sacubitril (BioDeep_00000699685)
代谢物信息卡片
sacubitril
化学式: C24H29NO5 (411.2046)
中文名称: 沙库比曲
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C(C)CC(CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O
InChI: InChI=1S/C24H29NO5/c1-3-30-24(29)17(2)15-21(25-22(26)13-14-23(27)28)16-18-9-11-20(12-10-18)19-7-5-4-6-8-19/h4-12,17,21H,3,13-16H2,1-2H3,(H,25,26)(H,27,28)/t17-,21+/m1/s1
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:134714
- KEGGdrug: D10225
- PubChem: 9811834
- DrugBank: DB09292
- ChEMBL: CHEMBL3137301
- CAS: 149709-62-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Fang Wang, Chengde Li, Xuezheng Zhang. Sacubitril/valsartan improves the prognosis of acute myocardial infarction: a meta-analysis.
Coronary artery disease.
2024 May; 35(3):231-238. doi:
10.1097/mca.0000000000001332. [PMID: 38299259] - Manzhi Li, Ao Zhong, Yifan Tang, Jinnuo Yu, Mengmeng Wu, Karthick Kumaran Munisamy Selvam, Dong Sun. Effect of sacubitril/valsartan on lipid metabolism in patients with chronic kidney disease combined with chronic heart failure: a retrospective study.
Lipids in health and disease.
2024 Feb; 23(1):63. doi:
10.1186/s12944-024-02051-x. [PMID: 38419057] - Z Dogan, D D Ergun, S Durmus, H Sahin, G E Senturk, R Gelisgen, A Senyigit, H Uzun. Empagliflozin and sacubitril/valsartan reverse methotrexate cardiotoxicity by repressing oxidative stress and hypoxia in heart embryonic H9c2 cardiomyocytes - the role of morphology of mitochondria observed on electron microscopy.
European review for medical and pharmacological sciences.
2023 05; 27(9):3979-3992. doi:
10.26355/eurrev_202305_32304. [PMID: 37203822] - Yuanrui Huang, Xu Wu, Xingyu Li, Zhengzhong Liu, Yunyi Li. Effect on the Quality of Life of Patients with Heart Failure and Reduced/Preserved Ejection Fraction Using Sacubitril/Valsartan.
Arquivos brasileiros de cardiologia.
2023; 120(8):e20220611. doi:
10.36660/abc.20220611. [PMID: 37971045] - Md Sayeed Akhtar, Md Quamrul Hassan, Obaid Afzal, Abdulmalik S A Altamimi, Mohd Zaheen Hassan, Arun Kumar, Asif Ansari Shaik Mohammad, Fauzia Tabassum. Comparative efficacy of levosimendan, ramipril, and sacubitril/valsartan in isoproterenol induced experimental heart failure: a hemodynamic and molecular approach.
Current molecular pharmacology.
2022 Sep; ?(?):. doi:
10.2174/1874467215666220919104526. [PMID: 36121084] - Dina Salem Abdelaziz Elshenawy, Nehal Mohammed Ramadan, Vivian Boshra Abdo, Rehab Hamdy Ashour. Sacubitril/valsartan combination enhanced cardiac glycophagy and prevented the progression of murine diabetic cardiomyopathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Sep; 153(?):113382. doi:
10.1016/j.biopha.2022.113382. [PMID: 36076522] - Yihai Liu, Chongxia Zhong, Jiayi Si, Shan Chen, Lina Kang, Biao Xu. The impact of Sacubitril/Valsartan on cardiac fibrosis early after myocardial infarction in hypertensive rats.
Journal of hypertension.
2022 09; 40(9):1822-1830. doi:
10.1097/hjh.0000000000003230. [PMID: 35943105] - Ruoyu Jia, Xuejie Zhang, Yizhou Xu, Zhifang Zheng, Luhua Jiang, Xin Zhang, Chen Sun, Xin Wu, Shulin Li, Ashok Raj, Dong Sun. Effect of Sacubitril/Valsartan on renal function in patients with chronic kidney disease and heart failure with preserved ejection fraction: A real-world 12-week study.
European journal of pharmacology.
2022 Aug; 928(?):175053. doi:
10.1016/j.ejphar.2022.175053. [PMID: 35709921] - Daniele Masarone, Ryan J Tedford, Enrico Melillo, Andrea Petraio, Giuseppe Pacileo. Angiotensin-converting enzyme inhibitor therapy after heart transplant: From molecular basis to clinical effects.
Clinical transplantation.
2022 Jul; 36(7):e14696. doi:
10.1111/ctr.14696. [PMID: 35523577] - Lei Yang, Nan Ye, Weijing Bian, Hong Cheng. Efficacy of medication therapy for patients with chronic kidney disease and heart failure with preserved ejection fraction: a systematic review and meta-analysis.
International urology and nephrology.
2022 Jun; 54(6):1435-1444. doi:
10.1007/s11255-021-03025-z. [PMID: 34669107] - Hasan Ali Barman, Selim Tanyolaç, Omer Dogan, Erdem Bal, Adem Atıcı, Serhan Özyıldırım, Zerrin Yiğit. Impact of Sacubitril/Valsartan on Lipid Parameters in Patients with Heart Failure with Reduced Ejection Fraction.
Clinical drug investigation.
2022 Jun; 42(6):533-540. doi:
10.1007/s40261-022-01161-7. [PMID: 35635714] - James P Curtain, Ross T Campbell, Mark C Petrie, Alice M Jackson, William T Abraham, Akshay S Desai, Kenneth Dickstein, Lars Køber, Jean L Rouleau, Karl Swedberg, Michael R Zile, Scott D Solomon, Pardeep S Jhund, John J V McMurray. Clinical Outcomes Related to Background Diuretic Use and New Diuretic Initiation in Patients With HFrEF.
JACC. Heart failure.
2022 Jun; 10(6):415-427. doi:
10.1016/j.jchf.2022.01.020. [PMID: 35654526] - Alice M Jackson, Lina Benson, Gianluigi Savarese, Camilla Hage, Pardeep S Jhund, Mark C Petrie, Ulf Dahlström, John J V McMurray, Lars H Lund. Apparent Treatment-Resistant Hypertension Across the Spectrum of Heart Failure Phenotypes in the Swedish HF Registry.
JACC. Heart failure.
2022 Jun; 10(6):380-392. doi:
10.1016/j.jchf.2022.04.006. [PMID: 35654522] - Patrick Savage, Brian Cox, Katie Linden, Jaimie Coburn, Michael Shahmohammadi, Ian Menown. Advances in Clinical Cardiology 2021: A Summary of Key Clinical Trials.
Advances in therapy.
2022 06; 39(6):2398-2437. doi:
10.1007/s12325-022-02136-y. [PMID: 35482250] - Paolo Tolomeo, Ottavio Zucchetti, Emanuele D'Aniello, Noemi Punzo, Federico Marchini, Luca Di Ienno, Elisabetta Tonet, Rita Pavasini, Claudio Rapezzi, Gianluca Campo, Matteo Serenelli. Left ventricular output indices and sacubitril/valsartan titration: role of stroke volume index.
ESC heart failure.
2022 06; 9(3):2037-2043. doi:
10.1002/ehf2.13891. [PMID: 35318819] - Thibault Michel, Hélène Nougué, Jérôme Cartailler, Guillaume Lefèvre, Malha Sadoune, François Picard, Alain Cohen-Solal, Damien Logeart, Jean-Marie Launay, Nicolas Vodovar. proANP Metabolism Provides New Insights Into Sacubitril/Valsartan Mode of Action.
Circulation research.
2022 05; 130(11):e44-e57. doi:
10.1161/circresaha.122.320882. [PMID: 35485239] - Shanshan Zhou, Xiaocong Wang, Hui Xu, Jing Li, Liping Zhang, Hang Li. Fabry disease with acute myocardial infarction, left ventricular thrombosis, and pericardial effusion: A case report.
Medicine.
2022 May; 101(21):e29427. doi:
10.1097/md.0000000000029427. [PMID: 35623077] - Simon Thonsgaard, Timothy C R Prickett, Lasse H Hansen, Nicolai J Wewer Albrechtsen, Ulrik Ø Andersen, Dijana Terzic, Peter Plomgaard, Finn Gustafsson, Jens P Goetze, Peter D Mark. Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men.
Clinical chemistry.
2022 05; 68(5):713-720. doi:
10.1093/clinchem/hvac005. [PMID: 35175317] - Giovanni Battista Bolla, Antonella Fedele, Andrea Faggiano, Carla Sala, Gloria Santangelo, Stefano Carugo. Effects of Sacubitril/Valsartan on biomarkers of fibrosis and inflammation in patients with heart failure with reduced ejection fraction.
BMC cardiovascular disorders.
2022 05; 22(1):217. doi:
10.1186/s12872-022-02647-0. [PMID: 35562650] - Geert H D Voordes, Hiddo J L Heerspink, Jozine M Ter Maaten. The interplay between sacubitril/valsartan, heart failure with preserved ejection fraction, diabetes and kidney function.
European journal of heart failure.
2022 May; 24(5):804-806. doi:
10.1002/ejhf.2501. [PMID: 35415946] - Alexander Peikert, Muthiah Vaduganathan, Finnian Mc Causland, Brian L Claggett, Safia Chatur, Milton Packer, Marc A Pfeffer, Faiez Zannad, Martin P Lefkowitz, Burkert Pieske, Hans-Dirk Düngen, John J V McMurray, Scott D Solomon. Effects of sacubitril/valsartan versus valsartan on renal function in patients with and without diabetes and heart failure with preserved ejection fraction: insights from PARAGON-HF.
European journal of heart failure.
2022 May; 24(5):794-803. doi:
10.1002/ejhf.2450. [PMID: 35119183] - Giuseppe M C Rosano, Simone Celant, Pier Paolo Olimpieri, Antonietta Colatrella, Graziano Onder, Andrea Di Lenarda, Giuseppe Ambrosio, Gianpaolo Reboldi, Gian Franco Gensini, Furio Colivicchi, Pierluigi Russo. Impact of the COVID-19 pandemic on prescription of sacubitril/valsartan in Italy.
European journal of heart failure.
2022 May; 24(5):855-860. doi:
10.1002/ejhf.2490. [PMID: 35303393] - Niti M Patel, Britney A Stottlemyer, Matthew P Gray, Richard D Boyce, Sandra L Kane-Gill. A Pharmacovigilance Study of Adverse Drug Reactions Reported for Cardiovascular Disease Medications Approved Between 2012 and 2017 in the United States Food and Drug Administration Adverse Event Reporting System (FAERS) Database.
Cardiovascular drugs and therapy.
2022 04; 36(2):309-322. doi:
10.1007/s10557-021-07157-3. [PMID: 33599896] - Pei-Hsun Sung, Han-Tan Chai, Chih-Chao Yang, John Y Chiang, Chih-Hung Chen, Yi-Ling Chen, Hon-Kan Yip. Combined levosimendan and Sacubitril/Valsartan markedly protected the heart and kidney against cardiorenal syndrome in rat.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112745. doi:
10.1016/j.biopha.2022.112745. [PMID: 35202913] - Ulrich Salzer, Alisa Müller, Qian Zhou, Alexandra Nieters, Sebastian Grundmann, Claudia Wehr. Susceptibility to infections and adaptive immunity in adults with heart failure.
ESC heart failure.
2022 04; 9(2):1195-1205. doi:
10.1002/ehf2.13793. [PMID: 35032103] - Kristian Hellenkamp, Kathleen Nolte, Stephan von Haehling. Pharmacological treatment options for heart failure with reduced ejection fraction: A 2022 update.
Expert opinion on pharmacotherapy.
2022 Apr; 23(6):673-680. doi:
10.1080/14656566.2022.2047647. [PMID: 35260016] - Nathalie Esser, Stephen M Mongovin, Jacqueline Parilla, Breanne M Barrow, Thomas O Mundinger, Brendy S Fountaine, Megan J Larmore, Joseph J Castillo, Rehana Akter, Rebecca L Hull, Sakeneh Zraika. Neprilysin inhibition improves intravenous but not oral glucose-mediated insulin secretion via GLP-1R signaling in mice with β-cell dysfunction.
American journal of physiology. Endocrinology and metabolism.
2022 03; 322(3):E307-E318. doi:
10.1152/ajpendo.00234.2021. [PMID: 35128957] - Johann Bauersachs, Rudolf A de Boer, JoAnn Lindenfeld, Biykem Bozkurt. The year in cardiovascular medicine 2021: heart failure and cardiomyopathies.
European heart journal.
2022 Feb; 43(5):367-376. doi:
10.1093/eurheartj/ehab887. [PMID: 34974611] - Michael Böhm, Birgit Assmus, Stefan D Anker, Folkert W Asselbergs, Johannes Brachmann, Marie-Elena Brett, Jasper J Brugts, Georg Ertl, AiJia Wang, Lutz Hilker, Friedrich Koehler, Stephan Rosenkranz, David M Leistner, Amr Abdin, Jan Wintrich, Qian Zhou, Philip B Adamson, Christiane E Angermann. Less loop diuretic use in patients on sacubitril/valsartan undergoing remote pulmonary artery pressure monitoring.
ESC heart failure.
2022 02; 9(1):155-163. doi:
10.1002/ehf2.13665. [PMID: 34738340] - Jiafang Yao, Dan Liu. Clinical Effect of Qili Qiangxin Capsule Combined with Sacubitril-Valsartan in Patients with Chronic Heart Failure.
Journal of healthcare engineering.
2022; 2022(?):8598806. doi:
10.1155/2022/8598806. [PMID: 35368935] - Zhonglin Feng, Xipei Wang, Li Zhang, Rizvangul Apaer, Lixia Xu, Jianchao Ma, Xinyi Li, Huimin Che, Bin Tang, Yuwang Xiong, Yubin Xia, Jie Xiao, Xiaoyan Su, Yamei Wang, Xianrui Dou, Jinzhong Chen, Lifan Mei, Zhiqiang Xue, Yuanyuan Kong, Sijia Li, Hong Zhang, Ting Lin, Feng Wen, Xia Fu, Yiming Tao, Lei Fu, Zhuo Li, Renwei Huang, Zhiming Ye, Chaosheng He, Wei Shi, Xinling Liang, Guibao Ke, Shuangxin Liu. Pharmacokinetics and Pharmacodynamics of Sacubitril/Valsartan in Maintenance Hemodialysis Patients with Heart Failure.
Blood purification.
2022; 51(3):270-279. doi:
10.1159/000519643. [PMID: 34753147] - Bharathi Upadhya, Patrick M Kozak, Richard Brandon Stacey, Ramachandran S Vasan. Newer Drugs to Reduce High Blood Pressure and Mitigate Hypertensive Target Organ Damage.
Current hypertension reports.
2022 01; 24(1):1-20. doi:
10.1007/s11906-022-01166-9. [PMID: 35165832] - Haiping Du, Xiao Li, Weifang Zhao, Ning Jiang. The Difference between Sacubitril Valsartan and Valsartan on Vascular Endothelial Function, APN, MMP-9, and BNP Levels in Patients with Hypertension and Chronic Heart Failure.
Journal of healthcare engineering.
2022; 2022(?):9494981. doi:
10.1155/2022/9494981. [PMID: 35222898] - Iuliia Polina, Morgan J Spicer, Mark Domondon, Ryan S Schibalski, Elizaveta Sarsenova, Regina F Sultanova, Daria V Ilatovskaya. Inhibition of neprilysin with sacubitril without RAS blockage aggravates renal disease in Dahl SS rats.
Renal failure.
2021 Dec; 43(1):315-324. doi:
10.1080/0886022x.2021.1879856. [PMID: 33541194] - Bo Xiong, Dan Nie, Jun Qian, Yuanqing Yao, Gang Yang, Shunkang Rong, Que Zhu, Yun Du, Yonghong Jiang, Jing Huang. The benefits of sacubitril-valsartan in patients with acute myocardial infarction: a systematic review and meta-analysis.
ESC heart failure.
2021 12; 8(6):4852-4862. doi:
10.1002/ehf2.13677. [PMID: 34716749] - Xuefei Liu, Kaushik P Patel, Hong Zheng. Role of Renal Sympathetic Nerves in GLP-1 (Glucagon-Like Peptide-1) Receptor Agonist Exendin-4-Mediated Diuresis and Natriuresis in Diet-Induced Obese Rats.
Journal of the American Heart Association.
2021 11; 10(21):e022542. doi:
10.1161/jaha.121.022542. [PMID: 34713714] - Valentin R Teyssier, François Tournoux, José-Mathieu Simard, Fleur Gaudette, Mehdi Boudjemeline, Daniil R Petrenyov, Jean N DaSilva. Novel O-[11C]-methylated derivatives of the neprilysin inhibitor sacubitril: Radiosynthesis, autoradiography and plasma stability evaluation.
Nuclear medicine and biology.
2021 Nov; 102-103(?):34-44. doi:
10.1016/j.nucmedbio.2021.09.001. [PMID: 34601168] - Roberto Pontremoli, Claudio Borghi, Pasquale Perrone Filardi. Renal protection in chronic heart failure: focus on sacubitril/valsartan.
European heart journal. Cardiovascular pharmacotherapy.
2021 09; 7(5):445-452. doi:
10.1093/ehjcvp/pvab030. [PMID: 33822031] - Huang Kuang, Xin Huang, Zhifeng Zhou, Xuexin Cheng, Gaosi Xu. Sacubitril/valsartan in chronic kidney disease: From pharmacological mechanism to clinical application.
European journal of pharmacology.
2021 Sep; 907(?):174288. doi:
10.1016/j.ejphar.2021.174288. [PMID: 34216577] - Senthil Selvaraj, Brian L Claggett, Milton Packer, Faiez Zannad, Inder S Anand, Burkert Pieske, Ziqiang Zhao, Victor C Shi, Martin P Lefkowitz, John J V McMurray, Scott D Solomon. Effects of Sacubitril/Valsartan on Serum Lipids in Heart Failure With Preserved Ejection Fraction.
Journal of the American Heart Association.
2021 09; 10(17):e022069. doi:
10.1161/jaha.121.022069. [PMID: 33998278] - Munaza Riaz, Steven M Smith, Eric A Dietrich, Carl J Pepine, Haesuk Park. Effectiveness of sacubitril/valsartan versus aldosterone antagonists in heart failure with reduced ejection fraction: A retrospective cohort study.
Pharmacotherapy.
2021 09; 41(9):710-721. doi:
10.1002/phar.2610. [PMID: 34170559] - Yasir AlSiraj, Sean E Thatcher, Ching Ling Liang, Heba Ali, Mark Ensor, Lisa A Cassis. Therapeutic Assessment of Combination Therapy with a Neprilysin Inhibitor and Angiotensin Type 1 Receptor Antagonist on Angiotensin II-Induced Atherosclerosis, Abdominal Aortic Aneurysms, and Hypertension.
The Journal of pharmacology and experimental therapeutics.
2021 06; 377(3):326-335. doi:
10.1124/jpet.121.000525. [PMID: 33707301] - Hui-Ling Hsieh, Chun-You Chen, Cheng-Hsien Chen, Shih-Chang Hsu, Wen-Cheng Huang, Yuh-Mou Sue, Feng-Yen Lin, Chun-Ming Shih, Yue-Cune Chang, Po-Hsun Huang, Chung-Te Liu. Renal protective effect of sacubitril/valsartan in patients with heart failure.
Scientific reports.
2021 02; 11(1):4593. doi:
10.1038/s41598-021-84118-8. [PMID: 33633282] - Poonam Giri, Vipul Joshi, Shyamkumar Giri, Prashant Delvadia, Mukul R Jain. Simultaneous determination of sacubitrilat and fimasartan in rat plasma by a triple quad liquid chromatography-tandem mass spectrometry method utilizing electrospray ionization in positive mode.
Biomedical chromatography : BMC.
2021 Feb; 35(2):e4981. doi:
10.1002/bmc.4981. [PMID: 32895916] - Raed Aqel, Tareq Z Alzughayyar, Sadi A Abukhalaf, Rami A Misk, Jihad Samer Zalloum. Long-Term Mortality and Morbidity Related to Congestive Heart Failure with Reduced Ejection Fraction (CHFrEF) in Palestinian Patients Maintained on Submaximal Sacubitril/Valsartan Doses: A Pilot Study.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):1829873. doi:
10.1155/2021/1829873. [PMID: 35027945] - Yasunori Suematsu, Kohei Tashiro, Hidetaka Morita, Akihito Ideishi, Takashi Kuwano, Shin-Ichiro Miura. Angiotensin Receptor Blocker and Neprilysin Inhibitor Suppresses Cardiac Dysfunction by Accelerating Myocardial Angiogenesis in Apolipoprotein E-Knockout Mice Fed a High-Fat Diet.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2021; 2021(?):9916789. doi:
10.1155/2021/9916789. [PMID: 34394711] - Finnian R Mc Causland, Martin P Lefkowitz, Brian Claggett, Nagesh S Anavekar, Michele Senni, Mauro Gori, Pardeep S Jhund, Martina M McGrath, Milton Packer, Victor Shi, Dirk J Van Veldhuisen, Faiez Zannad, Josep Comin-Colet, Marc A Pfeffer, John J V McMurray, Scott D Solomon. Angiotensin-Neprilysin Inhibition and Renal Outcomes in Heart Failure With Preserved Ejection Fraction.
Circulation.
2020 09; 142(13):1236-1245. doi:
10.1161/circulationaha.120.047643. [PMID: 32845715] - Toshio Kawanami, Rajeshri G Karki, Emma Cody, Qian Liu, Guiqing Liang, Gary M Ksander, Dean F Rigel, Nikolaus Schiering, Yongjin Gong, Gary M Coppola, Yuki Iwaki, Robert Sun, Alan Neubert, Li Fan, Sara Ingles, Allan D'Arcy, Frederic Villard, Paul Ramage, Arco Y Jeng, Jennifer Leung-Chu, Jing Liu, Michael Beil, Fumin Fu, Wei Chen, Frederic Cumin, Christian Wiesmann, Muneto Mogi. Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
ACS medicinal chemistry letters.
2020 Feb; 11(2):188-194. doi:
10.1021/acsmedchemlett.9b00578. [PMID: 32071687] - Guoxing Wang, Qian Zhang, Wei Yuan, Junyuan Wu, Chunsheng Li. Enalapril protects against myocardial ischemia/reperfusion injury in a swine model of cardiac arrest and resuscitation.
International journal of molecular medicine.
2016 Nov; 38(5):1463-1473. doi:
10.3892/ijmm.2016.2737. [PMID: 27633002] - Jessie Gu, Adele Noe, Priya Chandra, Suliman Al-Fayoumi, Monica Ligueros-Saylan, Ramesh Sarangapani, Suzanne Maahs, Gary Ksander, Dean F Rigel, Arco Y Jeng, Tsu-Han Lin, Weiyi Zheng, William P Dole. Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).
Journal of clinical pharmacology.
2010 Apr; 50(4):401-14. doi:
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