Pyrithione (BioDeep_00000701168)

   


代谢物信息卡片


Pyrithione

化学式: C5H5NOS (127.009184)
中文名称: 2-巯基吡啶 N-氧化物, 1-氧化-2-巯基吡啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=S)N(C=C1)O
InChI: InChI=1S/C5H5NOS/c7-6-4-2-1-3-5(6)8/h1-4,7H

描述信息

C78284 - Agent Affecting Integumentary System > C29708 - Anti-psoriatic Agent
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent

同义名列表

1 个代谢物同义名

Pyrithione



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Pınar Arslan, Göktuğ Gül, Aysel Çağlan Günal. How do biocidals affect the non-target marine organisms: the short-term effects of antifouling agent sodium pyrithione on Mediterranean mussels (Mytilus galloprovincialis, Lamark 1819). Environmental science and pollution research international. 2023 Dec; 30(56):118332-118340. doi: 10.1007/s11356-023-30611-8. [PMID: 37910376]
  • Olga Yu Selyutina, Viktor A Timoshnikov, Nikolay E Polyakov, George J Kontoghiorghes. Metal Complexes of Omadine (N-Hydroxypyridine-2-thione): Differences of Antioxidant and Pro-Oxidant Behavior in Light and Dark Conditions with Possible Toxicity Implications. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28104210. [PMID: 37241949]
  • Mengge Chen, Yanpeng Ding, Yuan Ke, Yifei Zeng, Nuomin Liu, Yahua Zhong, Xinying Hua, Zheng Li, Yudi Xiong, Chaoyan Wu, Haijun Yu. Anti-tumour activity of zinc ionophore pyrithione in human ovarian cancer cells through inhibition of proliferation and migration and promotion of lysosome-mitochondrial apoptosis. Artificial cells, nanomedicine, and biotechnology. 2020 Dec; 48(1):824-833. doi: 10.1080/21691401.2020.1770266. [PMID: 32456481]
  • Katarina Marković, Radmila Milačič, Stefan Marković, Jerneja Kladnik, Iztok Turel, Janez Ščančar. Binding Kinetics of Ruthenium Pyrithione Chemotherapeutic Candidates to Human Serum Proteins Studied by HPLC-ICP-MS. Molecules (Basel, Switzerland). 2020 Mar; 25(7):. doi: 10.3390/molecules25071512. [PMID: 32225069]
  • Sebastian Faßbender, Ann-Katrin Döring, Björn Meermann. Development of complementary CE-MS methods for speciation analysis of pyrithione-based antifouling agents. Analytical and bioanalytical chemistry. 2019 Nov; 411(27):7261-7272. doi: 10.1007/s00216-019-02094-5. [PMID: 31494688]
  • Manal H Al Khabbas, Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak. Synthesis and characterization of new 1-hydroxy-2-pyridinethione derivatives: Their lead complexes and efficacy in the treatment of acute lead poisoning in rats. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2017 Dec; 44(?):209-217. doi: 10.1016/j.jtemb.2017.08.004. [PMID: 28965578]
  • Ramaiah Muthyala, Woo Shik Shin, Jiashu Xie, Yuk Yin Sham. Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia. Bioorganic & medicinal chemistry letters. 2015 Oct; 25(19):4320-4. doi: 10.1016/j.bmcl.2015.07.065. [PMID: 26264503]
  • H Haase, S Hebel, G Engelhardt, L Rink. The biochemical effects of extracellular Zn(2+) and other metal ions are severely affected by their speciation in cell culture media. Metallomics : integrated biometal science. 2015 Jan; 7(1):102-11. doi: 10.1039/c4mt00206g. [PMID: 25360687]
  • Petra Krejčová, Petra Kučerová, Gary I Stafford, Anna K Jäger, Roman Kubec. Antiinflammatory and neurological activity of pyrithione and related sulfur-containing pyridine N-oxides from Persian shallot (Allium stipitatum). Journal of ethnopharmacology. 2014 May; 154(1):176-82. doi: 10.1016/j.jep.2014.03.066. [PMID: 24721027]
  • Nikolai V Gorbunov, James L Atkins, Narasimman Gurusamy, Bruce R Pitt. Iron-induced remodeling in cultured rat pulmonary artery endothelial cells. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 2012 Feb; 25(1):203-17. doi: 10.1007/s10534-011-9498-2. [PMID: 22089858]
  • Carrie I Morgan, John R Ledford, Ping Zhou, Kristen Page. Zinc supplementation alters airway inflammation and airway hyperresponsiveness to a common allergen. Journal of inflammation (London, England). 2011 Dec; 8(?):36. doi: 10.1186/1476-9255-8-36. [PMID: 22151973]
  • Wan-Seob Cho, Rodger Duffin, Sarah E M Howie, Chris J Scotton, William A H Wallace, William Macnee, Mark Bradley, Ian L Megson, Ken Donaldson. Progressive severe lung injury by zinc oxide nanoparticles; the role of Zn2+ dissolution inside lysosomes. Particle and fibre toxicology. 2011 Sep; 8(?):27. doi: 10.1186/1743-8977-8-27. [PMID: 21896169]
  • Thomas Backhaus, Tobias Porsbring, Asa Arrhenius, Sara Brosche, Per Johansson, Hans Blanck. Single-substance and mixture toxicity of five pharmaceuticals and personal care products to marine periphyton communities. Environmental toxicology and chemistry. 2011 Sep; 30(9):2030-40. doi: 10.1002/etc.586. [PMID: 21647943]
  • M Hiren Joshi, P Balamurugan, V P Venugopalan, T S Rao. Dense fouling in acid transfer pipelines by an acidophilic rubber degrading fungus. Biofouling. 2011 Jul; 27(6):621-9. doi: 10.1080/08927014.2011.594162. [PMID: 21722066]
  • Roman Kubec, Petra Krejcová, Petr Simek, Lukás Václavík, Jana Hajslová, Jan Schraml. Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum. Journal of agricultural and food chemistry. 2011 May; 59(10):5763-70. doi: 10.1021/jf200704n. [PMID: 21510712]
  • Aartjan J W te Velthuis, Sjoerd H E van den Worm, Amy C Sims, Ralph S Baric, Eric J Snijder, Martijn J van Hemert. Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS pathogens. 2010 Nov; 6(11):e1001176. doi: 10.1371/journal.ppat.1001176. [PMID: 21079686]
  • Carlos R Arias-Barreiro, Keisuke Okazaki, Apostolos Koutsaftis, Salmaan H Inayat-Hussain, Akio Tani, Maki Katsuhara, Kazuhide Kimbara, Izumi C Mori. A bacterial biosensor for oxidative stress using the constitutively expressed redox-sensitive protein roGFP2. Sensors (Basel, Switzerland). 2010; 10(7):6290-6306. doi: 10.3390/s100706290. [PMID: 22163550]
  • Stuart E Lind, Jong Sung Park, John W Drexler. Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes. Translational research : the journal of laboratory and clinical medicine. 2009 Sep; 154(3):153-9. doi: 10.1016/j.trsl.2009.06.002. [PMID: 19665691]
  • Robert A Colvin, Ashley I Bush, Irene Volitakis, Charles P Fontaine, Dustin Thomas, Kazuya Kikuchi, William R Holmes. Insights into Zn2+ homeostasis in neurons from experimental and modeling studies. American journal of physiology. Cell physiology. 2008 Mar; 294(3):C726-42. doi: 10.1152/ajpcell.00541.2007. [PMID: 18184873]
  • Ronald J Knox, Kim L Keen, Laurelee Luchansky, Ei Terasawa, Hugh Freyer, Steven J Barbee, Leonard K Kaczmarek. Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons. Biochemical and biophysical research communications. 2008 Feb; 366(1):48-53. doi: 10.1016/j.bbrc.2007.11.083. [PMID: 18053804]
  • M Aldaghi, S Massart, Ph Druart, A Bertaccini, M H Jijakli, P Lepoivre. Preliminary evaluation of antimicrobial activity of some chemicals on in vitro apple shoots infected by 'Candidatus Phytoplasma mali'. Communications in agricultural and applied biological sciences. 2008; 73(2):335-41. doi: ". [PMID: 19226772]
  • Joseph S Tauskela, Eric Brunette, Lech Kiedrowski, Karine Lortie, Melissa Hewitt, Paul Morley. Unconventional neuroprotection against Ca2+ -dependent insults by metalloporphyrin catalytic antioxidants. Journal of neurochemistry. 2006 Aug; 98(4):1324-42. doi: 10.1111/j.1471-4159.2006.03973.x. [PMID: 16895586]
  • Ronald J Knox, Neil S Magoski, David Wing, Steven J Barbee, Leonard K Kaczmarek. Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia. Journal of neurobiology. 2004 Sep; 60(4):411-23. doi: 10.1002/neu.20029. [PMID: 15307146]
  • Jie-Jen Lee, Wu-Tein Huang, Dong-Zi Shao, Jyh-Fei Liao, Mao-Tsun Lin. Blocking NF-kappaB activation may be an effective strategy in the fever therapy. The Japanese journal of physiology. 2003 Oct; 53(5):367-75. doi: 10.2170/jjphysiol.53.367. [PMID: 14975183]
  • Mathew L Thakur, Ron Coss, Roger Howell, Donka Vassileva-Belnikolovska, Jeff Liu, Sampath P Rao, Greg Spana, Phyllis Wachsberger, Dennis L Leeper. Role of lipid-soluble complexes in targeted tumor therapy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2003 Aug; 44(8):1293-300. doi: ". [PMID: 12902421]
  • Darren Tobin, Morfakis Arvanitidis, Roger H Bisby. One-electron oxidation of 'photo-Fenton' reagents and inhibition of lipid peroxidation. Biochemical and biophysical research communications. 2002 Nov; 299(1):155-9. doi: 10.1016/s0006-291x(02)02594-9. [PMID: 12435402]
  • K E Dineley, J B Brocard, I J Reynolds. Elevated intracellular zinc and altered proton homeostasis in forebrain neurons. Neuroscience. 2002; 114(2):439-49. doi: 10.1016/s0306-4522(02)00294-4. [PMID: 12204213]
  • Z L Tang, K Wasserloos, C M St Croix, B R Pitt. Role of zinc in pulmonary endothelial cell response to oxidative stress. American journal of physiology. Lung cellular and molecular physiology. 2001 Jul; 281(1):L243-9. doi: 10.1152/ajplung.2001.281.1.l243. [PMID: 11404267]
  • E Ermolayeva, D Sanders. Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Applied and environmental microbiology. 1995 Sep; 61(9):3385-90. doi: 10.1128/aem.61.9.3385-3390.1995. [PMID: 7574648]
  • E J Lesnefsky, J Ye. Exogenous intracellular, but not extracellular, iron augments myocardial reperfusion injury. The American journal of physiology. 1994 Feb; 266(2 Pt 2):H384-92. doi: 10.1152/ajpheart.1994.266.2.h384. [PMID: 8141338]
  • M A Kowalska, D Juliano, M Trybulec, W Lu, S Niewiarowski. Zinc ions potentiate adenosine diphosphate-induced platelet aggregation by activation of protein kinase C. The Journal of laboratory and clinical medicine. 1994 Jan; 123(1):102-9. doi: NULL. [PMID: 8288949]
  • P R Mayer, R C Couch, M K Erickson, C B Wooldridge, R K Brazzell. Topical and systemic absorption of sodium pyrithione following topical application to the nails of the rhesus monkey. Skin pharmacology : the official journal of the Skin Pharmacology Society. 1992; 5(3):154-9. doi: 10.1159/000211032. [PMID: 1445705]
  • Y Isaka, K Kimura, M Matsumoto, T Kamada, M Imaizumi. Functional alterations of human platelets following indium-111 labelling using different incubation media and labelling agents. European journal of nuclear medicine. 1991; 18(5):326-31. doi: 10.1007/bf02285460. [PMID: 1936041]
  • M K Dewanjee, R P Robinson, R L Hellman, W I Ganz, A N Serafini, G N Sfakianakis. Technetium-99m-labeled platelets: comparison of labeling with a new lipid-soluble Sn(II)-mercaptopyridine-N-oxide and 99mTc-HMPAO. International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology. 1991; 18(5):461-8. doi: 10.1016/0883-2897(91)90106-u. [PMID: 1917515]
  • M Mieno, Y Isaka, K Kimura, M Matsumoto, H Etani, A Uehara, K Hashikawa, R Hata, H Moriwaki, K Ashida. [Functional alterations of human platelets following 111In labeling with different ligands and incubation media]. Kaku igaku. The Japanese journal of nuclear medicine. 1990 May; 27(5):443-9. doi: NULL. [PMID: 2118576]
  • M K Dewanjee, M Kapadvanjwala, S Dewanjee, A K Ghafouripour, A N Serafini, G N Sfakianakis. New efficient cell-labeling method with Tc-99m pertechnetate via neutral and lipid soluble Sn(II)--mercaptopyridine N-oxide complex and comparative evaluation with Tc-99m HMPAO labeled platelets. Progress in clinical and biological research. 1990; 355(?):1-9. doi: ". [PMID: 2177894]
  • E Mazoyer, D Carpenter, S Ebbe, Y Yano, K Dalal, M Singh, B Mazoyer. Survival of rabbit platelets labeled with gallium 67. The Journal of laboratory and clinical medicine. 1988 Feb; 111(2):218-23. doi: NULL. [PMID: 3339275]
  • L Mortelmans, A Verbruggen, S Malbrain, M J Heynen, C de Bakker, M Boogaerts, M de Roo. Evaluation of 111In labelled white blood cells by in vitro functional tests and electron microscopy. Comparison of three labelling methods. European journal of nuclear medicine. 1988; 14(3):159-64. doi: 10.1007/bf00293542. [PMID: 3136018]
  • M F Tsan, R L Hill-Zobel. Should platelets be radiolabelled in plasma medium?. American journal of hematology. 1987 Jul; 25(3):355-9. doi: 10.1002/ajh.2830250318. [PMID: 3111252]
  • W T Goedemans, M M de Jong. Comparison of several indium-111 ligands in labeling blood cells: effect of diethylpyrocarbonate and CO2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1987 Jun; 28(6):1020-6. doi: . [PMID: 3108467]
  • C M Intenzo, A G Desai, M L Thakur, C H Park. Comparison of leukocytes labeled with indium-111-2-mercaptopyridine-N-oxide and indium-111 oxine for abscess detection. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1987 Apr; 28(4):438-41. doi: NULL. [PMID: 3106593]
  • R L Hill-Zobel, S Gannon, B McCandless, M F Tsan. Effects of chelates and incubation media on platelet labeling with indium-111. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1987 Feb; 28(2):223-8. doi: NULL. [PMID: 3100733]
  • H J Danpure, S Osman. The importance of radiolabelling human granulocytes with 111In-tropolonate or 111In-2-mercaptopyridine-N-oxide in plasma containing acid-citrate-dextrose. The British journal of radiology. 1986 Sep; 59(705):907-10. doi: 10.1259/0007-1285-59-705-907. [PMID: 3756387]
  • G J Kontoghiorghes, A Piga, A V Hoffbrand. Cytotoxic effects of the lipophilic iron chelator omadine. FEBS letters. 1986 Aug; 204(2):208-12. doi: 10.1016/0014-5793(86)80813-4. [PMID: 3460820]
  • S Jasim, H Tjälve. Effects of sodium pyridinethione on the uptake and distribution of nickel, cadmium and zinc in pregnant and non-pregnant mice. Toxicology. 1986 Mar; 38(3):327-50. doi: 10.1016/0300-483x(86)90148-4. [PMID: 3952760]
  • M L Thakur, S M McKenney. Indium 111-mercaptopyridine N-oxide-labeled human leukocytes and platelets: mechanism of labeling and intracellular location of 111In and mercaptopyridine N-oxide. The Journal of laboratory and clinical medicine. 1986 Feb; 107(2):141-7. doi: NULL. [PMID: 3944495]
  • Y Yano, T F Budinger, S N Ebbe, C A Mathis, M Singh, K M Brennan, B R Moyer. Gallium-68 lipophilic complexes for labeling platelets. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1985 Dec; 26(12):1429-37. doi: NULL. [PMID: 3934349]
  • M L Thakur, S L McKenney, C H Park. Evaluation of indium-111-2-mercaptopyridine-N-oxide for labeling leukocytes in plasma: a kit preparation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1985 May; 26(5):518-23. doi: NULL. [PMID: 3857295]
  • M L Thakur, S L McKenney, C H Park. Simplified and efficient labeling of human platelets in plasma using indium-111-2-mercaptopyridine-N-oxide: preparation and evaluation. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 1985 May; 26(5):510-7. doi: . [PMID: 3989607]
  • W T Gibson, M Chamberlain, J F Parsons, J E Brunskill, D Leftwich, S Lock, R J Safford. The effect and mode of action of zinc pyrithione on cell growth. I. In vitro studies. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985 Jan; 23(1):93-102. doi: 10.1016/0278-6915(85)90226-1. [PMID: 3882533]
  • J H Wedig, S J Barbee, C Mitoma. Pyrithione: plasma metabolite in man. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1984 Jun; 4(3 Pt 1):497-8. doi: 10.1016/0272-0590(84)90209-4. [PMID: 6745540]
  • C Mitoma, T Steeger, J Rogers, D Thomas, J H Wedig. Metabolic disposition of pyrithiones. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1983 Jul; 3(4):256-63. doi: 10.1016/s0272-0590(83)80137-7. [PMID: 6628887]
  • R C Spiker, H P Ciuchta. Effects of pyrithiones and surfactants on zinc and enzyme levels in rabbits. American Industrial Hygiene Association journal. 1980 Apr; 41(4):248-52. doi: 10.1080/15298668091424690. [PMID: 7395740]
  • D Howes, J G Black. Comparative percutaneous absorption of pyrithiones. Toxicology. 1975 Nov; 5(2):209-20. doi: 10.1016/0300-483x(75)90118-3. [PMID: 1209651]