damage in rat pups exposed to polychlorinated biphenyls and the protective effect of curcumin in the prenatal period. Journal of basic and clinical physiology and pharmacology. 2019 Mar; 30(3):. doi: 10.1515/jbcpp-2018-0182. [PMID: 30917103]
  • Carlotta Granchi. ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism. European journal of medicinal chemistry. 2018 Sep; 157(?):1276-1291. doi: 10.1016/j.ejmech.2018.09.001. [PMID: 30195238]
  • Shuhao Su, Guangyuan Wu, Xiaodong Cheng, Junshu Fan, Jie Peng, Hongfei Su, Zhongrui Xu, Meng Cao, Zi Long, Yiming Hao, Ge Li, Shuang Li, Chunxu Hai, Xin Wang. Oleanolic acid attenuates PCBs-induced adiposity and insulin resistance via HNF1b-mediated regulation of redox and PPARγ signaling. Free radical biology & medicine. 2018 08; 124(?):122-134. doi: 10.1016/j.freeradbiomed.2018.06.003. [PMID: 29879443]
  • Margaret R Bell, Ariel Dryden, Ryan Will, Andrea C Gore. Sex differences in effects of gestational polychlorinated biphenyl exposure on hypothalamic neuroimmune and neuromodulator systems in neonatal rats. Toxicology and applied pharmacology. 2018 08; 353(?):55-66. doi: 10.1016/j.taap.2018.06.002. [PMID: 29879404]
  • Sevtap Aydin, Pinar Erkekoglu, Nurşen Başaran, Belma Kocer-Gumusel. Impact of selenium status on Aroclor 1254-induced DNA damage in sperm and different tissues of rats. Toxicology mechanisms and methods. 2018 May; 28(4):252-261. doi: 10.1080/15376516.2017.1397234. [PMID: 29082812]
  • Sathish Kumar Thangavelu, Sugantha Priya Elaiyapillai, Ilangovan Ramachandran, Ravi Sankar Bhaskaran, Arunakaran Jagadeesan. Lactational exposure of polychlorinated biphenyls impair Leydig cellular steroidogenesis in F1 progeny rats. Reproductive toxicology (Elmsford, N.Y.). 2018 01; 75(?):73-85. doi: 10.1016/j.reprotox.2017.11.009. [PMID: 29208485]
  • T Sathish Kumar, E Sugantha Priya, P Raja Singh, J Arunakaran. Lactational exposure of polychlorinated biphenyls downregulates critical genes in Leydig cells of F1 male progeny (PND21). Andrologia. 2017 Oct; 49(8):. doi: 10.1111/and.12734. [PMID: 27785823]
  • Samuel Mucio-Ramírez, Eduardo Sánchez-Islas, Edith Sánchez-Jaramillo, Margarita Currás-Collazo, Victor R Juárez-González, Mhar Y Álvarez-González, L E Orser, Borin Hou, Francisco Pellicer, Prasada Rao S Kodavanti, Martha León-Olea. Perinatal exposure to organohalogen pollutants decreases vasopressin content and its mRNA expression in magnocellular neuroendocrine cells activated by osmotic stress in adult rats. Toxicology and applied pharmacology. 2017 Aug; 329(?):173-189. doi: 10.1016/j.taap.2017.05.039. [PMID: 28579251]
  • Nehad F Mazen, Rania A Zidan. Histological study on the effect of aroclor 1254 on the epididymis of adult rats and the role of L-NAME administration. Ultrastructural pathology. 2017 Mar; 41(2):154-167. doi: 10.1080/01913123.2016.1278065. [PMID: 28151076]
  • Thangarajan Sumathi, Deivasigamani Asha, Ganesan Nagarajan, Arivazhagan Sreenivas, Rajendran Nivedha. L-Theanine alleviates the neuropathological changes induced by PCB (Aroclor 1254) via inhibiting upregulation of inflammatory cytokines and oxidative stress in rat brain. Environmental toxicology and pharmacology. 2016 Mar; 42(?):99-117. doi: 10.1016/j.etap.2016.01.008. [PMID: 26826962]
  • Özay Güleş, Ülker Eren. Protective role of alpha lipoic acid against polychlorobiphenyl (Aroclor 1254)-induced testicular toxicity in rats. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie. 2016; 57(2):451-9. doi: NULL. [PMID: 27516018]
  • Wei Tang, Jin Ping Cheng, Yi Chen Yang, Wen Hua Wang. Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring. Biomedical and environmental sciences : BES. 2015 Sep; 28(9):687-90. doi: 10.3967/bes2015.097. [PMID: 26464258]
  • Shiqi Zhang, Tian Wu, Meng Chen, Zhizhun Guo, Zhibin Yang, Zhenghong Zuo, Chonggang Wang. Chronic Exposure to Aroclor 1254 Disrupts Glucose Homeostasis in Male Mice via Inhibition of the Insulin Receptor Signal Pathway. Environmental science & technology. 2015 Aug; 49(16):10084-92. doi: 10.1021/acs.est.5b01597. [PMID: 26190026]
  • Leanne M Flahr, Nicole L Michel, Alexander R D Zahara, Paul D Jones, Christy A Morrissey. Developmental Exposure to Aroclor 1254 Alters Migratory Behavior in Juvenile European Starlings (Sturnus vulgaris). Environmental science & technology. 2015 May; 49(10):6274-83. doi: 10.1021/acs.est.5b01185. [PMID: 25893686]
  • Jia-Li Cai, Ling-Bin Sun, Zhi-Zhun Guo, Xiao-Ming Jiang, Guan-Chao Zheng, Hui-Ling Qiu, Ai-Guo Sha, Chong-Gang Wang, Jian-Zhi Ren, Zheng-Hong Zuo. Decrease in prosaposin in spermatozoon is associated with polychlorinated biphenyl exposure. International journal of clinical and experimental pathology. 2015; 8(3):2436-48. doi: NULL. [PMID: 26045750]
  • Javier Esteban, Lubna E Elabbas, Daniel Borg, Maria Herlin, Agneta Åkesson, Xavier Barber, Gerd Hamscher, Heinz Nau, Wayne J Bowers, Jamie S Nakai, Matti Viluksela, Helen Håkansson. Gestational and lactational exposure to the polychlorinated biphenyl mixture Aroclor 1254 modulates retinoid homeostasis in rat offspring. Toxicology letters. 2014 Aug; 229(1):41-51. doi: 10.1016/j.toxlet.2014.04.021. [PMID: 24887809]
  • Nancy B Hopf, Avima M Ruder, Paul Succop, Martha A Waters. Evaluation of cumulative PCB exposure estimated by a job exposure matrix versus PCB serum concentrations. Environmental science and pollution research international. 2014 May; 21(10):6314-23. doi: 10.1007/s11356-013-1574-4. [PMID: 23475397]
  • Sandra Halwachs, Louise Wassermann, Walther Honscha. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicology in vitro : an international journal published in association with BIBRA. 2014 Apr; 28(3):432-41. doi: 10.1016/j.tiv.2013.12.015. [PMID: 24389113]
  • G A Montoya, V Strauss, E Fabian, H Kamp, W Mellert, T Walk, R Looser, M Herold, G Krennrich, E Peter, B van Ravenzwaay. Mechanistic analysis of metabolomics patterns in rat plasma during administration of direct thyroid hormone synthesis inhibitors or compounds increasing thyroid hormone clearance. Toxicology letters. 2014 Mar; 225(2):240-51. doi: 10.1016/j.toxlet.2013.12.010. [PMID: 24370789]
  • Yunsung Nam, Eun-Joo Shin, Seung Woo Shin, Yong Kwang Lim, Jong Ho Jung, Jeong Hyun Lee, Jong Ryul Ha, Jong Seok Chae, Sung Kwon Ko, Ji Hoon Jeong, Choon-Gon Jang, Hyoung-Chun Kim. YY162 prevents ADHD-like behavioral side effects and cytotoxicity induced by Aroclor1254 via interactive signaling between antioxidant potential, BDNF/TrkB, DAT and NET. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Mar; 65(?):280-92. doi: 10.1016/j.fct.2013.12.046. [PMID: 24394491]
  • Elise Naveau, Anneline Pinson, Arlette Gérard, Laurent Nguyen, Corinne Charlier, Jean-Pierre Thomé, R Thomas Zoeller, Jean-Pierre Bourguignon, Anne-Simone Parent. Alteration of rat fetal cerebral cortex development after prenatal exposure to polychlorinated biphenyls. PloS one. 2014; 9(3):e91903. doi: 10.1371/journal.pone.0091903. [PMID: 24642964]
  • Manickavel Vinoth Raj, Kandaswamy Selvakumar, Gunasekaran Krishnamoorthy, Soundarrajan Revathy, Perumal Elumalai, Jagadeesan Arunakaran. Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat. Reproductive sciences (Thousand Oaks, Calif.). 2014 Jan; 21(1):89-101. doi: 10.1177/1933719113492213. [PMID: 23749762]
  • Yifei Dong, Hua Tian, Wei Wang, Xiaona Zhang, Jinxiang Liu, Shaoguo Ru. Disruption of the thyroid system by the thyroid-disrupting compound Aroclor 1254 in juvenile Japanese flounder (Paralichthys olivaceus). PloS one. 2014; 9(8):e104196. doi: 10.1371/journal.pone.0104196. [PMID: 25090620]
  • Lina Xu, Liyun Sun, Liqin Lu, Xiuhui Zhong, Yuzhong Ma, Jianhua Qin. Effects of quercetin on CYP450 and cytokines in Aroclor 1254 injured endometrial cells of the pregnant rats. BioMed research international. 2014; 2014(?):497508. doi: 10.1155/2014/497508. [PMID: 24711995]
  • M B Wigestrand, M Stenberg, S I Walaas, F Fonnum, P L Andersson. Non-dioxin-like PCBs inhibit [(3)H]WIN-35,428 binding to the dopamine transporter: a structure-activity relationship study. Neurotoxicology. 2013 Dec; 39(?):18-24. doi: 10.1016/j.neuro.2013.07.005. [PMID: 23933243]
  • Hamdy A A Aly. Aroclor 1254 induced oxidative stress and mitochondria mediated apoptosis in adult rat sperm in vitro. Environmental toxicology and pharmacology. 2013 Sep; 36(2):274-283. doi: 10.1016/j.etap.2013.04.006. [PMID: 23686007]
  • Anne Augustine Williams, Jayaraman Selvaraj, Chinnapaiyan Srinivasan, Sampath Sathish, Parsanathan Rajesh, Venkataraman Balaji, Jagadeesan Arunakaran, Karundevi Balasubramanian. Protective role of lycopene against Aroclor 1254-induced changes on GLUT4 in the skeletal muscles of adult male rat. Drug and chemical toxicology. 2013 Jul; 36(3):320-8. doi: 10.3109/01480545.2012.720991. [PMID: 23035738]
  • Hanish J C Singh, Tauqeer U B Syeda, Rahul M Kakalij, Valluri V L N Prasad, Prakash V Diwan. Erythropoietin protects polychlorinated biphenyl (Aroclor 1254) induced neurotoxicity in mice. European journal of pharmacology. 2013 May; 707(1-3):54-60. doi: 10.1016/j.ejphar.2013.03.009. [PMID: 23524097]
  • Mari Bratberg, Pål A Olsvik, Rolf B Edvardsen, Hans Kristian Brekken, Reidun Vadla, Sonnich Meier. Effects of oil pollution and persistent organic pollutants (POPs) on glycerophospholipids in liver and brain of male Atlantic cod (Gadus morhua). Chemosphere. 2013 Feb; 90(7):2157-71. doi: 10.1016/j.chemosphere.2012.11.026. [PMID: 23266412]
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  • Hamdy A A Aly, Oscar Domènech, Ashraf B Abdel-Naim. Aroclor 1254 impairs spermatogenesis and induces oxidative stress in rat testicular mitochondria. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2009 Aug; 47(8):1733-8. doi: 10.1016/j.fct.2009.03.019. [PMID: 19306909]
  • Prabhu Venkataraman, Gunasekaran Krishnamoorthy, Kandaswamy Selvakumar, Jagadeesan Arunakaran. Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin. Basic & clinical pharmacology & toxicology. 2009 Aug; 105(2):92-7. doi: 10.1111/j.1742-7843.2009.00406.x. [PMID: 19389042]
  • Virginie Gillardin, Frédéric Silvestre, Céline Divoy, Jean-Pierre Thomé, Patrick Kestemont. Effects of Aroclor 1254 on oxidative stress in developing Xenopus laevis tadpoles. Ecotoxicology and environmental safety. 2009 Feb; 72(2):546-51. doi: 10.1016/j.ecoenv.2008.02.010. [PMID: 18407353]
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